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Disclosery

ORKA ORUKA THERAPEUTICS INC

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Stock (common), issuer CIK 907654

141 managers (143 13F filers) reported a position in ORKA shares at 2025-12-31, 52,851,763 shares in all. 39 filers opened a position and 8 filers sold out during the quarter.

Managers
141
13F filers
143
New
39
Added
54
Reduced
16
Sold out
8
Shares held by filers
52,851,763

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC7,261,384$220M0.01%+3,76313F-HRTimelineGroup
Venrock Adviser, LLC4,148,428$126M6.21%013F-HRTimeline
Fairmount Funds Management LLCin group Fairmount Funds Management LLC3,705,262$112M8.55%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,539,415$107M<0.01%+1,334,86413F-HRTimelineGroup
VIKING GLOBAL INVESTORS LPin group VIKING GLOBAL INVESTORS LP2,666,690$80.8M0.21%013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,453,530$74.4M<0.01%+676,86513F-HRTimelineGroup
Deep Track Capital, LP2,161,510$65.5M1.49%-493,27113F-HRTimeline
RTW INVESTMENTS, LP2,058,148$62.4M0.62%+112,49913F-HRTimeline
Commodore Capital LPin group Commodore Capital LP1,753,054$53.1M3.54%013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,710,316$51.8M1.39%new13F-HRTimelineGroup
Remedium Capital Partners, LLC1,552,414$47.1M27.64%13F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,476,501$44.8M0.82%+208,48013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,383,847$41.9M<0.01%+731,81913F-HRTimelineGroup
Avoro Capital Advisors LLC1,333,340$40.4M0.4%013F-HR/ATimeline
Blackstone Inc.in group Blackstone Inc.1,165,408$35.3M0.12%+315,00813F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Polar Capital Holdings Plcin group Polar Capital Holdings Plc978,288$29.7M0.14%-54,01913F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC942,507$28.6M<0.01%+252,53513F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources938,421$28.4M0.01%-127,36113F-HRTimelineGroup
Affinity Asset Advisors, LLC802,342$24.3M1.75%-156,83813F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV745,277$22.6M0.03%-107,13413F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC726,118$22M0.01%+409,23213F-HRTimelineGroup
Avidity Partners Management LP660,424$20M5.77%013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/649,346$19.7M<0.01%+22,54013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.600,000$18.2M0.03%-437,00213F-HRTimelineGroup
Woodline Partners LP574,553$17.4M0.07%+22313F-HRTimeline
Cormorant Asset Management, LP533,340$16.2M0.92%013F-HRTimeline
Synergy Asset Management, LLCin group Synergy Asset Management, LLC458,946$13.9M1.45%new13F-HRTimelineGroup
SR One Capital Management, LP430,330$13M1.85%013F-HRTimeline
Candriam S.C.A.400,509$12.1M0.06%+33,51513F-HR/ATimeline
Cable Car Capital, LP400,000$12.1M0.75%-100,00013F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co329,496$9.99M<0.01%+82,57013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding285,257$8.65M+198,697Timeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP280,904$8.51M<0.01%+61,19513F-HRTimelineGroup
Soleus Capital Management, L.P.190,000$5.76M0.24%new13F-HRTimeline
GREAT POINT PARTNERS LLC183,330$5.56M1.8%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC173,329$5.25M<0.01%+77,99913F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.143,121$4.34M<0.01%+126,80313F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/139,272$4.22M<0.01%+60,27713F-HRTimelineGroup
Longaeva Partners L.P.128,110$3.88M0.46%new13F-HRTimeline
Moody Aldrich Partners LLC126,812$3.84M0.72%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY122,198$3.7M<0.01%-12,63513F-HR/ATimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\119,329$3.62M<0.01%+97,21013F-HRTimelineGroup
Kalehua Capital Management LLC118,524$3.59M3.55%13F-HRTimeline
Sio Capital Management, LLC118,126$3.58M0.59%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp114,173$3.46M<0.01%+43,54113F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.100,000$3.03M0.01%new13F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC92,995$2.82M<0.01%+73,22013F-HR/ATimelineGroup
Nuveen, LLCin group TIAA86,347$2.62M<0.01%+51,03413F-HRTimelineGroup
BRAIDWELL LP84,795$2.57M0.08%-1,297,55513F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…84,716$2.57M<0.01%-6,37813F-HRTimelineGroup
Secure Asset Management, LLC81,664$2.48M0.39%new13F-HRTimeline
TD Asset Management Inc79,896$2.42M<0.01%+34,02013F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.76,415$2.32M<0.01%-19,00213F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc75,680$2.29M<0.01%013F-HRTimelineGroup
B Group, Inc.75,000$2.27M1.68%013F-HRTimeline
Palo Alto Investors LP59,985$1.82M0.25%013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …61,358$1.8M<0.01%+9,45013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC58,723$1.78M<0.01%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC57,080$1.73M<0.01%+22,96913F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC48,686$1.48M0.03%+42013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN43,261$1.31M<0.01%+22,40513F-HRTimelineGroup
Swiss National Bank43,000$1.3M<0.01%new13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC42,503$1.29M<0.01%new13F-HRTimelineGroup
RHUMBLINE ADVISERS41,017$1.24M<0.01%+10,69013F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC39,751$1.2M0.01%new13F-HRTimelineGroup
Rafferty Asset Management, LLC38,485$1.17M<0.01%+25,69813F-HRTimeline
ALLIANCEBERNSTEIN L.P.37,800$1.15M<0.01%new13F-HRTimeline
Verition Fund Management LLC35,710$1.08M0.01%new13F-HRTimeline
Financial Enhancement Group LLC31,293$1.08M0.14%-1,52613F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP28,566$866K<0.01%013F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP29,184$850K<0.01%013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC27,671$839K<0.01%new13F-HRTimelineGroup
Voleon Capital Management LP23,548$714K0.02%new13F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD22,968$696K<0.01%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding22,504$679K+7,913Timeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…21,658$656K<0.01%+19,96013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…21,362$647K<0.01%+4,84913F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC20,840$632K0.05%013F-HR/ATimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO20,417$619K<0.01%+5,93813F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…20,000$606K<0.01%new13F-HRTimelineGroup
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA19,485$591K<0.01%13F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc18,744$568K<0.01%+16,26713F-HRTimelineGroup
Brookwood Investment Group LLC16,569$502K0.06%new13F-HRTimeline
Empirical Financial Services, LLC d.b.a…15,406$467K0.01%013F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC15,247$462K<0.01%new13F-HRTimelineGroup
AlphaQuest LLC14,901$452K0.03%+4,14013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC14,813$449K<0.01%+2,30713F-HRTimeline
PROFUND ADVISORS LLC14,623$443K0.01%new13F-HRTimeline
Resolute Capital Asset Partners LLC12,500$379K0.18%-62,50013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson12,100$367K<0.01%new13F-HRTimelineGroup
AlphaCentric Advisors LLC10,880$330K0.33%13F-HRTimeline
ALTFEST L J & CO INC10,857$329K0.04%-2,44013F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE10,300$312K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…10,207$309K<0.01%+2,84913F-HRTimeline
CITIGROUP INCin group CITIGROUP INC9,828$298K<0.01%+6,45713F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO9,676$293K<0.01%new13F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…9,416$285K0.01%new13F-HRTimelineGroup
ProShare Advisors LLC9,189$279K<0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…8,814$267K0.07%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…8,665$263K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND8,600$261K<0.01%013F-HRTimeline
SG Americas Securities, LLC8,275$251K<0.01%new13F-HRTimeline
KLP KAPITALFORVALTNING AS8,000$242K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…7,888$239K0.02%+1,32313F-HRTimeline
Creative Planningin group Creative Planning7,696$233K<0.01%new13F-HRTimelineGroup
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…7,447$226K0.02%new13F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS5,892$179K<0.01%+14513F-HRTimelineGroup
Seven Fleet Capital Management LP5,240$159K0.11%13F-HR/ATimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…3,132$94.9K<0.01%+35513F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…3,041$92.2K<0.01%+78813F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\2,925$88.7K<0.01%+2,74713F-HRTimelineGroup
Sterling Capital Management LLC2,224$67.4K<0.01%+34713F-HRTimeline
Caitong International Asset Management …2,214$67.1K0.02%new13F-HR/ATimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,450$44K<0.01%-56413F-HRTimelineGroup
AMALGAMATED BANK1,212$37K<0.01%+28313F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC1,302$36.6K<0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,139$34K<0.01%+36513F-HRTimelineGroup
Stone House Investment Management, LLC1,000$30.3K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.950$28.8K<0.01%+14413F-HRTimeline
CWM, LLCin group CWM, LLC586$18K<0.01%+19213F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management536$16.2K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…495$15K<0.01%-1,72313F-HRTimelineGroup
DV Trading LLC492$14.9K<0.01%13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC282$8.55K<0.01%new13F-HRTimeline
GROUP ONE TRADING LLC200$6.06K<0.01%+10013F-HRTimeline
Activest Wealth Management166$5.03K<0.01%013F-HRTimeline
J.Safra Asset Management Corp155$4.7K<0.01%+13113F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.116$4K<0.01%013F-HRTimelineGroup
Allworth Financial LP114$3.46K<0.01%+10913F-HRTimeline
GAMMA Investing LLC101$3.06K<0.01%new13F-HRTimeline
Essential Partners LLC27$818<0.01%013F-HRTimeline
True Wealth Design, LLC26$789<0.01%013F-HRTimeline
Aster Capital Management (DIFC) Ltd25$758<0.01%new13F-HRTimeline
Cornerstone Financial Management LLC21$637<0.01%13F-HR/ATimeline
Parallel Advisors, LLC20$606<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…16$485<0.01%013F-HRTimelineGroup
Larson Financial Group LLC13$394<0.01%+213F-HRTimeline
Farther Finance Advisors, LLC10$303<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.4$121<0.01%+313F-HRTimelineGroup
IFP Advisors, Inc3$91<0.01%013F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.1$30<0.01%013F-HRTimelineGroup