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Disclosery

AMLX AMYLYX PHARMACEUTICALS INC

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COM (common), issuer CIK 1658551

162 managers (171 13F filers) reported a position in AMLX shares at 2026-03-31, 114,149,878 shares in all. 21 filers opened a position and 36 filers sold out during the quarter.

Managers
162
13F filers
171
New
21
Added
63
Reduced
53
Sold out
36
Shares held by filers
114,149,878

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
MILNE GEORGE M JRdirector2026-10-05-30,000 S$27.6968Form 4

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC16,630,541$231M0.01%+112,12213F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.8,828,836$123M<0.01%-225,59513F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC8,284,882$115M2.27%013F-HR/ATimelineGroup
TCG Crossover Management, LLC6,243,812$86.8M2.48%013F-HRTimeline
VANGUARD GROUP INCgroup of 7 filers holding5,805,427$80.7M+5,784,587Timeline
Commodore Capital LPin group Commodore Capital LP5,650,000$78.5M4.54%013F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson4,986,073$69.3M0.03%+520,20113F-HR/ATimelineGroup
Saturn V Capital Management LP4,349,885$60.5M10.95%-146,60213F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…3,560,764$49.5M0.08%+783,70913F-HRTimelineGroup
First Light Asset Management, LLC3,190,645$44.3M3.97%-164,89413F-HRTimeline
Driehaus Capital Management LLC2,987,147$41.5M0.31%-122,35613F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,625,991$36.5M<0.01%+12,77013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,363,161$32.8M<0.01%+293,27713F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources2,261,569$31.4M0.01%+1,061,47313F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,210,932$30.7M<0.01%+45,39813F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY2,175,547$30.2M<0.01%-184,27713F-HRTimelineGroup
Almitas Capital LLC2,122,597$29.5M6.67%013F-HRTimeline
GREAT POINT PARTNERS LLC1,750,000$24.3M5.96%013F-HRTimeline
Jones Hill Capital LP1,598,794$22.2M4.76%13F-HRTimeline
683 Capital Management, LLCin group 683 Capital Management, LLC1,530,000$21.3M1.97%-120,00013F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC1,513,958$21M0.35%+81013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,330,689$18.5M<0.01%-5,32113F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,267,785$17.6M0.01%-65,45113F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,230,000$17.1M0.47%new13F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management1,107,271$15.4M0.03%+248,58713F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC1,000,604$13.9M0.84%+110,24813F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC971,854$13.5M<0.01%+676,67713F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP903,192$12.5M<0.01%+131,94413F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…868,325$12.1M0.03%-135,69613F-HRTimeline
Woodline Partners LP845,800$11.8M0.04%+39213F-HR/ATimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC800,000$11.1M1.46%013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP779,908$10.8M<0.01%-157,85613F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co716,225$9.96M<0.01%+3,23513F-HRTimelineGroup
Qube Research & Technologies Ltd702,236$9.76M0.01%+289,36313F-HRTimeline
Logos Global Management LP700,000$9.73M0.5%-250,00013F-HRTimeline
STEMPOINT CAPITAL LP669,685$9.31M1.79%+104,54513F-HR/ATimeline
Parkman Healthcare Partners LLC621,458$8.64M0.9%+239,69813F-HRTimeline
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD592,654$8.24M0.04%+577,08013F-HRTimelineGroup
Nantahala Capital Management, LLCin group Nantahala Capital Management,…535,684$7.45M0.46%-300,00013F-HRTimelineGroup
Rock Springs Capital Management LP499,764$6.95M0.41%013F-HRTimeline
UBS Group AGgroup of 2 filers holding481,408$6.69M-160,753Timeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC411,532$5.72M<0.01%+66,56413F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.363,546$5.05M0.01%-93,86613F-HRTimelineGroup
HighVista Strategies LLC352,085$4.89M1.35%+113,27313F-HRTimeline
Cormorant Asset Management, LP350,000$4.87M0.25%-50,00013F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd317,877$4.42M0.87%+45,04913F-HRTimelineGroup
iA Global Asset Management Inc.304,786$4.24M0.06%new13F-HRTimeline
Nuveen, LLCin group TIAA264,897$3.68M<0.01%-19,05113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp251,104$3.49M<0.01%+33,75713F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…241,552$3.36M<0.01%+15,77013F-HRTimelineGroup
SummitTX Capital, L.P.227,010$3.16M0.1%+8,61113F-HRTimeline
Aldebaran Capital, LLC197,892$2.75M2.1%-61613F-HRTimeline
Invesco Ltd.in group Invesco Ltd.171,620$2.39M<0.01%-4,29413F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP161,945$2.25M<0.01%-182,45613F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC151,067$2.1M1.49%-182,19113F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO159,663$2.04M<0.01%+93,11613F-HR/ATimelineGroup
PFM Health Sciences, LP145,275$2.02M0.21%+10,72613F-HRTimeline
Alpha Wave Global, LP142,336$1.98M0.25%-175,34213F-HRTimeline
Swiss National Bank130,300$1.81M<0.01%-31,40013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/121,439$1.69M<0.01%+13,89113F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC114,877$1.6M<0.01%+38,31513F-HRTimelineGroup
Elmind Capital, LP112,000$1.56M0.44%013F-HRTimeline
RHUMBLINE ADVISERS108,467$1.51M<0.01%+9,19313F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.106,535$1.48M<0.01%-228,46513F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC89,983$1.25M0.01%-18913F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO85,279$1.19M<0.01%+32,42313F-HRTimelineGroup
Schonfeld Strategic Advisors LLC77,794$1.08M0.01%+56,74213F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN75,083$1.04M<0.01%-71,22613F-HR/ATimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.74,230$1.03M<0.01%+1,00613F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD72,061$1M<0.01%-12,08313F-HRTimeline
ALLIANCEBERNSTEIN L.P.80,800$976K<0.01%+9,30013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…65,002$904K<0.01%-14,08813F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding61,711$858K+53,146Timeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…59,346$825K<0.01%-6,09213F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc55,773$775K<0.01%-16,83913F-HRTimelineGroup
Campbell & CO Investment Adviser LLC54,422$756K0.04%-24,34113F-HRTimeline
Informed Momentum Co LLC53,256$740K0.09%013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…51,587$717K<0.01%+1,93313F-HRTimelineGroup
Maven Securities LTDin group Maven Securities LTD50,000$695K0.04%new13F-HRTimelineGroup
Numerai GP LLC48,553$675K0.07%-64,09513F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding48,281$671K+1,778Timeline
Zurcher Kantonalbank (Zurich Cantonalba…40,790$567K<0.01%+4,91313F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…39,802$553K<0.01%-29,09013F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …38,781$539K<0.01%+11,79313F-HRTimelineGroup
OPTIMIZE FINANCIAL INC.32,001$445K0.22%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC31,782$442K<0.01%-6,25013F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL31,334$436K<0.01%+8,93213F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC29,089$404K<0.01%+1,24213F-HRTimelineGroup
Integrated Quantitative Investments LLC27,234$379K0.07%013F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC25,513$355K<0.01%+27013F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC24,921$346K<0.01%-7,08513F-HRTimeline
Police & Firemen's Retirement System of…23,752$330K<0.01%013F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…22,519$313K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND21,900$304K<0.01%013F-HRTimeline
PARSONS CAPITAL MANAGEMENT INC/RI21,645$301K0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS21,140$294K<0.01%-4,06113F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…20,815$289K0.08%+50813F-HRTimelineGroup
Premier Path Wealth Partners, LLC20,265$282K0.04%013F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC19,930$277K<0.01%013F-HRTimelineGroup
Headlands Technologies LLC19,814$275K0.03%-10,72913F-HRTimeline
China Universal Asset Management Co., L…19,488$271K0.02%+1,59313F-HRTimeline
ProShare Advisors LLC18,154$252K<0.01%-2,91413F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM18,099$252K<0.01%-4,81513F-HRTimeline
Creative Planningin group Creative Planning17,883$249K<0.01%new13F-HRTimelineGroup
KLP KAPITALFORVALTNING AS17,400$242K<0.01%013F-HRTimeline
PROFUND ADVISORS LLC17,152$238K0.01%-3,43713F-HRTimeline
Seven Fleet Capital Management LP16,671$232K0.07%+5,10013F-HR/ATimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC15,227$212K<0.01%-2013F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC14,120$196K<0.01%new13F-HRTimelineGroup
Verition Fund Management LLC13,264$184K<0.01%-16,22313F-HRTimeline
Amundiin group Amundi12,895$179K<0.01%new13F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA12,383$172K<0.01%-3,26013F-HRTimelineGroup
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…12,226$170K0.01%013F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC11,414$157K<0.01%new13F-HRTimelineGroup
PSP Research LLC10,838$151K0.11%-33,38513F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…10,768$150K<0.01%new13F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC10,644$148K<0.01%+9213F-HRTimeline
GREAT LAKES ADVISORS, LLC10,380$144K<0.01%new13F-HRTimeline
Valeo Financial Advisors, LLC10,000$139K<0.01%-5,00013F-HRTimeline
MAI Capital Management9,014$125K<0.01%new13F-HRTimeline
ACT CAPITAL MANAGEMENT, LLC9,000$125K0.1%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…7,913$110K<0.01%-18213F-HRTimelineGroup
Ameritas Investment Partners, Inc.group of 2 filers holding7,206$100K+3Timeline
STRS OHIO3,400$47.3K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.2,455$34.1K<0.01%+29713F-HRTimeline
LORING WOLCOTT & COOLIDGE FIDUCIARY ADV…1,803$29.5K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\2,063$28.7K<0.01%+6313F-HRTimelineGroup
State of Wyoming1,883$26.2K<0.01%+50213F-HRTimeline
KBC Group NVin group KBC Group NV1,863$26K<0.01%new13F-HRTimelineGroup
Arax Advisory Partners1,494$20.8K<0.01%-1,05613F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,418$19.7K<0.01%+10313F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…1,274$17.7K<0.01%+1,01313F-HRTimelineGroup
CWM, LLCin group CWM, LLC1,263$17.6K<0.01%+7013F-HRTimelineGroup
Sterling Capital Management LLC1,137$15.8K<0.01%-49013F-HRTimeline
Steward Partners Investment Advisory, L…1,000$13.9K<0.01%-50013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC922$12.8K<0.01%013F-HRTimeline
Westfuller Advisors, LLC819$11.4K<0.01%013F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…755$10.5K<0.01%new13F-HRTimelineGroup
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.661$9.19K<0.01%-1,43813F-HRTimelineGroup
Dunhill Financial, LLC600$8.34K<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.528$7.34K<0.01%+27913F-HRTimelineGroup
GAMMA Investing LLC417$5.8K<0.01%+15013F-HRTimeline
J.Safra Asset Management Corp377$5.24K<0.01%+25413F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC325$4.52K<0.01%-52713F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…283$3.93K<0.01%-15513F-HRTimelineGroup
MassMutual Private Wealth & Trust, FSB282$3.92K<0.01%+12913F-HRTimeline
Physician Wealth Advisors, Inc.274$3.81K<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP270$3.66K<0.01%+24013F-HRTimelineGroup
SIGNATUREFD, LLC254$3.53K<0.01%new13F-HRTimeline
Larson Financial Group LLC201$2.79K<0.01%+16013F-HRTimeline
EASTERN BANK200$2.78K<0.01%new13F-HRTimeline
HARBOUR INVESTMENTS, INC.90$1.25K<0.01%013F-HRTimeline
Stone House Investment Management, LLC73$1.01K<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$765<0.01%new13F-HRTimeline
SALEM INVESTMENT COUNSELORS INC55$765<0.01%new13F-HR/ATimeline
Allworth Financial LP40$556<0.01%+2813F-HRTimeline
Caitong International Asset Management …36$500<0.01%-3,82313F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…26$361<0.01%+113F-HR/ATimelineGroup
Farther Finance Advisors, LLC22$316<0.01%+213F-HRTimeline
Essential Partners LLC15$209<0.01%-213F-HRTimeline
SBI Securities Co., Ltd.1$14<0.01%013F-HRTimeline
Covestor Ltd9$00%new13F-HRTimelineValue filed as zero, left out of ratios.

Events

  • MILNE GEORGE M JR sold 30,000 AMLX shares on 2026-10-05, Form 4 filed 2026-10-07. 0001193125-26-416950

    Accepted , ingested