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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

128 managers (131 13F filers) reported a position in SYRE shares at 2025-03-31, 62,108,057 shares in all. 19 filers opened a position and 21 filers sold out during the quarter.

Managers
128
13F filers
131
New
19
Added
52
Reduced
35
Sold out
21
Shares held by filers
62,108,057

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2025

Filers in the available 13F reports with a share position at 2025-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC9,038,553$146M0.01%+237,28713F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC4,018,101$64.8M10.06%013F-HRTimelineGroup
RTW INVESTMENTS, LP3,621,996$58.4M0.89%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.3,572,674$57.6M<0.01%+173,08313F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,898,267$46.8M<0.01%+51,79413F-HRTimelineGroup
Driehaus Capital Management LLC2,717,312$43.8M0.42%-86,34313F-HRTimeline
Venrock Adviser, LLC2,685,448$43.3M3.69%013F-HRTimeline
BRAIDWELL LP2,578,404$41.6M1.46%013F-HRTimeline
Capital International Investorsin group Capital International Investo…2,392,541$38.6M0.01%new13F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,313,272$37.3M1.32%-261,45113F-HR/ATimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …2,127,205$34.3M1.58%+600,00013F-HRTimelineGroup
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC2,050,000$33.1M1.83%new13F-HRTimelineGroup
Commodore Capital LPin group Commodore Capital LP1,988,084$32.1M2.36%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,697,115$27.4M<0.01%+16,17913F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,593,678$25.7M<0.01%-10,83013F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.1,248,854$20.2M0.35%+31,90013F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,041,410$18.7M0.01%-415,33013F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…1,068,892$17.2M0.02%-23,23213F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,059,563$17.1M<0.01%+93,43413F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding937,249$15.1M+4,074Timeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc825,000$13.3M0.08%+75,00013F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…803,200$13M0.02%-226,80013F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources760,628$12.3M<0.01%-1413F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding604,381$9.75M+163,203Timeline
Blackstone Inc.in group Blackstone Inc.489,248$7.89M0.03%+40,04713F-HRTimelineGroup
Affinity Asset Advisors, LLC481,678$7.77M1.22%-342,65013F-HRTimeline
Woodline Partners LP464,808$7.5M0.05%+112,12813F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…450,000$7.26M0.14%013F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/427,075$6.89M<0.01%+419,93313F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co382,636$6.17M<0.01%+2,98613F-HR/ATimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP379,875$6.13M<0.01%+30,89213F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.368,598$5.95M0.34%-5,40213F-HR/ATimelineGroup
Capital World Investors350,774$5.66M<0.01%-27,79913F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY335,467$5.41M<0.01%+80,21113F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC257,432$4.15M0.02%+141,96213F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC251,846$4.06M<0.01%-16,23013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/248,542$4.01M<0.01%-257,90813F-HRTimeline
Candriam S.C.A.246,030$3.97M0.02%-1,56113F-HRTimeline
Deep Track Capital, LP219,015$3.53M0.11%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC214,606$3.46M<0.01%+91,53513F-HR/ATimelineGroup
ARMISTICE CAPITAL, LLC200,000$3.23M0.09%013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC197,068$3.18M<0.01%-550,48413F-HR/ATimelineGroup
Nuveen, LLCin group TIAA140,129$2.26M<0.01%13F-HRTimelineGroup
STEMPOINT CAPITAL LP136,139$2.2M0.7%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC130,884$2.11M<0.01%-948,42313F-HRTimelineGroup
SOROS FUND MANAGEMENT LLCin group SOROS FUND MANAGEMENT LLC125,000$2.02M0.04%-125,00013F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP108,504$1.95M<0.01%-5,11613F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …120,321$1.94M<0.01%-1,83213F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp114,240$1.84M<0.01%+10,55213F-HRTimelineGroup
HighVista Strategies LLC95,159$1.54M0.59%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC83,464$1.35M<0.01%+9,71213F-HRTimelineGroup
EFG Asset Management (North America) Co…82,472$1.33M0.22%-34613F-HRTimeline
Prosight Management, LP74,921$1.21M0.4%-5,07913F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC72,011$1.16M<0.01%+56,78013F-HR/ATimelineGroup
Rafferty Asset Management, LLC70,323$1.13M<0.01%-6,41713F-HRTimeline
B Group, Inc.70,000$1.13M0.98%+20,00013F-HRTimeline
Swiss National Bank68,600$1.11M<0.01%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…58,696$947K<0.01%+35,60713F-HRTimelineGroup
RHUMBLINE ADVISERS56,023$904K<0.01%-1,63413F-HR/ATimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS55,833$901K<0.01%+37,04913F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …53,901$870K<0.01%+1,13913F-HRTimelineGroup
F/m Investments LLC51,844$837K0.03%+3,03813F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO41,556$671K<0.01%+6,30813F-HRTimelineGroup
WEXFORD CAPITAL LP38,292$618K0.16%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc37,844$611K<0.01%+35413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.36,230$585K<0.01%013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD34,901$563K<0.01%+3,41713F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…32,598$526K<0.01%013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN30,035$485K<0.01%+5,31713F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding29,034$478K+4,338Timeline
XTX Topco Ltdin group XTX Topco Ltd28,499$460K0.02%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\28,483$460K<0.01%-2,93513F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$416K<0.01%013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.25,207$407K<0.01%+5,54413F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…23,733$383K<0.01%+2,35113F-HRTimelineGroup
Assenagon Asset Management S.A.22,726$367K<0.01%+7413F-HRTimeline
TD Asset Management Inc22,368$361K<0.01%-42,60013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC20,428$330K<0.01%+6,38513F-HRTimeline
Corebridge Financial, Inc.in group Corebridge Financial, Inc.19,595$316K<0.01%+2,38213F-HRTimelineGroup
NBW CAPITAL LLC19,430$314K0.07%013F-HRTimeline
Waverly Advisors, LLC19,430$314K<0.01%new13F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …18,184$293K0.04%013F-HRTimelineGroup
NATIXIS ADVISORS, LLCin group Natixis Investment Managers16,401$265K<0.01%-89913F-HRTimelineGroup
ExodusPoint Capital Management, LP15,055$243K<0.01%-1,63613F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC15,033$243K0.05%new13F-HRTimelineGroup
PROFUND ADVISORS LLC14,662$237K0.01%-20013F-HRTimeline
Aquatic Capital Management LLC12,903$208K0.01%+1,13613F-HRTimeline
China Universal Asset Management Co., L…12,087$195K0.02%-35313F-HRTimeline
ProShare Advisors LLC11,378$184K<0.01%-1,15313F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC10,348$167K<0.01%-14713F-HR/ATimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND10,265$166K<0.01%013F-HR/ATimeline
ARIZONA STATE RETIREMENT SYSTEM10,017$162K<0.01%-9813F-HRTimeline
Police & Firemen's Retirement System of…8,767$141K<0.01%+1,38913F-HRTimeline
KLP KAPITALFORVALTNING AS7,800$126K<0.01%013F-HRTimeline
SG Americas Securities, LLC7,122$115K<0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCgroup of 2 filers holding6,861$111K+3,889Timeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,046$65.3K<0.01%+65413F-HRTimelineGroup
AlphaQuest LLC3,191$51.5K0.01%+99313F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA2,172$35K<0.01%-1,85013F-HR/ATimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,044$33K<0.01%-6,53013F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…1,589$26K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,502$24.2K<0.01%+27013F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK1,470$23.7K<0.01%013F-HRTimelineGroup
AMALGAMATED BANK1,379$22K<0.01%+18113F-HRTimeline
Sterling Capital Management LLC629$10.1K<0.01%-38013F-HRTimeline
CWM, LLCin group CWM, LLC374$6K<0.01%+36613F-HRTimelineGroup
GAMMA Investing LLC270$4.36K<0.01%new13F-HR/ATimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.238$3.84K<0.01%+13313F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.206$3K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC184$2.97K<0.01%+6413F-HRTimeline
Aster Capital Management (DIFC) Ltd126$2.48K<0.01%new13F-HRTimeline
SUMMIT SECURITIES GROUP LLC133$2.15K<0.01%new13F-HRTimeline
IFP Advisors, Inc109$1.92K<0.01%013F-HRTimeline
Lindbrook Capital, LLC78$1.26K<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC50$807<0.01%+1013F-HRTimeline
Larson Financial Group LLC44$710<0.01%new13F-HRTimeline
CoreCap Advisors, LLC41$662<0.01%new13F-HRTimeline
Caitong International Asset Management …28$452<0.01%+1413F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…24$387<0.01%+1613F-HRTimelineGroup
Stephens Consulting, LLC20$323<0.01%new13F-HRTimeline
Parallel Advisors, LLC14$226<0.01%new13F-HRTimeline
Allworth Financial LP13$195<0.01%+413F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\9$145<0.01%new13F-HRTimelineGroup
SBI Securities Co., Ltd.5$81<0.01%013F-HRTimeline
Amundiin group Amundi5$70<0.01%-2713F-HRTimelineGroup
Covestor Ltd4$00%013F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Fairmount Funds Management LLC and 3 other reporting persons reported 10,185,961 SYRE shares, 9.99% of the class, as of 2026-10-07, in a 13D/A filed 2026-10-09. 0001104659-26-115087

    Accepted , ingested

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested