13F-HR filed by Frazier Life Sciences Management, L.P.
Frazier Life Sciences Management, L.P. filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 47 holding rows worth $3,337,397,700.
- Accession
- 0001892134-25-000012
- Filer
- CIK 1892134
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 47 entries on the cover page, a total value of $3,337,397,700 stated on the cover page (in dollars after the unit check, H1), rows summing to $3,337,397,700 with VALUE read as dollars as filed, 13F file number 028-22504. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 6,795,121 | $498,150,321 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 16,701,956 | $475,003,629 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 3,383,950 | $361,101,305 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 3,845,457 | $199,733,037 | dollars as filed | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 9,874,511 | $186,134,532 | dollars as filed | |
| PHATHOM PHARMACEUTICALS INC | 71722W107 | COMMON STOCK | 12,466,489 | $146,730,576 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 688,460 | $121,533,844 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 4,567,274 | $118,429,415 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 6,652,013 | $116,410,228 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,438,534 | $95,058,327 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 10,259,409 | $93,873,592 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 1,167,527 | $69,386,130 | dollars as filed | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 5,039,867 | $61,385,580 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 1,627,320 | $55,149,875 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 1,279,754 | $51,369,326 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 22,729,436 | $49,550,170 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 890,445 | $48,938,857 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 997,455 | $46,581,149 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 722,400 | $45,287,256 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 11,462,301 | $40,920,415 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 2,718,105 | $34,384,028 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 378,300 | $32,117,670 | dollars as filed | |
| AURA BIOSCIENCES INC | 05153U107 | COMMON STOCK | 5,100,000 | $31,518,000 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 983,715 | $29,590,147 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 4,424,725 | $29,380,174 | dollars as filed | |
| Valneva SE ADR | 92025Y103 | COM | 2,291,666 | $27,958,325 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 625,000 | $27,231,250 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 133,333 | $26,507,934 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 700,647 | $21,019,410 | dollars as filed | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 9,440,112 | $19,446,631 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 366,784 | $17,414,904 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 474,405 | $17,088,068 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 2,630,665 | $16,152,283 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 1,953,547 | $14,710,209 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 384,782 | $13,979,130 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 613,837 | $13,099,282 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 1,413,280 | $12,196,606 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 456,249 | $11,679,974 | dollars as filed | |
| ADVERUM BIOTECHNOLOGIES INC | 00773U207 | COM NEW | 2,077,431 | $9,410,762 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 392,092 | $9,370,999 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 500,333 | $8,560,698 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 1,157,380 | $7,904,905 | dollars as filed | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 4,623,324 | $7,536,018 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 3,175,665 | $5,335,117 | dollars as filed | |
| SILENCE THERAPEUTICS PLC | 82686Q101 | ADS | 970,130 | $5,034,975 | dollars as filed | |
| ALLOGENE THERAPEUTICS INC | 019770106 | COM | 3,868,750 | $4,797,250 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 272,951 | $3,245,387 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001892134-25-000012 | this filing | 2025-11-14 | acceptance time not in the bulk data set |