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Disclosery

AMLX AMYLYX PHARMACEUTICALS INC

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COM (common), issuer CIK 1658551

175 managers (180 13F filers) reported a position in AMLX shares at 2025-12-31, 112,319,309 shares in all. 36 filers opened a position and 27 filers sold out during the quarter.

Managers
175
13F filers
180
New
36
Added
72
Reduced
44
Sold out
27
Shares held by filers
112,319,309

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
MILNE GEORGE M JRdirector2026-10-05-30,000 S$27.6968Form 4

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC16,518,419$200M0.01%+5,139,21213F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.9,054,431$109M<0.01%+1,913,73913F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC8,284,882$100M1.83%-667,48313F-HRTimelineGroup
TCG Crossover Management, LLC6,243,812$75.4M2.5%013F-HRTimeline
VANGUARD GROUP INCgroup of 2 filers holding5,825,752$70.4M+530,901Timeline
Commodore Capital LPin group Commodore Capital LP5,650,000$68.3M4.54%+1,574,52213F-HRTimelineGroup
Saturn V Capital Management LP4,496,487$54.3M9.97%-108,39113F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson4,465,872$54M0.02%+1,929,63913F-HRTimelineGroup
First Light Asset Management, LLC3,355,539$40.5M3.1%-34313F-HRTimeline
Driehaus Capital Management LLC3,109,503$37.6M0.26%+688,73613F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…2,777,055$33.5M0.05%-4,039,77313F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,613,221$31.6M<0.01%+602,58813F-HR/ATimelineGroup
MORGAN STANLEYin group MORGAN STANLEY2,359,824$28.5M<0.01%+409,52313F-HR/ATimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,165,534$26.2M<0.01%+353,49513F-HRTimelineGroup
Almitas Capital LLC2,122,597$25.6M5.65%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP2,069,884$25M<0.01%+448,62413F-HRTimelineGroup
GREAT POINT PARTNERS LLC1,750,000$21.1M6.85%+50,00013F-HRTimeline
683 Capital Management, LLCin group 683 Capital Management, LLC1,650,000$19.9M1.66%-110,00013F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC1,513,148$18.3M0.29%+64813F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,336,010$16.1M<0.01%+906,49413F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,333,236$16.1M0.01%-32,28513F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources1,200,096$14.5M<0.01%new13F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…1,004,021$12.1M0.03%-102,98713F-HRTimeline
Logos Global Management LP950,000$11.5M0.76%-500,00013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP937,764$11.3M<0.01%+115,52713F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC890,356$10.8M0.8%+24,15413F-HR/ATimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management858,684$10.4M0.02%-617,61813F-HRTimelineGroup
Woodline Partners LP845,408$10.2M0.04%+11813F-HRTimeline
Nantahala Capital Management, LLCin group Nantahala Capital Management,…835,684$10.1M0.6%-100,00013F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC800,000$9.66M2.12%-100,00013F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP771,248$9.32M<0.01%+261,46813F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co712,990$8.61M<0.01%+67,80513F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding672,802$8.13M+431,386Timeline
UBS Group AGgroup of 2 filers holding642,161$7.76M-762,310Timeline
STEMPOINT CAPITAL LP565,140$6.83M1.17%+288,25613F-HRTimeline
Sofinnova Investments, Inc.527,099$6.37M0.27%new13F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…506,242$6.12M0.88%-193,75813F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC502,366$6.07M<0.01%+368,85813F-HRTimelineGroup
Rock Springs Capital Management LP499,764$6.04M0.31%013F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.457,412$5.53M0.01%+245,03313F-HRTimelineGroup
Qube Research & Technologies Ltd412,873$4.99M0.01%+245,76713F-HRTimeline
Cormorant Asset Management, LP400,000$4.83M0.27%-100,00013F-HRTimeline
Parkman Healthcare Partners LLC381,760$4.61M0.44%-197,41413F-HRTimeline
Patient Square Capital LP350,000$4.23M0.91%+33,68813F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC344,968$4.17M<0.01%+110,29513F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.335,000$4.05M0.01%-2,455,06613F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC333,258$4.03M2.73%013F-HRTimeline
Alpha Wave Global, LP317,678$3.84M0.47%-9,63413F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC295,177$3.57M<0.01%-118,93513F-HRTimelineGroup
Nuveen, LLCin group TIAA283,948$3.43M<0.01%+123,52913F-HRTimelineGroup
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd272,828$3.3M0.69%+14,58613F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC263,235$3.18M<0.01%new13F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC254,328$3.07M0.01%-113,00313F-HRTimelineGroup
HighVista Strategies LLC238,812$2.88M0.74%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…225,782$2.73M<0.01%-10,41513F-HRTimelineGroup
SummitTX Capital, L.P.218,399$2.64M0.08%+50,39913F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp217,347$2.63M<0.01%+34,39113F-HRTimelineGroup
Aldebaran Capital, LLC198,508$2.4M2.15%-5,96613F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC192,500$2.33M<0.01%+172,60013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd189,673$2.29M0.06%new13F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.175,914$2.13M<0.01%-634,72613F-HRTimelineGroup
Swiss National Bank161,700$1.95M<0.01%new13F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC153,363$1.85M0.01%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN146,309$1.77M<0.01%+52,61813F-HRTimelineGroup
Atom Investors LP139,422$1.68M0.13%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/138,525$1.67M<0.01%-5,22713F-HRTimelineGroup
PFM Health Sciences, LP134,549$1.63M0.16%-301,60713F-HRTimeline
Numerai GP LLC112,648$1.36M0.16%+45,49513F-HRTimeline
Elmind Capital, LP112,000$1.35M0.4%13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/107,548$1.3M<0.01%+7,10313F-HRTimeline
RHUMBLINE ADVISERS99,274$1.2M<0.01%+61713F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC90,172$1.09M0.01%new13F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD84,144$1.02M<0.01%+70,26913F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…79,090$955K<0.01%+74,75913F-HRTimeline
Campbell & CO Investment Adviser LLC78,763$951K0.05%+54,28113F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC76,562$925K<0.01%new13F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.73,224$885K<0.01%+4,34713F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc72,612$877K<0.01%+5,40013F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.71,500$864K<0.01%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…68,892$832K<0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO66,547$804K<0.01%+30,70313F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…65,438$790K<0.01%+10,03213F-HRTimelineGroup
Kennondale Capital Management LLC53,423$645K0.47%-55,19213F-HRTimeline
Informed Momentum Co LLC53,256$643K0.07%-21,85513F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO52,856$638K<0.01%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…49,654$600K<0.01%+6,72513F-HRTimelineGroup
Trexquant Investment LP48,112$581K0.01%-174,76413F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding46,503$562K+11,057Timeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC46,455$561K<0.01%-371,31613F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC46,342$560K<0.01%-1,68513F-HRTimelineGroup
PSP Research LLC44,223$534K0.47%13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC38,032$459K<0.01%-5113F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP36,758$444K0.04%-15,34913F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…35,877$433K<0.01%+33,97113F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.35,409$428K0.07%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC32,006$387K<0.01%+12,51213F-HRTimeline
Persistent Asset Partners Ltd31,147$376K0.18%+8,23413F-HRTimeline
Headlands Technologies LLC30,543$369K0.03%new13F-HRTimeline
Verition Fund Management LLC29,487$356K<0.01%-34,40913F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC27,847$336K<0.01%-45,79313F-HRTimelineGroup
Integrated Quantitative Investments LLC27,234$329K0.07%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …26,988$326K<0.01%+3,19813F-HRTimelineGroup
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC25,243$305K<0.01%+34413F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS25,201$304K<0.01%+10,59213F-HRTimelineGroup
Aquatic Capital Management LLC24,352$294K0.01%new13F-HRTimeline
Police & Firemen's Retirement System of…23,752$287K<0.01%+4,49013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM22,914$277K<0.01%new13F-HRTimeline
TUDOR INVESTMENT CORP ET AL22,402$271K<0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND21,900$265K<0.01%013F-HRTimeline
PARSONS CAPITAL MANAGEMENT INC/RI21,645$261K0.01%013F-HRTimeline
ProShare Advisors LLC21,068$255K<0.01%+6,03013F-HRTimeline
Schonfeld Strategic Advisors LLC21,052$254K<0.01%-22,58513F-HRTimeline
SG Americas Securities, LLC20,846$252K<0.01%+9,02713F-HRTimeline
PROFUND ADVISORS LLC20,589$249K0.01%+7,17113F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…20,307$245K0.07%new13F-HRTimelineGroup
Premier Path Wealth Partners, LLC20,265$245K0.03%013F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC19,930$241K<0.01%013F-HRTimelineGroup
Engineers Gate Manager LP18,358$222K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…17,895$216K0.02%+2,26513F-HRTimeline
Rafferty Asset Management, LLC17,673$213K<0.01%new13F-HRTimeline
KLP KAPITALFORVALTNING AS17,400$210K<0.01%new13F-HRTimeline
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD15,574$188K<0.01%new13F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA15,643$188K<0.01%-77,36913F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd15,465$187K<0.01%-12,82113F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC15,247$184K<0.01%+2,25713F-HRTimelineGroup
Valeo Financial Advisors, LLC15,000$181K<0.01%+5,00013F-HRTimeline
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…12,226$148K0.01%+1,82513F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS12,174$147K<0.01%new13F-HRTimeline
Seven Fleet Capital Management LP11,571$140K0.09%13F-HR/ATimeline
VICTORY CAPITAL MANAGEMENT INC10,552$127K<0.01%new13F-HRTimeline
EntryPoint Capital, LLC10,487$127K0.05%-6,67913F-HRTimeline
ACT CAPITAL MANAGEMENT, LLC9,000$109K0.09%13F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding8,565$103KnewTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…8,095$97.8K<0.01%+1,50513F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…7,203$87K<0.01%+1,40913F-HRTimelineGroup
AlphaQuest LLC7,195$86.9K<0.01%-6,44113F-HRTimeline
T. Rowe Price Investment Management, In…4,517$55K<0.01%-1,193,54713F-HR/ATimeline
Caitong International Asset Management …3,859$46.6K0.01%+3,49313F-HR/ATimeline
SIMPLEX TRADING, LLC3,727$45K<0.01%new13F-HRTimeline
STRS OHIO3,400$41.1K<0.01%013F-HRTimeline
AMALGAMATED BANK2,788$34K<0.01%+41913F-HRTimeline
Arax Advisory Partners2,550$30.8K<0.01%+30613F-HRTimeline
LORING WOLCOTT & COOLIDGE FIDUCIARY ADV…1,803$27.9K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.2,158$26.1K<0.01%+24013F-HRTimeline
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.2,099$25.4K<0.01%new13F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\2,000$24.2K<0.01%-2,00013F-HRTimelineGroup
Sterling Capital Management LLC1,627$19.7K<0.01%+41813F-HRTimeline
Steward Partners Investment Advisory, L…1,500$18.1K<0.01%013F-HRTimeline
State of Wyoming1,381$16.7K<0.01%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,315$16K<0.01%new13F-HRTimelineGroup
CWM, LLCin group CWM, LLC1,193$14K<0.01%+713F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC852$12K<0.01%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC922$11.1K<0.01%+63713F-HRTimeline
Westfuller Advisors, LLC819$9.89K<0.01%new13F-HRTimeline
Dunhill Financial, LLC600$7.25K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…438$5.29K<0.01%-4713F-HRTimelineGroup
Physician Wealth Advisors, Inc.274$3.31K<0.01%013F-HRTimeline
GAMMA Investing LLC267$3.23K<0.01%+14213F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…261$3.15K<0.01%+25613F-HR/ATimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.249$3.01K<0.01%+2413F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.266$3K<0.01%013F-HRTimelineGroup
EVOLUTION WEALTH MANAGEMENT INC.165$1.99K<0.01%013F-HRTimeline
MassMutual Private Wealth & Trust, FSB153$1.85K<0.01%-8713F-HRTimeline
J.Safra Asset Management Corp123$1.49K<0.01%new13F-HRTimeline
HARBOUR INVESTMENTS, INC.90$1.09K<0.01%013F-HRTimeline
Catherine Avery Investment Management L…87$1.05K<0.01%013F-HRTimeline
Larson Financial Group LLC41$495<0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP30$362<0.01%013F-HRTimelineGroup
FINANCIAL CONSULATE, INC25$302<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…25$302<0.01%013F-HRTimelineGroup
Farther Finance Advisors, LLC20$242<0.01%013F-HRTimeline
Essential Partners LLC17$205<0.01%+113F-HRTimeline
Allworth Financial LP12$145<0.01%013F-HRTimeline
IFP Advisors, Inc1$12<0.01%013F-HRTimeline
SBI Securities Co., Ltd.1$12<0.01%-1,25013F-HRTimeline

Events

  • MILNE GEORGE M JR sold 30,000 AMLX shares on 2026-10-05, Form 4 filed 2026-10-07. 0001193125-26-416950

    Accepted , ingested