13F-HR filed by Paradigm Biocapital Advisors LP
Paradigm Biocapital Advisors LP filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 36 holding rows worth $3,516,196,926.
- Accession
- 0001855655-25-000014
- Filer
- CIK 1855655
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 36 entries on the cover page, a total value of $3,516,196,926 stated on the cover page (in dollars after the unit check, H1), rows summing to $3,516,196,926 with VALUE read as dollars as filed, 13F file number 028-21950. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| NUVALENT INC COM | 670703107 | Stock | 5,269,433 | $455,700,566 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 4,373,770 | $411,790,446 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 4,649,016 | $381,684,214 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 6,223,291 | $290,627,690 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 2,665,698 | $158,422,432 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 3,784,755 | $136,326,875 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 1,564,196 | $132,800,240 | dollars as filed | |
| GENMAB A/S | 372303206 | Ordinary Shares, nominal value DKK 1 per share | 3,816,851 | $117,062,820 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 2,673,555 | $107,316,498 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 2,550,774 | $106,239,737 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,000,000 | $100,200,000 | dollars as filed | put |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 6,170,131 | $100,079,525 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 961,164 | $92,041,065 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 4,216,084 | $84,110,876 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 2,009,745 | $74,842,904 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 2,920,258 | $71,371,106 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 6,794,172 | $66,514,944 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,521,757 | $60,459,406 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 2,609,353 | $56,309,838 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 1,719,334 | $51,580,020 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 1,073,461 | $50,001,813 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 1,835,494 | $45,795,575 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 3,156,398 | $45,325,875 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 3,497,307 | $40,883,519 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 684,277 | $35,541,347 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 13,560,017 | $29,560,837 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 2,005,365 | $28,556,398 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 300,000 | $28,245,000 | dollars as filed | call |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 3,086,184 | $25,923,946 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 1,900,000 | $25,821,000 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,467,266 | $24,591,378 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 1,898,950 | $24,021,718 | dollars as filed | |
| BRIDGEBIO ONCOLOGY THERAPEUT | 107924102 | COM NEW | 1,866,141 | $21,609,913 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 247,716 | $16,369,073 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 372,869 | $10,440,332 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 200,000 | $8,028,000 | dollars as filed | call |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001855655-25-000014 | this filing | 2025-11-14 | acceptance time not in the bulk data set |