FMR LLC in group FMR LLC More: the full row for FMR LLC 5,561,808 $57.1M <0.01% +49,508 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 4,148,428 $42.6M 3.62% +862,808 13F-HR Timeline Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,371,922 $34.6M 5.37% 0 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,945,649 $20M 0.31% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,637,433 $16.8M <0.01% +26,782 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 1,572,426 $16.1M 0.57% +424,750 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,444,709 $14.8M 0.48% +694,709 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,419,714 $14.6M 1.07% 0 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,050,000 $10.8M 0.07% +500,000 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 783,653 $8.04M 0.04% +543,479 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 747,674 $7.67M <0.01% -3,757 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 720,547 $7.39M <0.01% 0 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 583,327 $5.98M 0.27% 0 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 545,362 $5.6M 0.88% +176,664 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 527,791 $5.42M <0.01% +121,793 13F-HR Timeline Group Cable Car Capital, LP More: the full row for Cable Car Capital, LP 450,000 $4.62M 5.24% +116,629 13F-HR Timeline SR One Capital Management, LP More: the full row for SR One Capital Management, LP 430,330 $4.42M 1.13% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 411,602 $4.22M <0.01% -915,291 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 405,029 $4.16M 0.07% +55,000 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 390,804 $4.01M 0.03% -165 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 386,963 $3.97M 0.38% -24,765 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 352,585 $3.62M <0.01% +10,167 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 352,124 $3.61M 0.75% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 350,036 $3.59M 0.01% new 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 342,399 $3.51M 0.01% -18,333 13F-HR/A Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 244,199 $2.51M <0.01% new 13F-HR/A Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 175,000 $1.8M 0.58% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 132,780 $1.36M 0.26% new 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 116,698 $1.2M 0.01% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 87,501 $898K <0.01% -7,588 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 86,681 $889K <0.01% +61,658 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 75,333 $773K <0.01% +750 13F-HR/A Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 65,749 $675K 0.02% +5,255 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 59,585 $611K <0.01% -4,459 13F-HR Timeline Group TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 58,332 $598K <0.01% 0 13F-HR Timeline Group B Group, Inc. More: the full row for B Group, Inc. 58,215 $597K 0.52% +38,215 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 54,126 $555K <0.01% +23,821 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 53,615 $550K 0.02% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 52,026 $534K <0.01% -100,056 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 46,511 $477K <0.01% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 45,876 $471K <0.01% -49,200 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 44,900 $461K <0.01% +25,100 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 42,919 $440K <0.01% +621 13F-HR Timeline Group Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 40,000 $410K 0.01% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 35,912 $368K <0.01% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 35,800 $367K <0.01% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 33,883 $348K <0.01% +8,721 13F-HR Timeline Group OCCUDO QUANTITATIVE STRATEGIES LP More: the full row for OCCUDO QUANTITATIVE STRATEGIES LP 24,804 $310K 0.04% new 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 29,365 $301K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 22,022 $226K <0.01% +9,847 13F-HR/A Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 21,831 $224K <0.01% new 13F-HR Timeline Group Allostery Investments LP More: the full row for Allostery Investments LP 20,000 $205K 0.3% 0 13F-HR Timeline Cannon Global Investment Management, LLC More: the full row for Cannon Global Investment Management, LLC 19,000 $195K 0.54% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 16,335 $168K 0.02% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 15,608 $160K <0.01% 0 13F-HR/A Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,509 $77K 0.01% +88 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 7,380 $75.7K 0.02% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 4,863 $49.9K <0.01% +4,665 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 2,310 $23.7K <0.01% -490 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 2,108 $21.6K <0.01% +2,085 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,554 $15.9K <0.01% -6,474 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,253 $15.7K <0.01% +87 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 896 $9.19K <0.01% +161 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 754 $7.74K <0.01% +170 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 497 $5.1K <0.01% +29 13F-HR Timeline Group COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 180 $1.85K <0.01% new 13F-HR Timeline Activest Wealth Management More: the full row for Activest Wealth Management 166 $1.7K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 116 $1K <0.01% 0 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 20 $205 <0.01% 0 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 8 $82 <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 10 $0 0% -45 13F-HR/A Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.