ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 7,959,538 $123M 2.51% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 7,107,635 $109M 0.01% -21,561 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 4,692,809 $72.3M 4.81% 0 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 3,830,000 $59M 2.16% +2,670,000 13F-HR Timeline Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,711,444 $57.2M 4.35% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,613,326 $55.6M <0.01% +94,802 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 3,513,680 $54.1M 0.25% +418,673 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,226,331 $49.7M 2.45% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,801,665 $43.1M <0.01% +248,651 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,671,724 $25.7M 0.01% -121,859 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,504,601 $23.2M 0.04% +464,191 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,480,000 $22.8M 1.77% +53,740 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,424,344 $21.9M 0.01% +263,841 13F-HR Timeline Group Capital Research Global Investors in group Capital Research Global Inves… More: the full row for Capital Research Global Investors 1,304,346 $20.1M <0.01% -11,119 13F-HR Timeline Group Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,303,235 $20.1M 0.02% -94,852 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,052,862 $16.2M <0.01% +87,725 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,048,722 $16.2M <0.01% -36,291 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 1,025,000 $15.8M 0.67% new 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 954,946 $14.7M 0.05% -365,646 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 798,405 $12.3M 0.63% +112,298 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 772,477 $11.9M 3.74% 0 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 453,019 $6.98M 0.03% -156,333 13F-HR/A Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 446,084 $6.87M 2.27% 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 411,823 $6.34M <0.01% +153,439 13F-HR/A Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 398,893 $6.14M <0.01% +238,434 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 371,906 $5.73M 0.01% +31,424 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 355,192 $5.47M <0.01% -8,010 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 352,239 $5.42M <0.01% -42,213 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 340,000 $5.24M 0.35% 0 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 308,141 $4.75M 1.02% +57,303 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 301,023 $4.64M 0.02% +524 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 296,947 $4.57M <0.01% -84,458 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 271,406 $4.18M 0.02% +156,573 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 237,204 $3.65M <0.01% -25,068 13F-HR/A Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 226,765 $3.49M 0.73% +60,000 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 222,308 $3.42M 1.69% new 13F-HR Timeline Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 199,306 $3.07M 0.76% 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 194,735 $3M 0.01% +159,956 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 140,300 $2.16M 0.62% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 129,876 $2M <0.01% +21,316 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 113,078 $1.74M -18,113 Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 110,569 $1.7M <0.01% -5,047 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 105,448 $1.62M <0.01% -2,796 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 101,971 $1.57M <0.01% new 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 99,953 $1.54M 1.04% 13F-HR/A Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 82,536 $1.27M 0.33% -176,599 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 69,875 $1.08M <0.01% -814 13F-HR Timeline Group Lighthouse Investment Partners, LLC in group Lighthouse Investment Partner… More: the full row for Lighthouse Investment Partners, LLC 65,000 $1M 0.03% new 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 64,273 $990K <0.01% +1,100 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 60,702 $935K 0.02% +50,101 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 60,415 $930K 0.01% +12,280 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 52,578 $810K 0.06% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 50,509 $778K <0.01% -9,651 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 48,741 $751K -14,436 Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 45,792 $705K <0.01% +34,283 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 45,354 $698K 0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 43,056 $663K <0.01% +17,232 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 36,840 $567K <0.01% 0 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 35,580 $548K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 32,711 $504K <0.01% +9,168 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 32,206 $496K <0.01% +11,870 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 31,420 $484K <0.01% +6,231 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 30,000 $462K 0.03% new 13F-HR/A Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 29,673 $457K <0.01% +13,370 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 27,955 $431K 0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 27,059 $417K <0.01% -6,706 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 24,720 $381K <0.01% +1,624 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 24,556 $378K <0.01% 0 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 23,800 $367K <0.01% -207,504 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 21,171 $326K -648 Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 20,763 $320K <0.01% -15,082 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 20,701 $319K <0.01% -4,117 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 20,398 $314K <0.01% -27,274 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 20,167 $311K <0.01% -410,073 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 19,336 $298K <0.01% -24,668 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 18,949 $292K <0.01% -104,387 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 18,489 $285K <0.01% +6,743 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 16,729 $258K <0.01% +2,256 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 15,778 $243K 0.07% +9,991 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 14,244 $219K 0.05% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 14,035 $216K <0.01% -8,207 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 12,432 $191K 0.03% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 11,162 $172K <0.01% +123 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 10,800 $166K <0.01% new 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 10,480 $161K <0.01% 0 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 10,337 $159K 0.01% +5,636 13F-HR Timeline LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 10,301 $159K 0.01% 0 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 10,179 $157K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 9,672 $149K <0.01% +528 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,671 $149K 0.01% -712 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,097 $140K <0.01% -6,000 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 5,409 $130K <0.01% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,800 $105K <0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 6,163 $94.9K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,449 $53.1K <0.01% 0 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,121 $48.1K <0.01% -521 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 2,649 $40.8K <0.01% +2,480 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,304 $35.5K <0.01% +728 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 1,770 $27.3K <0.01% -376 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,237 $19K <0.01% +19 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,219 $18K <0.01% -33,853 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,165 $17.9K <0.01% -109 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 940 $14.5K <0.01% +932 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 688 $10.6K <0.01% +682 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 635 $10K <0.01% +158 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 589 $9.07K <0.01% -27 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 295 $4.54K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 279 $4.3K <0.01% +177 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 212 $3.27K <0.01% -333 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 190 $2.93K <0.01% -12 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 137 $2.11K <0.01% -16 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 152 $2K <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 106 $1.63K <0.01% -13 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 100 $1.54K <0.01% +30 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 94 $1K <0.01% -18 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 64 $986 <0.01% -44 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 60 $924 <0.01% -25 13F-HR Timeline Group Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 42 $647 <0.01% 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 37 $570 <0.01% -1 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 26 $400 <0.01% -21 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 22 $339 <0.01% +3 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $308 <0.01% -25 13F-HR Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 1 $16 <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 6 $0 0% -11 13F-HR Timeline Value filed as zero, left out of ratios. BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 0 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios. NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.