TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 5,673,078 $104M 2.51% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,932,149 $90.8M <0.01% +3,392,479 13F-HR Timeline Group FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 4,117,354 $75.8M 10.1% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,468,107 $63.8M <0.01% +2,673,348 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,041,719 $56M 1.7% 0 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 2,743,343 $50.5M +1,111,677 Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,616,336 $48.2M <0.01% +1,497,878 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 2,543,939 $46.8M 1.02% 0 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 2,402,095 $44.2M 0.38% -3,002,903 13F-HR Timeline Group Caligan Partners LP More: the full row for Caligan Partners LP 1,925,066 $35.4M 1.71% 0 13F-HR Timeline Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,750,000 $32.2M 0.6% 0 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,700,000 $31.3M 7.37% -50,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,062,469 $19.6M <0.01% +719,896 13F-HR Timeline Group NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 889,164 $16.4M 7.53% -110,803 13F-HR Timeline Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 845,000 $15.6M 0.94% new 13F-HR/A Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 680,626 $12.5M 0.59% new 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 650,000 $12M 0.52% -100,000 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 648,600 $11.9M 4.49% -51,400 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 646,550 $11.9M 1.18% new 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 573,104 $10.6M 0.39% +106,330 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 558,702 $10.3M 0.19% +3,000 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 493,278 $9.08M <0.01% +4,910 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 428,067 $7.88M 0.01% +169,480 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 416,417 $7.67M 1.1% +94,500 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 379,723 $6.99M 0.02% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 328,892 $6.05M <0.01% +67,001 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 328,742 $6.05M <0.01% +264,193 13F-HR Timeline Group Clearline Capital LP More: the full row for Clearline Capital LP 285,276 $5.25M 0.34% -40,892 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 177,739 $3.27M <0.01% +64,847 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 160,414 $2.95M <0.01% +11,646 13F-HR Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 149,681 $2.76M 0.15% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 121,398 $2.23M <0.01% +99,182 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 97,722 $1.8M <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 95,643 $1.76M <0.01% -1,057,633 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 94,815 $1.75M <0.01% new 13F-HR Timeline Group AXIOM INVESTORS LLC /DE More: the full row for AXIOM INVESTORS LLC /DE 92,105 $1.7M 0.01% -3,640 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 82,645 $1.52M 0.02% new 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 70,889 $1.31M 0.01% -102,139 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 68,301 $1.26M <0.01% +56,701 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 63,130 $1.16M <0.01% +57,757 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 61,561 $1.13M <0.01% -55,160 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 57,528 $1.06M <0.01% new 13F-HR Timeline ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 54,998 $1.01M <0.01% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 54,671 $1.01M <0.01% new 13F-HR Timeline Group JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 53,732 $989K 0.12% 0 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 48,818 $899K <0.01% -1,687 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 46,612 $858K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 41,815 $770K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 40,351 $743K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 37,210 $685K <0.01% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 37,012 $681K <0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 36,951 $680K 0.01% +10,071 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 36,273 $668K <0.01% +36,272 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 33,011 $608K <0.01% -95,828 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 32,663 $601K 0.01% new 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 27,100 $499K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 26,804 $495K +21,125 Timeline Sarissa Capital Management LP More: the full row for Sarissa Capital Management LP 25,399 $468K 0.26% 0 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 24,591 $453K 0.01% +2,576 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 24,442 $450K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 23,231 $428K <0.01% -2,251 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 23,019 $424K <0.01% +9,303 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 22,785 $419K 0.1% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 21,621 $402K <0.01% +17,257 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 19,620 $361K <0.01% -132,951 13F-HR Timeline Scientech Research LLC More: the full row for Scientech Research LLC 18,828 $347K 0.28% +3,781 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 17,238 $317K 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 16,454 $303K <0.01% -216,154 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 15,301 $282K 0.05% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 14,565 $268K <0.01% +14,429 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 14,300 $263K <0.01% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 13,695 $252K 0.03% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 12,035 $222K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 10,793 $199K <0.01% new 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 10,785 $199K 0.05% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 10,708 $197K <0.01% +7,864 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,624 $159K 0.01% +1,256 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 8,011 $147K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. group of 2 filers holding More: the full row for Ameritas Investment Partners, Inc. 3,703 $68.2K +3,666 Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,256 $59.9K <0.01% new 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 2,963 $54.5K <0.01% -6,102 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 2,089 $38.5K <0.01% 13F-HR Timeline Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 1,975 $36.4K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,741 $32.1K <0.01% -1,725 13F-HR Timeline Group Winthrop Capital Management, LLC More: the full row for Winthrop Capital Management, LLC 1,481 $27K 0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,260 $23K <0.01% +1,061 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,072 $19.7K <0.01% +700 13F-HR Timeline Pacer Advisors, Inc. More: the full row for Pacer Advisors, Inc. 815 $15K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 562 $10.3K <0.01% new 13F-HR/A Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 355 $6.54K <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 308 $5.67K <0.01% +62 13F-HR Timeline Group NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 180 $3.31K <0.01% new 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 147 $2.71K <0.01% +108 13F-HR Timeline WPG Advisers, LLC More: the full row for WPG Advisers, LLC 22 $405 <0.01% +1 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 10 $185 <0.01% -63 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 5 $92 <0.01% -43 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 3 $55 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2 $37 <0.01% new 13F-HR Timeline Group