13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-14, with 105 holding rows worth $766,539,858.
- Accession
- 0001496201-26-000004
- Filer
- CIK 1496201
- Filed
- 2026-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 106 entries on the cover page, a total value of $766,539,858 stated on the cover page (in dollars after the unit check, H1), rows summing to $766,539,858 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,500,082 | $50,822,778 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 1,469,971 | $39,659,818 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 108,265 | $28,218,190 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 150,000 | $23,737,500 | dollars as filed | put |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 1,014,606 | $22,179,287 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 100,000 | $21,606,000 | dollars as filed | call |
| BIOGEN INC COM | 09062X103 | Stock | 96,626 | $20,877,014 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 588,494 | $19,649,815 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 328,550 | $18,799,631 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 219,987 | $18,740,693 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 245,346 | $18,273,370 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 459,340 | $17,776,458 | dollars as filed | |
| NOVA LTD COM | M7516K103 | Stock | 25,169 | $13,665,257 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 118,800 | $12,666,456 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 417,564 | $12,460,110 | dollars as filed | |
| ASTRAZENECA PLC ORD | G0593M107 | ADR | 62,530 | $11,856,939 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 269,515 | $11,497,510 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 1,620,753 | $10,713,177 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 8,040 | $9,643,417 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 17,419 | $9,353,132 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 499,029 | $9,306,891 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 356,534 | $9,020,310 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 240,868 | $8,962,698 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 80,400 | $8,926,812 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 100,000 | $8,519,000 | dollars as filed | call |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 752,983 | $8,154,806 | dollars as filed | |
| Lam Research Corporation | 512807306 | COM | 18,470 | $8,003,605 | dollars as filed | |
| Applied Materials,Inc. | 038222105 | COM | 11,040 | $7,981,920 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 254,250 | $7,947,855 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 50,000 | $7,832,904 | dollars as filed | |
| Solaredge Technologies Inc Note 2.250 percent 7/0 | 83417MAE4 | Convertible | 4,000,000 | $7,747,190 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 416,417 | $7,666,237 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 30,256 | $7,613,620 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 58,600 | $7,530,100 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 28,831 | $7,322,209 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 196,408 | $7,320,126 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 720,057 | $7,294,177 | dollars as filed | |
| NUVECTIS PHARMA INC | 67080T108 | COMMON STOCK | 382,945 | $7,042,359 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 286,000 | $6,886,880 | dollars as filed | |
| HARMONY BIOSCIENCES HLDGS IN | 413197104 | COM | 176,663 | $6,432,300 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 105,000 | $6,337,800 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 483,747 | $6,308,061 | dollars as filed | |
| ZENAS BIOPHARMA INC COM | 98937L105 | Stock | 230,834 | $5,858,567 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 120,677 | $5,785,255 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 112,765 | $5,722,824 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 1,019,832 | $5,435,705 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 102,000 | $5,346,840 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 249,693 | $5,305,976 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 213,671 | $5,237,076 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 94,265 | $5,184,575 | dollars as filed | |
| SATELLOS BIOSCIENCE INC | 80401L803 | COM | 652,590 | $5,073,887 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 2,257,106 | $4,717,352 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 1,191,187 | $4,693,277 | dollars as filed | |
| VISTRA CORP COM | 92840M102 | Stock | 29,450 | $4,671,654 | dollars as filed | |
| TALEN ENERGY CORP COM | 87422Q109 | Stock | 12,135 | $4,662,995 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 756,164 | $4,657,970 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 63,538 | $4,647,169 | dollars as filed | |
| GLOBAL X FDS | 37954Y442 | CLOUD COMPUTNG | 195,900 | $4,454,766 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 199,594 | $4,432,983 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 233,836 | $4,375,072 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 232,294 | $4,292,793 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M505 | COM SHS | 325,591 | $4,284,784 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 422,051 | $4,220,510 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 22,400 | $4,195,072 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 12,500 | $4,184,875 | dollars as filed | call |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 1,329,012 | $4,133,227 | dollars as filed | |
| GENERATE BIOMEDICINES INC | 370920100 | COMMON STOCK | 245,000 | $4,133,150 | dollars as filed | |
| ISHARES TR | 464287432 | 20 YR TR BD ETF | 47,000 | $4,061,740 | dollars as filed | call |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 273,192 | $4,015,922 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 545,816 | $3,940,792 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 638,272 | $3,708,360 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 244,961 | $3,659,717 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 1,353,000 | $3,639,570 | dollars as filed | |
| BRIDGEBIO ONCOLOGY THERAPEUT | 107924102 | COM NEW | 460,985 | $3,512,706 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 879,000 | $3,296,250 | dollars as filed | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 1,757,458 | $3,268,872 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 10,800 | $3,251,124 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 295,039 | $3,236,578 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 81,796 | $3,186,772 | dollars as filed | |
| ORMAT TECHNOLOGIES INC | 686688102 | COM | 28,015 | $3,050,834 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 183,475 | $3,007,155 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 926,004 | $2,824,312 | dollars as filed | |
| IMMIX BIOPHARMA INC | 45258H106 | COMMON STOCK | 270,000 | $2,783,700 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 7,500 | $2,715,900 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 20,000 | $2,665,200 | dollars as filed | put |
| BIOHAVEN LTD | G1110E107 | COM | 164,437 | $2,446,823 | dollars as filed | |
| CONSTELLATION ENERGY CORP COM | 21037T109 | Stock | 9,850 | $2,446,445 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 632,632 | $2,416,654 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 127,600 | $1,856,580 | dollars as filed | call |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 120,200 | $1,748,910 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 250,000 | $1,702,500 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 28,600 | $1,534,962 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 219,700 | $1,520,324 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 427,554 | $1,496,439 | dollars as filed | |
| ORGANOGENESIS HOLDINGS INC | 68621F102 | COMMON STOCK | 550,000 | $1,336,500 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 649,309 | $1,318,097 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 100,000 | $1,083,000 | dollars as filed | call |
| CURIS INC | 231269309 | COM | 98,996 | $1,033,717 | dollars as filed | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 86,461 | $600,039 | dollars as filed | |
| FIRST TRACKS BIOTHERAPEUTICS | 337185102 | ORD SHS *A* | 27,876 | $560,865 | dollars as filed | |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 678,928 | $470,701 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 398,486 | $336,043 | dollars as filed | |
| EVOMMUNE INC | 30054Y107 | COMMON STOCK | 22,632 | $300,779 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $225,589 | dollars as filed | |
| APREA THERAPEUTICS INC | 03836J201 | COM NEW | 270,000 | $216,621 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-26-000004 | this filing | 2026-08-14 | acceptance time not in the bulk data set |