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Disclosery

ORKA ORUKA THERAPEUTICS INC

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Stock (common), issuer CIK 907654

104 managers (105 13F filers) reported a position in ORKA shares at 2025-09-30, 45,557,449 shares in all. 32 filers opened a position and 8 filers sold out during the quarter.

Managers
104
13F filers
105
New
32
Added
31
Reduced
22
Sold out
8
Shares held by filers
45,557,449

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC7,257,621$140M0.01%+1,641,15013F-HRTimelineGroup
Venrock Adviser, LLC4,148,428$79.8M4.49%013F-HRTimeline
Fairmount Funds Management LLCin group Fairmount Funds Management LLC3,705,262$71.3M6.41%+333,34013F-HRTimelineGroup
VIKING GLOBAL INVESTORS LPin group VIKING GLOBAL INVESTORS LP2,666,690$51.3M0.13%new13F-HRTimelineGroup
Deep Track Capital, LP2,654,781$51.1M1.42%+735,98313F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.2,204,551$42.4M<0.01%+215,67113F-HRTimelineGroup
RTW INVESTMENTS, LP1,945,649$37.4M0.46%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC1,776,665$34.2M<0.01%-40,64213F-HRTimelineGroup
Commodore Capital LPin group Commodore Capital LP1,753,054$33.7M1.65%+333,34013F-HRTimelineGroup
BRAIDWELL LP1,382,350$26.6M0.79%-142,49213F-HRTimeline
Avoro Capital Advisors LLC1,333,340$25.6M0.33%new13F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,268,021$24.4M0.7%new13F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources1,065,782$20.5M0.01%+52,81413F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.1,037,002$19.9M0.04%+707,00213F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,032,307$19.9M0.1%+57,30713F-HRTimelineGroup
Affinity Asset Advisors, LLC959,180$18.4M1.72%+355,70113F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV852,411$16.4M0.03%+7313F-HRTimeline
Blackstone Inc.in group Blackstone Inc.850,400$16.4M0.07%+23,67613F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC689,972$13.3M<0.01%-17,43413F-HRTimelineGroup
Avidity Partners Management LP660,424$12.7M2.89%+308,30013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP652,028$12.5M<0.01%+279,22213F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/626,806$12.1M<0.01%+215,92513F-HRTimeline
Woodline Partners LP574,330$11M0.05%+183,42613F-HRTimeline
Cormorant Asset Management, LP533,340$10.3M0.71%new13F-HRTimeline
Cable Car Capital, LP500,000$9.62M4.12%-100,00013F-HRTimeline
SR One Capital Management, LP430,330$8.28M1.2%013F-HRTimeline
Candriam S.C.A.366,994$7.06M0.04%+250,29613F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC316,886$6.09M<0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co246,926$4.75M<0.01%+162,92413F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP219,709$4.23M<0.01%-2,46913F-HRTimelineGroup
GREAT POINT PARTNERS LLC183,330$3.53M1.47%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY134,833$2.59M<0.01%-73,49513F-HR/ATimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.95,417$1.83M<0.01%+27,77213F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC95,330$1.83M<0.01%+4,16613F-HR/ATimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…91,094$1.75M<0.01%new13F-HRTimelineGroup
UBS Group AGin group UBS Group AG86,560$1.66M<0.01%-24,08613F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/78,995$1.52M<0.01%+60,14613F-HR/ATimelineGroup
Aberdeen Group plcin group Aberdeen Group plc75,680$1.46M<0.01%-2,70013F-HRTimelineGroup
Resolute Capital Asset Partners LLC75,000$1.44M0.75%new13F-HRTimeline
B Group, Inc.75,000$1.44M1.38%013F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp70,632$1.36M<0.01%+7,12313F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.64,991$1.25M0.01%013F-HRTimelineGroup
TORONTO DOMINION BANKin group TORONTO DOMINION BANK58,332$1.12M<0.01%013F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …51,908$998K<0.01%-83913F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC48,266$928K0.02%-16,66013F-HRTimeline
TD Asset Management Inc45,876$882K<0.01%013F-HRTimeline
Palo Alto Investors LP59,985$791K0.15%new13F-HRTimeline
Financial Enhancement Group LLC32,819$742K0.1%new13F-HRTimeline
Nuveen, LLCin group TIAA35,313$679K<0.01%013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC34,111$656K<0.01%new13F-HRTimelineGroup
RHUMBLINE ADVISERS30,327$583K<0.01%+1,75713F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP29,184$563K<0.01%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP28,566$549K<0.01%-3,77613F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\22,119$425K<0.01%+2,75813F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN20,856$401K<0.01%+3,40113F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC20,840$401K0.04%-121,94013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC19,775$380K<0.01%-52,47413F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…16,513$318K<0.01%013F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.16,318$314K<0.01%+1,00813F-HRTimelineGroup
Empirical Financial Services, LLC d.b.a…15,406$296K0.01%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding14,591$281K-1,747Timeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO14,479$278K<0.01%-94613F-HR/ATimelineGroup
ALTFEST L J & CO INC13,297$256K0.03%new13F-HRTimeline
Rafferty Asset Management, LLC12,787$246K<0.01%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC12,506$240K<0.01%-2,51913F-HRTimeline
AlphaQuest LLC10,761$207K0.01%-5,30313F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND8,600$165K<0.01%013F-HRTimeline
Police & Firemen's Retirement System of…7,358$141K<0.01%+1,25013F-HRTimeline
China Universal Asset Management Co., L…6,565$126K0.01%-95513F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS5,747$111K<0.01%+2,94413F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC3,371$64.8K<0.01%-6,46913F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,777$53.4K<0.01%013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc2,477$47.6K<0.01%013F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…2,253$43.3K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,218$42.7K<0.01%-13113F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…2,014$38.7K<0.01%new13F-HRTimelineGroup
Caption Management, LLC2,000$38.5K<0.01%new13F-HRTimeline
Sterling Capital Management LLC1,877$36.1K<0.01%+1,14313F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,698$32.7K<0.01%+113F-HRTimeline
Stone House Investment Management, LLC1,000$19.2K<0.01%new13F-HRTimeline
AMALGAMATED BANK929$18K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.806$15.5K<0.01%-9013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA774$14K<0.01%-1,73013F-HRTimelineGroup
SIMPLEX TRADING, LLC729$14K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC394$8K<0.01%new13F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\178$3.42K<0.01%new13F-HRTimelineGroup
Activest Wealth Management166$3.19K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.116$2K<0.01%013F-HRTimelineGroup
GROUP ONE TRADING LLC100$1.92K<0.01%new13F-HRTimeline
Arax Advisory Partners72$1.39K<0.01%new13F-HRTimeline
Rise Advisors, LLC36$692<0.01%new13F-HRTimeline
Essential Partners LLC27$519<0.01%new13F-HRTimeline
True Wealth Design, LLC26$500<0.01%new13F-HRTimeline
J.Safra Asset Management Corp24$462<0.01%013F-HRTimeline
Parallel Advisors, LLC20$385<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…16$308<0.01%new13F-HRTimelineGroup
Larson Financial Group LLC11$212<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC10$192<0.01%new13F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/8$153<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.6$115<0.01%+413F-HRTimeline
Allworth Financial LP5$97<0.01%013F-HRTimeline
IFP Advisors, Inc3$58<0.01%new13F-HR/ATimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.1$19<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1$19<0.01%013F-HRTimelineGroup