13F-HR filed by Soleus Capital Management, L.P.
Soleus Capital Management, L.P. filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 88 holding rows worth $1,986,446,914.
- Accession
- 0001802630-25-000018
- Filer
- CIK 1802630
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 88 entries on the cover page, a total value of $1,986,446,914 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,986,446,914 with VALUE read as dollars as filed, 13F file number 028-20043. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 1,018,831 | $179,854,236 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 3,844,731 | $138,890,907 | dollars as filed | |
| NOVOCURE LTD | G6674U108 | ORD SHS | 9,644,872 | $124,611,746 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,150,000 | $115,230,000 | dollars as filed | put |
| Elevance Health, Inc. | 036752103 | COM | 259,650 | $83,898,108 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 3,870,158 | $76,900,039 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 150,000 | $62,881,500 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 8,127,100 | $61,034,521 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 1,178,860 | $58,235,684 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 728,188 | $54,031,550 | dollars as filed | |
| TWIST BIOSCIENCE CORP | 90184D100 | COM | 1,866,234 | $52,515,825 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 69,426 | $51,205,841 | dollars as filed | |
| ORGANOGENESIS HOLDINGS INC | 68621F102 | COMMON STOCK | 12,131,699 | $51,195,770 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 890,304 | $48,218,865 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 493,811 | $47,287,341 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 859,166 | $45,535,798 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 4,690,000 | $36,957,200 | dollars as filed | |
| Indivior PLC | G4766E116 | Common Stock | 1,466,000 | $35,345,260 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 68,336 | $31,342,990 | dollars as filed | |
| ANI PHARMACEUTICALS INC | 00182C103 | COM | 340,243 | $31,166,259 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 2,012,110 | $30,956,312 | dollars as filed | |
| AXOGEN INC | 05463X106 | COM | 1,726,553 | $30,801,706 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 2,957,957 | $30,496,537 | dollars as filed | |
| GRIFOLS S A | 398438408 | SP ADR REP B NVT | 2,500,000 | $24,900,000 | dollars as filed | |
| GERON CORP | 374163103 | COM | 17,290,000 | $23,687,300 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 2,422,833 | $22,386,977 | dollars as filed | |
| INTEGRA LIFESCIENCES HLDGS C | 457985208 | COM NEW | 1,440,818 | $20,646,922 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 138,000 | $19,372,440 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 626,040 | $19,169,345 | dollars as filed | |
| EDAP TMS S A | 268311107 | SPONSORED ADR | 7,309,254 | $16,738,192 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 647,052 | $16,143,947 | dollars as filed | |
| VERICEL CORP | 92346J108 | COM | 497,953 | $15,670,581 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 7,053,942 | $15,659,751 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 210,000 | $15,540,000 | dollars as filed | |
| VERACYTE INC COM | 92337F107 | Stock | 422,055 | $14,489,148 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 537,903 | $13,872,518 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 679,000 | $13,546,050 | dollars as filed | |
| STAAR SURGICAL CO COM PAR $0.01 | 852312305 | Stock | 500,000 | $13,435,000 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 413,500 | $12,161,035 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 290,000 | $11,681,200 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 200,000 | $11,674,000 | dollars as filed | |
| QUIDELORTHO CORP COM | 219798105 | Stock | 375,000 | $11,043,750 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 148,696 | $10,900,904 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 738,000 | $10,819,080 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 6,325,000 | $10,246,500 | dollars as filed | |
| GLOBUS MED INC CL A | 379577208 | Stock | 176,000 | $10,079,520 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 220,000 | $9,495,200 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559702 | COMMON STOCK | 330,010 | $9,349,183 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 1,450,000 | $8,903,000 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 935,909 | $8,264,076 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 100,000 | $8,210,000 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 88,000 | $7,610,240 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 15,250 | $6,954,000 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 796,744 | $6,875,901 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 400,000 | $6,316,000 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 619,874 | $6,068,566 | dollars as filed | |
| KINIKSA PHARMACEUTICALS INTL P ORD SHS CL A | G52694109 | Stock | 150,000 | $5,824,500 | dollars as filed | |
| ESTABLISHMENT LABS HOLDINGS | G31249108 | COMMON STOCK | 139,512 | $5,718,597 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 275,000 | $4,812,500 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 2,162,162 | $4,713,513 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 200,000 | $4,346,000 | dollars as filed | |
| CERIBELL INC | 15678C102 | COMMON STOCK | 360,000 | $4,136,400 | dollars as filed | |
| HARROW INC | 415858109 | COM | 85,498 | $4,119,294 | dollars as filed | |
| FRACTYL HEALTH INC | 35168W103 | COM | 2,500,000 | $3,975,000 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 1,494,420 | $3,556,720 | dollars as filed | |
| INSPIREMD INC | 45779A846 | COM | 1,470,934 | $3,544,951 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 71,000 | $3,371,080 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 100,000 | $2,721,000 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 300,000 | $2,520,000 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 200,000 | $2,378,000 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 80,000 | $2,376,000 | dollars as filed | |
| ORTHOPEDIATRICS CORP | 68752L100 | COMMON STOCK | 128,000 | $2,371,840 | dollars as filed | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 976,707 | $2,119,454 | dollars as filed | |
| CALCIMEDICA INC | 38942Q202 | COM NEW | 683,904 | $2,103,552 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 550,000 | $1,952,500 | dollars as filed | |
| MANNKIND CORP COM NEW | 56400P706 | Stock | 300,000 | $1,611,000 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 1,580,007 | $1,392,934 | dollars as filed | |
| ADVERUM BIOTECHNOLOGIES INC | 00773U207 | COM NEW | 287,246 | $1,301,224 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 50,000 | $1,137,000 | dollars as filed | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 4,362,026 | $833,147 | dollars as filed | |
| MYOMO INC | 62857J201 | COM NEW | 704,275 | $628,213 | dollars as filed | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 299,711 | $617,405 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 25,000 | $392,250 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 2,550 | $367,226 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 18,260 | $343,471 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 19,644 | $321,572 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 25,000 | $228,750 | dollars as filed | |
| DELCATH SYSTEMS INC | 24661P807 | COMMON STOCK | 10,000 | $107,500 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001802630-25-000018 | this filing | 2025-11-14 | acceptance time not in the bulk data set |