13F-HR filed by HighVista Strategies LLC
HighVista Strategies LLC filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-14, with 147 holding rows worth $438,599,158.
- Accession
- 0001172661-26-003470
- Filer
- CIK 1335325
- Filed
- 2026-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 147 entries on the cover page, a total value of $438,599,158 stated on the cover page (in dollars after the unit check, H1), rows summing to $438,599,158 with VALUE read as dollars as filed, 13F file number 028-14212. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerHighVista Private Capital Management LLC
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| DB COMMODITY INDEX TRACKING | 46138B103 | ETF | 1,057,238 | $28,185,965 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 113,031 | $15,062,511 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 66,983 | $12,544,576 | dollars as filed | |
| DEFINIUM THERAPEUTICS INC | 24477V105 | COM SHS | 242,884 | $11,425,263 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 277,873 | $10,706,447 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 30,210 | $10,114,006 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 506,235 | $9,471,675 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 179,256 | $9,392,118 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 149,739 | $8,704,329 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 260,070 | $8,129,788 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 97,896 | $7,805,248 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 188,780 | $7,305,786 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 130,784 | $7,019,177 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 137,866 | $6,996,700 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 386,080 | $6,933,997 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 77,807 | $6,907,706 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 211,511 | $6,864,590 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 78,003 | $6,645,076 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 1,348,136 | $6,295,800 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 184,774 | $5,901,681 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 199,968 | $5,627,100 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 160,494 | $5,549,882 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 87,060 | $5,479,557 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 371,120 | $5,251,349 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 51,125 | $4,983,665 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 203,739 | $4,942,709 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 20,183 | $4,940,193 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 86,233 | $4,898,896 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 105,907 | $4,544,470 | dollars as filed | |
| NVIDIA Corp | 67066G104 | COM | 21,792 | $4,360,361 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 158,770 | $4,267,737 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 2,030,927 | $4,244,638 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 4,561 | $4,231,559 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 136,572 | $4,075,308 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 408,534 | $4,011,804 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 41,902 | $3,987,813 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 171,961 | $3,819,254 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 90,996 | $3,697,168 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 187,946 | $3,659,308 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 31,256 | $3,332,515 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 86,964 | $3,235,930 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 13,397 | $3,193,041 | dollars as filed | |
| INVENTIVA SA | 46124U107 | ADS | 831,442 | $3,142,851 | dollars as filed | |
| TALEN ENERGY CORP COM | 87422Q109 | Stock | 8,148 | $3,130,951 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 445,799 | $3,084,929 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 24,460 | $2,998,307 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 160,328 | $2,937,208 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 159,885 | $2,937,087 | dollars as filed | |
| HEWLETT PACKARD ENTERPRISE CO COM | 42824C109 | Stock | 59,081 | $2,665,143 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 86,085 | $2,322,573 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 15,419 | $2,313,313 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 122,610 | $2,265,832 | dollars as filed | |
| JAMES HARDIE INDS PLC ORD SHS | G4253H101 | Stock | 85,198 | $2,230,484 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 155,704 | $2,226,567 | dollars as filed | |
| MASTEC INC COM | 576323109 | Stock | 5,137 | $2,137,300 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 35,318 | $2,131,795 | dollars as filed | |
| RBC BEARINGS INC COM | 75524B104 | Stock | 3,223 | $2,075,805 | dollars as filed | |
| Visa Inc | 92826C839 | COM | 5,961 | $2,045,160 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 73,405 | $2,017,170 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 61,316 | $2,006,260 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 160,167 | $2,003,689 | dollars as filed | |
| ROCKET COS INC | 77311W101 | COM CL A | 125,530 | $1,977,098 | dollars as filed | |
| XPO INC COM | 983793100 | Stock | 9,623 | $1,975,506 | dollars as filed | |
| WESTERN DIGITAL CORP | 958102105 | COM | 3,050 | $1,948,096 | dollars as filed | |
| CORE SCIENTIFIC INC NEW | 21874A106 | COM | 75,712 | $1,937,470 | dollars as filed | |
| Texas Instruments Incorporated | 882508104 | COM | 6,500 | $1,937,455 | dollars as filed | |
| KBR INC COM | 48242W106 | Stock | 54,206 | $1,871,733 | dollars as filed | |
| FLOWSERVE CORP | 34354P105 | COM | 24,958 | $1,850,886 | dollars as filed | |
| Alphabet Inc. Reg. Shares C | 02079K107 | COM | 5,127 | $1,811,523 | dollars as filed | |
| SEAGATE TECHNOLOGY HLDNGS | G7997R103 | ORD SHS | 1,870 | $1,804,550 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 14,892 | $1,743,407 | dollars as filed | |
| DNOW INC | 67011P100 | COMMON STOCK | 132,900 | $1,723,713 | dollars as filed | |
| ON SEMICONDUCTOR CORP COM | 682189105 | Stock | 18,200 | $1,720,628 | dollars as filed | |
| NUCOR CORP COM | 670346105 | Stock | 7,600 | $1,692,900 | dollars as filed | |
| USA TODAY CO INC | 36472T109 | COM | 188,500 | $1,611,675 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 4,199 | $1,586,172 | dollars as filed | |
| CALUMET INC | 131428104 | COM | 44,000 | $1,584,880 | dollars as filed | |
| QNITY ELECTRONICS INC COMMON STOCK | 74743L100 | Stock | 9,700 | $1,584,107 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 40,590 | $1,581,387 | dollars as filed | |
| CREDO TECHNOLOGY GROUP HOLDING ORDINARY SHARES | G25457105 | Stock | 5,800 | $1,577,310 | dollars as filed | |
| KNIGHT-SWIFT TRANSN HLDGS IN | 499049104 | CL A | 20,100 | $1,565,187 | dollars as filed | |
| BRINKS CO | 109696104 | COM | 16,414 | $1,550,959 | dollars as filed | |
| ASTERA LABS INC COM | 04626A103 | COM | 3,198 | $1,544,698 | dollars as filed | |
| S&P Global,Inc. | 78409V104 | COM | 3,782 | $1,540,257 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 2,852 | $1,531,381 | dollars as filed | |
| EQUIFAX INC COM | 294429105 | Stock | 9,572 | $1,519,268 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 13,657 | $1,516,337 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 242,379 | $1,493,054 | dollars as filed | |
| DOMINOS PIZZA INC COM | 25754A201 | Stock | 4,991 | $1,477,536 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 9,554 | $1,471,173 | dollars as filed | |
| Micron Technology,Inc. | 595112103 | COM | 1,260 | $1,454,406 | dollars as filed | |
| CIENA CORP COM NEW | 171779309 | Stock | 2,925 | $1,434,888 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 13,472 | $1,409,440 | dollars as filed | |
| QXO INC COM NEW | 82846H405 | Stock | 81,420 | $1,406,938 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 43,185 | $1,371,125 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 18,867 | $1,340,500 | dollars as filed | |
| US FOODS HLDG CORP COM | 912008109 | Stock | 13,000 | $1,329,250 | dollars as filed | |
| TRANSDIGM GROUP INC COM | 893641100 | Stock | 985 | $1,312,059 | dollars as filed | |
| LUMENTUM HLDGS INC COM | 55024U109 | Stock | 1,517 | $1,301,677 | dollars as filed | |
| FIRSTENERGY CORP | 337932107 | COM | 26,100 | $1,240,794 | dollars as filed | |
| MasterCard, Inc | 57636Q104 | COM | 2,384 | $1,224,422 | dollars as filed | |
| ENTERGY CORP NEW COM | 29364G103 | Stock | 10,628 | $1,220,732 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 3,260 | $1,211,644 | dollars as filed | |
| MOODYS CORP COM | 615369105 | Stock | 2,670 | $1,209,296 | dollars as filed | |
| Applied Materials,Inc. | 038222105 | COM | 1,640 | $1,185,720 | dollars as filed | |
| XCELENERGY INC | 98389B100 | COM | 14,758 | $1,185,067 | dollars as filed | |
| NextEra Energy,Inc. | 65339F101 | COM | 13,338 | $1,170,677 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 2,095 | $1,135,134 | dollars as filed | |
| GOLAR LNG LTD | G9456A100 | SHS | 22,100 | $1,101,464 | dollars as filed | |
| DOORDASH INC CL A | 25809K105 | Stock | 5,810 | $1,072,119 | dollars as filed | |
| ICICI BANK LIMITED ADR | 45104G104 | ADR | 35,884 | $1,041,713 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 14,219 | $1,039,978 | dollars as filed | |
| AMPHENOL CORP NEW | 032095101 | COM | 5,781 | $1,019,306 | dollars as filed | |
| UNITY SOFTWARE INC COM | 91332U101 | Stock | 35,163 | $1,004,958 | dollars as filed | |
| FERGUSON ENTERPRISES INC COMMON STOCK NEW | 31488V107 | Stock | 4,173 | $990,378 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 53,033 | $989,065 | dollars as filed | |
| STMICROELECTRONICS N V NY REGISTRY | 861012102 | ADR | 13,200 | $988,548 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 29,337 | $982,496 | dollars as filed | |
| FULL TRUCK ALLIANCE CO LTD SPONSORED ADS | 35969L108 | ADR | 120,847 | $981,278 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 13,156 | $979,859 | dollars as filed | |
| ARM HOLDINGS PLC | 042068205 | SPONSORED ADS | 2,700 | $957,339 | dollars as filed | |
| TAPESTRY INC COM | 876030107 | Stock | 6,500 | $951,470 | dollars as filed | |
| NEW ORIENTAL ED & TECHNOLOGY SPON ADR | 647581206 | ADR | 20,537 | $942,853 | dollars as filed | |
| SILICON MOTION TECHNOLOGY CORP SPONSORED ADR | 82706C108 | ADR | 2,800 | $933,324 | dollars as filed | |
| API GROUP CORP COM STK | 00187Y100 | Stock | 21,958 | $929,921 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 24,968 | $918,822 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 2,413 | $900,097 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 34,013 | $889,100 | dollars as filed | |
| ADVANCED ENERGY INDS COM | 007973100 | Stock | 2,240 | $835,229 | dollars as filed | |
| KASPI KZ JSC | 48581R205 | SPONSORED ADS | 9,400 | $814,416 | dollars as filed | |
| HDFC BANK LTD SPONSORED ADS | 40415F101 | ADR | 30,927 | $798,845 | dollars as filed | |
| VISTRA CORP COM | 92840M102 | Stock | 4,900 | $777,287 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 48,376 | $743,056 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 20,905 | $708,470 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 1,162 | $654,543 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 11,634 | $642,197 | dollars as filed | |
| NU HLDGS LTD | G6683N103 | ORD SHS CL A | 47,970 | $640,879 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 169,831 | $636,866 | dollars as filed | |
| MERCADOLIBREINC | 58733R102 | STOK | 375 | $636,521 | dollars as filed | |
| CONSTELLATION ENERGY CORP COM | 21037T109 | Stock | 2,490 | $618,442 | dollars as filed | |
| NEKTAR THERAPEUTICS | 640268306 | COMMON STOCK | 8,708 | $607,906 | dollars as filed | |
| AKAMAI TECHNOLOGIES INC COM | 00971T101 | Stock | 4,900 | $579,229 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 26,822 | $431,834 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 3,731 | $427,834 | dollars as filed | |
| PDD HOLDINGS INC SPONSORED ADS | 722304102 | ADR | 5,500 | $419,540 | dollars as filed | |
| JD.COM INC SPON ADS CL A | 47215P106 | ADR | 14,163 | $360,873 | dollars as filed | |
| BANCO BRADESCO S A | 059460303 | SP ADR PFD NEW | 103,132 | $357,868 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-26-003470 | this filing | 2026-08-14 | acceptance time not in the bulk data set |