RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 17,955,642 $174M 1.51% +8,102,340 13F-HR Timeline Group VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 2,604,166 $25.3M 0.07% new 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 2,403,437 $23.3M 0.08% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 2,353,304 $22.8M 7.93% 0 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 2,043,596 $19.8M 0.6% +434,027 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,997,223 $19.4M <0.01% +1,476,896 13F-HR Timeline Group Caligan Partners LP More: the full row for Caligan Partners LP 1,736,111 $16.8M 0.81% new 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 1,173,299 $11.4M +932,803 Timeline SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 954,861 $9.26M 0.76% new 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 874,542 $8.48M 1.29% new 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 696,436 $6.76M 3.54% +550,067 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 694,726 $6.74M <0.01% +481,338 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 609,376 $5.91M <0.01% +593,506 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 525,000 $5.09M 0.57% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 353,845 $3.43M <0.01% +252,150 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 314,375 $3.05M 0.06% new 13F-HR Timeline Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 300,000 $2.91M 0.18% new 13F-HR/A Timeline Revelation Capital Management, LLC More: the full row for Revelation Capital Management, LLC 299,311 $2.9M 2.65% 0 13F-HR Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 273,615 $2.65M 0.01% +173,615 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 260,416 $2.53M 1.76% new 13F-HR Timeline KVP Capital Advisors, LP More: the full row for KVP Capital Advisors, LP 200,000 $1.94M 1.42% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 194,108 $1.88M <0.01% 0 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 184,020 $1.78M <0.01% +182,493 13F-HR Timeline Group SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 175,000 $1.7M 0.07% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 165,764 $1.61M <0.01% +129,940 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 151,000 $1.46M <0.01% +70,962 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 118,624 $1.15M 0.05% new 13F-HR Timeline Group Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 101,355 $983K 0.01% +78,125 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 85,000 $824K 0.01% +50,000 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 78,575 $762K <0.01% -36,466 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 76,423 $741K <0.01% +64,215 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 67,101 $651K 0.12% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 49,345 $479K <0.01% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 44,815 $435K <0.01% +24,445 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 42,509 $412K 0.01% +22,239 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 25,000 $242K 0.15% 0 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 22,854 $222K 0.02% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 22,940 $221K <0.01% new 13F-HR Timeline Group BAILARD, INC. More: the full row for BAILARD, INC. 20,700 $201K <0.01% 0 13F-HR Timeline Spark Investment Management LLC More: the full row for Spark Investment Management LLC 16,500 $160K 0.31% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 15,780 $153K <0.01% +4,315 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 14,855 $144K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 13,980 $136K <0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 11,896 $115K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,100 $59.2K <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 5,861 $56.9K <0.01% +370 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,480 $53.2K <0.01% +3,980 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 4,588 $44.5K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 4,191 $40.1K <0.01% +3,968 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 3,558 $34.5K <0.01% +29 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 3,336 $32.4K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,066 $30K <0.01% +2,878 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 3,039 $29.5K <0.01% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,212 $21.5K <0.01% -14,165 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 2,143 $20.8K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 2,136 $20.7K <0.01% new 13F-HR Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 2,000 $19.4K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 1,600 $15.5K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,148 $11.1K <0.01% +606 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 566 $5.49K <0.01% new 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 500 $4.85K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 421 $4.08K <0.01% new 13F-HR Timeline Group MARK SHEPTOFF FINANCIAL PLANNING, LLC More: the full row for MARK SHEPTOFF FINANCIAL PLANNING, LLC 400 $3.88K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 247 $2.4K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 235 $2.28K <0.01% new 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 94 $912 <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 72 $698 <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 13 $126 <0.01% new 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 11 $106 <0.01% new 13F-HR Timeline Group