13F-HR filed by Ikarian Capital, LLC
Ikarian Capital, LLC filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 169 holding rows worth $990,387,589.
- Accession
- 0001420506-25-003413
- Filer
- CIK 1778253
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 169 entries on the cover page, a total value of $990,387,589 stated on the cover page (in dollars after the unit check, H1), rows summing to $990,387,589 with VALUE read as dollars as filed, 13F file number 028-19721. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 209,800 | $87,950,258 | dollars as filed | put |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 750,000 | $75,150,000 | dollars as filed | put |
| GENMAB A/S | 372303206 | Ordinary Shares, nominal value DKK 1 per share | 175,000 | $53,021,552 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 800,000 | $36,080,000 | dollars as filed | put |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 396,098 | $33,416,358 | dollars as filed | |
| UNIQURE NV | N90064901 | CALL | 535,600 | $31,262,972 | dollars as filed | call |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 415,163 | $27,159,964 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 277,704 | $26,592,935 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 561,600 | $20,913,984 | dollars as filed | call |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 740,825 | $19,209,592 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 280,551 | $17,217,414 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 615,000 | $15,860,850 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 100,000 | $14,401,000 | dollars as filed | put |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 100,000 | $14,401,000 | dollars as filed | call |
| HARROW INC | 415858109 | COM | 289,700 | $13,957,746 | dollars as filed | call |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 346,001 | $13,615,140 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 213,000 | $13,071,810 | dollars as filed | call |
| CYTOKINETICS INC | 23282W605 | COM NEW | 222,674 | $12,238,163 | dollars as filed | |
| BIOHAVEN LTD | G1110E907 | COM | 796,400 | $11,953,964 | dollars as filed | call |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 176,100 | $11,904,360 | dollars as filed | call |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 1,289,225 | $11,860,870 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 311,682 | $11,226,785 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 3,372,616 | $10,758,645 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 257,700 | $10,733,205 | dollars as filed | call |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 77,800 | $10,254,041 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 451,902 | $10,226,541 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 249,473 | $10,048,772 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 206,854 | $9,821,428 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC | G50871905 | SHS USD | 70,700 | $9,318,260 | dollars as filed | call |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 2,132,322 | $9,232,953 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 150,000 | $8,323,500 | dollars as filed | call |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 358,000 | $8,101,540 | dollars as filed | call |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 307,700 | $7,461,725 | dollars as filed | call |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 967,600 | $7,363,436 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 413,841 | $6,774,577 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 174,959 | $6,320,394 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 946,259 | $6,160,146 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 110,900 | $6,095,064 | dollars as filed | call |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 150,000 | $6,021,000 | dollars as filed | call |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 562,400 | $5,652,120 | dollars as filed | call |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 130,902 | $5,452,068 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 100,000 | $5,300,000 | dollars as filed | call |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 245,518 | $5,298,278 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 210,165 | $5,243,617 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 333,733 | $5,134,482 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 214,500 | $5,126,550 | dollars as filed | call |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 126,979 | $5,096,937 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 161,100 | $4,932,882 | dollars as filed | put |
| ANAPTYSBIO INC | 032724106 | COM | 161,100 | $4,932,882 | dollars as filed | call |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 400,000 | $4,872,000 | dollars as filed | call |
| DELCATH SYSTEMS INC | 24661P807 | COMMON STOCK | 431,251 | $4,635,949 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 163,237 | $4,570,636 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 190,781 | $4,559,666 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 200,000 | $4,548,000 | dollars as filed | call |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 175,000 | $4,513,250 | dollars as filed | call |
| METSERA INC | 59267L107 | COM | 86,000 | $4,500,380 | dollars as filed | put |
| METSERA INC | 59267L107 | COM | 86,000 | $4,500,380 | dollars as filed | call |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 300,000 | $4,500,000 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 95,000 | $4,436,500 | dollars as filed | call |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 612,200 | $4,389,474 | dollars as filed | call |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 73,619 | $4,375,178 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 24,421 | $4,311,039 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 5,942 | $4,303,146 | dollars as filed | |
| ARCTURUS THERAPEUTICS HLDGS | 03969T109 | COM | 227,200 | $4,187,296 | dollars as filed | call |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 1,309,604 | $4,072,869 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 64,746 | $4,058,926 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 200,000 | $4,040,000 | dollars as filed | call |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 55,946 | $3,781,950 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 1,000,000 | $3,770,000 | dollars as filed | call |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 567,601 | $3,768,870 | dollars as filed | |
| DIREXION SHARES ETF TRUST | 25461H853 | CMN | 91,959 | $3,718,822 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 1,843,060 | $3,704,551 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 96,200 | $3,582,488 | dollars as filed | put |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 200,000 | $3,500,000 | dollars as filed | put |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 200,000 | $3,500,000 | dollars as filed | call |
| UNIQURE NV | N90064101 | SHS | 58,610 | $3,421,066 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 593,374 | $3,388,167 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 50,000 | $3,380,000 | dollars as filed | put |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 450,000 | $3,226,500 | dollars as filed | put |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 435,839 | $3,124,965 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 106,800 | $3,037,393 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 161,113 | $3,030,535 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 468,000 | $2,887,560 | dollars as filed | call |
| FRACTYL HEALTH INC | 35168W103 | COM | 1,800,000 | $2,862,000 | dollars as filed | |
| BRIDGEBIO ONCOLOGY THERAPEUT | 107924102 | COM NEW | 245,231 | $2,839,774 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 92,600 | $2,785,408 | dollars as filed | put |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 51,967 | $2,699,166 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 137,000 | $2,639,990 | dollars as filed | call |
| PEPGEN INC COM | 713317105 | Stock | 535,967 | $2,476,168 | dollars as filed | |
| NEURONETICS INC | 64131A105 | COM | 905,716 | $2,472,605 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 467,362 | $2,439,630 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 159,854 | $2,343,460 | dollars as filed | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 116,388 | $2,292,844 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 400,000 | $2,292,000 | dollars as filed | call |
| INVIVYD INC | 00534A102 | COMMON STOCK | 2,078,706 | $2,286,577 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 760,000 | $2,249,601 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 620,869 | $2,204,084 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 159,777 | $2,030,766 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 13,751 | $1,980,281 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 41,600 | $1,975,168 | dollars as filed | call |
| ARVINAS INC | 04335A105 | COM | 226,257 | $1,927,710 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 264,642 | $1,908,069 | dollars as filed | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 892,229 | $1,900,447 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 548,400 | $1,771,332 | dollars as filed | call |
| PELTHOS THERAPEUTICS INC | 171126204 | COM SHS | 62,451 | $1,748,628 | dollars as filed | |
| CUMBERLAND PHARMACEUTICALS I | 230770109 | COM | 555,932 | $1,734,508 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 28,571 | $1,514,263 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 48,410 | $1,482,314 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 113,837 | $1,440,039 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 1,095,574 | $1,424,247 | dollars as filed | |
| PRIME MEDICINE INC | 74168J101 | COM | 250,000 | $1,385,000 | dollars as filed | put |
| PRIME MEDICINE INC | 74168J101 | COM | 250,000 | $1,385,000 | dollars as filed | call |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 54,691 | $1,336,648 | dollars as filed | |
| SILENCE THERAPEUTICS PLC | 82686Q101 | ADS | 900,784 | $1,306,136 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 72,787 | $1,243,202 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 164,202 | $1,233,157 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 176,690 | $1,090,177 | dollars as filed | |
| Inflarx Nv | N44821101 | COM | 722,066 | $967,568 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 2,300 | $964,183 | dollars as filed | call |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 15,431 | $936,044 | dollars as filed | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 1,294,652 | $871,819 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 13,300 | $870,086 | dollars as filed | call |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 48,071 | $841,243 | dollars as filed | |
| PRIME MEDICINE INC | 74168J101 | COM | 150,000 | $831,000 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 140,475 | $827,398 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 914,170 | $805,932 | dollars as filed | |
| TVARDI THERAPEUTICS INC | 140755307 | COM | 19,000 | $740,430 | dollars as filed | call |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 62,691 | $739,128 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 100,000 | $721,000 | dollars as filed | put |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 100,000 | $721,000 | dollars as filed | call |
| LYELL IMMUNOPHARMA INC COM NEW | 55083R203 | Stock | 43,799 | $711,296 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 95,955 | $702,390 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 54,800 | $693,220 | dollars as filed | call |
| SONNET BIOTHERAPEUTC HLDNG I | 83548R402 | COM NEW | 150,000 | $687,000 | dollars as filed | |
| IO BIOTECH INC | 449778109 | COM | 1,525,893 | $554,051 | dollars as filed | |
| VERU INC | 92536C202 | COM NEW | 142,523 | $541,588 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 617,327 | $511,023 | dollars as filed | |
| EQUILLIUM INC | 29446K106 | COM | 332,297 | $475,185 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 265,769 | $454,465 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 110,000 | $442,199 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 49,396 | $420,854 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 106,901 | $416,914 | dollars as filed | |
| ANEBULO PHARMACEUTICALS INC | 034569103 | COM | 157,720 | $394,300 | dollars as filed | |
| EVAXION AS | 29970R303 | SPONSORED ADS | 80,000 | $300,801 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 10,000 | $262,800 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 55,766 | $260,428 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 7,000 | $252,140 | dollars as filed | call |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 176,479 | $238,247 | dollars as filed | |
| NYXOAH S A | B6S7WD106 | SHS | 50,627 | $232,883 | dollars as filed | |
| CARTESIAN THERAPEUTICS INC | 816212302 | COMMON STOCK | 22,166 | $226,537 | dollars as filed | |
| FAETH THERAPEUTICS INC | 81728A207 | COM NEW | 22,497 | $212,596 | dollars as filed | |
| BIOMX INC | 09090D301 | COM | 392,976 | $206,312 | dollars as filed | |
| ARCTURUS THERAPEUTICS HLDGS | 03969T109 | COM | 10,721 | $197,588 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 27,257 | $178,261 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 11,280 | $161,981 | dollars as filed | |
| AIRSCULPT TECHNOLOGIES INC | 009496100 | COMMON STOCK | 17,951 | $143,967 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C203 | SPONSORED ADS | 53,262 | $140,079 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L204 | COM NEW | 21,161 | $139,452 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 97,500 | $136,500 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 80,071 | $134,519 | dollars as filed | |
| SPRUCE BIOSCIENCES INC | 85209E208 | COM NEW | 13,332 | $119,322 | dollars as filed | |
| AETHLON MED INC | 00808Y505 | COM NEW | 153,659 | $115,044 | dollars as filed | |
| VYNE THERAPEUTICS INC | 92941V308 | COM | 290,000 | $97,149 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 25,107 | $59,754 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 28,493 | $52,712 | dollars as filed | |
| THERIVA BIOLOGICS INC | 87164U508 | COM NEW | 120,031 | $48,625 | dollars as filed | |
| SYNLOGIC INC | 87166L209 | COM | 20,422 | $34,513 | dollars as filed | |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 12,498 | $22,747 | dollars as filed | |
| AUTONOMIX MED INC | 05330T205 | COM NEW | 20,000 | $21,601 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001420506-25-003413 | this filing | 2025-11-14 | acceptance time not in the bulk data set |