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Disclosery

SEPN SEPTERNA INC

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Stock (common), issuer CIK 1984086

120 managers (122 13F filers) reported a position in SEPN shares at 2025-12-31, 45,588,030 shares in all. 41 filers opened a position and 5 filers sold out during the quarter.

Managers
120
13F filers
122
New
41
Added
31
Reduced
27
Sold out
5
Shares held by filers
45,588,030

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,995,858$195M2%013F-HRTimelineGroup
TRV GP V, LLC6,215,591$173M40.38%013F-HRTimeline
Driehaus Capital Management LLC4,809,470$134M0.91%-110,42613F-HRTimeline
TRV GP VI, LLC4,211,659$117M79.05%013F-HRTimeline
SAMSARA BIOCAPITAL, LLC3,149,128$87.8M9.06%013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,715,129$75.7M0.01%+1,260,40913F-HR/ATimelineGroup
Siren, L.L.C.in group Siren, L.L.C.2,000,000$55.8M1.66%-202,51413F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.1,801,328$50.2M<0.01%+341,53313F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL1,720,782$48M1.61%-2,295,00813F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,508,195$42M<0.01%-10,56213F-HRTimelineGroup
Avoro Capital Advisors LLC1,337,500$37.3M0.37%013F-HR/ATimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC1,157,611$32.3M2.41%-18,88013F-HR/ATimelineGroup
First Light Asset Management, LLC620,811$17.3M1.32%new13F-HRTimeline
Venrock Adviser, LLC610,808$17M0.84%013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC572,734$16M<0.01%+27,03313F-HRTimelineGroup
Casdin Capital, LLC553,268$15.4M0.96%013F-HRTimeline
PRIMECAP MANAGEMENT CO/CA/546,100$15.2M0.01%new13F-HRTimeline
STATE STREET CORPin group STATE STREET CORP540,028$15.1M<0.01%+121,06813F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC433,160$12.1M0.22%-108,29013F-HRTimelineGroup
Woodline Partners LP385,310$10.7M0.04%+102,72513F-HRTimeline
Soleus Capital Management, L.P.383,368$10.7M0.45%+365,10813F-HRTimeline
Catalio Capital Management, LP294,360$8.21M1.45%013F-HR/ATimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP226,901$6.33M0.01%new13F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …222,702$6.21M0.01%013F-HRTimelineGroup
Kalehua Capital Management LLC194,544$5.42M5.36%13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co187,241$5.22M<0.01%+33713F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.162,014$4.52M<0.01%-15,05613F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP154,196$4.3M<0.01%-13,14913F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding118,509$3.3M+5,475Timeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC107,463$3M<0.01%-276,73713F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY103,985$2.9M<0.01%+49,52713F-HR/ATimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.78,905$2.2M<0.01%new13F-HRTimelineGroup
HighVista Strategies LLC78,682$2.19M0.56%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC75,945$2.12M<0.01%new13F-HRTimelineGroup
UBS Group AGin group UBS Group AG68,817$1.92M<0.01%+9,77113F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO68,338$1.91M<0.01%+59,60213F-HRTimelineGroup
Rangeley Capital, LLC65,800$1.83M1.58%-22,20013F-HRTimeline
JACOBS LEVY EQUITY MANAGEMENT, INC61,370$1.71M0.01%+25,59213F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp55,332$1.54M<0.01%+3,70113F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC50,689$1.41M<0.01%+25,40613F-HRTimelineGroup
Longaeva Partners L.P.49,902$1.39M0.17%-7,16213F-HRTimeline
Numerai GP LLC45,866$1.28M0.15%new13F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC44,070$1.23M<0.01%new13F-HRTimelineGroup
Trexquant Investment LP44,005$1.23M0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC38,147$1.06M<0.01%+8,04513F-HRTimelineGroup
ExodusPoint Capital Management, LP37,867$1.06M0.01%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/37,594$1.05M<0.01%-13,90113F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.35,000$976K<0.01%013F-HRTimelineGroup
ALGERT GLOBAL LLC34,944$974K0.02%new13F-HR/ATimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC30,877$858K<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN26,529$740K<0.01%+6,38213F-HRTimelineGroup
RHUMBLINE ADVISERS26,419$737K<0.01%-1,18513F-HRTimeline
Nuveen, LLCin group TIAA25,798$719K<0.01%+1,83713F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/25,443$710K<0.01%-1,98113F-HRTimeline
Logos Global Management LP23,548$657K0.04%-60,00013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd23,315$650K0.02%new13F-HRTimelineGroup
VARCOV Co.22,634$631K0.25%13F-HRTimeline
ALLIANCEBERNSTEIN L.P.19,600$546K<0.01%-2,50013F-HRTimeline
TUDOR INVESTMENT CORP ET AL18,053$503K<0.01%new13F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources16,852$470K<0.01%new13F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…15,310$427K<0.01%+13,41413F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\14,879$415K<0.01%+74413F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC14,847$414K<0.01%new13F-HRTimelineGroup
STRS OHIO14,600$407K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC18,550$399K<0.01%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC14,090$393K<0.01%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…13,685$382K<0.01%013F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC13,283$370K<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.12,693$354K<0.01%-17013F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding12,110$338K+2,319Timeline
Seven Fleet Capital Management LP11,445$319K0.22%13F-HR/ATimeline
Dynamic Technology Lab Private Ltd10,810$301K0.07%new13F-HRTimeline
PharVision Advisers, LLC10,739$299K0.15%-1,19313F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…10,594$295K<0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…10,457$292K0.08%new13F-HRTimelineGroup
China Universal Asset Management Co., L…10,296$287K0.02%new13F-HRTimeline
Baader Bank Aktiengesellschaft10,000$279K0.02%new13F-HRTimeline
Atom Investors LP9,791$273K0.02%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC9,561$267K<0.01%+9,31213F-HRTimelineGroup
Graham Capital Management, L.P.8,971$250K0.01%new13F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC8,399$234K<0.01%new13F-HRTimelineGroup
BANK OF NOVA SCOTIAin group BANK OF NOVA SCOTIA8,300$231K<0.01%new13F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC7,826$218K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND5,600$156K<0.01%+2,70013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS5,449$152K<0.01%+1,29413F-HRTimelineGroup
Police & Firemen's Retirement System of…5,175$144K<0.01%013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management3,571$99.6K<0.01%new13F-HRTimelineGroup
FMR LLCin group FMR LLC3,307$92.2K<0.01%-13113F-HRTimelineGroup
Caitong International Asset Management …3,170$88.4K0.02%new13F-HR/ATimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,156$60.1K<0.01%+1,19713F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,944$54.2K<0.01%013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc1,945$54.2K<0.01%013F-HRTimelineGroup
Covestor Ltd1,941$54K0.03%-1,67913F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,316$36.7K<0.01%-5513F-HRTimeline
Global Retirement Partners, LLC1,256$35K<0.01%new13F-HRTimeline
Sterling Capital Management LLC1,232$34.3K<0.01%-24313F-HRTimeline
SIGNATUREFD, LLC989$27.6K<0.01%+2313F-HRTimeline
GROUP ONE TRADING LLC944$26.3K<0.01%-74513F-HRTimeline
GAMMA Investing LLC916$25.5K<0.01%+11213F-HRTimeline
CWM, LLCin group CWM, LLC888$25K<0.01%+413F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.878$24.5K<0.01%new13F-HRTimeline
Quarry LP724$20.2K<0.01%-1,01213F-HRTimeline
AMALGAMATED BANK672$19K<0.01%+3813F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA628$18K<0.01%-45513F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC341$9.51K<0.01%+19813F-HRTimeline
Pinnacle Wealth Planning Services, Inc.322$8.98K<0.01%new13F-HRTimeline
Versant Capital Management, Inc261$7.28K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…198$5.52K<0.01%013F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\190$5.3K<0.01%-7513F-HRTimelineGroup
N.E.W. Advisory Services LLC180$5.02K<0.01%new13F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.149$4K<0.01%new13F-HRTimelineGroup
Fortitude Family Office, LLC71$1.98K<0.01%013F-HRTimeline
MassMutual Private Wealth & Trust, FSB63$1.76K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…63$1.76K<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.55$1.53K<0.01%+513F-HRTimeline
Cornerstone Financial Management LLC52$1.45K<0.01%13F-HR/ATimeline
ROTHSCHILD INVESTMENT LLC30$836<0.01%013F-HRTimeline
Aster Capital Management (DIFC) Ltd20$558<0.01%new13F-HRTimeline
Arax Advisory Partners3$84<0.01%-6013F-HRTimeline
Farther Finance Advisors, LLC1$28<0.01%new13F-HRTimeline