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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

189 managers (199 13F filers) reported a position in SYRE shares at 2026-03-31, 82,677,179 shares in all. 51 filers opened a position and 11 filers sold out during the quarter.

Managers
189
13F filers
199
New
51
Added
67
Reduced
49
Sold out
11
Shares held by filers
82,677,179

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC11,781,024$594M0.03%+142,20513F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.5,521,221$278M<0.01%-88013F-HRTimelineGroup
VANGUARD GROUP INCgroup of 7 filers holding4,188,765$211MnewTimeline
RTW INVESTMENTS, LP4,171,996$210M2.09%013F-HRTimeline
Fairmount Funds Management LLCin group Fairmount Funds Management LLC4,018,101$203M14.64%013F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC3,783,225$191M3.77%+714,00013F-HR/ATimelineGroup
Venrock Adviser, LLC3,685,448$186M6.94%013F-HRTimeline
Driehaus Capital Management LLC2,790,785$141M1.03%-91,63513F-HRTimeline
STATE STREET CORPin group STATE STREET CORP2,607,031$131M<0.01%+344,19213F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,957,266$98.7M2.02%+490,00013F-HRTimelineGroup
Commodore Capital LPin group Commodore Capital LP1,912,380$96.5M5.58%-475,86513F-HRTimelineGroup
TCG Crossover Management, LLC1,900,582$95.9M2.74%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,892,200$95.4M4.85%013F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,824,811$92M0.02%+275,52713F-HRTimelineGroup
Capital International Investorsin group Capital International Investo…1,746,129$88.1M0.02%-1,746,41213F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,720,912$86.8M0.01%+61,77213F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,656,164$83.6M0.04%-172,84513F-HR/ATimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,621,620$81.8M0.87%013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,598,730$80.6M0.01%-3,15213F-HRTimeline
Remedium Capital Partners, LLC1,456,231$73.5M26.13%013F-HR/ATimeline
Affinity Asset Advisors, LLC1,279,134$64.5M3.78%-153,45713F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,228,093$61.9M<0.01%+808,36613F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding1,021,478$51.5M-27,002Timeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,000,000$50.4M0.29%013F-HRTimelineGroup
BRAIDWELL LP932,823$47.1M1.57%-701,79213F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources882,833$44.5M0.01%-226,44113F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO979,299$44.5M<0.01%+916,34813F-HR/ATimelineGroup
UBS Group AGgroup of 2 filers holding878,549$44.3M+135,767Timeline
Caligan Partners LP878,127$44.3M3.13%new13F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.818,598$41.3M1.14%013F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc792,847$40M0.17%+52,52113F-HRTimelineGroup
Capital World Investors666,564$33.6M<0.01%+466,39213F-HRTimeline
Candriam S.C.A.610,282$30.8M0.16%+184,74813F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP578,907$29.2M<0.01%+17,88413F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co562,653$28.4M<0.01%-11,96913F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…491,649$24.8M0.03%-422,31113F-HRTimelineGroup
SAMLYN CAPITAL, LLCin group SAMLYN CAPITAL, LLC396,661$20M0.34%new13F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC338,323$17.1M1.03%+304,27213F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.292,847$14.8M0.05%-208,15113F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
VICTORY CAPITAL MANAGEMENT INC292,126$14.7M0.01%+146,04713F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC269,938$13.6M<0.01%-5,12713F-HRTimelineGroup
Woodline Partners LP265,892$13.4M0.05%013F-HR/ATimeline
MORGAN STANLEYin group MORGAN STANLEY246,719$12.4M<0.01%+63,98513F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC193,031$9.74M0.22%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp191,395$9.65M<0.01%-1,43513F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…186,618$9.41M1.11%-1,11913F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP178,389$9M0.01%new13F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …170,381$8.59M0.01%-83013F-HRTimelineGroup
STEMPOINT CAPITAL LP167,606$8.45M1.62%+135,22913F-HR/ATimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC159,217$8.03M<0.01%+120,96113F-HR/ATimelineGroup
Nuveen, LLCin group TIAA153,899$7.76M<0.01%+2,91913F-HRTimelineGroup
Ensign Peak Advisors, Inc148,537$7.49M0.01%new13F-HR/ATimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC146,639$7.4M0.01%+70,44513F-HRTimelineGroup
HighVista Strategies LLC146,264$7.38M2.04%-41,94213F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP139,259$7.02M0.01%new13F-HRTimelineGroup
TD Asset Management Inc137,390$6.93M0.01%-12,43213F-HRTimeline
Invesco Ltd.in group Invesco Ltd.132,390$6.68M<0.01%-18,54413F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\129,242$6.52M<0.01%+7,30113F-HRTimelineGroup
ARMISTICE CAPITAL, LLC120,931$6.1M0.2%-75,49513F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …112,841$5.69M<0.01%-16,17213F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC108,135$5.45M<0.01%+44,23113F-HRTimelineGroup
SEVEN GRAND MANAGERS, LLC100,000$5.04M0.34%013F-HRTimeline
B Group, Inc.100,000$5.04M3.74%013F-HRTimeline
F/m Investments LLC99,460$5.02M0.33%-4,25813F-HRTimeline
Swiss National Bank96,500$4.87M<0.01%013F-HRTimeline
ExodusPoint Capital Management, LP87,065$4.39M0.04%+49,19413F-HRTimeline
RHUMBLINE ADVISERS85,121$4.29M<0.01%+2,16513F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding82,063$4.14M+22,851Timeline
MERCER GLOBAL ADVISORS INC /ADV71,091$3.59M0.01%-35,22513F-HRTimeline
Atle Fund Management AB62,735$3.49M1.13%new13F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…64,002$3.23M0.01%+63,45313F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC63,939$3.23M0.02%+23113F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC59,555$3M<0.01%new13F-HRTimelineGroup
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC59,453$3M0.01%new13F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…59,242$2.99M<0.01%+11,20413F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP63,684$2.89M<0.01%+2,11013F-HRTimeline
Rafferty Asset Management, LLC56,920$2.87M0.01%+3,51013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management55,477$2.8M0.01%-17,98813F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC53,970$2.72M<0.01%+26,69313F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP47,697$2.41M<0.01%-29,59313F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.70,900$2.32M<0.01%+3,40013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC45,786$2.31M<0.01%-136,73813F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc44,792$2.26M<0.01%-11,65613F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding40,420$2.02M+1,506Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…38,407$1.94M0.01%+39613F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN33,208$1.68M<0.01%-49,20813F-HR/ATimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al27,550$1.39M0.01%+2,60013F-HRTimeline
Cinctive Capital Management LP27,430$1.38M0.09%-8,50513F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD26,523$1.34M<0.01%-72913F-HRTimeline
PROFUND ADVISORS LLC26,043$1.31M0.05%+5,45013F-HRTimeline
Waverly Advisors, LLC25,966$1.31M0.01%+1213F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$1.3M0.01%013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd24,435$1.23M0.02%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND22,265$1.12M<0.01%+3,10013F-HRTimeline
Ellsworth Advisors, LLC21,963$1.11M0.21%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC20,874$1.05M<0.01%+3,05413F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC19,755$996K<0.01%new13F-HRTimelineGroup
Seven Fleet Capital Management LP19,690$993K0.31%new13F-HR/ATimeline
Assenagon Asset Management S.A.18,647$941K<0.01%-3,48913F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS18,630$940K<0.01%+6,78613F-HRTimelineGroup
Police & Firemen's Retirement System of…18,360$926K0.01%013F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …18,184$917K0.1%013F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC16,873$851K0.02%new13F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…16,720$843K<0.01%+2213F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC16,443$829K0.01%-1,83113F-HRTimeline
Creative Planningin group Creative Planning15,486$781K<0.01%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…13,955$704K<0.01%+2,79113F-HRTimeline
China Universal Asset Management Co., L…13,938$703K0.05%+1,29413F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…13,905$701K<0.01%+4,87513F-HRTimeline
ProShare Advisors LLC13,498$681K<0.01%-2,49113F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM13,438$678K<0.01%-35913F-HRTimeline
SG Americas Securities, LLC13,396$676K<0.01%-9,94713F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC12,400$625K<0.01%new13F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC12,006$606K<0.01%-88,05213F-HRTimelineGroup
KLP KAPITALFORVALTNING AS10,900$550K<0.01%+50013F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…9,931$501K<0.01%+4,37713F-HRTimelineGroup
Carlyle Group Inc.in group Carlyle Group Inc.9,620$485K<0.01%013F-HRTimelineGroup
Man Group plcin group Man Group plc9,546$482K<0.01%new13F-HRTimelineGroup
MARTINGALE ASSET MANAGEMENT L P9,080$458K0.01%+2,15013F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO8,975$453K<0.01%+2,85813F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…8,790$443K0.01%+8,36513F-HRTimelineGroup
Bridgefront Capital, LLC8,652$436K0.11%new13F-HRTimeline
TUDOR INVESTMENT CORP ET AL8,364$422K<0.01%-1,76313F-HRTimeline
RWC Asset Management LLPin group RWC ASSET ADVISORS (US) LLC8,166$412K0.02%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…8,110$409K0.11%+19713F-HRTimelineGroup
Virtu Financial LLCin group Virtu Financial LLC8,091$408K0.02%new13F-HRTimelineGroup
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…7,537$380K<0.01%new13F-HRTimelineGroup
E Fund Management Co., Ltd.7,156$361K0.01%13F-HRTimeline
Scientech Research LLC7,088$358K0.3%new13F-HRTimeline
TWO SIGMA SECURITIES, LLC6,851$346K0.04%new13F-HRTimeline
AlphaCentric Advisors LLC6,634$335K0.33%new13F-HRTimeline
XPONANCE LLC6,445$325K<0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS6,280$317K<0.01%-89313F-HRTimeline
Arrowpoint Investment Partners (Singapo…in group Arrowpoint Investment Partner…6,140$310K0.45%-7,58413F-HRTimelineGroup
High Net Worth Advisory Group LLC6,000$303K0.07%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC5,858$295K<0.01%-7,02413F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,593$282K0.01%013F-HRTimelineGroup
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…5,200$262K0.02%new13F-HRTimelineGroup
PSP Research LLC5,159$260K0.18%-10,68113F-HRTimeline
Persistent Asset Partners Ltd4,803$242K0.09%+2,55713F-HRTimeline
DeepCurrents Investment Group LLC4,740$239K0.01%new13F-HRTimeline
Quantinno Capital Management LP4,561$230K<0.01%new13F-HRTimeline
STRS OHIO4,500$227K<0.01%new13F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC4,299$217K<0.01%new13F-HRTimelineGroup
ABS Direct Equity Fund LLC2,800$194K0.15%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA3,250$164K<0.01%+1,26213F-HRTimelineGroup
Union Bancaire Privee, UBP SA3,880$159K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC2,105$106K<0.01%+13513F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC1,916$96.6K<0.01%+1,21113F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,743$87.9K<0.01%+22013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…1,589$80K<0.01%013F-HRTimeline
KBC Group NVin group KBC Group NV1,372$69K<0.01%new13F-HRTimelineGroup
Sterling Capital Management LLC1,051$53K<0.01%-55913F-HRTimeline
Patient Square Capital LP1,000$50.4K0.01%-149,00013F-HRTimeline
GROUP ONE TRADING LLC901$45.4K<0.01%+50113F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …888$44.8K<0.01%+23213F-HRTimelineGroup
Neo Ivy Capital Management598$30.2K0.01%-17,66313F-HRTimeline
Kemnay Advisory Services Inc.574$29K<0.01%new13F-HRTimeline
SUMMIT SECURITIES GROUP LLC562$28.3K0.01%new13F-HRTimeline
GAMMA Investing LLC523$26.4K<0.01%+19313F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.498$25.1K<0.01%+13113F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.288$14.5K<0.01%+4813F-HR/ATimelineGroup
Caitong International Asset Management …286$14.4K<0.01%new13F-HRTimeline
Delos Wealth Advisors, LLC250$12.6K0.01%new13F-HRTimeline
QUADRANT CAPITAL GROUP LLC146$7.37K<0.01%new13F-HR/ATimeline
Smartleaf Asset Management LLC157$7.13K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…123$6.2K<0.01%+3713F-HRTimelineGroup
Allworth Financial LP117$5.9K<0.01%+5913F-HRTimeline
ROTHSCHILD INVESTMENT LLC99$4.99K<0.01%+1713F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\97$4.89K<0.01%+8713F-HRTimelineGroup
Quantbot Technologies LP88$4.44K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…79$3.98K<0.01%+1413F-HR/ATimelineGroup
Farther Finance Advisors, LLC74$3.62K<0.01%+3713F-HRTimeline
SIGNATUREFD, LLC70$3.53K<0.01%013F-HRTimeline
Larson Financial Group LLC36$1.82K<0.01%-10813F-HRTimeline
Parkside Financial Bank & Trust35$1.77K<0.01%013F-HRTimeline
Parallel Advisors, LLC32$1.61K<0.01%new13F-HR/ATimeline
IFP Advisors, Inc24$1.21K<0.01%013F-HRTimeline
Arax Advisory Partners18$908<0.01%new13F-HRTimeline
Bare Financial Services, Inc16$807<0.01%new13F-HRTimeline
MAI Capital Management13$656<0.01%new13F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…5$252<0.01%new13F-HRTimelineGroup
SBI Securities Co., Ltd.5$252<0.01%013F-HRTimeline
Keating Financial Advisory Services, In…4$202<0.01%new13F-HRTimeline
MassMutual Private Wealth & Trust, FSB3$151<0.01%new13F-HRTimeline
TWIN PEAKS WEALTH ADVISORS, LLC3$151<0.01%new13F-HRTimeline
Essential Partners LLC2$101<0.01%new13F-HRTimeline
Covestor Ltd4$00%-213F-HRTimelineValue filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Fairmount Funds Management LLC and 3 other reporting persons reported 10,185,961 SYRE shares, 9.99% of the class, as of 2026-10-07, in a 13D/A filed 2026-10-09. 0001104659-26-115087

    Accepted , ingested

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested