13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 114 holding rows worth $474,069,298.
- Accession
- 0001496201-25-000017
- Filer
- CIK 1496201
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 115 entries on the cover page, a total value of $474,069,298 stated on the cover page (in dollars after the unit check, H1), rows summing to $474,069,298 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,507,025 | $30,441,905 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 157,400 | $22,788,372 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 311,802 | $22,543,285 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 150,000 | $14,122,500 | dollars as filed | call |
| NOVA LTD COM | M7516K103 | Stock | 43,896 | $14,031,795 | dollars as filed | |
| INVESCO QQQ TR | 46090E103 | COM | 22,960 | $13,784,495 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 82,738 | $11,589,939 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 352,558 | $10,604,945 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 135,060 | $10,361,803 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 219,515 | $10,361,108 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 100,000 | $9,576,000 | dollars as filed | call |
| CYTOKINETICS INC | 23282W605 | COM NEW | 161,517 | $8,876,974 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 219,910 | $8,338,987 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 991,142 | $7,810,199 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 10,040 | $7,660,520 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 40,831 | $7,570,884 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 75,743 | $7,253,150 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 474,309 | $7,114,635 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 130,000 | $6,752,200 | dollars as filed | call |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 387,716 | $5,965,011 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 643,957 | $5,892,207 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 105,677 | $5,864,017 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 25,256 | $5,847,774 | dollars as filed | |
| CELLEBRITE DI LTD ORDINARY SHARES | M2197Q107 | Stock | 298,948 | $5,539,506 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 1,794,387 | $5,472,880 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 426,518 | $5,395,453 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 207,764 | $5,374,855 | dollars as filed | |
| Solaredge Technologies Inc Note 2.250 percent 7/0 | 83417MAE4 | Convertible | 4,000,000 | $5,332,890 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 122,000 | $5,265,520 | dollars as filed | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 140,966 | $5,215,742 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 431,693 | $5,180,316 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 583,105 | $4,968,055 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 173,931 | $4,870,068 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 1,350,333 | $4,820,689 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 37,000 | $4,744,880 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 157,533 | $4,678,730 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 75,000 | $4,377,750 | dollars as filed | put |
| VARONIS SYS INC | 922280102 | COM | 73,900 | $4,247,033 | dollars as filed | |
| ISHARES TR | 464287432 | 20 YR TR BD ETF | 47,000 | $4,200,390 | dollars as filed | call |
| IMMUNOVANT INC | 45258J102 | COM | 256,743 | $4,138,697 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 48,600 | $4,078,998 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 154,343 | $4,002,114 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 504,409 | $3,445,113 | dollars as filed | |
| ELBIT SYS LTD ORD | M3760D101 | Stock | 6,740 | $3,436,052 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 363,947 | $3,421,102 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 166,765 | $3,413,680 | dollars as filed | |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 185,270 | $3,338,565 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 1,280,233 | $3,315,803 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 148,900 | $3,177,526 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 57,901 | $3,068,753 | dollars as filed | |
| CAMTEK LTD ORD | M20791105 | Stock | 29,048 | $3,051,492 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 13,760 | $3,021,283 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 407,709 | $3,004,815 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 119,406 | $2,979,180 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 150,000 | $2,890,500 | dollars as filed | call |
| META PLATFORMS INC CL A | 30303M102 | COM | 3,924 | $2,881,707 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 41,606 | $2,812,566 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 60,000 | $2,802,000 | dollars as filed | |
| ORMAT TECHNOLOGIES INC | 686688102 | COM | 29,000 | $2,791,250 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 100,000 | $2,721,000 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 9,500 | $2,680,900 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 50,000 | $2,650,000 | dollars as filed | call |
| Advanced Micro Devices,Inc. | 007903107 | COM | 15,470 | $2,502,891 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 101,800 | $2,433,020 | dollars as filed | call |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 151,600 | $2,293,708 | dollars as filed | call |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 338,752 | $2,205,276 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 86,000 | $2,191,280 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 370,376 | $2,181,515 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 245,522 | $2,172,870 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 6,555 | $2,162,560 | dollars as filed | |
| CEVA INC | 157210105 | COMMON STOCK | 81,085 | $2,141,455 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 40,746 | $2,116,347 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 85,840 | $2,097,930 | dollars as filed | |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 478,928 | $1,882,187 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 251,225 | $1,828,918 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 115,908 | $1,818,597 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 50,000 | $1,801,000 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V302 | COMMON STOCK | 510,343 | $1,750,476 | dollars as filed | |
| IMMUNOME INC | 45257U108 | COM | 147,200 | $1,723,712 | dollars as filed | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 820,000 | $1,640,000 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 629,470 | $1,498,139 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 24,900 | $1,453,413 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 63,660 | $1,440,626 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 98,526 | $1,414,833 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 50,000 | $1,400,000 | dollars as filed | call |
| IShares Bitcoin Trust Registered | 46438F101 | SHS | 21,455 | $1,394,575 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 440,114 | $1,368,755 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 91,155 | $1,368,237 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 85,747 | $1,353,945 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 408,146 | $1,334,637 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 175,371 | $1,236,366 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $1,234,816 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 129,200 | $1,182,180 | dollars as filed | call |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 566,395 | $1,138,454 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 26,700 | $944,913 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 199,761 | $932,884 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 434,837 | $874,022 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 260,385 | $841,044 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 171,467 | $792,178 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 17,500 | $789,250 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 78,307 | $691,451 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 42,571 | $644,099 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 39,675 | $583,223 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 200,000 | $518,000 | dollars as filed | put |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 71,010 | $509,142 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C203 | SPONSORED ADS | 179,425 | $471,888 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 12,496 | $430,987 | dollars as filed | |
| APREA THERAPEUTICS INC | 03836J201 | COM NEW | 270,000 | $398,250 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 50,000 | $366,000 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 60,454 | $166,249 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 21,918 | $165,043 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M406 | COM NEW | 295,187 | $125,454 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 10,000 | $71,700 | dollars as filed | call |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 50,000 | $30,245 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-25-000017 | this filing | 2025-11-14 | acceptance time not in the bulk data set |