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Disclosery

PRAX PRAXIS PRECISION MEDICINES I

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COM NEW (common), issuer CIK 1689548

247 managers (251 13F filers) reported a position in PRAX shares at 2025-12-31, 29,469,062 shares in all. 104 filers opened a position and 15 filers sold out during the quarter.

Managers
247
13F filers
251
New
104
Added
87
Reduced
44
Sold out
15
Shares held by filers
29,469,062

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
JANUS HENDERSON GROUP PLCin group Janus Henderson3,240,086$955M0.43%+476,22713F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.2,078,500$613M0.01%+277,42013F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,995,986$588M10.78%+431,43213F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,460,933$431M0.01%+193,64713F-HRTimelineGroup
FMR LLCin group FMR LLC1,358,675$400M0.02%+1,315,46413F-HRTimelineGroup
Orbis Allan Gray Ltdin group Orbis Allan Gray Ltd1,255,162$370M1.55%new13F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,126,488$332M1.94%+437,00013F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…965,313$285M0.43%-1,408,77213F-HRTimelineGroup
Cormorant Asset Management, LP950,000$280M15.87%-50,00013F-HRTimeline
Driehaus Capital Management LLC933,061$275M1.87%+432,51013F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…903,351$266M3.41%+62,50013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY889,889$262M0.02%+246,39413F-HR/ATimelineGroup
STATE STREET CORPin group STATE STREET CORP882,215$260M0.01%-24,89313F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/785,987$232M0.02%-217,50313F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC716,184$211M0.03%+123,16313F-HR/ATimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC562,379$166M0.01%+105,34713F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC530,751$156M0.06%+454,11413F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/522,763$154M0.01%+39,90213F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.492,346$145M0.23%-1,003,64013F-HRTimelineGroup
Assenagon Asset Management S.A.408,787$120M0.18%-99213F-HRTimeline
Logos Global Management LP375,000$111M7.37%+250,00013F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.373,787$110M1.13%new13F-HRTimelineGroup
Soleus Capital Management, L.P.362,966$107M4.54%-496,20013F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources356,074$105M0.03%+41,91713F-HRTimelineGroup
Vivo Capital, LLC328,895$96.9M6.27%+130,00013F-HRTimeline
Hood River Capital Management LLC289,467$85.3M0.94%new13F-HRTimeline
T. Rowe Price Investment Management, In…276,392$81.5M0.05%new13F-HR/ATimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…240,588$71.1M0.07%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co198,301$58.4M0.01%+36,64013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP192,284$56.7M0.01%+23,93113F-HRTimelineGroup
Affinity Asset Advisors, LLC185,000$54.5M3.92%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…176,562$52M0.01%+115,32113F-HRTimelineGroup
Qube Research & Technologies Ltd168,897$49.8M0.07%+111,59313F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc134,992$39.8M0.06%new13F-HRTimelineGroup
Sofinnova Investments, Inc.125,722$37.1M1.6%-47,11113F-HRTimeline
UBS Group AGgroup of 2 filers holding124,488$36.7M+3,920Timeline
Candriam S.C.A.110,590$32.6M0.16%+47,72413F-HR/ATimeline
Woodline Partners LP105,412$31.1M0.12%-312,25713F-HRTimeline
Velan Capital Investment Management LP100,781$29.7M17.28%-32,02413F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC94,500$27.9M0.57%new13F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP88,704$26.1M0.02%+59,73813F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC86,581$25.5M3.3%+58,01013F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC83,036$24.5M16.62%+33,28513F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…82,465$24.3M3.52%+31,25513F-HRTimelineGroup
ALGERT GLOBAL LLC80,640$23.8M0.37%-80,17813F-HR/ATimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp77,897$23M<0.01%+21,60913F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.77,088$22.7M<0.01%+56,22013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC75,366$22.2M0.01%+60,09813F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.74,376$21.9M0.06%-67,14013F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD69,712$20.5M0.01%new13F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP69,242$20.4M0.02%+1,10113F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC67,100$19.8M0.31%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC66,230$19.5M0.03%new13F-HRTimeline
72 Investment Holdings, LLC65,933$19.4M38.42%013F-HRTimeline
Ensign Peak Advisors, Inc64,283$18.9M0.03%new13F-HR/ATimeline
Exome Asset Management LLC58,122$17.1M8.46%-43,87413F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO55,300$16.3M<0.01%+29,09213F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\50,811$15M<0.01%+36,95513F-HRTimelineGroup
Nuveen, LLCin group TIAA49,970$14.7M<0.01%+11,42113F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC46,457$13.7M3%new13F-HRTimelineGroup
TD Asset Management Inc46,146$13.6M0.01%+5,26213F-HRTimeline
KVP Capital Advisors, LP42,900$12.6M13.06%13F-HRTimeline
Moody Aldrich Partners LLC41,731$12.3M2.3%new13F-HRTimeline
SummitTX Capital, L.P.41,629$12.3M0.37%+6,70113F-HRTimeline
Swiss National Bank40,500$11.9M0.01%+5,00013F-HRTimeline
Integral Health Asset Management, LLC40,000$11.8M0.6%new13F-HRTimeline
Ishara Investments LP40,000$11.8M13.72%13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.37,481$11M0.01%+17,68513F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …37,377$11M0.02%new13F-HRTimelineGroup
Empowered Funds, LLC36,852$10.9M0.18%new13F-HR/ATimeline
READYSTATE ASSET MANAGEMENT LP36,792$10.8M0.48%-72,38513F-HRTimeline
First Turn Management, LLC35,749$10.5M1.2%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC34,917$10.3M0.01%+27,11913F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …33,291$9.86M0.01%-2,53813F-HRTimelineGroup
Caption Management, LLC33,300$9.81M0.43%+26,94313F-HRTimeline
B Group, Inc.33,237$9.8M7.26%+1,73713F-HRTimeline
CONGRESS ASSET MANAGEMENT CO31,246$9.21M0.06%+80713F-HRTimeline
PFM Health Sciences, LP31,163$9.18M0.93%-29,41513F-HRTimeline
LORD, ABBETT & CO. LLC30,756$9.06M0.03%new13F-HRTimeline
ArrowMark Colorado Holdings LLC30,000$8.84M0.19%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC28,828$8.5M<0.01%+6,92413F-HRTimelineGroup
RHUMBLINE ADVISERS28,324$8.35M0.01%+1,53013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding26,774$7.89M+3,124Timeline
HighVista Strategies LLC25,841$7.62M1.96%-69,16113F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC25,678$7.57M0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding25,594$7.54M-26,994Timeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN25,235$7.44M<0.01%+11,63013F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.25,070$7.39M<0.01%+7,01013F-HRTimeline
Burkehill Global Management, LP25,000$7.37M0.49%new13F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP23,543$6.94M<0.01%-13,87113F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP23,098$6.81M0.01%+17,59013F-HRTimelineGroup
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd22,952$6.76M1.43%new13F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC22,715$6.7M<0.01%new13F-HRTimelineGroup
Rafferty Asset Management, LLC22,240$6.56M0.02%-15,33313F-HRTimeline
Man Group plcin group Man Group plc21,170$6.24M0.01%new13F-HRTimelineGroup
STEMPOINT CAPITAL LP21,067$6.21M1.07%new13F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC20,974$6.18M0.16%-18,68613F-HRTimeline
Informed Momentum Co LLC20,941$6.17M0.69%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…20,612$6.08M0.01%+16,20813F-HRTimelineGroup
Ally Bridge Group (NY) LLC19,882$5.86M9.3%new13F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…19,671$5.8M0.01%+1,08813F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc17,981$5.3M<0.01%+1,15713F-HRTimelineGroup
Atom Investors LP16,487$4.86M0.39%new13F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC16,038$4.73M0.35%-12,06413F-HRTimeline
TUDOR INVESTMENT CORP ET AL16,009$4.72M0.03%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO15,796$4.66M<0.01%new13F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD15,231$4.49M0.01%+6,19813F-HRTimeline
Eagle Health Investments LP14,951$4.41M0.97%new13F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC14,862$4.38M0.01%new13F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC13,655$4.02M<0.01%new13F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC13,298$3.92M<0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…12,424$3.66M0.02%+1,90413F-HRTimelineGroup
Erste Asset Management GmbHin group Erste Asset Management GmbH10,500$3.2M0.03%new13F-HRTimelineGroup
Creative Planningin group Creative Planning10,843$3.2M<0.01%+4,18313F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC10,140$2.99M0.01%-3,75813F-HRTimeline
SG Americas Securities, LLC9,965$2.94M<0.01%-3,53113F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC8,734$2.57M0.02%+98013F-HRTimeline
PROFUND ADVISORS LLC8,455$2.49M0.08%+37613F-HRTimeline
HUSSMAN STRATEGIC ADVISORS, INC.8,400$2.48M0.6%-2,10013F-HRTimeline
Trexquant Investment LP8,331$2.46M0.02%-57413F-HRTimeline
NISA INVESTMENT ADVISORS, LLC7,770$2.29M0.01%+64113F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND7,300$2.15M<0.01%+70013F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…7,018$2.07M0.01%new13F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…6,870$2.02M0.01%new13F-HRTimeline
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA6,288$1.85M0.01%13F-HRTimelineGroup
Police & Firemen's Retirement System of…6,057$1.79M0.01%+1,14213F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…5,806$1.71M<0.01%-61913F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM5,723$1.69M0.01%+30613F-HRTimeline
CITIGROUP INCin group CITIGROUP INC5,586$1.65M<0.01%+2,77913F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC5,550$1.64M<0.01%new13F-HRTimelineGroup
J. Goldman & Co LP5,550$1.64M0.06%new13F-HRTimeline
GROUP ONE TRADING LLC5,539$1.63M0.05%-11,08913F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC5,235$1.54M<0.01%new13F-HRTimelineGroup
ProShare Advisors LLC5,214$1.54M<0.01%+1,38813F-HRTimeline
China Universal Asset Management Co., L…4,875$1.44M0.11%+1,18613F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS4,626$1.36M<0.01%+24113F-HRTimelineGroup
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…4,587$1.35M<0.01%new13F-HRTimeline
Vestmark Advisory Solutions, Inc.4,505$1.33M0.02%new13F-HRTimeline
Lion Point Capital, LP4,450$1.31M6.79%-1,25013F-HRTimeline
KLP KAPITALFORVALTNING AS4,400$1.3M0.01%+40013F-HRTimeline
NORGES BANK4,354$1.28M<0.01%new13F-HRTimeline
Coastal Bridge Advisors, LLC4,154$1.22M0.09%+30813F-HRTimeline
Quarry LP4,000$1.18M0.19%-16,00113F-HRTimeline
Cerity Partners LLCin group Cerity Partners LLC3,927$1.16M<0.01%-1,52313F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC3,587$1.06M0.01%new13F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al3,500$1.03M0.01%-40013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA3,378$995K<0.01%-57813F-HRTimelineGroup
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…3,316$977K<0.01%new13F-HRTimelineGroup
Public Sector Pension Investment Board3,297$972K<0.01%new13F-HRTimeline
STRS OHIO3,200$943K<0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS3,053$900K<0.01%-1,41613F-HRTimeline
Quantinno Capital Management LP2,723$803K<0.01%new13F-HRTimeline
Seven Fleet Capital Management LP2,700$796K0.54%13F-HR/ATimeline
Artia Global Partners LP2,500$737K0.12%new13F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE2,400$707K<0.01%new13F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,390$704K<0.01%+2,17313F-HRTimeline
Brooklyn Investment Group2,179$664K0.03%new13F-HRTimeline
Ethic Inc.2,193$646K0.01%new13F-HRTimeline
Arrowpoint Investment Partners (Singapo…in group Arrowpoint Investment Partner…2,082$614K0.09%new13F-HRTimelineGroup
Quinn Opportunity Partners LLC2,000$589K0.03%new13F-HRTimeline
Orion Porfolio Solutions, LLC1,985$585K<0.01%new13F-HRTimeline
PSP Research LLC1,982$584K0.51%13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC1,890$557K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,866$550K0.02%+34713F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd1,856$547K0.01%-30,33013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\1,825$538K<0.01%+1,71313F-HRTimelineGroup
Total Clarity Wealth Management, Inc.1,820$536K0.13%new13F-HRTimeline
StoneX Group Inc.in group StoneX Group Inc.1,766$521K0.02%new13F-HRTimelineGroup
XPONANCE LLC1,764$520K<0.01%new13F-HRTimeline
Allspring Global Investments Holdings, …in group Allspring Global Investments …1,732$496K<0.01%new13F-HRTimelineGroup
CIBC Bancorp USA Inc.group of 2 filers holding1,507$444KnewTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC1,500$442K0.03%new13F-HR/ATimelineGroup
MACKENZIE FINANCIAL CORP1,399$415K<0.01%new13F-HRTimeline
Persistent Asset Partners Ltd1,407$415K0.2%new13F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV1,212$357K<0.01%new13F-HRTimeline
Sterling Capital Management LLC1,211$357K0.01%+6513F-HRTimeline
Kestra Advisory Services, LLCin group Kestra Advisory Services, LLC1,180$348K<0.01%new13F-HRTimelineGroup
OPAL CAPITAL LLC996$318K0.08%13F-HRTimeline
AlphaQuest LLC1,075$317K0.02%-92413F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P1,056$311K0.01%new13F-HRTimeline
Abel Hall, LLC1,032$304K0.07%new13F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC995$293K<0.01%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…989$291K0.08%-1,53813F-HRTimelineGroup
Carl P. Sherr & Co., LLC897$282K0.13%new13F-HRTimeline
Swiss Life Asset Management Ltdin group Swiss Life Asset Management L…946$279K<0.01%new13F-HRTimelineGroup
CIBC Asset Management Inc900$265K<0.01%-387,85913F-HRTimeline
EntryPoint Capital, LLC887$261K0.1%new13F-HRTimeline
M&T Bank Corpin group M&T Bank Corp885$261K<0.01%new13F-HR/ATimelineGroup
CWM, LLCin group CWM, LLC874$258K<0.01%+11713F-HRTimelineGroup
Inscription Capital, LLC866$255K0.03%new13F-HRTimeline
MML INVESTORS SERVICES, LLC864$255K<0.01%new13F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC825$244K<0.01%-10,34713F-HR/ATimelineGroup
IEQ CAPITAL, LLC815$240K<0.01%new13F-HRTimeline
Amundiin group Amundi790$233K<0.01%new13F-HRTimelineGroup
O'SHAUGHNESSY ASSET MANAGEMENT, LLC768$226K<0.01%new13F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC745$220K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…714$210K<0.01%+69013F-HRTimelineGroup
AMALGAMATED BANK708$209K<0.01%+10913F-HRTimeline
ACT CAPITAL MANAGEMENT, LLC700$206K0.17%13F-HRTimeline
Sanctuary Advisors, LLC681$201K<0.01%new13F-HRTimeline