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Disclosery

APGE APOGEE THERAPEUTICS INC

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Stock (common)

205 managers (208 13F filers) reported a position in APGE shares at 2025-12-31, 69,771,335 shares in all. 45 filers opened a position and 18 filers sold out during the quarter.

Managers
205
13F filers
208
New
45
Added
86
Reduced
46
Sold out
18
Shares held by filers
69,771,335

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Venrock Adviser, LLC8,493,321$641M31.67%013F-HRTimeline
FMR LLCin group FMR LLC8,225,038$621M0.03%+1,308,57613F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…4,746,585$358M0.06%+22,88413F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,783,994$286M<0.01%+1,097,96813F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,857,824$216M<0.01%+612,19313F-HRTimelineGroup
T. Rowe Price Investment Management, In…2,732,456$206M0.13%+2,731,01513F-HR/ATimeline
RTW INVESTMENTS, LP2,712,097$205M2.05%013F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,330,651$176M3.22%+978,66213F-HRTimelineGroup
Driehaus Capital Management LLC2,183,704$165M1.12%+25,20213F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson2,062,604$156M0.07%+1,576,62613F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC2,048,647$155M11.77%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,690,186$128M<0.01%+34,63813F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,373,066$104M0.01%+235,33513F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,237,135$93.4M0.01%+486,60613F-HRTimeline
Affinity Asset Advisors, LLC1,234,926$93.2M6.7%+61,50013F-HRTimeline
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,123,243$84.8M2.27%-398,51413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.1,093,657$82.5M0.03%-325,47513F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,059,085$80M<0.01%+166,88213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding1,024,631$77.3M+194,003Timeline
MERCER GLOBAL ADVISORS INC /ADV890,665$67.2M0.1%-79,91613F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY890,264$67.2M<0.01%+425,30113F-HR/ATimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/793,695$59.9M<0.01%+399,78313F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC766,981$57.9M0.04%-402,26313F-HRTimelineGroup
Remedium Capital Partners, LLC583,591$44M25.88%13F-HRTimeline
JENNISON ASSOCIATES LLC578,627$43.7M0.03%new13F-HRTimeline
BRAIDWELL LP575,067$43.4M1.39%-863,67813F-HRTimeline
NOVO HOLDINGS A/S570,000$43M3.34%+70,00013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC565,410$42.7M0.01%-34,20613F-HR/ATimelineGroup
Vestal Point Capital, LP550,000$41.5M1.52%+125,00013F-HRTimeline
Sofinnova Investments, Inc.534,845$40.4M1.74%-30,57213F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc503,539$38M0.17%-20,55513F-HRTimelineGroup
Avoro Capital Advisors LLC500,000$37.7M0.37%new13F-HR/ATimeline
FRONTIER CAPITAL MANAGEMENT CO LLC480,453$36.3M0.38%+106,04613F-HRTimeline
First Turn Management, LLC474,839$35.8M4.1%+72,02813F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources451,002$34M0.01%-279,75913F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC436,015$32.9M0.51%new13F-HRTimeline
Opaleye Management Inc.388,257$29.3M3.87%+25,00013F-HR/ATimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co381,362$28.8M<0.01%+61,45913F-HRTimelineGroup
GREAT POINT PARTNERS LLC374,000$28.2M9.15%+70,00013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP327,376$24.7M<0.01%+42,89313F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…312,883$23.6M0.02%new13F-HRTimelineGroup
First Light Asset Management, LLC284,991$21.5M1.64%new13F-HRTimeline
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P255,439$19.3M0.02%new13F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…240,000$18.1M0.03%+5,00013F-HRTimelineGroup
Woodline Partners LP210,466$15.9M0.06%+153,14513F-HRTimeline
Trails Edge Capital Partners, LP192,000$14.5M3.58%13F-HRTimeline
Candriam S.C.A.191,318$14.4M0.07%+65,23713F-HR/ATimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC140,727$10.6M0.01%-289,73613F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC133,193$10.1M<0.01%-509,12313F-HRTimelineGroup
Parkman Healthcare Partners LLC130,069$9.82M0.93%+24,23813F-HRTimeline
TD Asset Management Inc129,290$9.76M0.01%+46,05013F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.127,931$9.66M0.02%new13F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …127,629$9.63M0.02%-3,80713F-HRTimelineGroup
Capital World Investors127,618$9.63M<0.01%013F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC124,979$9.43M0.2%+92813F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC122,900$9.28M<0.01%+19,74813F-HRTimelineGroup
Nuveen, LLCin group TIAA121,050$9.14M<0.01%+37,75913F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp118,084$8.91M<0.01%+10,54413F-HRTimelineGroup
Nicholas Investment Partners, LP112,924$8.52M0.62%new13F-HRTimeline
ArrowMark Colorado Holdings LLC109,410$8.26M0.18%013F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC108,267$8.17M<0.01%-108,94613F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP105,000$7.95M0.01%-110,84613F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP105,241$7.94M0.01%-17,13413F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC99,648$7.52M0.01%new13F-HRTimelineGroup
Granahan Investment Management, LLC94,720$7.15M0.31%-37,68013F-HRTimeline
HighVista Strategies LLC89,229$6.74M1.73%-17,87813F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …80,832$6.12M0.01%+17,60713F-HRTimelineGroup
STEMPOINT CAPITAL LP80,574$6.08M1.04%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\79,361$5.99M<0.01%+2,81413F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding76,898$5.8MnewTimeline
SG Americas Securities, LLC73,262$5.53M0.01%-60,96413F-HRTimeline
Invesco Ltd.in group Invesco Ltd.70,687$5.34M<0.01%+41,54913F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC70,000$5.28M1.16%+20,00013F-HRTimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD69,212$5.22M1.21%-24,51613F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.63,250$4.77M<0.01%-37,32013F-HRTimelineGroup
Swiss National Bank62,900$4.75M<0.01%+19,50013F-HRTimeline
SIMPLEX TRADING, LLC62,799$4.74M0.13%new13F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC54,300$4.1M<0.01%+41,44013F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.51,827$3.91M0.01%-138,52513F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
MARSHALL WACE, LLPin group MARSHALL WACE, LLP50,744$3.83M<0.01%+43,71713F-HRTimelineGroup
SEVEN GRAND MANAGERS, LLC50,000$3.77M0.29%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…49,999$3.77M<0.01%+6,32613F-HRTimelineGroup
Rafferty Asset Management, LLC48,619$3.67M0.01%-17,17713F-HRTimeline
RHUMBLINE ADVISERS45,971$3.47M<0.01%-1,82813F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC44,922$3.39M0.02%+22,41613F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN42,499$3.21M<0.01%+20,50913F-HRTimelineGroup
BANQUE PICTET & CIE SA41,800$3.16M0.03%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …39,846$3.01M<0.01%+39,64413F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc36,103$2.73M<0.01%-18,65713F-HRTimelineGroup
COMERICA BANK35,872$2.71M0.01%+33813F-HRTimeline
Cinctive Capital Management LP33,264$2.51M0.14%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc32,856$2.48M<0.01%+5,19313F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…30,758$2.32M<0.01%+9,37113F-HRTimeline
TUDOR INVESTMENT CORP ET AL30,039$2.27M0.01%new13F-HRTimeline
Schonfeld Strategic Advisors LLC29,145$2.2M0.01%new13F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH24,000$1.83M0.02%013F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding23,374$1.77M+3,012Timeline
NEW YORK STATE COMMON RETIREMENT FUND22,484$1.7M<0.01%+12,59713F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…21,311$1.61M0.01%+2,07313F-HRTimelineGroup
SummitTX Capital, L.P.20,972$1.58M0.05%-5,63513F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD20,313$1.53M<0.01%+12,21813F-HRTimeline
B Group, Inc.20,000$1.51M1.12%-15,00013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd19,026$1.44M0.04%+13,17413F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC18,492$1.4M<0.01%+9,11813F-HRTimelineGroup
PROFUND ADVISORS LLC18,276$1.38M0.04%+4,10513F-HRTimeline
FORA Capital, LLC18,200$1.37M0.17%new13F-HRTimeline
Moody Aldrich Partners LLC17,164$1.3M0.24%-84813F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO16,329$1.23M<0.01%new13F-HRTimelineGroup
Birchview Capital, LP16,000$1.21M0.71%013F-HRTimeline
Qube Research & Technologies Ltd14,283$1.08M<0.01%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC13,701$1.03M0.01%013F-HRTimeline
Legato Capital Management LLC13,551$1.02M0.09%new13F-HRTimeline
Handelsbanken Fonder AB12,700$959K<0.01%+4,20013F-HRTimeline
Verition Fund Management LLC12,700$959K0.01%-36,82313F-HRTimeline
Connor, Clark & Lunn Investment Managem…12,689$958K<0.01%new13F-HRTimeline
Vestmark Advisory Solutions, Inc.12,674$957K0.01%new13F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC12,192$920K<0.01%-65,43413F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…11,879$897K<0.01%+2,91913F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…11,644$879K0.01%013F-HRTimeline
LMR Partners LLPin group LMR Partners LLP11,461$865K0.01%-7,50013F-HRTimelineGroup
Man Group plcin group Man Group plc11,163$843K<0.01%new13F-HRTimelineGroup
Neo Ivy Capital Management10,910$823K0.13%new13F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…10,879$821K<0.01%new13F-HRTimelineGroup
AlphaCentric Advisors LLC10,751$811K0.81%13F-HRTimeline
Police & Firemen's Retirement System of…10,330$780K0.01%+98913F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS9,965$752K<0.01%-28,25813F-HRTimelineGroup
ProShare Advisors LLC9,464$714K<0.01%+2,22113F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…9,350$706K<0.01%013F-HRTimeline
Mariner, LLCin group Mariner, LLC9,101$687K<0.01%+3,22413F-HRTimelineGroup
China Universal Asset Management Co., L…8,935$674K0.05%+85313F-HRTimeline
Creative Planningin group Creative Planning8,904$672K<0.01%+1,55713F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC8,882$670K<0.01%+2,37813F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM8,763$661K<0.01%+2,16113F-HRTimeline
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA8,512$642K<0.01%13F-HRTimelineGroup
Global Endowment Management, LPin group Global Endowment Management, …7,797$589K0.07%013F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC7,151$540K<0.01%+15213F-HRTimeline
ACT CAPITAL MANAGEMENT, LLC7,000$528K0.43%13F-HRTimeline
PSP Research LLC6,984$527K0.46%13F-HRTimeline
KLP KAPITALFORVALTNING AS6,800$513K<0.01%+2,70013F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.6,371$481K0.07%new13F-HRTimeline
Arrowpoint Investment Partners (Singapo…in group Arrowpoint Investment Partner…6,324$477K0.07%new13F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS5,775$436K<0.01%new13F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …5,435$412K<0.01%new13F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP5,214$394K<0.01%+17513F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…4,919$371K<0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS4,705$355K<0.01%-78213F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…4,634$350K<0.01%-12,05513F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,670$277K0.01%+70613F-HRTimelineGroup
J. Goldman & Co LP3,466$262K0.01%-59,11113F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…3,451$260K0.07%+73313F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP3,418$258K<0.01%new13F-HRTimelineGroup
Quantbot Technologies LP3,340$252K0.01%+93313F-HRTimeline
STRS OHIO3,300$249K<0.01%new13F-HRTimeline
Boyer Financial Services, Inc.3,126$237K0.25%13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…3,126$236K0.01%+39013F-HRTimelineGroup
Baader Bank Aktiengesellschaft3,100$234K0.02%new13F-HRTimeline
XPONANCE LLC3,015$228K<0.01%new13F-HRTimeline
Vident Advisory, LLCin group Vident Advisory, LLC2,891$218K<0.01%new13F-HRTimelineGroup
AlphaQuest LLC2,524$191K0.01%-2,38713F-HRTimeline
Quarry LP2,500$189K0.03%new13F-HRTimeline
Persistent Asset Partners Ltd2,445$185K0.09%-12,37413F-HRTimeline
Ensign Peak Advisors, Inc2,250$170K<0.01%new13F-HR/ATimeline
Seven Fleet Capital Management LP1,800$136K0.09%13F-HR/ATimeline
AMALGAMATED BANK1,210$91K<0.01%+14913F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,138$85K<0.01%-2,88213F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,077$81.3K<0.01%+8513F-HRTimeline
GROUP ONE TRADING LLC1,057$79.8K<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.959$72.4K<0.01%+41013F-HRTimelineGroup
ANTIPODES PARTNERS Ltd723$54.6K<0.01%-12013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC701$52.9K<0.01%-5413F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC516$39K<0.01%+1113F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…399$30.1K<0.01%+12413F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC490$27.5K<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\346$26.1K<0.01%-5413F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…337$25.4K<0.01%new13F-HR/ATimelineGroup
Smartleaf Asset Management LLC276$20.9K<0.01%+17513F-HRTimeline
Sterling Capital Management LLC252$19K<0.01%+17313F-HRTimeline
Versant Capital Management, Inc229$17.3K<0.01%013F-HRTimeline
GAMMA Investing LLC216$16.3K<0.01%+7313F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.166$13K<0.01%013F-HRTimelineGroup
Larson Financial Group LLC157$11.8K<0.01%+8413F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.156$11.8K<0.01%-11413F-HRTimelineGroup
Kemnay Advisory Services Inc.118$8.91K<0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP98$7.4K<0.01%013F-HRTimelineGroup
QUADRANT CAPITAL GROUP LLC91$6.87K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…82$6.19K<0.01%+113F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC77$5.81K<0.01%+213F-HRTimeline
Red Tortoise LLC69$5.21K<0.01%013F-HRTimeline
Exane Asset Management52$4.61K<0.01%-51,49113F-HRTimeline
CWM, LLCin group CWM, LLC58$4K<0.01%+913F-HRTimelineGroup
Farther Finance Advisors, LLC50$3.77K<0.01%+2313F-HRTimeline
Parkside Financial Bank & Trust31$2.34K<0.01%013F-HRTimeline
Cornerstone Financial Management LLC30$2.26K<0.01%13F-HR/ATimeline
Arax Advisory Partners26$1.96K<0.01%-5813F-HRTimeline
BELLEVUE ASSET MANAGEMENT, LLC24$1.81K<0.01%-1213F-HRTimeline
TD PRIVATE CLIENT WEALTH LLC18$1.36K<0.01%013F-HRTimeline
Hughes Financial Services, LLC18$1.36K<0.01%+113F-HRTimeline
Bare Financial Services, Inc15$1.13K<0.01%new13F-HRTimeline
SIGNATUREFD, LLC13$981<0.01%013F-HRTimeline
Blue Trust, Inc.8$604<0.01%new13F-HRTimeline