13F-HR filed by PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-14, with 109 holding rows worth $6,661,817,069.
- Accession
- 0001012975-26-000777
- Filer
- CIK 1224962
- Filed
- 2026-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 109 entries on the cover page, a total value of $6,661,817,069 stated on the cover page (in dollars after the unit check, H1), rows summing to $6,661,817,069 with VALUE read as dollars as filed, 13F file number 028-10438. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 2,035,986 | $681,627,753 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 4,319,496 | $383,484,855 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 3,197,200 | $334,491,064 | dollars as filed | |
| ASCENDIS PHARMA A/S | K08588103 | ORD SHS *A* | 1,163,721 | $310,387,665 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 2,586,295 | $287,156,334 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 8,085,461 | $286,144,465 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 14,106,187 | $263,926,759 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 3,752,574 | $213,183,729 | dollars as filed | |
| KARDIGAN INC | 485925101 | CMN | 8,200,662 | $195,585,788 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,580,505 | $195,192,368 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 4,373,974 | $177,714,564 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,308,113 | $173,625,838 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 8,334,882 | $149,694,481 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 10,786,658 | $145,727,749 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 1,345,063 | $128,009,646 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 1,297,763 | $122,963,044 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 981,879 | $120,358,728 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 11,906,646 | $118,947,393 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 4,182,953 | $109,342,391 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 3,377,000 | $105,565,020 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 10,383,456 | $105,184,409 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 4,320,422 | $104,813,438 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 10,308,888 | $103,088,880 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 527,600 | $98,808,928 | dollars as filed | |
| AVALYN PHARMA INC | 05348Y105 | COMMON STOCK | 2,675,296 | $88,070,744 | dollars as filed | |
| MODERNA INC | 60770K107 | COM | 1,000,000 | $70,030,000 | dollars as filed | put |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 2,689,235 | $59,727,909 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 276,173 | $59,669,938 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 1,357,383 | $52,299,967 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 116,806 | $48,548,078 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 300,000 | $47,475,000 | dollars as filed | put |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 566,000 | $44,878,140 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367201 | COMMON STOCK | 1,304,846 | $43,320,887 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 1,609,893 | $42,485,076 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 170,000 | $40,964,900 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 2,667,441 | $39,851,569 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 905,000 | $39,810,950 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 10,439,185 | $39,146,944 | dollars as filed | |
| ARTIVION INC | 228903100 | COM | 1,737,290 | $39,036,906 | dollars as filed | |
| X4 PHARMACEUTICALS INC | 98420X202 | COMMON STOCK | 7,933,491 | $37,049,403 | dollars as filed | |
| CORCEPT THERAPEUTICS INC | 218352102 | COM | 398,385 | $34,639,576 | dollars as filed | |
| REPLIGEN CORP COM | 759916109 | Stock | 248,212 | $33,866,045 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 3,425,476 | $33,740,939 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 773,342 | $32,225,161 | dollars as filed | |
| DAMORA THERAPEUTICS INC | 36322Q206 | COMMON STOCK | 1,223,000 | $31,810,230 | dollars as filed | |
| CHARLES RIV LABS INTL INC | 159864107 | COM | 140,000 | $31,750,600 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 118,450 | $28,993,007 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 2,000,000 | $28,600,000 | dollars as filed | put |
| DBV TECHNOLOGIES S A | 23306J309 | SPONSORED ADS | 1,653,350 | $27,114,940 | dollars as filed | |
| IRHYTHM HOLDINGS INC COM | 450056106 | Stock | 223,766 | $26,616,966 | dollars as filed | |
| ADAPTIVE BIOTECHNOLOGIES CORP COM | 00650F109 | Stock | 1,217,325 | $26,111,621 | dollars as filed | |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 6,627,501 | $25,847,254 | dollars as filed | |
| Danaher Corporation | 235851102 | COM | 130,000 | $24,762,400 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 1,700,000 | $24,735,000 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 1,000,000 | $24,080,000 | dollars as filed | call |
| SELLAS LIFE SCIENCES GROUP I | 81642T209 | COM NEW | 1,500,000 | $22,140,000 | dollars as filed | put |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 11,634,211 | $21,755,974 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 5,037,906 | $21,738,564 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 51,884 | $20,633,229 | dollars as filed | |
| Adlai Nortye | 00704R109 | SPONSORED ADS | 1,793,190 | $20,621,685 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 1,255,592 | $20,579,153 | dollars as filed | |
| NUVECTIS PHARMA INC | 67080T108 | COMMON STOCK | 1,000,000 | $18,390,000 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 8,425,065 | $17,608,386 | dollars as filed | |
| OMADA HEALTH INC | 68170A108 | COM | 786,330 | $17,259,943 | dollars as filed | |
| LeonaBio Inc | 04746L203 | COM | 1,859,322 | $17,087,169 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 2,459,285 | $17,067,438 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 500,000 | $16,945,000 | dollars as filed | put |
| INVIVYD INC | 00534A102 | COMMON STOCK | 18,490,636 | $16,131,231 | dollars as filed | |
| CELCUITY INC | 15102KAA8 | NOTE 2.750% 8/0 | 6,500,000 | $14,629,442 | dollars as filed | principal |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 115,391 | $13,508,824 | dollars as filed | |
| SURROZEN INC | 86889P208 | COMMON STOCK | 503,985 | $13,078,411 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 832,944 | $13,052,232 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 500,000 | $12,040,000 | dollars as filed | put |
| AXOGEN INC | 05463X106 | COM | 247,312 | $11,423,341 | dollars as filed | |
| OSCAR HEALTH INC | 687793109 | CL A | 400,000 | $11,408,000 | dollars as filed | |
| OCULIS HOLDING AG | H5870P102 | CMN | 808,827 | $11,218,430 | dollars as filed | |
| SEAPORT THERAPEUTICS INC | 81221K108 | COMMON STOCK | 500,000 | $10,860,000 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 581,980 | $10,690,973 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 250,000 | $10,670,000 | dollars as filed | |
| BILLIONTOONE INC | 090168105 | CL A | 86,812 | $10,415,704 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 74,000 | $9,861,240 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 34,689 | $9,416,329 | dollars as filed | |
| ENGENE THERAPEUTICS INC | 29286X101 | COM | 4,822,169 | $8,342,352 | dollars as filed | |
| Research Alliance Corp Iii Ord Shs Cl A | G75226103 | Common Stock | 750,000 | $8,025,000 | dollars as filed | |
| AGOMAB THERAPEUTICS NV | 00860C102 | SPONSORED ADS | 600,000 | $7,788,000 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 426,478 | $7,766,164 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 168,000 | $7,738,080 | dollars as filed | |
| MOBIA MED INC | 60705V103 | COMMON STOCK | 523,654 | $7,016,963 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 9,876,586 | $6,439,534 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 41,327 | $6,200,290 | dollars as filed | |
| PHATHOM PHARMACEUTICALS INC | 71722W107 | COMMON STOCK | 532,000 | $5,772,200 | dollars as filed | |
| OUTLOOK THERAPEUTICS INC | 69012T305 | COM | 3,139,216 | $4,991,353 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 121,082 | $4,685,873 | dollars as filed | |
| EDESA BIOTECH INC | 27966L306 | COM NEW | 563,239 | $4,579,133 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 219,813 | $4,062,144 | dollars as filed | |
| TWIST BIOSCIENCE CORP | 90184D100 | COM | 36,812 | $3,787,219 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 206,942 | $3,724,956 | dollars as filed | |
| XERIS BIOPHARMA HOLDINGS INC | 98422E103 | COM | 467,013 | $3,698,743 | dollars as filed | |
| OUTSET MED INC | 690145206 | COM NEW | 833,333 | $3,599,998 | dollars as filed | |
| BIODESIX INC COM | 09075X207 | Stock | 108,694 | $2,451,049 | dollars as filed | |
| REVOLUTION MEDICINES INC | 76155X118 | *W EXP 12/17/202 | 250,000 | $2,344,975 | dollars as filed | |
| CONNECT BIOPHARMA HLDGS LTD | G23549101 | SHS | 792,696 | $1,886,616 | dollars as filed | |
| KIORA PHARMACEUTICALS INC | 49721T507 | COM | 438,471 | $1,153,179 | dollars as filed | |
| MEDLINE INC COM CL A | 58507V107 | Stock | 28,000 | $1,104,320 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 113,765 | $952,213 | dollars as filed | |
| CUMBERLAND PHARMACEUTICALS I | 230770109 | COM | 96,982 | $628,443 | dollars as filed | |
| EXAGEN INC | 30068X103 | COM | 114,893 | $534,252 | dollars as filed | |
| ENSYSCE BIOSCIENCES INC | 293602504 | COM NEW | 86,666 | $25,133 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 166,666 | $2,750 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001012975-26-000777 | this filing | 2026-08-14 | acceptance time not in the bulk data set |