ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 7,959,538 $160M 4.02% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 7,559,901 $152M 0.01% +950,372 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 4,692,809 $94.1M 6.64% +17,809 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 4,026,331 $80.8M 6.05% 0 13F-HR Timeline Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,711,444 $74.5M 9.65% +508,646 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 3,050,294 $61.2M 0.32% +685,000 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,967,134 $59.5M <0.01% -30,995 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,410,636 $48.4M <0.01% +438,397 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,716,412 $34.4M 0.02% +145,909 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,470,424 $29.5M 0.03% +347,286 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,353,078 $27.1M 0.06% +1,213,160 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 1,320,592 $26.5M 0.12% +558,285 13F-HR Timeline Group Capital Research Global Investors in group Capital Research Global Inves… More: the full row for Capital Research Global Investors 1,315,465 $26.4M 0.01% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,100,657 $22.1M 0.12% +295,500 13F-HR Timeline NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,084,432 $21.8M 1.54% new 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 967,502 $19.4M 0.02% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 882,753 $17.7M <0.01% +63,580 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 848,986 $17M 0.29% 0 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 816,242 $16.4M <0.01% +35,340 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 772,477 $15.5M 5.96% -550,000 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 701,408 $14.1M 0.88% +235,537 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 528,250 $10.6M <0.01% +512,090 13F-HR Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 509,987 $10.2M 1.91% -25,105 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 498,000 $9.99M 1.14% new 13F-HR Timeline Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 463,000 $9.29M 0.24% new 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 430,240 $8.63M <0.01% +410,034 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 416,650 $8.36M 0.05% new 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 400,000 $8.02M 1.19% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 350,000 $7.02M 0.94% +110,000 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 333,333 $6.69M 0.01% +322,173 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 324,628 $6.51M <0.01% -14,022 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 318,449 $6.39M 0.01% +185,562 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 305,660 $6.13M <0.01% +46,123 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 281,394 $5.64M 4.7% +111,620 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 254,848 $5.11M <0.01% +173,533 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 250,000 $5.01M 0.26% new 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 245,838 $4.93M 1.78% -8,000 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 221,334 $4.44M +115,000 Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 200,000 $4.01M 0.3% -50,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 189,505 $3.8M <0.01% -22,247 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 151,643 $3.04M +78,394 Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 141,516 $2.84M 1.04% +29,057 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 128,515 $2.58M 0.67% +16,772 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 114,833 $2.3M 0.02% 0 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 98,129 $1.97M <0.01% +4,562 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 96,000 $1.93M <0.01% -354,000 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 94,012 $1.89M <0.01% +9,312 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 89,712 $1.8M <0.01% -14,387 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 72,784 $1.46M <0.01% +22,427 13F-HR/A Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 67,864 $1.36M <0.01% +62,688 13F-HR/A Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 66,906 $1.34M <0.01% new 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 61,873 $1.24M <0.01% +20,000 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 59,244 $1.19M <0.01% +35,582 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 56,981 $1.14M <0.01% +27,630 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 56,782 $1.14M <0.01% +11,026 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 50,280 $1.01M <0.01% -2,222 13F-HR Timeline Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 47,622 $955K 0.02% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 46,851 $942K <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 44,151 $886K <0.01% +31,257 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 36,840 $739K <0.01% 0 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 36,373 $730K <0.01% +23,261 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 32,579 $654K 0.01% +8,931 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 32,579 $654K 0.17% +8,931 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 32,225 $646K <0.01% +11,058 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 29,547 $593K <0.01% -75,995 13F-HR Timeline Group Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 28,584 $573K 0.13% new 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 25,527 $512K 0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 24,508 $492K <0.01% +4,078 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 23,900 $479K <0.01% +12,000 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 22,475 $451K <0.01% -5,049 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 21,957 $440K <0.01% +913 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 21,211 $425K <0.01% -258 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 20,330 $408K <0.01% -584 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 19,552 $392K -3,812 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 19,064 $382K <0.01% -2,701 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 18,139 $364K <0.01% -12,700 13F-HR Timeline Group VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 17,656 $354K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 16,656 $334K <0.01% -1,057 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 16,098 $323K <0.01% -52,953 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,502 $291K <0.01% -5,601 13F-HR Timeline CAXTON CORP More: the full row for CAXTON CORP 13,097 $263K 2.67% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,362 $228K 0.01% -10,487 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 11,300 $227K 0.05% 0 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 10,480 $210K <0.01% 0 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 10,000 $201K 0.04% new 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,855 $198K 0.02% +55 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,797 $197K <0.01% 0 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,301 $167K <0.01% 0 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,800 $136K <0.01% +2,500 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 6,588 $132K 0.02% +4,293 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,286 $106K <0.01% +3,490 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 4,783 $95.9K 0.03% -2,359 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 4,477 $89.8K <0.01% +1,434 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,722 $74.7K <0.01% +930 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,449 $69.2K <0.01% 0 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 3,181 $63.8K <0.01% -16,205 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 1,536 $30.8K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,251 $25.1K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,218 $24K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 705 $14.1K <0.01% +23 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 383 $8K <0.01% new 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 279 $5.6K <0.01% +212 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 201 $4.03K <0.01% +63 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 183 $3K <0.01% +133 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 152 $3K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 149 $2.99K <0.01% new 13F-HR/A Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 119 $2.39K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 111 $2.23K <0.01% new 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 91 $2K <0.01% +61 13F-HR Timeline Group MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 84 $1.69K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 81 $1.62K <0.01% +14 13F-HR/A Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $1.34K <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 63 $1.26K <0.01% +50 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 45 $903 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 38 $763 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 37 $742 <0.01% 0 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 28 $562 <0.01% +18 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 26 $522 <0.01% new 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 25 $502 <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 6 $120 <0.01% 0 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 6 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios. NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.