13F-HR filed by PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC filed this 13F-HR for the quarter ended 2025-06-30, filed 2025-08-14, with 85 holding rows worth $2,697,358,275.
- Accession
- 0001012975-25-000446
- Filer
- CIK 1224962
- Filed
- 2025-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2025
A holdings report, 85 entries on the cover page, a total value of $2,697,358,275 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,697,358,275 with VALUE read as dollars as filed, 13F file number 028-10438. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 5,507,591 | $520,907,957 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 963,886 | $166,366,724 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 2,478,000 | $163,176,300 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 2,418,299 | $152,812,314 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,375,180 | $104,926,234 | dollars as filed | |
| ARTIVION INC | 228903100 | COM | 2,793,703 | $86,884,163 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 12,626,103 | $82,231,024 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 650,252 | $65,441,361 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 4,639,949 | $60,829,731 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 1,074,448 | $59,384,741 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 11,906,646 | $57,985,366 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,182,148 | $51,340,688 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 7,902,365 | $50,654,160 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 9,383,456 | $50,482,993 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 915,887 | $48,871,730 | dollars as filed | |
| OMADA HEALTH INC | 68170A108 | COM | 2,426,330 | $44,401,839 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 7,412,830 | $42,475,516 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 3,331,465 | $37,545,611 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 708,176 | $37,250,058 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 430,439 | $36,062,179 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 6,485,420 | $34,761,851 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 2,137,890 | $34,206,240 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 255,050 | $32,057,234 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 752,921 | $31,660,328 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 280,000 | $30,074,800 | dollars as filed | |
| CARIS LIFE SCIENCES INC | 142152107 | COMMON STOCK | 1,098,163 | $29,342,915 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 300,000 | $24,879,000 | dollars as filed | put |
| Intuitive Surgical,Inc. | 46120E602 | COM | 45,119 | $24,518,116 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 1,303,468 | $23,736,152 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 1,593,608 | $23,202,932 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,529,445 | $22,895,792 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 2,474,843 | $22,793,304 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 1,633,208 | $21,803,327 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 2,247,390 | $21,395,153 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 1,216,045 | $21,098,381 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 198,534 | $20,724,964 | dollars as filed | |
| REPLIGEN CORP COM | 759916109 | Stock | 166,000 | $20,647,080 | dollars as filed | |
| INSULET CORP COM | 45784P101 | Stock | 60,387 | $18,972,388 | dollars as filed | |
| OUTSET MED INC | 690145206 | COM NEW | 833,333 | $16,008,326 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 1,275,274 | $16,004,689 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 6,993,646 | $15,875,576 | dollars as filed | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 4,051,631 | $15,517,747 | dollars as filed | |
| CHARLES RIV LABS INTL INC | 159864107 | COM | 100,000 | $15,173,000 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 1,146,935 | $15,070,726 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 977,892 | $13,954,518 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 9,876,576 | $12,839,549 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 1,096,985 | $12,494,659 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 834,252 | $12,346,930 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 4,592,556 | $12,308,050 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 420,690 | $10,984,216 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 5,432,293 | $10,592,971 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 380,700 | $10,088,550 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 270,000 | $9,817,200 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 210,106 | $9,169,026 | dollars as filed | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 12,594,211 | $9,130,802 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 32,797 | $8,416,694 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 453,686 | $7,322,492 | dollars as filed | |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 2,190,420 | $7,250,290 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 292,686 | $6,761,047 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 1,705,130 | $6,462,443 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 650,000 | $6,454,500 | dollars as filed | put |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 200,791 | $6,284,758 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 447,507 | $6,256,148 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 1,438,595 | $5,754,380 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 541,450 | $5,723,127 | dollars as filed | |
| GLOBUS MED INC CL A | 379577208 | Stock | 88,500 | $5,223,270 | dollars as filed | |
| ENVVENO MEDICAL CORPORATION | 29415J106 | COM | 1,284,966 | $5,127,014 | dollars as filed | |
| HELIX ACQUISITION CORP II | G4444H101 | CL A ORD SHS | 398,000 | $4,226,760 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 4,325,000 | $4,074,583 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 699,486 | $2,776,959 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L204 | COM NEW | 255,150 | $2,286,144 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 500,000 | $1,905,000 | dollars as filed | |
| ATHIRA PHARMA INC | 04746L104 | COM | 5,402,964 | $1,631,695 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 183,890 | $1,471,120 | dollars as filed | |
| TRINITY BIOTECH INVT LTD | 896438504 | SPONS ADR NEW | 1,790,000 | $1,163,500 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 100,000 | $993,000 | dollars as filed | call |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 68,192 | $881,723 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 139,667 | $696,938 | dollars as filed | |
| BIODESIX INC | 09075X108 | COM | 2,173,880 | $613,034 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 139,835 | $562,137 | dollars as filed | |
| APYX MEDICAL CORPORATION | 03837C106 | COM | 150,000 | $337,500 | dollars as filed | |
| KALA BIO INC | 483119202 | COM NEW | 55,227 | $262,881 | dollars as filed | |
| ENSYSCE BIOSCIENCES INC | 293602504 | COM NEW | 86,666 | $193,265 | dollars as filed | |
| REVOLUTION MEDICINES INC | 76155X118 | *W EXP 12/17/202 | 250,000 | $65,675 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 166,666 | $3,017 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001012975-25-000446 | this filing | 2025-08-14 | acceptance time not in the bulk data set |