13F-HR filed by Paradigm Biocapital Advisors LP
Paradigm Biocapital Advisors LP filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-14, with 28 holding rows worth $5,340,558,034.
- Accession
- 0001855655-26-000014
- Filer
- CIK 1855655
- Filed
- 2026-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 28 entries on the cover page, a total value of $5,340,558,034 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,340,558,034 with VALUE read as dollars as filed, 13F file number 028-21950. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 6,361,323 | $1,191,348,571 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 5,924,433 | $731,667,476 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 10,215,455 | $415,053,937 | dollars as filed | |
| GENMAB A/S | 372303206 | Ordinary Shares, nominal value DKK 1 per share | 13,133,131 | $360,767,109 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 3,840,778 | $340,984,271 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,576,385 | $209,233,581 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 2,144,526 | $204,094,539 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 6,357,523 | $198,736,169 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 1,232,877 | $189,844,565 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 9,550,000 | $174,956,000 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 2,775,649 | $174,699,348 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 480,000 | $144,494,400 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 1,325,977 | $141,375,668 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 2,508,015 | $138,442,428 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 2,127,852 | $123,692,037 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 6,723,788 | $123,515,986 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 8,670,576 | $108,468,906 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 2,857,405 | $63,491,539 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 1,828,607 | $58,405,708 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 1,553,748 | $42,696,995 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 2,890,397 | $41,332,677 | dollars as filed | |
| ACHIEVE LIFE SCIENCES INC | 004468500 | COMMON STOCK | 4,951,856 | $32,335,620 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 1,750,000 | $32,217,500 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 685,852 | $24,580,936 | dollars as filed | |
| KARDIGAN INC | 485925101 | CMN | 900,000 | $21,465,000 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 4,175,382 | $19,436,403 | dollars as filed | |
| EDITAS MEDICINE INC | 28106W103 | COM | 5,586,625 | $18,100,665 | dollars as filed | |
| INVENTIVA SA | 46124U107 | ADS | 4,000,000 | $15,120,000 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001855655-26-000014 | this filing | 2026-08-14 | acceptance time not in the bulk data set |