13F-HR filed by RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. filed this 13F-HR for the quarter ended 2026-03-31, filed 2026-05-15, with 85 holding rows worth $9,437,744,027.
- Accession
- 0001104659-26-062637
- Filer
- CIK 1346824
- Filed
- 2026-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2026
A holdings report, 86 entries on the cover page, a total value of $9,437,744,027 stated on the cover page (in dollars after the unit check, H1), rows summing to $9,437,744,027 with VALUE read as dollars as filed, 13F file number 028-12884. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 10,281,496 | $2,351,686,580 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 11,474,599 | $666,788,948 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,666,837 | $579,814,814 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 12,198,625 | $467,207,338 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 9,905,045 | $397,093,254 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 10,428,437 | $328,495,766 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 9,550,191 | $305,701,614 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 2,534,145 | $259,623,155 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 2,611,733 | $219,176,633 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 7,692,750 | $208,396,598 | dollars as filed | |
| SPYGLASS PHARMA INC | 85220G109 | COMMON STOCK | 8,021,117 | $207,827,141 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 26,975,505 | $195,572,411 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 6,995,858 | $168,110,468 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 2,450,221 | $156,667,131 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 11,189,693 | $155,536,733 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 15,827,186 | $150,674,811 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 7,255,993 | $144,321,701 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 373,787 | $120,430,434 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 7,676,697 | $107,934,360 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 5,707,262 | $107,353,598 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 23,555,648 | $105,293,747 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 5,404,998 | $96,425,164 | dollars as filed | |
| GERON CORP | 374163103 | COM | 63,771,366 | $95,019,335 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 10,860,977 | $87,213,645 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 3,902,596 | $84,920,489 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,621,620 | $81,794,513 | dollars as filed | |
| EVOMMUNE INC | 30054Y107 | COMMON STOCK | 3,494,638 | $80,341,728 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 11,300,939 | $77,411,432 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 9,339,978 | $67,247,842 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 9,853,302 | $63,455,265 | dollars as filed | |
| DAMORA THERAPEUTICS INC | 36322Q206 | COMMON STOCK | 2,399,310 | $62,142,129 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 4,897,237 | $59,060,678 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 2,208,604 | $54,464,175 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 3,671,083 | $51,578,716 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 20,992,669 | $49,542,699 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 5,049,779 | $47,013,442 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 6,053,960 | $46,433,873 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 1,507,844 | $45,838,458 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 17,754,430 | $40,125,012 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 2,600,000 | $38,766,000 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 4,178,823 | $38,236,230 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 667,207 | $36,556,272 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 20,064,545 | $35,514,245 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 2,972,973 | $31,632,433 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 318,554 | $29,428,019 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 1,650,648 | $28,869,834 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 5,000,000 | $28,700,000 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 1,020,410 | $28,316,378 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 9,180,000 | $27,999,000 | dollars as filed | |
| AKTIS ONCOLOGY INC | 01021M104 | COMMON STOCK | 1,503,084 | $26,890,173 | dollars as filed | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 13,011,849 | $26,088,757 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 6,804,072 | $25,515,270 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 10,714,000 | $23,785,080 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 10,805,129 | $22,798,822 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 746,841 | $22,188,646 | dollars as filed | |
| GRAIL INC | 384747101 | COM | 428,266 | $22,132,787 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 8,000,000 | $21,040,000 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 2,947,369 | $20,513,688 | dollars as filed | |
| BENITEC BIOPHARMA INC | 08205P209 | COMMON STOCK | 1,850,000 | $19,702,500 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 265,000 | $19,337,050 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367201 | COMMON STOCK | 715,307 | $17,818,297 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 1,296,012 | $16,925,917 | dollars as filed | |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 4,401,500 | $16,857,745 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 325,663 | $16,797,698 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 3,000,000 | $16,650,000 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 3,998,333 | $16,553,099 | dollars as filed | |
| HINGE HEALTH INC A | 433313103 | COMMON STOCK | 364,613 | $14,059,477 | dollars as filed | |
| GENEDX HOLDINGS CORP | 81663L200 | COM CL A | 209,887 | $13,478,943 | dollars as filed | |
| WAYSTAR HLDG CORP | 946784105 | COM | 529,400 | $12,763,834 | dollars as filed | |
| HELIX ACQUISITION CORP III | G4444S107 | USD CL A ORD SHS | 1,250,000 | $12,700,000 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 7,124,116 | $12,467,203 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 8,340,508 | $11,593,306 | dollars as filed | |
| ATRIUM THERAPEUTICS INC COM | 04965N104 | Stock | 864,102 | $11,553,044 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 1,917,354 | $10,679,662 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 662,968 | $9,898,112 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 750,000 | $8,227,500 | dollars as filed | |
| ADICET BIO INC | 007002207 | COM NEW | 1,182,624 | $8,053,669 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 333,333 | $6,679,993 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 450,000 | $6,583,500 | dollars as filed | |
| RANI THERAPEUTICS HLDGS INC | 753018100 | CMN | 8,500,000 | $6,245,800 | dollars as filed | |
| EQUILLIUM INC | 29446K106 | COM | 3,096,336 | $6,192,672 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 6,681,307 | $5,562,856 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 1,864,176 | $5,387,469 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 248,294 | $5,047,817 | dollars as filed | |
| PALATIN TECHNOLOGIES INC | 696077601 | COM NEW | 70,000 | $1,219,400 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-062637 | this filing | 2026-05-15 | acceptance time not in the bulk data set |