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Disclosery

AMLX AMYLYX PHARMACEUTICALS INC

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COM (common), issuer CIK 1658551

166 managers (169 13F filers) reported a position in AMLX shares at 2025-09-30, 109,720,711 shares in all. 57 filers opened a position and 19 filers sold out during the quarter.

Managers
166
13F filers
169
New
57
Added
44
Reduced
48
Sold out
19
Shares held by filers
109,720,711

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
MILNE GEORGE M JRdirector2026-10-05-30,000 S$27.6968Form 4

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC11,379,207$155M0.01%+8,331,18813F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC8,952,365$122M3.52%+1,050,00013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.7,140,692$97M<0.01%+1,630,50313F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…6,816,828$92.6M0.15%-1,983,17213F-HRTimelineGroup
TCG Crossover Management, LLC6,243,812$84.9M4.17%+300,00013F-HRTimeline
VANGUARD GROUP INCgroup of 2 filers holding5,294,851$72M+775,700Timeline
Saturn V Capital Management LP4,604,878$62.6M13.72%+1,344,30813F-HRTimeline
Commodore Capital LPin group Commodore Capital LP4,075,478$55.4M2.7%new13F-HRTimelineGroup
First Light Asset Management, LLC3,355,882$45.6M4.3%new13F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.2,790,066$37.9M0.08%-1,746,20013F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson2,536,233$34.5M0.02%new13F-HRTimelineGroup
Driehaus Capital Management LLC2,420,767$32.9M0.24%+1,155,77013F-HRTimeline
Almitas Capital LLC2,122,597$28.8M6.6%013F-HR/ATimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,010,633$27.3M<0.01%+712,65113F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,950,301$26.5M<0.01%+1,463,40813F-HR/ATimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,900,000$25.8M0.76%new13F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,812,039$24.6M<0.01%+119,62613F-HRTimelineGroup
683 Capital Management, LLCin group 683 Capital Management, LLC1,760,000$23.9M2.17%-400,00013F-HRTimelineGroup
GREAT POINT PARTNERS LLC1,700,000$23.1M9.65%-300,00013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,621,260$22M<0.01%+612,35113F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC1,512,500$20.6M0.34%new13F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management1,476,302$20.1M0.04%new13F-HRTimelineGroup
Logos Global Management LP1,450,000$19.7M1.95%new13F-HRTimeline
UBS Group AGin group UBS Group AG1,404,471$19.1M<0.01%+151,12713F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,365,521$18.6M0.01%+748,60213F-HRTimelineGroup
T. Rowe Price Investment Management, In…1,198,064$16.3M0.01%new13F-HRTimeline
Connor, Clark & Lunn Investment Managem…1,107,008$15M0.05%-47,47713F-HRTimeline
Nantahala Capital Management, LLCin group Nantahala Capital Management,…935,684$12.7M0.79%-1,998,72113F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC900,000$12.2M3.9%-325,00013F-HR/ATimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC866,202$11.8M1.17%-338,89913F-HRTimelineGroup
Woodline Partners LP845,290$11.5M0.05%-355,00013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP822,237$11.2M<0.01%+2,07313F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.810,640$11M<0.01%+223,75713F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC750,600$10.2M0.24%+437,40013F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…700,000$9.51M1.38%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co645,185$8.77M<0.01%+56,77413F-HRTimelineGroup
BRAIDWELL LP612,841$8.33M0.25%new13F-HRTimeline
Parkman Healthcare Partners LLC579,174$7.87M0.86%-70,82613F-HRTimeline
JENNISON ASSOCIATES LLC578,659$7.86M<0.01%new13F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP509,780$6.94M<0.01%+136,04113F-HRTimelineGroup
Cormorant Asset Management, LP500,000$6.79M0.47%new13F-HRTimeline
Rock Springs Capital Management LP499,764$6.79M0.4%013F-HRTimeline
Ally Bridge Group (NY) LLC437,391$5.94M4.98%new13F-HRTimeline
PFM Health Sciences, LP436,156$5.93M0.51%-296,10013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/429,516$5.84M<0.01%-22,29213F-HR/ATimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC417,771$5.68M<0.01%-1,094,28713F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC414,112$5.63M<0.01%+283,83813F-HR/ATimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC367,331$4.99M0.01%-201,75213F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC333,258$4.53M4.68%new13F-HRTimeline
Alpha Wave Global, LP327,312$4.45M0.45%+51,47013F-HRTimeline
Patient Square Capital LP316,312$4.3M1.15%new13F-HRTimeline
STEMPOINT CAPITAL LP276,884$3.76M0.76%new13F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd258,242$3.51M0.51%+39,49213F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding241,416$3.28M-787,430Timeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…236,197$3.21M<0.01%-52,42113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC234,673$3.19M<0.01%-1,008,25413F-HRTimelineGroup
Trexquant Investment LP222,876$3.03M0.03%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.212,379$2.89M0.01%+8,44913F-HRTimelineGroup
Aldebaran Capital, LLC204,474$2.78M2.55%-13,35313F-HRTimeline
Longaeva Partners L.P.200,000$2.72M0.58%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp182,956$2.49M<0.01%+32,11913F-HRTimelineGroup
SummitTX Capital, L.P.168,000$2.28M0.09%new13F-HRTimeline
Qube Research & Technologies Ltd167,106$2.27M<0.01%-270,92013F-HRTimeline
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC164,042$2.23M0.01%new13F-HRTimelineGroup
Nuveen, LLCin group TIAA160,419$2.18M<0.01%+4,88313F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/143,752$1.95M<0.01%+24013F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC133,508$1.81M<0.01%+38,28913F-HRTimelineGroup
Kennondale Capital Management LLC108,615$1.48M1.13%+13,45013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/100,445$1.37M<0.01%+9,05313F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC100,000$1.36M0.05%013F-HRTimelineGroup
DIADEMA PARTNERS LP100,000$1.36M0.95%new13F-HRTimeline
RHUMBLINE ADVISERS98,657$1.34M<0.01%-1,91913F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN93,691$1.27M<0.01%+55,59013F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA93,012$1.26M<0.01%+80,87913F-HRTimelineGroup
DARK FOREST CAPITAL MANAGEMENT LP86,795$1.18M0.04%new13F-HR/ATimeline
Informed Momentum Co LLC75,111$1.02M0.12%-24,84913F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC73,640$1M<0.01%new13F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.71,500$972K<0.01%+40,90013F-HRTimeline
Maven Securities LTDin group Maven Securities LTD70,000$951K0.18%new13F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.68,877$936K<0.01%-82,62513F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc67,212$913K<0.01%+59,81013F-HRTimelineGroup
Numerai GP LLC67,153$913K0.13%new13F-HRTimeline
Verition Fund Management LLC63,896$868K<0.01%new13F-HRTimeline
READYSTATE ASSET MANAGEMENT LP59,132$804K0.04%new13F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…56,667$770K0.01%new13F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…55,406$753K<0.01%+49,17713F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP52,107$708K0.06%-118,42613F-HRTimeline
Mariner, LLCin group Mariner, LLC48,027$653K<0.01%-64113F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.47,898$651K0.02%-8,93313F-HRTimeline
Schonfeld Strategic Advisors LLC43,637$593K<0.01%-602,80613F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…42,929$583K<0.01%013F-HRTimelineGroup
TD Asset Management Inc40,966$557K<0.01%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC38,083$518K<0.01%+6,98513F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO35,844$487K<0.01%-52,14513F-HR/ATimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding35,446$482K-5,984Timeline
Monashee Investment Management LLC30,000$408K0.2%new13F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd28,286$384K<0.01%-1,14413F-HRTimelineGroup
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC24,899$338K<0.01%-10,85313F-HRTimelineGroup
Campbell & CO Investment Adviser LLC24,482$333K0.03%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …23,790$323K<0.01%-2,20913F-HRTimelineGroup
Persistent Asset Partners Ltd22,913$311K0.23%new13F-HR/ATimeline
NEW YORK STATE COMMON RETIREMENT FUND21,900$298K<0.01%013F-HRTimeline
PARSONS CAPITAL MANAGEMENT INC/RI21,645$294K0.02%013F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC19,369$278K<0.01%new13F-HRTimelineGroup
Premier Path Wealth Partners, LLC20,265$275K0.04%013F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC19,930$271K<0.01%013F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC19,900$270K<0.01%-376,30013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC19,494$265K<0.01%-16,82113F-HRTimeline
Police & Firemen's Retirement System of…19,262$262K<0.01%+3,27013F-HRTimeline
OXFORD ASSET MANAGEMENT LLP19,120$260K0.09%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
EntryPoint Capital, LLC17,166$233K0.09%new13F-HRTimeline
Quantbot Technologies LP16,653$226K0.01%new13F-HRTimeline
China Universal Asset Management Co., L…15,630$212K0.02%-2,27413F-HRTimeline
ProShare Advisors LLC15,038$204K<0.01%-2,51313F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS14,609$199K<0.01%+7,34213F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD13,875$189K<0.01%new13F-HRTimeline
AlphaQuest LLC13,636$185K0.01%new13F-HRTimeline
PROFUND ADVISORS LLC13,418$182K0.01%new13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC12,990$177K<0.01%-6,48613F-HRTimelineGroup
SG Americas Securities, LLC11,819$161K<0.01%new13F-HRTimeline
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…10,634$145K<0.01%new13F-HRTimelineGroup
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…10,401$141K0.01%new13F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC10,155$138K<0.01%-5,46513F-HRTimelineGroup
Valeo Financial Advisors, LLC10,000$136K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…6,590$89.6K<0.01%-87713F-HRTimelineGroup
Point72 (DIFC) Ltd5,967$81.1K0.01%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,794$78.7K<0.01%-1,28713F-HRTimelineGroup
Cubist Systematic Strategies, LLC5,603$76.1K<0.01%-117,63913F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…4,331$58.9K<0.01%+313F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\4,000$54.4K<0.01%013F-HRTimelineGroup
Aster Capital Management (DIFC) Ltd3,568$48.5K0.02%new13F-HRTimeline
STRS OHIO3,400$46.2K<0.01%-3,90013F-HRTimeline
AMALGAMATED BANK2,369$32K<0.01%013F-HRTimeline
Arax Advisory Partners2,244$30.5K<0.01%new13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,918$26.1K<0.01%+21813F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…1,906$25.9K<0.01%-91713F-HRTimeline
LORING WOLCOTT & COOLIDGE FIDUCIARY ADV…1,803$25.8K<0.01%013F-HRTimeline
Steward Partners Investment Advisory, L…1,500$20.4K<0.01%-50013F-HRTimeline
SBI Securities Co., Ltd.1,251$17K<0.01%+1,25013F-HRTimeline
Sterling Capital Management LLC1,209$16.4K<0.01%+65713F-HRTimeline
SUMMIT SECURITIES GROUP LLC1,191$16.2K0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC1,186$16K<0.01%+29613F-HRTimelineGroup
Global Retirement Partners, LLC1,000$13.6K<0.01%-1,50013F-HRTimeline
Dunhill Financial, LLC600$8.15K<0.01%013F-HRTimeline
North Capital, Inc.501$6.81K0.01%+113F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…485$6.59K<0.01%+43213F-HRTimelineGroup
Caitong International Asset Management …366$4.97K<0.01%-2,54713F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.266$4K<0.01%013F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC285$3.87K<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.274$3.72K<0.01%013F-HRTimeline
MassMutual Private Wealth & Trust, FSB240$3.26K<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.225$3.06K<0.01%-1513F-HRTimelineGroup
EVOLUTION WEALTH MANAGEMENT INC.165$2.24K<0.01%new13F-HR/ATimeline
GAMMA Investing LLC125$1.7K<0.01%new13F-HRTimeline
HARBOUR INVESTMENTS, INC.90$1.22K<0.01%013F-HRTimeline
Catherine Avery Investment Management L…87$1.18K<0.01%013F-HRTimeline
Rise Advisors, LLC64$870<0.01%new13F-HRTimeline
SALEM INVESTMENT COUNSELORS INC55$748<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP30$436<0.01%new13F-HRTimelineGroup
FINANCIAL CONSULATE, INC25$340<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…25$340<0.01%013F-HRTimelineGroup
Farther Finance Advisors, LLC20$272<0.01%new13F-HRTimeline
Essential Partners LLC16$217<0.01%new13F-HRTimeline
Allworth Financial LP12$164<0.01%new13F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…5$68<0.01%new13F-HRTimelineGroup
IFP Advisors, Inc1$14<0.01%new13F-HR/ATimeline

Events

  • MILNE GEORGE M JR sold 30,000 AMLX shares on 2026-10-05, Form 4 filed 2026-10-07. 0001193125-26-416950

    Accepted , ingested