Skip to content
Disclosery

RA CAPITAL MANAGEMENT, L.P.

Follow

13F filer, CIK 1346824, BOSTON, MA

RA CAPITAL MANAGEMENT, L.P. reported $9,760,868,193 across 71 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 65.63% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-26-016482

Period
2025-12-31
Reported value
$9.76B
Holdings
71
Top 10 weight
65.63%
New
22
Sold out
18

Part of the filer group RA CAPITAL MANAGEMENT, L.P.

How groups are built

Stakes and trades reported after 2025-12-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • WVE WAVE LIFE SCIENCES INC: Form 4 granted 10,700 shares on 2026-10-05, 0001231919-26-001433Timeline
    Accepted , ingested
  • CRBP CORBUS PHARMACEUTICALS HLDGS: 13G 1,914,788 shares, 9.9% of the class, 13G filed 2026-09-30, 0001346824-26-000243Timeline
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
BCRXnew+15,827,186$123M
PRAXnew+373,787$110M
RYTMadded+985,478$105M
OLMAnew+2,600,000$65M
NUVLadded+633,601$63.7M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
89BIO INCexited-19,889,683-$292M
CLYMreduced-20,125,439-$138M
ACLXreduced-1,769,371-$115M
BLTEreduced-442,516-$70.8M
PCVXreduced-1,241,392-$57.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001104659-26-016482, largest first. % of portfolio is the value over $9,760,868,193, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,710,428 shares; 2024Q4: 10,112,744 shares; 2025Q1: 10,281,496 shares; 2025Q2: 10,281,496 shares; 2025Q3: 10,281,496 shares; 2025Q4: 10,281,496 shares 10,281,496$2.19B22.46%0Timeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 703,080 shares; 2024Q4: 1,092,796 shares; 2025Q1: 1,092,796 shares; 2025Q2: 3,365,523 shares; 2025Q3: 3,365,523 shares; 2025Q4: 3,365,523 shares 3,365,523$743M7.62%0Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,084,412 shares; 2024Q4: 6,084,412 shares; 2025Q1: 6,084,412 shares; 2025Q2: 5,561,359 shares; 2025Q3: 5,681,359 shares; 2025Q4: 6,666,837 shares 6,666,837$714M7.31%+985,478Timeline
RNAMAVIDITY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,300,408 shares; 2024Q4: 6,300,408 shares; 2025Q1: 6,300,408 shares; 2025Q2: 7,266,031 shares; 2025Q3: 8,641,031 shares; 2025Q4: 8,641,031 shares 8,641,031$623M6.39%0Timeline
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,689,190 shares; 2024Q4: 8,689,190 shares; 2025Q1: 12,189,149 shares; 2025Q2: 11,965,991 shares; 2025Q3: 11,965,991 shares; 2025Q4: 10,724,599 shares 10,724,599$495M5.07%-1,241,392Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 10,445,322 shares; 2025Q2: 10,445,322 shares; 2025Q3: 10,445,322 shares; 2025Q4: 9,905,045 shares 9,905,045$407M4.17%-540,277Timeline
NAMSNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,064,000 shares; 2024Q4: 8,845,000 shares; 2025Q1: 10,138,938 shares; 2025Q2: 10,138,938 shares; 2025Q3: 10,138,938 shares; 2025Q4: 9,550,191 shares 9,550,191$335M3.43%-588,747Timeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,416,609 shares; 2024Q4: 10,637,290 shares; 2025Q1: 10,637,290 shares; 2025Q2: 12,198,625 shares; 2025Q3: 12,198,625 shares; 2025Q4: 12,198,625 shares 12,198,625$321M3.29%0Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 18,202,009 shares; 2024Q4: 18,202,009 shares; 2025Q1: 18,202,009 shares; 2025Q2: 18,202,009 shares; 2025Q3: 18,202,009 shares; 2025Q4: 18,203,009 shares 18,203,009$309M3.17%+1,000Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,850,984 shares; 2024Q4: 4,850,984 shares; 2025Q1: 6,147,280 shares; 2025Q2: 6,147,280 shares; 2025Q3: 7,323,750 shares; 2025Q4: 7,323,750 shares 7,323,750$266M2.72%0Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,909,091 shares; 2024Q4: 8,909,091 shares; 2025Q1: 8,909,091 shares; 2025Q2: 9,902,633 shares; 2025Q3: 10,428,437 shares; 2025Q4: 10,428,437 shares 10,428,437$259M2.65%0Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 6,995,858 shares; 2025Q1: 6,995,858 shares; 2025Q2: 6,995,858 shares; 2025Q3: 6,995,858 shares; 2025Q4: 6,995,858 shares 6,995,858$195M2%0Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 176,281 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,246,456 shares; 2025Q4: 1,880,057 shares 1,880,057$189M1.94%+633,601Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,577,106 shares; 2025Q2: 1,577,106 shares; 2025Q3: 1,577,106 shares; 2025Q4: 1,976,132 shares 1,976,132$157M1.61%+399,026Timeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,165,652 shares; 2024Q4: 10,365,652 shares; 2025Q1: 11,189,693 shares; 2025Q2: 11,189,693 shares; 2025Q3: 11,189,693 shares; 2025Q4: 11,189,693 shares 11,189,693$154M1.58%0Timeline
PEPGPEPGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,689,545 shares; 2024Q4: 10,689,545 shares; 2025Q1: 10,689,545 shares; 2025Q2: 10,689,545 shares; 2025Q3: 20,064,545 shares; 2025Q4: 20,064,545 shares 20,064,545$131M1.34%0Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,872,503 shares; 2024Q4: 10,872,503 shares; 2025Q1: 10,872,503 shares; 2025Q2: 23,555,648 shares; 2025Q3: 23,555,648 shares; 2025Q4: 23,555,648 shares 23,555,648$130M1.33%0Timeline
SPRYARS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,860,977 shares; 2024Q4: 10,860,977 shares; 2025Q1: 10,860,977 shares; 2025Q2: 10,860,977 shares; 2025Q3: 10,860,977 shares; 2025Q4: 10,860,977 shares 10,860,977$127M1.3%0Timeline
BCRXBIOCRYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 15,827,186 shares 15,827,186$123M1.26%newTimeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,955,993 shares; 2024Q4: 6,955,993 shares; 2025Q1: 6,955,993 shares; 2025Q2: 6,955,993 shares; 2025Q3: 6,955,993 shares; 2025Q4: 6,955,993 shares 6,955,993$117M1.2%0Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 761,955 shares; 2024Q4: 761,955 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 373,787 shares 373,787$110M1.13%newTimeline
GHRSGH RESEARCH PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,686,689 shares; 2024Q4: 6,686,689 shares; 2025Q1: 6,944,648 shares; 2025Q2: 7,676,697 shares; 2025Q3: 7,676,697 shares; 2025Q4: 7,676,697 shares 7,676,697$97.5M1%0Timeline
GERNGERON CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 32,285,755 shares; 2024Q4: 30,009,536 shares; 2025Q1: 60,379,366 shares; 2025Q2: 60,379,366 shares; 2025Q3: 60,379,366 shares; 2025Q4: 63,771,366 shares 63,771,366$84.2M0.86%+3,392,000Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,851,479 shares; 2024Q4: 2,787,327 shares; 2025Q1: 3,036,527 shares; 2025Q2: 3,036,527 shares; 2025Q3: 3,036,527 shares; 2025Q4: 1,267,156 shares 1,267,156$82.6M0.85%-1,769,371Timeline
CLYMCLIMB BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 31,419,267 shares; 2024Q4: 31,419,267 shares; 2025Q1: 31,419,267 shares; 2025Q2: 31,419,267 shares; 2025Q3: 31,419,267 shares; 2025Q4: 11,293,828 shares 11,293,828$77.7M0.8%-20,125,439Timeline
VORVOR BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,982,301 shares; 2025Q4: 5,404,998 shares 5,404,998$70.7M0.72%+3,422,697Timeline
BLTEBELITE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 875,000 shares; 2025Q4: 432,484 shares 432,484$69.2M0.71%-442,516Timeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,229,099 shares; 2024Q4: 10,229,099 shares; 2025Q1: 10,229,099 shares; 2025Q2: 10,229,099 shares; 2025Q3: 10,229,099 shares; 2025Q4: 6,053,960 shares 6,053,960$68.5M0.7%-4,175,139Timeline
LENZLENZ THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,178,823 shares; 2024Q4: 4,178,823 shares; 2025Q1: 4,178,823 shares; 2025Q2: 4,178,823 shares; 2025Q3: 4,178,823 shares; 2025Q4: 4,178,823 shares 4,178,823$66.9M0.68%0Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,333,000 shares; 2024Q4: 1,866,400 shares; 2025Q1: 2,866,733 shares; 2025Q2: 2,866,733 shares; 2025Q3: 2,866,733 shares; 2025Q4: 1,611,733 shares 1,611,733$66.4M0.68%-1,255,000Timeline
OLMAOLEMA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,600,000 shares 2,600,000$65M0.67%newTimeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,458,770 shares 3,458,770$59.2M0.61%newTimeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,062,326 shares; 2025Q3: 1,062,326 shares; 2025Q4: 3,671,083 shares 3,671,083$56.6M0.58%+2,608,757Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,621,620 shares 1,621,620$53.1M0.54%newTimeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 546,554 shares; 2024Q4: 546,554 shares; 2025Q1: 546,554 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 5,000,000 shares 5,000,000$49.6M0.51%newTimeline
LBRXLB PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,776,958 shares; 2025Q4: 2,208,604 shares 2,208,604$49.2M0.5%+431,646Timeline
MNPRMONOPAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 511,207 shares; 2025Q1: 511,207 shares; 2025Q2: 511,207 shares; 2025Q3: 511,207 shares; 2025Q4: 667,207 shares 667,207$43.6M0.45%+156,000Timeline
CAPRCAPRICOR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,507,844 shares 1,507,844$43.5M0.45%newTimeline
FDMT4D MOLECULAR THERAPEUTICS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,098,211 shares; 2024Q4: 4,563,211 shares; 2025Q1: 4,563,211 shares; 2025Q2: 4,563,211 shares; 2025Q3: 4,563,211 shares; 2025Q4: 5,653,211 shares 5,653,211$42.4M0.43%+1,090,000Timeline
IVVDINVIVYD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 17,119,096 shares; 2025Q4: 17,119,096 shares 17,119,096$42.3M0.43%0Timeline
ARTVARTIVA BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,853,302 shares; 2024Q4: 9,853,302 shares; 2025Q1: 9,853,302 shares; 2025Q2: 9,853,302 shares; 2025Q3: 9,853,302 shares; 2025Q4: 9,853,302 shares 9,853,302$42.3M0.43%0Timeline
GRALGRAIL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 428,266 shares 428,266$36.7M0.38%newTimeline
ASMBASSEMBLY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,020,410 shares; 2025Q4: 1,020,410 shares 1,020,410$34.7M0.36%0Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,330,446 shares; 2024Q4: 4,330,446 shares; 2025Q1: 4,330,446 shares; 2025Q2: 5,811,323 shares; 2025Q3: 5,811,423 shares; 2025Q4: 5,811,423 shares 5,811,423$32.8M0.34%0Timeline
ABOSACUMEN PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 14,932,063 shares; 2024Q4: 14,932,063 shares; 2025Q1: 14,932,063 shares; 2025Q2: 14,932,063 shares; 2025Q3: 14,932,063 shares; 2025Q4: 14,932,063 shares 14,932,063$31.5M0.32%0Timeline
BNTCBENITEC BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,850,000 shares 1,850,000$24.9M0.26%newTimeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,122,000 shares; 2025Q4: 2,179,711 shares 2,179,711$24.9M0.26%+57,711Timeline
RZLTREZOLUTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 9,180,000 shares 9,180,000$21.7M0.22%newTimeline
ACRVACRIVON THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,340,508 shares; 2024Q4: 8,340,508 shares; 2025Q1: 8,340,508 shares; 2025Q2: 8,340,508 shares; 2025Q3: 8,340,508 shares; 2025Q4: 8,340,508 shares 8,340,508$20.1M0.21%0Timeline
NKTXNKARTA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,805,129 shares; 2024Q4: 10,805,129 shares; 2025Q1: 10,805,129 shares; 2025Q2: 10,805,129 shares; 2025Q3: 10,805,129 shares; 2025Q4: 10,805,129 shares 10,805,129$20M0.2%0Timeline
OVIDOVID THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 10,714,000 shares 10,714,000$17.5M0.18%newTimeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 7,124,116 shares 7,124,116$16.7M0.17%newTimeline
SABSSAB BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 4,401,500 shares; 2025Q4: 4,401,500 shares 4,401,500$16.5M0.17%0Timeline
CCCCC4 THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,878,000 shares; 2024Q4: 4,878,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 8,000,000 shares 8,000,000$15.3M0.16%newTimeline
MDLNMEDLINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 335,000 shares 335,000$14.1M0.14%newTimeline
DSGNDESIGN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 475,699 shares; 2025Q4: 1,461,381 shares 1,461,381$13.7M0.14%+985,682Timeline
INSPINSPIRE MED SYS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 114,901 shares; 2025Q4: 141,964 shares 141,964$13.1M0.13%+27,063Timeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 967,000 shares; 2024Q4: 967,000 shares; 2025Q1: 967,000 shares; 2025Q2: 932,973 shares; 2025Q3: 662,968 shares; 2025Q4: 662,968 shares 662,968$12M0.12%0Timeline
RANIRANI THERAPEUTICS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 8,500,000 shares 8,500,000$11.5M0.12%newTimeline
FRNMPERCEPTIVE CAP SOLUTIONS CORQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 750,000 shares; 2024Q4: 750,000 shares; 2025Q1: 750,000 shares; 2025Q2: 750,000 shares; 2025Q3: 750,000 shares; 2025Q4: 750,000 shares 750,000$9.77M0.1%0Timeline
ACETADICET BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 948,249 shares 948,249$7.98M0.08%newTimeline
NAMSWNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 333,333 shares; 2024Q4: 333,333 shares; 2025Q1: 333,333 shares; 2025Q2: 333,333 shares; 2025Q3: 333,333 shares; 2025Q4: 333,333 shares 333,333$7.67M0.08%0Timeline
WGSGENEDX HOLDINGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 58,044 shares; 2025Q3: 58,044 shares; 2025Q4: 58,044 shares 58,044$7.55M0.08%0Timeline
WAYWAYSTAR HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 144,400 shares 144,400$4.73M0.05%newTimeline
HOWLWEREWOLF THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,144,881 shares; 2024Q4: 6,144,881 shares; 2025Q1: 6,144,881 shares; 2025Q2: 6,681,307 shares; 2025Q3: 6,681,307 shares; 2025Q4: 6,681,307 shares 6,681,307$4.23M0.04%0Timeline
HNGEHINGE HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 300,000 shares; 2025Q3: not reported; 2025Q4: 80,113 shares 80,113$3.72M0.04%newTimeline
PGNYPROGYNY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 96,628 shares; 2025Q4: 96,628 shares 96,628$2.48M0.03%0Timeline
QIAGEN N.V.QIAGEN N.V.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 43,976 shares 43,976$2.08M0.02%new
KIDSORTHOPEDIATRICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 109,959 shares 109,959$1.95M0.02%newTimeline
HCATHEALTH CATALYST INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 793,749 shares 793,749$1.9M0.02%newTimeline
PTNPALATIN TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 70,000 shares 70,000$1.08M0.01%newTimeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
89BIO INC89BIO INC19,889,683$292Mshares
SRRKSCHOLAR ROCK HLDG CORP1,166,788$43.5Mshares
GPCRSTRUCTURE THERAPEUTICS INC1,517,418$42.5Mshares
MTSRMETSERA INC675,525$35.4Mshares
TVTXTRAVERE THERAPEUTICS INC1,150,000$27.5Mshares
LRMRLARIMAR THERAPEUTICS INC6,045,351$19.5Mshares
TNGXTANGO THERAPEUTICS INC2,000,000$16.8Mshares
PRMEPRIME MEDICINE INC3,000,000$16.6Mshares
RCUSARCUS BIOSCIENCES INC1,136,364$15.5Mshares
QUREUNIQURE NV200,000$11.7Mshares
ELDNELEDON PHARMACEUTICALS INC3,566,338$9.24Mshares
CTMXCYTOMX THERAPEUTICS INC.2,661,331$8.49Mshares
SRZNSURROZEN INC602,626$7.76Mshares
ADICET BIO INCADICET BIO INC7,541,000$6.11Mshares
EVHEVOLENT HEALTH INC579,052$4.9Mshares
GKOSGLAUKOS CORP54,180$4.42Mshares
EXASEXACT SCIENCES CORP54,939$3.01Mshares
IFRXINFLARX NV1,973,233$2.64Mshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-26-016482 base2026-02-17acceptance time not in the bulk data set