13F-HR filed by Siren, L.L.C.
Siren, L.L.C. filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-13, with 117 holding rows worth $4,941,404,255.
- Accession
- 0002005245-26-000008
- Filer
- CIK 2005245
- Filed
- 2026-08-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 119 entries on the cover page, a total value of $4,941,404,255 stated on the cover page (in dollars after the unit check, H1), rows summing to $4,941,404,255 with VALUE read as dollars as filed, 13F file number 028-24464. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerInvus Financial Advisors, LLC028-19938
- included managerInvus Group, LLC028-24462
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 9,575,013 | $526,625,715 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 2,935,830 | $336,651,626 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 11,397,781 | $208,807,348 | dollars as filed | |
| VERADERMICS INC | 922967104 | COMMON STOCK | 1,655,374 | $203,511,680 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 6,179,364 | $193,166,919 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 900,000 | $168,552,000 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 5,602,970 | $166,352,179 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 1,715,476 | $139,828,449 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 465,000 | $132,511,050 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 3,184,629 | $129,391,476 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 1,136,275 | $126,160,613 | dollars as filed | |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 44,303,518 | $106,328,443 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 1,774,411 | $90,051,358 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 968,598 | $85,992,130 | dollars as filed | |
| PARABILIS MEDICINES INC COM | 698955101 | Stock | 2,992,259 | $81,898,129 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 1,318,564 | $79,588,523 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 7,690,405 | $76,827,146 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 576,000 | $76,757,760 | dollars as filed | |
| HEMAB THERAPEUTICS HLDGS INC | 423494103 | COM SHS | 2,086,834 | $76,649,413 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 2,420,430 | $74,621,857 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 1,859,279 | $71,954,097 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 3,650,000 | $68,291,500 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 9,846,579 | $67,055,203 | dollars as filed | |
| DEFINIUM THERAPEUTICS INC | 24477V105 | COM SHS | 1,419,493 | $66,772,951 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 1,995,347 | $65,287,754 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 888,401 | $64,977,649 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 758,952 | $64,655,121 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 1,900,000 | $63,631,000 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 4,856,949 | $60,760,432 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 1,420,788 | $53,165,887 | dollars as filed | |
| KAILERA THERAPEUTICS INC | 482931102 | COMMON STOCK | 2,214,286 | $48,780,721 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 2,129,125 | $47,287,866 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 872,967 | $46,852,139 | dollars as filed | |
| TABOOLA.COM LTD | M8744T106 | ORD SHS | 8,423,410 | $42,117,050 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 257,485 | $39,348,858 | dollars as filed | |
| SILENCE THERAPEUTICS PLC | 82686Q101 | ADS | 3,311,438 | $36,359,589 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 1,396,513 | $35,918,314 | dollars as filed | |
| REMITLY GLOBAL INC | 75960P104 | COM | 1,543,271 | $34,584,703 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,893,410 | $34,478,996 | dollars as filed | |
| CAPITAL ONE FINL CORP | 14040H105 | COM | 171,615 | $34,429,401 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 1,786,867 | $33,325,070 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 2,998,192 | $32,470,419 | dollars as filed | |
| Alphabet Inc. Reg. Shares A | 02079K305 | COM | 90,000 | $32,163,300 | dollars as filed | |
| DBV TECHNOLOGIES S A | 23306J309 | SPONSORED ADS | 1,857,362 | $30,460,737 | dollars as filed | |
| ABSCI CORPORATION | 00091E109 | COM | 2,474,764 | $28,682,515 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 610,515 | $26,856,555 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 641,469 | $26,730,013 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 1,480,586 | $26,591,325 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 4,458,646 | $25,458,869 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 270,118 | $25,010,226 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 250,000 | $23,792,500 | dollars as filed | |
| SEAPORT THERAPEUTICS INC | 81221K108 | COMMON STOCK | 1,095,316 | $23,790,264 | dollars as filed | |
| DAMORA THERAPEUTICS INC | 36322Q206 | COMMON STOCK | 900,000 | $23,409,000 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 725,000 | $23,156,500 | dollars as filed | |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 3,734,866 | $22,035,709 | dollars as filed | |
| TAIWAN SEMICONDUCTOR MFG | 874039100 | SPONSORED ADS | 44,700 | $21,347,379 | dollars as filed | |
| NVIDIA Corp | 67066G104 | COM | 95,000 | $19,008,550 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 3,328,287 | $17,307,092 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 450,000 | $16,128,000 | dollars as filed | |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 8,497,822 | $14,446,297 | dollars as filed | |
| NEBIUS GROUP N.V. | N97284108 | SHS CLASS A | 52,000 | $14,360,840 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 37,500 | $13,988,250 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 3,457,711 | $12,966,416 | dollars as filed | |
| GENERATE BIOMEDICINES INC | 370920100 | COMMON STOCK | 736,104 | $12,418,075 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 5,850,000 | $11,875,500 | dollars as filed | |
| ADAGENE INC | 005329107 | CMN | 2,666,666 | $11,199,997 | dollars as filed | |
| ENGENE THERAPEUTICS INC | 29286X101 | COM | 6,256,662 | $10,824,025 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 2,337,102 | $10,703,927 | dollars as filed | |
| DATADOGINCCLASSA | 23804L103 | STOK | 40,000 | $10,414,400 | dollars as filed | |
| ServiceNow,Inc. | 81762P102 | COM | 100,000 | $9,928,000 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 25,000 | $9,443,750 | dollars as filed | |
| IONQ INC COM | 46222L108 | Stock | 170,000 | $9,054,200 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 24,000 | $8,952,480 | dollars as filed | call |
| JFROG LTD ORD SHS | M6191J100 | Stock | 95,500 | $8,679,040 | dollars as filed | |
| OCULIS HOLDING AG | H5870P102 | CMN | 625,000 | $8,668,750 | dollars as filed | |
| IRENLTDF | Q4982L109 | STOK | 175,000 | $8,002,750 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 32,500 | $7,746,050 | dollars as filed | |
| CROWDSTRIKE HLDGS INC | 22788C105 | COM | 10,000 | $7,631,400 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 523,212 | $7,570,878 | dollars as filed | |
| PDD HOLDINGS INC SPONSORED ADS | 722304102 | ADR | 95,000 | $7,246,600 | dollars as filed | |
| SATELLOS BIOSCIENCE INC | 80401L803 | COM | 892,074 | $6,935,875 | dollars as filed | |
| DYNATRACE INC COM NEW | 268150109 | Stock | 155,000 | $6,806,050 | dollars as filed | |
| Apple Inc | 037833100 | COM | 23,000 | $6,655,280 | dollars as filed | call |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 427,141 | $6,214,902 | dollars as filed | |
| VTV THERAPEUTICS INC | 918385204 | CL A NEW | 163,000 | $6,136,950 | dollars as filed | |
| ELOXX PHARMACEUTICALS INC | 29014R301 | COM NEW | 400,000 | $5,552,000 | dollars as filed | |
| AGOMAB THERAPEUTICS NV | 00860C102 | SPONSORED ADS | 411,250 | $5,338,025 | dollars as filed | |
| ALIBABA GROUP HLDG LTD | 01609W102 | SPONSORED ADS | 50,000 | $4,799,000 | dollars as filed | |
| KORRO BIO INC | 500946108 | COMMON STOCK | 347,718 | $4,582,923 | dollars as filed | |
| CELLEBRITE DI LTD ORDINARY SHARES | M2197Q107 | Stock | 311,544 | $4,548,542 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 5,000,000 | $4,362,000 | dollars as filed | |
| OUSTER INC COM NEW | 68989M202 | Stock | 67,500 | $4,220,100 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 2,000,000 | $4,180,000 | dollars as filed | |
| AEVA TECHNOLOGIES INC COM NEW | 00835Q202 | Stock | 145,459 | $4,177,582 | dollars as filed | |
| SEER INC | 81578P106 | COM CL A | 2,458,673 | $4,081,397 | dollars as filed | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 2,004,739 | $3,909,241 | dollars as filed | |
| GITLAB INC CLASS A COM | 37637K108 | Stock | 125,000 | $3,816,250 | dollars as filed | |
| Odyssey Therapeutics, Inc. | 67613T104 | COMMON STOCK | 200,000 | $3,742,000 | dollars as filed | |
| FOGHORN THERAPEUTICS INC | 344174107 | COMMON STOCK | 720,720 | $3,517,114 | dollars as filed | |
| AGENUS INC | 00847G804 | COM NEW | 1,064,250 | $3,256,605 | dollars as filed | |
| MONDAY COM LTD SHS | M7S64H106 | Stock | 42,500 | $3,076,575 | dollars as filed | |
| ZOETIS INC CL A | 98978V103 | Stock | 35,000 | $2,515,100 | dollars as filed | |
| WORKIVA INC COM CL A | 98139A105 | Stock | 45,000 | $2,182,950 | dollars as filed | |
| Netflix, Inc | 64110L106 | COM | 25,000 | $1,784,925 | dollars as filed | |
| KALARIS THERAPEUTICS INC | 482929106 | COM | 435,798 | $1,773,698 | dollars as filed | |
| QUANTINUUM INC | 74768A104 | CL A COM | 20,000 | $1,634,800 | dollars as filed | |
| RANI THERAPEUTICS HLDGS INC | 753018100 | CMN | 2,000,000 | $1,520,800 | dollars as filed | |
| Tesla Motors, Inc | 88160R101 | COM | 3,500 | $1,472,100 | dollars as filed | |
| KE HLDGS INC SPONSORED ADS | 482497104 | ADR | 100,000 | $1,453,000 | dollars as filed | |
| ENTERA BIO LTD | M40527109 | SHS | 736,457 | $1,303,529 | dollars as filed | |
| MEDLINE INC COM CL A | 58507V107 | Stock | 25,000 | $986,000 | dollars as filed | |
| LUMENTUM HLDGS INC COM | 55024U109 | Stock | 1,055 | $905,253 | dollars as filed | |
| FIGMA INC CL A | 316841105 | COM | 50,000 | $904,500 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 5,208,968 | $857,396 | dollars as filed | |
| FOX CORP CL A COM | 35137L105 | Stock | 10,000 | $521,600 | dollars as filed | |
| AT&T Inc | 00206R102 | COM | 25,000 | $517,500 | dollars as filed | |
| NU HLDGS LTD | G6683N103 | ORD SHS CL A | 25,000 | $334,000 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0002005245-26-000008 | this filing | 2026-08-13 | acceptance time not in the bulk data set |