ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 7,959,538 $157M 3.76% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 6,609,529 $130M 0.01% +113,658 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 4,675,000 $92M 6.78% +470,000 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 4,026,331 $79.2M 6.74% 0 13F-HR Timeline Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,202,798 $63M 9.78% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,998,129 $59M <0.01% +33,001 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,365,294 $46.5M 0.28% -24,374 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,972,239 $38.8M <0.01% -3,416 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,570,503 $33.1M 0.02% +238,626 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 1,322,477 $26M 9.84% -307,288 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,123,138 $22.1M 0.02% -615,394 13F-HR Timeline Group Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 967,502 $19M 0.02% -4,791 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 848,986 $16.7M 0.28% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 819,173 $16.1M <0.01% +56,455 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 805,157 $15.8M 0.1% -765 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 780,902 $15.4M <0.01% -20,930 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 762,307 $15M 0.07% +388,984 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 671,358 $13.2M 3.97% 0 13F-HR/A Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 535,092 $10.5M 2.12% 0 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 465,871 $9.17M 0.52% +37,300 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 450,000 $8.86M 0.02% -200,000 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 338,650 $6.66M <0.01% +7,150 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 289,538 $5.7M 1.86% -105,000 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 265,269 $5.22M 6.05% -2,099 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 259,537 $5.11M <0.01% -2,351 13F-HR/A Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 253,838 $5M 2.07% +29,800 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 250,000 $4.92M 0.37% 0 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 240,000 $4.72M 0.84% +100,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 211,752 $4.17M <0.01% +80,506 13F-HR/A Timeline Group LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 197,279 $3.88M 0.01% -188,932 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 169,774 $3.34M 3.01% +28,064 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 139,918 $2.75M 0.01% new 13F-HR/A Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 132,887 $2.62M <0.01% +82,083 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 120,430 $2.37M 0.76% +23,714 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 114,833 $2.26M 0.03% 0 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 112,459 $2.21M 0.85% 0 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 111,743 $2.2M 0.54% new 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 106,334 $2.09M -24,568 Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 105,542 $2.08M <0.01% +105,471 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 104,099 $2.05M <0.01% 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 93,567 $1.84M <0.01% +3,992 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 84,700 $1.67M <0.01% +3,784 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 81,315 $1.6M <0.01% -29,291 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 76,975 $1.51M 0.05% -27,915 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 73,249 $1.44M +57,719 Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 69,051 $1.36M <0.01% -48,501 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 52,502 $1.03M <0.01% +2,466 13F-HR/A Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 50,357 $991K <0.01% -14,206 13F-HR/A Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 45,756 $900K <0.01% +18,921 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 41,873 $824K <0.01% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 36,840 $725K <0.01% 0 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 33,984 $669K 0.01% +25,084 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 33,547 $660K 0.05% -478 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 32,573 $641K 0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 30,839 $607K <0.01% -2,709 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 29,351 $578K <0.01% new 13F-HR/A Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 27,524 $542K <0.01% -2,992 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 23,662 $466K <0.01% -11,397 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 23,648 $465K 0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 23,648 $465K 0.14% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 23,364 $462K +1,700 Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 21,849 $430K 0.02% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 21,765 $428K <0.01% +2,020 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 21,469 $423K <0.01% -277 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 21,167 $417K <0.01% +27 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 21,044 $414K <0.01% +5,972 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 20,914 $412K <0.01% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 20,430 $402K <0.01% -13,757 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 20,206 $398K <0.01% +55 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 20,103 $396K <0.01% +3,781 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 19,997 $394K 0.01% +4,819 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 19,386 $382K 0.05% new 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 17,925 $353K <0.01% +425 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 17,713 $349K <0.01% +1,047 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 16,160 $319K <0.01% +2,533 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 13,363 $263K <0.01% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 13,112 $258K <0.01% -3,517 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 12,894 $254K <0.01% -3,942 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 11,900 $234K <0.01% new 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 11,300 $222K 0.05% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 11,160 $220K <0.01% -30,222 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 10,480 $206K <0.01% 0 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 10,125 $199K <0.01% -2,104 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,800 $193K 0.02% -560 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,797 $193K <0.01% -15,226 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,301 $163K <0.01% +1,224 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 7,142 $141K +4,051 Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 6,055 $119K <0.01% -1,428 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5,176 $102K <0.01% new 13F-HR/A Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 4,300 $84.6K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,449 $67.9K <0.01% 0 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 3,043 $59.9K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,792 $54.9K <0.01% -2,199 13F-HR Timeline Group Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 2,295 $45.2K 0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,796 $35.3K <0.01% +198 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,251 $24.6K <0.01% +225 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,218 $24K <0.01% 0 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 776 $15.3K <0.01% +54 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 682 $13.4K <0.01% -11 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 215 $4.23K <0.01% +205 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 152 $3K <0.01% 0 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 138 $2.72K <0.01% +52 13F-HR/A Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 84 $1.65K <0.01% new 13F-HR Timeline SUMMIT SECURITIES GROUP LLC More: the full row for SUMMIT SECURITIES GROUP LLC 76 $1.5K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 67 $1.32K <0.01% -28 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 67 $1.32K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 30 $1K <0.01% +16 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 45 $886 <0.01% +5 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 37 $728 <0.01% 0 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 23 $461 <0.01% 0 13F-HR Timeline Group Stephens Consulting, LLC More: the full row for Stephens Consulting, LLC 20 $394 <0.01% new 13F-HR Timeline TD Capital Management LLC More: the full row for TD Capital Management LLC 16 $315 <0.01% new 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 14 $276 <0.01% -7 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 13 $256 <0.01% +11 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 10 $197 <0.01% +6 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 6 $113 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $98 <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 50 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios. Covestor Ltd More: the full row for Covestor Ltd 6 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios. NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.