13F-HR filed by RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-14, with 84 holding rows worth $11,507,522,068.
- Accession
- 0001104659-26-097251
- Filer
- CIK 1346824
- Filed
- 2026-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 85 entries on the cover page, a total value of $11,507,522,068 stated on the cover page (in dollars after the unit check, H1), rows summing to $11,507,522,068 with VALUE read as dollars as filed, 13F file number 028-12884. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S | K08588103 | ORD SHS *A* | 10,281,496 | $2,742,280,613 | dollars as filed | |
| PARABILIS MEDICINES INC COM | 698955101 | Stock | 28,933,371 | $791,906,364 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,666,837 | $740,218,912 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 11,474,599 | $667,018,440 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 9,905,045 | $435,722,930 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 12,198,625 | $389,624,083 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 8,392,730 | $340,996,620 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 9,550,191 | $323,655,973 | dollars as filed | |
| HEMAB THERAPEUTICS HLDGS INC | 423494103 | COM SHS | 7,808,627 | $286,810,870 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 6,995,858 | $234,291,284 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 7,255,993 | $215,430,432 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 7,692,750 | $207,550,395 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 7,636,813 | $205,277,533 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 2,450,221 | $179,209,164 | dollars as filed | |
| SPYGLASS PHARMA INC | 85220G109 | COMMON STOCK | 8,021,117 | $178,550,064 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 17,955,642 | $174,169,727 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 11,189,693 | $171,873,684 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 23,555,648 | $160,413,963 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 15,827,186 | $158,271,860 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 26,975,505 | $156,727,684 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,246,456 | $153,937,316 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 1,132,557 | $150,924,546 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 1,554,597 | $147,950,996 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 11,300,939 | $147,364,245 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 12,036,126 | $120,240,899 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 5,743,533 | $109,127,127 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 10,860,977 | $86,996,426 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 5,274,274 | $84,915,811 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 3,671,083 | $81,571,464 | dollars as filed | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 4,526,926 | $76,595,588 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 2,208,604 | $71,680,243 | dollars as filed | |
| DEFINIUM THERAPEUTICS INC | 24477V105 | COM SHS | 1,500,000 | $70,560,000 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 12,723,026 | $67,304,808 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 5,049,779 | $67,162,061 | dollars as filed | |
| SANA BIOTECHNOLOGY INC | 799566104 | COM | 18,750,000 | $65,437,500 | dollars as filed | |
| DAMORA THERAPEUTICS INC | 36322Q206 | COMMON STOCK | 2,399,702 | $62,416,249 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 667,207 | $61,776,696 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 20,992,669 | $56,050,426 | dollars as filed | |
| GERON CORP | 374163103 | COM | 42,809,751 | $54,796,481 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 9,445,039 | $49,114,203 | dollars as filed | |
| EVOMMUNE INC | 30054Y107 | COMMON STOCK | 3,494,638 | $46,443,739 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 2,402,095 | $44,222,569 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 17,754,430 | $43,498,354 | dollars as filed | |
| AKTIS ONCOLOGY INC | 01021M104 | COMMON STOCK | 1,314,405 | $42,363,273 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 1,671,648 | $40,972,092 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 8,000,000 | $37,360,000 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 318,554 | $37,293,117 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 1,507,844 | $36,308,884 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 20,064,545 | $36,116,181 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 6,475,882 | $34,516,451 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 10,805,129 | $30,578,515 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 2,332,457 | $29,715,502 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 3,000,000 | $29,550,000 | dollars as filed | |
| EDITAS MEDICINE INC | 28106W103 | COM | 8,889,000 | $28,800,360 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 10,500,968 | $28,247,604 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 1,020,410 | $28,040,867 | dollars as filed | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 13,011,849 | $26,934,527 | dollars as filed | |
| BENITEC BIOPHARMA INC | 08205P209 | COMMON STOCK | 1,850,000 | $24,753,000 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 4,178,823 | $23,735,715 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 5,000,000 | $23,275,000 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 12,229,396 | $21,768,325 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 6,500,000 | $19,760,000 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 1,917,354 | $18,732,549 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 265,000 | $18,603,000 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 1,000,000 | $18,480,000 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 3,998,333 | $18,232,398 | dollars as filed | |
| FAETH THERAPEUTICS INC | 81728A207 | COM NEW | 722,020 | $18,050,500 | dollars as filed | |
| AURA BIOSCIENCES INC | 05153U107 | COMMON STOCK | 2,500,000 | $17,750,000 | dollars as filed | |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 4,401,500 | $17,165,850 | dollars as filed | |
| SEAPORT THERAPEUTICS INC | 81221K108 | COMMON STOCK | 700,000 | $15,204,000 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 7,124,116 | $14,889,402 | dollars as filed | |
| HELIX ACQUISITION CORP III | G4444S107 | USD CL A ORD SHS | 1,250,000 | $13,300,000 | dollars as filed | |
| WAYSTAR HLDG CORP | 946784105 | COM | 529,400 | $10,868,582 | dollars as filed | |
| EQUILLIUM INC | 29446K106 | COM | 3,096,336 | $9,908,275 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 1,864,176 | $8,612,493 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 750,000 | $8,160,000 | dollars as filed | |
| ADICET BIO INC | 007002207 | COM NEW | 932,624 | $8,057,871 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 333,333 | $7,123,326 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 450,000 | $6,723,000 | dollars as filed | |
| RANI THERAPEUTICS HLDGS INC | 753018100 | CMN | 8,500,000 | $6,463,400 | dollars as filed | |
| JATT II ACQUISITION CORP | G50765109 | ORD SHS | 500,000 | $5,680,000 | dollars as filed | |
| AMANAT ACQUISITION CORP | G0375M101 | CL A ORD | 375,000 | $3,810,000 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 2,387,744 | $859,349 | dollars as filed | |
| PALATIN TECHNOLOGIES INC | 696077601 | COM NEW | 62,124 | $670,318 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-097251 | this filing | 2026-08-14 | acceptance time not in the bulk data set |