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Disclosery

APGE APOGEE THERAPEUTICS INC

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Stock (common)

172 managers (174 13F filers) reported a position in APGE shares at 2025-09-30, 59,584,024 shares in all. 24 filers opened a position and 33 filers sold out during the quarter.

Managers
172
13F filers
174
New
24
Added
63
Reduced
57
Sold out
33
Shares held by filers
59,584,024

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Venrock Adviser, LLC8,493,321$337M18.99%013F-HRTimeline
FMR LLCin group FMR LLC6,916,462$275M0.01%+9,36213F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…4,723,701$188M0.03%+917,99113F-HRTimelineGroup
RTW INVESTMENTS, LP2,712,097$108M1.33%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.2,686,026$107M<0.01%+123,48713F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,245,631$89.2M<0.01%+136,69313F-HRTimelineGroup
Driehaus Capital Management LLC2,158,502$85.8M0.61%-152,25313F-HRTimeline
Fairmount Funds Management LLCin group Fairmount Funds Management LLC2,048,647$81.4M7.32%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,655,548$65.8M<0.01%+396,29013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,521,757$60.5M1.79%+563,12713F-HRTimelineGroup
BRAIDWELL LP1,438,745$57.2M1.7%-39,76713F-HRTimeline
ALLIANCEBERNSTEIN L.P.1,419,132$56.4M0.02%+30,98313F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,351,989$53.7M1.55%+169,84113F-HRTimelineGroup
Affinity Asset Advisors, LLC1,173,426$46.6M4.34%+481,52713F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,169,244$46.5M0.04%+673,58513F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,137,731$45.2M<0.01%+12,16113F-HR/ATimelineGroup
MERCER GLOBAL ADVISORS INC /ADV970,581$38.6M0.06%+150,20513F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC892,203$35.5M<0.01%+109,56213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding830,628$33M+668,409Timeline
PRICE T ROWE ASSOCIATES INC /MD/750,529$29.8M<0.01%-10,31513F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources730,761$29M0.01%-121,77013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC642,316$25.5M0.01%+33,49413F-HR/ATimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC599,616$23.8M<0.01%-59,57013F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.568,084$22.6M0.21%-74,27313F-HRTimelineGroup
Sofinnova Investments, Inc.565,417$22.5M1.38%+489,23713F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc524,094$20.8M0.1%+29,09413F-HRTimelineGroup
NOVO HOLDINGS A/S500,000$19.9M1.28%+50,60813F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson485,978$19.3M0.01%-23,34313F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY464,963$18.5M<0.01%-9,73913F-HR/ATimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC430,463$17.1M0.01%+185,33013F-HRTimelineGroup
Vestal Point Capital, LP425,000$16.9M0.77%new13F-HRTimeline
First Turn Management, LLC402,811$16M2.4%+91,32113F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/393,912$15.7M<0.01%-115,07513F-HR/ATimelineGroup
FRONTIER CAPITAL MANAGEMENT CO LLC374,407$14.9M0.13%+65,34113F-HRTimeline
Opaleye Management Inc.363,257$14.4M2.04%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co319,903$12.7M<0.01%+53,51913F-HRTimelineGroup
GREAT POINT PARTNERS LLC304,000$12.1M5.04%new13F-HRTimeline
Commodore Capital LPin group Commodore Capital LP290,000$11.5M0.56%013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP284,483$11.3M<0.01%+20,29513F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…235,000$9.34M0.01%-1,055,46413F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC217,213$8.63M0.01%-37,55713F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP215,846$8.6M0.01%+96,60013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC200,000$7.95M0.31%013F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.190,352$7.56M0.03%+11,80613F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
SG Americas Securities, LLC134,226$5.33M0.02%new13F-HRTimeline
Granahan Investment Management, LLC132,400$5.26M0.22%+1,26213F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …131,436$5.22M0.01%+5,60713F-HRTimelineGroup
Capital World Investors127,618$5.07M<0.01%-66,27713F-HRTimeline
Candriam S.C.A.126,081$5.01M0.03%new13F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC124,051$4.93M0.11%+48,15413F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding122,375$4.86M+381Timeline
ArrowMark Colorado Holdings LLC109,410$4.35M0.08%013F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp107,540$4.27M<0.01%-93,61113F-HRTimelineGroup
HighVista Strategies LLC107,107$4.26M1.04%+62,05513F-HRTimeline
Parkman Healthcare Partners LLC105,831$4.2M0.46%+50,42713F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC103,152$4.1M<0.01%-52,95613F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.100,570$4M<0.01%-93,95813F-HRTimelineGroup
Exome Asset Management LLC94,400$3.75M2.48%new13F-HRTimeline
PLATINUM INVESTMENT MANAGEMENT LTD93,728$3.72M0.24%+7,21613F-HRTimeline
Nuveen, LLCin group TIAA83,291$3.31M<0.01%013F-HRTimelineGroup
TD Asset Management Inc83,240$3.31M<0.01%-11,34813F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC77,626$3.08M<0.01%+69,39113F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\76,547$3.04M<0.01%+52,83813F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management72,348$2.87M0.01%-86,28713F-HRTimelineGroup
Rafferty Asset Management, LLC65,796$2.61M0.01%+23,58513F-HRTimeline
DIADEMA PARTNERS LP64,250$2.55M1.78%+53,67813F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …63,225$2.51M<0.01%-9,71413F-HRTimelineGroup
J. Goldman & Co LP62,577$2.49M0.09%+27,97213F-HRTimeline
Exane Asset Management51,543$2.41M0.81%new13F-HRTimeline
Woodline Partners LP57,321$2.28M0.01%-812,88713F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc54,760$2.18M<0.01%new13F-HRTimelineGroup
Boxer Capital Management, LLCin group Boxer Capital Management, LLC50,000$1.99M0.63%new13F-HR/ATimelineGroup
Verition Fund Management LLC49,523$1.97M0.01%new13F-HRTimeline
RHUMBLINE ADVISERS47,799$1.9M<0.01%-1,41713F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…43,673$1.74M<0.01%+21,90513F-HRTimelineGroup
Swiss National Bank43,400$1.72M<0.01%+80013F-HRTimeline
Aquatic Capital Management LLC39,332$1.56M0.03%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS38,223$1.52M<0.01%+34,57413F-HRTimelineGroup
ExodusPoint Capital Management, LP37,535$1.49M0.02%new13F-HRTimeline
COMERICA BANK35,534$1.41M0.01%+6,06513F-HRTimeline
B Group, Inc.35,000$1.39M1.33%013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.29,138$1.16M<0.01%+2,27213F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc27,663$1.1M<0.01%-2613F-HRTimelineGroup
SummitTX Capital, L.P.26,607$1.06M0.04%new13F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC26,241$1.04M0.08%new13F-HRTimeline
AXA Investment Managers S.A.24,554$976K<0.01%13F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH24,000$956K0.01%013F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC22,506$894K<0.01%-2,34413F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN21,990$874K<0.01%+5,13713F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…21,387$850K<0.01%+113F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding20,362$809K-972Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…19,238$764K<0.01%013F-HRTimelineGroup
LMR Partners LLPin group LMR Partners LLP18,961$753K0.01%new13F-HRTimelineGroup
Moody Aldrich Partners LLC18,012$716K0.14%-3,62013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…16,689$663K<0.01%-22,00813F-HRTimelineGroup
Birchview Capital, LP16,000$636K0.48%013F-HRTimeline
Persistent Asset Partners Ltd14,819$589K0.43%+12,39413F-HR/ATimeline
PROFUND ADVISORS LLC14,171$563K0.02%+5,19013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC13,701$544K<0.01%-2,36913F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC12,860$511K<0.01%-55,98513F-HRTimelineGroup
NATIXIS ADVISORS, LLCin group Natixis Investment Managers12,475$496K<0.01%-2,55613F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…11,644$463K<0.01%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND9,887$393K<0.01%013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC9,374$372K<0.01%-3,07113F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…9,350$371K<0.01%013F-HRTimeline
Police & Firemen's Retirement System of…9,341$371K<0.01%+1,99213F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…8,960$356K<0.01%013F-HRTimeline
Handelsbanken Fonder AB8,500$338K<0.01%013F-HRTimeline
Glenmede Investment Management, LP8,127$323K<0.01%-73013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD8,095$322K<0.01%-4,21013F-HRTimeline
China Universal Asset Management Co., L…8,082$321K0.03%-6,16613F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …7,797$310K0.04%013F-HRTimelineGroup
Creative Planningin group Creative Planning7,347$292K<0.01%-1,68413F-HRTimelineGroup
ProShare Advisors LLC7,243$288K<0.01%-1,02213F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP7,027$279K<0.01%-83,54113F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC6,999$278K<0.01%+9913F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM6,602$262K<0.01%+11413F-HRTimeline
CITIGROUP INCin group CITIGROUP INC6,504$258K<0.01%-16,42413F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC5,877$233K<0.01%-3,39013F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd5,852$232K0.01%-6,46913F-HRTimelineGroup
Family Manage LLC5,589$222K0.03%-1,27113F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS5,487$218K<0.01%-52613F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP5,039$200K<0.01%new13F-HRTimelineGroup
AlphaQuest LLC4,911$195K0.01%-16213F-HRTimeline
Caption Management, LLC4,800$191K0.01%-5,22913F-HRTimeline
KLP KAPITALFORVALTNING AS4,100$163K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA4,020$160K<0.01%+3,93513F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,964$118K<0.01%-5,45513F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,736$109K<0.01%-52313F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…2,718$108K0.03%+47213F-HRTimelineGroup
Quantbot Technologies LP2,407$95.6K<0.01%new13F-HRTimeline
T. Rowe Price Investment Management, In…1,441$58K<0.01%+97713F-HRTimeline
AMALGAMATED BANK1,061$42K<0.01%-25113F-HRTimeline
GF FUND MANAGEMENT CO. LTD.992$39.4K<0.01%-16113F-HRTimeline
ANTIPODES PARTNERS Ltd843$33.5K<0.01%+24613F-HRTimeline
NISA INVESTMENT ADVISORS, LLC755$30K<0.01%-1413F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.549$20.4K<0.01%+30113F-HRTimelineGroup
BESSEMER GROUP INCin group BESSEMER GROUP INC505$20K<0.01%+46513F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\400$15.9K<0.01%-2213F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…275$10.9K<0.01%+22113F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.270$10.7K<0.01%new13F-HRTimelineGroup
Versant Capital Management, Inc229$9.1K<0.01%013F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …202$8K<0.01%013F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.166$7K<0.01%013F-HRTimelineGroup
GAMMA Investing LLC143$5.68K<0.01%+2213F-HRTimeline
Smartleaf Asset Management LLC101$4.02K<0.01%+2213F-HRTimeline
Caitong International Asset Management …97$3.85K<0.01%-9113F-HRTimeline
Washington Trust Advisors, Inc.96$3.81K<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP98$3.75K<0.01%new13F-HRTimelineGroup
QUADRANT CAPITAL GROUP LLC91$3.62K<0.01%new13F-HRTimeline
Arax Advisory Partners84$3.34K<0.01%+5813F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…81$3.22K<0.01%-5413F-HRTimelineGroup
Sterling Capital Management LLC79$3.14K<0.01%+213F-HRTimeline
ROTHSCHILD INVESTMENT LLC75$2.98K<0.01%-1013F-HRTimeline
Larson Financial Group LLC73$2.9K<0.01%-12113F-HRTimeline
Red Tortoise LLC69$2.74K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC49$2K<0.01%-3113F-HRTimelineGroup
BELLEVUE ASSET MANAGEMENT, LLC36$1.43K<0.01%013F-HRTimeline
Parkside Financial Bank & Trust31$1.23K<0.01%+2113F-HRTimeline
Farther Finance Advisors, LLC27$1.07K<0.01%-3313F-HRTimeline
Hughes Financial Services, LLC17$965<0.01%013F-HRTimeline
TD PRIVATE CLIENT WEALTH LLC18$715<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.17$675<0.01%new13F-HRTimeline
Rise Advisors, LLC16$636<0.01%013F-HRTimeline
SIGNATUREFD, LLC13$516<0.01%-1513F-HRTimeline
Federation des caisses Desjardins du Qu…10$397<0.01%013F-HRTimeline
PRINCIPAL SECURITIES, INC.in group PRINCIPAL FINANCIAL GROUP INC5$199<0.01%013F-HRTimelineGroup
MONTAG A & ASSOCIATES INC4$159<0.01%new13F-HRTimeline
Sunbelt Securities, Inc.3$119<0.01%new13F-HRTimeline
IFP Advisors, Inc2$79<0.01%+213F-HR/ATimeline
Allworth Financial LP1$40<0.01%-5413F-HRTimeline
Covestor Ltd3$00%013F-HRTimelineValue filed as zero, left out of ratios.