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New Leaf Venture Partners, L.L.C.

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13F filer, CIK 1631614, New York, NY

New Leaf Venture Partners, L.L.C. reported $43,047,844 across 7 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001193125-25-280589

Period
2025-09-30
Reported value
$43M
Holdings
7
Top 10 weight
100%
New
0
Sold out
1

Largest buys vs the previous quarter

None.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PASSAGE BIO INCreduced-2,410,496-$19.4M
ITRMFexited-345,020-$343K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001193125-25-280589, largest first. % of portfolio is the value over $43,047,844, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 1,553,661 shares; 2024Q1: 1,553,661 shares; 2024Q2: 1,553,661 shares; 2024Q3: 1,553,661 shares; 2024Q4: 1,030,161 shares; 2025Q1: 1,030,161 shares; 2025Q2: 1,030,161 shares; 2025Q3: 1,030,161 shares 1,030,161$16.7M38.82%0Timeline
ARVNARVINAS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 1,289,521 shares; 2024Q1: 1,289,521 shares; 2024Q2: 1,289,521 shares; 2024Q3: 1,434,721 shares; 2024Q4: 1,585,721 shares; 2025Q1: 1,585,721 shares; 2025Q2: 1,585,721 shares; 2025Q3: 1,585,721 shares 1,585,721$13.5M31.38%0Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 141,000 shares; 2024Q1: 141,000 shares; 2024Q2: 141,000 shares; 2024Q3: 141,000 shares; 2024Q4: 141,000 shares; 2025Q1: 141,000 shares; 2025Q2: 141,000 shares; 2025Q3: 141,000 shares 141,000$5.87M13.64%0Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 250,765 shares; 2024Q1: 250,765 shares; 2024Q2: 250,765 shares; 2024Q3: 250,765 shares; 2024Q4: 250,765 shares; 2025Q1: 250,765 shares; 2025Q2: 250,765 shares; 2025Q3: 250,765 shares 250,765$3.6M8.37%0Timeline
RALLYBIO CORPRALLYBIO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 3,301,603 shares; 2024Q1: 3,301,603 shares; 2024Q2: 3,301,603 shares; 2024Q3: 3,301,603 shares; 2024Q4: 3,301,603 shares; 2025Q1: 3,301,603 shares; 2025Q2: 3,301,603 shares; 2025Q3: 3,301,603 shares 3,301,603$1.65M3.83%0
ALECALECTOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 339,569 shares; 2024Q1: 339,569 shares; 2024Q2: 339,569 shares; 2024Q3: 339,569 shares; 2024Q4: 339,569 shares; 2025Q1: 339,569 shares; 2025Q2: 339,569 shares; 2025Q3: 339,569 shares 339,569$1.01M2.33%0Timeline
PASSAGE BIO INCPASSAGE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 2,497,922 shares; 2024Q1: 2,497,922 shares; 2024Q2: 2,497,922 shares; 2024Q3: 2,497,922 shares; 2024Q4: 2,497,922 shares; 2025Q1: 2,497,922 shares; 2025Q2: 2,497,922 shares; 2025Q3: 87,426 shares 87,426$702K1.63%-2,410,496

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ITRMFITERUM THERAPEUTICS PLC345,020$343Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001193125-25-280589 base2025-11-14acceptance time not in the bulk data set

Filings

Every filing of this filer: 13F reports and notices, the 13D and 13G it filed or is a reporting person of, and Forms 3, 4 and 5 it reported as an owner.

FilingSubjectFiledAcceptedIngested
13F-HR 0001193125-25-280589 Quarter ended 2025-09-302025-11-14acceptance time not in the bulk data set
13F-HR 0000950123-25-007852 Quarter ended 2025-06-302025-08-13acceptance time not in the bulk data set
13F-HR 0000950123-25-004966 Quarter ended 2025-03-312025-05-13acceptance time not in the bulk data set
13F-HR 0000950123-25-002058 Quarter ended 2024-12-312025-02-13acceptance time not in the bulk data set
13F-HR 0000950123-24-011274 Quarter ended 2024-09-302024-11-13acceptance time not in the bulk data set
13F-HR 0000950123-24-008255 Quarter ended 2024-06-302024-08-14acceptance time not in the bulk data set
13F-HR 0000950123-24-005071 Quarter ended 2024-03-312024-05-14acceptance time not in the bulk data set
13F-HR 0000950123-24-002003 Quarter ended 2023-12-312024-02-14acceptance time not in the bulk data set
13F-HR 0000950123-23-010254 Quarter ended 2023-09-302023-11-14acceptance time not in the bulk data set
13F-HR 0000950123-23-007238 Quarter ended 2023-06-302023-08-10acceptance time not in the bulk data set
13F-HR 0000950123-23-004364 Quarter ended 2023-03-312023-05-11acceptance time not in the bulk data set
13F-HR 0000950123-23-000807 Quarter ended 2022-12-312023-02-06acceptance time not in the bulk data set
13F-HR 0000950123-22-011473 Quarter ended 2022-09-302022-11-10acceptance time not in the bulk data set
13F-HR 0000950123-22-008147 Quarter ended 2022-06-302022-08-09acceptance time not in the bulk data set
13F-HR 0000950123-22-004719 Quarter ended 2022-03-312022-05-06acceptance time not in the bulk data set
13F-HR 0000950123-22-002158 Quarter ended 2021-12-312022-02-11acceptance time not in the bulk data set
13F-HR 0000950123-21-015005 Quarter ended 2021-09-302021-11-12acceptance time not in the bulk data set
13F-HR 0000950123-21-010563 Quarter ended 2021-06-302021-08-12acceptance time not in the bulk data set
13F-HR/A 0000950123-21-010559 Quarter ended 2021-03-312021-08-12acceptance time not in the bulk data set
13F-HR 0000950123-21-006051 Quarter ended 2021-03-312021-05-12acceptance time not in the bulk data set
13F-HR 0000950123-21-001531 Quarter ended 2020-12-312021-02-10acceptance time not in the bulk data set
13F-HR 0000950123-20-011526 Quarter ended 2020-09-302020-11-12acceptance time not in the bulk data set
13F-HR 0000950123-20-008667 Quarter ended 2020-06-302020-08-13acceptance time not in the bulk data set
13F-HR 0000950123-20-004944 Quarter ended 2020-03-312020-05-14acceptance time not in the bulk data set
13F-HR 0000950123-20-001663 Quarter ended 2019-12-312020-02-13acceptance time not in the bulk data set
13F-HR 0000950123-19-011396 Quarter ended 2019-09-302019-11-14acceptance time not in the bulk data set
13F-HR 0000950123-19-007826 Quarter ended 2019-06-302019-08-13acceptance time not in the bulk data set
13F-HR/A 0000950123-19-005820 Quarter ended 2019-03-312019-06-04acceptance time not in the bulk data set
13F-HR 0000950123-19-004959 Quarter ended 2019-03-312019-05-15acceptance time not in the bulk data set
13F-HR 0000950123-19-001688 Quarter ended 2018-12-312019-02-13acceptance time not in the bulk data set
13F-HR 0000950123-18-011341 Quarter ended 2018-09-302018-11-13acceptance time not in the bulk data set
13F-HR 0000950123-18-008914 Quarter ended 2018-06-302018-08-14acceptance time not in the bulk data set
13F-HR 0000950123-18-005795 Quarter ended 2018-03-312018-05-15acceptance time not in the bulk data set
13F-HR 0000950123-18-002471 Quarter ended 2017-12-312018-02-14acceptance time not in the bulk data set
13F-HR 0000950123-17-010937 Quarter ended 2017-09-302017-11-14acceptance time not in the bulk data set
13F-HR 0001012975-17-000625 Quarter ended 2017-06-302017-08-14acceptance time not in the bulk data set
13F-HR 0001012975-17-000408 Quarter ended 2017-03-312017-05-15acceptance time not in the bulk data set
13F-HR 0001012975-17-000134 Quarter ended 2016-12-312017-02-14acceptance time not in the bulk data set
13F-HR 0001631614-16-000007 Quarter ended 2016-09-302016-11-14acceptance time not in the bulk data set
13F-HR 0001631614-16-000006 Quarter ended 2016-06-302016-08-15acceptance time not in the bulk data set
13F-HR 0001012975-16-001257 Quarter ended 2016-03-312016-05-16acceptance time not in the bulk data set
13F-HR 0001631614-16-000005 Quarter ended 2015-12-312016-02-16acceptance time not in the bulk data set
13F-HR 0001631614-15-000004 Quarter ended 2015-09-302015-11-16acceptance time not in the bulk data set
13F-HR 0001631614-15-000003 Quarter ended 2015-06-302015-08-14acceptance time not in the bulk data set
13F-HR 0001012975-15-000410 Quarter ended 2015-03-312015-05-15acceptance time not in the bulk data set
13F-HR 0001631614-15-000001 Quarter ended 2014-12-312015-02-17acceptance time not in the bulk data set