ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 7,959,538 $163M 3.91% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 7,129,196 $146M 0.01% -430,705 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 4,692,809 $96.1M 4.69% 0 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,711,444 $76M 6.84% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,518,524 $72M <0.01% +551,390 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,226,331 $66M 3.72% -800,000 13F-HR Timeline Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 3,095,007 $63.4M 0.31% +44,713 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,553,014 $52.3M <0.01% +142,378 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,793,583 $36.7M 0.02% +77,171 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,426,260 $29.2M 1.88% +341,828 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,398,087 $28.6M 0.03% +430,585 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 1,320,592 $27M 0.12% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Capital Research Global Investors in group Capital Research Global Inves… More: the full row for Capital Research Global Investors 1,315,465 $26.9M 0.01% 0 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,160,503 $23.8M 0.02% -309,921 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,160,000 $23.7M 1.08% +910,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,085,013 $22.2M <0.01% +202,260 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,040,410 $21.3M 0.05% -312,668 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 965,137 $19.8M <0.01% +148,895 13F-HR Timeline Group Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 947,405 $19.4M 0.49% +484,405 13F-HR Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 783,411 $16M 2.41% +273,424 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 772,477 $15.8M 5.79% 0 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 686,107 $14M 0.82% -15,301 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 609,352 $12.5M 0.07% +192,702 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 430,240 $8.81M <0.01% 0 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 400,000 $8.19M 0.76% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 394,452 $8.07M <0.01% +69,824 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 381,405 $7.81M 0.01% +62,956 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 363,202 $7.43M <0.01% +57,542 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 340,482 $6.97M 0.01% +7,149 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 340,000 $6.96M 0.69% -10,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 300,499 $6.15M 0.03% -800,158 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 262,272 $5.37M <0.01% +72,767 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 259,135 $5.3M 1.3% +117,619 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 258,384 $5.29M <0.01% +3,536 13F-HR/A Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 250,838 $5.13M 1.37% +5,000 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 231,304 $4.74M <0.01% -296,946 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 200,000 $4.09M 0.28% 0 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 166,765 $3.41M 0.81% +38,250 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 160,459 $3.28M <0.01% +113,608 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 156,463 $3.2M 0.27% new 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 140,300 $2.87M 0.65% +129,000 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 131,191 $2.69M -90,143 Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 123,336 $2.52M <0.01% +64,092 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 115,616 $2.37M <0.01% +17,487 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 114,833 $2.35M 0.02% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 108,560 $2.22M <0.01% +14,548 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 108,244 $2.22M <0.01% +18,532 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 73,000 $1.49M <0.01% -23,000 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 70,689 $1.45M <0.01% -2,095 13F-HR/A Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 63,177 $1.29M -88,466 Timeline Swiss National Bank More: the full row for Swiss National Bank 63,173 $1.29M <0.01% +1,300 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 60,160 $1.23M <0.01% +9,880 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 59,000 $1.21M <0.01% +35,100 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 50,492 $1.03M 0.01% +24,965 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 48,135 $985K 0.01% new 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 47,672 $976K <0.01% -9,110 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 44,004 $901K <0.01% -147 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 40,314 $825K 0.01% +7,735 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 40,314 $825K 0.07% +7,735 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 36,840 $754K <0.01% 0 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 35,845 $734K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 35,072 $718K <0.01% -32,792 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 34,779 $712K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 33,765 $691K <0.01% +1,540 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 27,518 $563K <0.01% -39,388 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 25,824 $529K <0.01% +9,168 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 25,189 $516K <0.01% +2,714 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 24,818 $508K <0.01% +5,754 13F-HR/A Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 24,556 $503K <0.01% +3,345 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 23,543 $482K <0.01% -965 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 23,096 $473K <0.01% +1,139 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 22,242 $455K <0.01% -14,131 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 21,819 $447K +2,267 Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 20,336 $416K <0.01% +6 13F-HR Timeline WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 16,458 $337K 0.01% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 16,303 $334K <0.01% new 13F-HR/A Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 15,097 $309K <0.01% +5,300 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,473 $296K <0.01% -29 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 13,371 $274K <0.01% new 13F-HR Timeline Group CAXTON CORP More: the full row for CAXTON CORP 13,097 $268K 1.17% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 11,746 $240K <0.01% -6,393 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 11,509 $236K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 11,039 $226K <0.01% +2,738 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 10,811 $221K <0.01% -5,287 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 10,675 $219K 0.03% +675 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 10,480 $215K <0.01% 0 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,383 $213K 0.02% +528 13F-HR Timeline LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 10,301 $211K 0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 9,144 $187K <0.01% +5,422 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,800 $139K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 5,787 $118K 0.03% +1,004 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 4,701 $96.2K 0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,642 $74.6K <0.01% -25,905 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,449 $70.6K <0.01% 0 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 3,181 $65.1K <0.01% 0 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 2,773 $56.8K 0.01% -3,815 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 2,146 $43.9K <0.01% -2,331 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,576 $32.3K <0.01% -3,710 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,274 $26.1K <0.01% +23 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,218 $25K <0.01% 0 13F-HR Timeline Point72 Europe (London) LLP More: the full row for Point72 Europe (London) LLP 712 $14.6K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 616 $12.6K <0.01% -89 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 545 $11.2K <0.01% +266 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 491 $10.1K <0.01% +463 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 477 $10K <0.01% +94 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 295 $6.04K <0.01% new 13F-HR Timeline ORG Partners LLC More: the full row for ORG Partners LLC 225 $4.61K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 202 $4.13K <0.01% +1 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 153 $3.13K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 169 $3K <0.01% -14 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 152 $3K <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 119 $2.44K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 111 $2.27K <0.01% 0 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 108 $2.21K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 102 $2.09K <0.01% +21 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 112 $2K <0.01% +21 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 85 $1.74K <0.01% -64 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 84 $1.72K <0.01% +21 13F-HR Timeline Group MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 70 $1.43K <0.01% -14 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 47 $962 <0.01% +21 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 45 $921 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 38 $778 <0.01% +1 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 34 $696 <0.01% new 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 25 $512 <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 19 $389 <0.01% new 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 8 $164 <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 6 $123 <0.01% 0 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 5 $103 <0.01% new 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 2 $41 <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 10,601 $0 0% -761 13F-HR Timeline Group Value filed as zero, left out of ratios. Covestor Ltd More: the full row for Covestor Ltd 17 $0 0% +11 13F-HR Timeline Value filed as zero, left out of ratios. NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.