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Disclosery

SEPN SEPTERNA INC

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Stock (common), issuer CIK 1984086

117 managers (124 13F filers) reported a position in SEPN shares at 2026-03-31, 45,721,668 shares in all. 22 filers opened a position and 24 filers sold out during the quarter.

Managers
117
13F filers
124
New
22
Added
43
Reduced
30
Sold out
24
Shares held by filers
45,721,668

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,995,858$168M1.78%013F-HRTimelineGroup
TRV GP V, LLC6,215,591$149M37.25%013F-HRTimeline
Driehaus Capital Management LLC4,395,572$106M0.78%-413,89813F-HRTimeline
TRV GP VI, LLC4,211,659$101M74.64%013F-HRTimeline
SAMSARA BIOCAPITAL, LLC3,149,128$75.7M7.35%013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,906,427$69.8M0.01%+191,29813F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.2,000,000$48.1M1.33%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.1,822,174$43.8M<0.01%+20,84613F-HRTimelineGroup
VANGUARD GROUP INCgroup of 6 filers holding1,574,051$37.8MnewTimeline
BVF INC/ILin group BVF INC/IL1,353,249$32.5M1.04%-367,53313F-HRTimelineGroup
Avoro Capital Advisors LLC1,337,500$32.1M0.32%013F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC1,089,818$26.2M1.57%-67,79313F-HRTimelineGroup
PRIMECAP MANAGEMENT CO/CA/1,048,834$25.2M0.02%+502,73413F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson890,754$21.3M0.01%new13F-HR/ATimelineGroup
First Light Asset Management, LLC732,860$17.6M1.58%+112,04913F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC645,146$15.5M<0.01%+72,41213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP631,447$15.2M<0.01%+91,41913F-HRTimelineGroup
Casdin Capital, LLC553,268$13.3M1.01%013F-HRTimeline
Venrock Adviser, LLC506,056$12.2M0.45%-104,75213F-HRTimeline
Catalio Capital Management, LP294,360$7.07M1.48%013F-HRTimeline
Soleus Capital Management, L.P.275,000$6.61M0.27%-108,36813F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management236,679$5.69M0.01%+233,10813F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …223,995$5.38M0.01%+1,29313F-HRTimelineGroup
Kalehua Capital Management LLC194,544$4.67M3.31%013F-HR/ATimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co181,580$4.36M<0.01%-5,66113F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP164,530$3.95M<0.01%+10,33413F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC124,101$2.98M<0.01%+16,63813F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding117,134$2.81M+48,317Timeline
MORGAN STANLEYin group MORGAN STANLEY110,530$2.66M<0.01%+6,54513F-HRTimelineGroup
HUSSMAN STRATEGIC ADVISORS, INC.105,000$2.52M0.55%new13F-HRTimeline
Checkpoint Capital L.P.100,300$2.41M0.86%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.89,301$2.15M<0.01%+10,39613F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.82,868$1.99M<0.01%-79,14613F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO84,674$1.97M<0.01%+16,33613F-HR/ATimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP75,367$1.81M<0.01%-17,44213F-HRTimelineGroup
Longaeva Partners L.P.74,567$1.79M0.09%+24,66513F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC61,290$1.47M<0.01%+10,60113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp58,709$1.41M<0.01%+3,37713F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC53,011$1.27M0.02%+44,61213F-HRTimelineGroup
Sofinnova Investments, Inc.47,506$1.14M0.06%new13F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP39,840$957K<0.01%-187,06113F-HRTimelineGroup
Rangeley Capital, LLC39,800$956K1.03%-26,00013F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC37,700$906K<0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd36,723$882K0.02%+13,40813F-HRTimelineGroup
Trexquant Investment LP35,301$848K0.01%-8,70413F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.35,000$841K<0.01%013F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC30,978$741K<0.01%+10113F-HRTimelineGroup
Nuveen, LLCin group TIAA29,176$701K<0.01%+3,37813F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC28,436$683K<0.01%-32,93413F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/28,076$675K<0.01%+2,63313F-HRTimeline
RHUMBLINE ADVISERS26,604$639K<0.01%+18513F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/25,973$624K<0.01%-11,62113F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd25,770$619K0.01%new13F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…24,000$577K<0.01%new13F-HRTimelineGroup
Logos Global Management LP23,548$566K0.03%013F-HRTimeline
FMR LLCin group FMR LLC23,446$563K<0.01%+20,13913F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.19,600$546K<0.01%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC22,714$546K<0.01%-15,43313F-HRTimelineGroup
Swiss National Bank22,100$531K<0.01%new13F-HRTimeline
ALGERT GLOBAL LLC21,035$505K0.01%-13,90913F-HR/ATimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC18,083$435K<0.01%+3,23613F-HRTimelineGroup
STRS OHIO17,200$413K<0.01%+2,60013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\16,843$405K<0.01%+1,96413F-HRTimelineGroup
VARCOV Co.16,752$403K0.15%-5,88213F-HRTimeline
Engineers Gate Manager LP16,528$397K<0.01%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC15,375$369K<0.01%+7,54913F-HRTimelineGroup
Numerai GP LLC15,082$362K0.04%-30,78413F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC14,214$342K<0.01%-4,33613F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…13,685$329K<0.01%013F-HRTimelineGroup
EntryPoint Capital, LLC12,776$307K0.09%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.12,698$305K<0.01%+513F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding12,356$297K+246Timeline
Verition Fund Management LLC12,343$297K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…11,946$287K0.02%+1,65013F-HRTimeline
Man Group plcin group Man Group plc11,858$285K<0.01%new13F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…11,515$277K<0.01%-3,79513F-HRTimelineGroup
Seven Fleet Capital Management LP11,445$275K0.09%013F-HR/ATimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…10,719$258K0.07%+26213F-HRTimelineGroup
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…10,382$249K<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN9,869$237K<0.01%-16,66013F-HR/ATimelineGroup
CITIGROUP INCin group CITIGROUP INC9,195$221K<0.01%-36613F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd8,842$212K0.01%new13F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc5,735$138K<0.01%+3,79013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND5,600$135K<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS5,361$129K<0.01%-8813F-HRTimelineGroup
Police & Firemen's Retirement System of…5,175$124K<0.01%013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…3,374$81.1K<0.01%-7,22013F-HRTimeline
KLP KAPITALFORVALTNING AS2,500$60.1K<0.01%new13F-HRTimeline
Covestor Ltd2,260$54K0.04%+31913F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,944$46.7K<0.01%013F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,157$27.8K<0.01%-15913F-HRTimeline
GAMMA Investing LLC1,110$26.7K<0.01%+19413F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,006$24.2K<0.01%+12813F-HRTimeline
SIGNATUREFD, LLC966$23.2K<0.01%-2313F-HRTimeline
CWM, LLCin group CWM, LLC894$21.5K<0.01%+613F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC841$20.2K<0.01%+50013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…717$17.2K<0.01%-1,43913F-HRTimelineGroup
Sterling Capital Management LLC712$17.1K<0.01%-52013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…508$12.2K<0.01%new13F-HRTimeline
Pinnacle Wealth Planning Services, Inc.322$7.74K<0.01%013F-HRTimeline
Versant Capital Management, Inc261$6.27K<0.01%013F-HRTimeline
Larson Financial Group LLC204$4.9K<0.01%new13F-HRTimeline
DIADEMA PARTNERS LP202$4.85K<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\197$4.73K<0.01%+713F-HRTimelineGroup
N.E.W. Advisory Services LLC180$4.33K<0.01%013F-HRTimeline
MassMutual Private Wealth & Trust, FSB135$3.24K<0.01%+7213F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…68$1.63K<0.01%+513F-HR/ATimelineGroup
SBI Securities Co., Ltd.55$1.32K<0.01%013F-HRTimeline
Cornerstone Financial Management LLC52$1.25K<0.01%013F-HR/ATimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…43$1.03K<0.01%-15513F-HRTimelineGroup
Caitong International Asset Management …38$913<0.01%-3,13213F-HRTimeline
ROTHSCHILD INVESTMENT LLC30$721<0.01%013F-HRTimeline
Fortitude Family Office, LLC20$481<0.01%-5113F-HRTimeline
Allworth Financial LP17$409<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC7$171<0.01%+613F-HRTimeline
QUADRANT CAPITAL GROUP LLC7$169<0.01%new13F-HR/ATimeline
MAI Capital Management6$145<0.01%new13F-HRTimeline