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Disclosery

ZYME ZYMEWORKS INC

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COM (common), issuer CIK 1937653

206 managers (210 13F filers) reported a position in ZYME shares at 2025-12-31, 71,465,075 shares in all. 41 filers opened a position and 19 filers sold out during the quarter.

Managers
206
13F filers
210
New
41
Added
71
Reduced
62
Sold out
19
Shares held by filers
71,465,075

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09-13,832 S$25.85Form 4
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09+37,037 M$0Form 4

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC22,970,388$605M27.61%013F-HRTimeline
Rubric Capital Management LP5,750,000$151M1.81%+1,039,44913F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.4,595,548$121M<0.01%+606,01513F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL3,938,641$104M3.49%013F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC3,261,850$85.9M1.57%+1,171,18713F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY2,593,080$68.3M<0.01%-1,391,50513F-HR/ATimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,328,727$61.3M<0.01%+174,29313F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,822,048$48M0.06%new13F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,680,121$44.2M1.32%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,595,833$42M0.01%+50,93513F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,159,215$30.5M0.01%-31,62313F-HRTimelineGroup
Nextech Invest Ltd.1,113,946$29.3M2.84%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,037,642$27.3M<0.01%-43,54713F-HRTimelineGroup
Capricorn Fund Managers Ltd1,022,840$26.9M6.49%new13F-HRTimeline
Vestal Point Capital, LP865,000$22.8M0.84%-900,00013F-HRTimeline
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …700,002$18.4M0.01%+386,24913F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…663,546$17.5M0.03%+99,54613F-HRTimelineGroup
Nuveen, LLCin group TIAA648,326$17.1M<0.01%+82,94113F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC647,970$17.1M<0.01%-30,66613F-HRTimelineGroup
Assenagon Asset Management S.A.647,374$17M0.03%-679,40013F-HRTimeline
UBS Group AGgroup of 2 filers holding599,115$15.8M-1,163,189Timeline
FMR LLCin group FMR LLC560,086$14.7M<0.01%+556,57213F-HRTimelineGroup
Prosight Management, LP530,393$14M2.89%-219,21813F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC491,654$12.9M0.95%-3,214,09613F-HRTimelineGroup
Qube Research & Technologies Ltd474,290$12.5M0.02%+219,28813F-HRTimeline
ALGERT GLOBAL LLC423,646$11.2M0.17%+215,72013F-HR/ATimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC420,207$11.1M<0.01%-23,31813F-HR/ATimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC381,621$10M0.01%-723,19213F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP307,979$8.11M<0.01%-40,27413F-HRTimelineGroup
Schonfeld Strategic Advisors LLC288,571$7.6M0.04%+180,78313F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding275,883$7.26M+139,634Timeline
Invesco Ltd.in group Invesco Ltd.257,580$6.78M<0.01%+163,92313F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC255,351$6.72M<0.01%+48,49313F-HRTimelineGroup
PICTON MAHONEY ASSET MANAGEMENT244,798$6.45M0.07%+38,47613F-HRTimeline
Hillsdale Investment Management Inc.237,922$6.26M0.17%+21,50013F-HRTimeline
Granahan Investment Management, LLC224,408$5.91M0.25%-120,92313F-HRTimeline
SummitTX Capital, L.P.224,268$5.9M0.18%new13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.223,786$5.89M<0.01%+96,86313F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co220,909$5.82M<0.01%+27,54913F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC220,877$5.82M0.01%-210,82313F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN208,313$5.48M<0.01%+31,67913F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC187,685$4.94M<0.01%+64,81713F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC181,790$4.79M0.03%-91,00713F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…181,705$4.78M<0.01%+13,02013F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.152,689$4.02M0.01%-30,15813F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC145,534$3.83M0.08%-90613F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp128,131$3.37M<0.01%-9,42113F-HRTimelineGroup
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD125,506$3.3M0.03%-225,15413F-HRTimelineGroup
HRT FINANCIAL LP121,064$3.19M0.01%+52,60313F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC113,141$2.98M<0.01%+37,21313F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC111,207$2.93M<0.01%-6,59713F-HRTimelineGroup
Opaleye Management Inc.108,929$2.87M0.38%+8,92913F-HR/ATimeline
PLATINUM INVESTMENT MANAGEMENT LTD105,184$2.77M0.64%-19,60013F-HRTimeline
Trexquant Investment LP101,274$2.67M0.02%new13F-HRTimeline
Soleus Capital Management, L.P.100,000$2.63M0.11%new13F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP97,907$2.6M<0.01%-63,57913F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd93,469$2.46M0.06%new13F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC91,075$2.4M<0.01%-61,55713F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/89,524$2.36M<0.01%+14,19713F-HRTimelineGroup
KORNITZER CAPITAL MANAGEMENT INC /KS88,800$2.34M0.05%new13F-HRTimeline
ACUTA CAPITAL PARTNERS, LLC80,143$2.11M1.43%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC79,966$2.11M<0.01%-119,05713F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC78,336$2.06M0.01%-27,73613F-HRTimeline
NEOS Investment Management LLC77,115$2.03M0.01%+13,45213F-HRTimeline
Tema ETFs LLC75,975$2M0.16%+12,31213F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP75,847$2M<0.01%+3,31713F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD75,566$1.99M<0.01%+19,29213F-HRTimeline
RHUMBLINE ADVISERS75,498$1.99M<0.01%-10,40413F-HRTimeline
Man Group plcin group Man Group plc75,318$1.98M<0.01%-83,29813F-HRTimelineGroup
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A75,000$1.97M0.01%new13F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…73,627$1.97M<0.01%new13F-HRTimelineGroup
Swiss National Bank74,200$1.95M<0.01%+1,10013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC70,445$1.85M<0.01%-74,76113F-HRTimelineGroup
Fisher Asset Management, LLC68,197$1.8M<0.01%-3,77713F-HRTimeline
Penserra Capital Management LLCin group Penserra Capital Management L…60,146$1.58M0.02%new13F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources58,987$1.55M<0.01%+25,16613F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC58,832$1.55M<0.01%+7,81613F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…58,350$1.54M<0.01%+90213F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA55,055$1.45M<0.01%-2,87013F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.50,030$1.32M<0.01%013F-HRTimeline
Dana Investment Advisors, Inc.48,318$1.27M0.04%new13F-HRTimeline
SIMPLEX TRADING, LLC48,040$1.26M0.04%+19,27913F-HRTimeline
MACKENZIE FINANCIAL CORP45,460$1.2M<0.01%-10,91713F-HRTimeline
North Growth Management Ltd.45,000$1.18M0.19%-37,00013F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC43,052$1.13M0.01%+1,28413F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC42,905$1.13M<0.01%+8,39513F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC40,812$1.07M<0.01%+26,23813F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…37,761$994K<0.01%+2,53013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO35,008$922K<0.01%+1,12413F-HRTimelineGroup
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC34,631$912K0.05%-1,065,36913F-HRTimelineGroup
Campbell & CO Investment Adviser LLC33,588$884K0.04%+1,09513F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …32,815$864K<0.01%+2,38313F-HRTimelineGroup
SBI Okasan Asset Management Co.Ltd.32,000$856K0.05%13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc32,149$846K<0.01%+3,78013F-HRTimelineGroup
TWO SIGMA ADVISERS, LPin group TWO SIGMA INVESTMENTS, LP31,415$827K<0.01%new13F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL30,324$798K<0.01%-7,25913F-HRTimeline
JOURNEY STRATEGIC WEALTH LLC29,050$765K0.02%013F-HRTimeline
Quantinno Capital Management LP28,883$760K<0.01%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/28,784$758K<0.01%+1,96813F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…28,630$754K<0.01%-4,67913F-HRTimelineGroup
Creative Planningin group Creative Planning28,293$745K<0.01%+97913F-HRTimelineGroup
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…28,083$739K<0.01%-93213F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al27,935$736K<0.01%-28,04013F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding26,919$709K+26,843Timeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding26,746$704K+895Timeline
STRS OHIO26,600$700K<0.01%-14,30013F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC26,095$687K<0.01%-5,14213F-HRTimeline
RITHOLTZ WEALTH MANAGEMENT24,338$641K0.01%-38413F-HRTimeline
Aquatic Capital Management LLC24,103$635K0.02%new13F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…23,333$614K0.01%+8,81513F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS23,298$613K<0.01%+7,83813F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd23,017$606K0.01%new13F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd22,643$596K0.01%new13F-HRTimeline
Seven Fleet Capital Management LP20,600$542K0.37%13F-HR/ATimeline
Zurcher Kantonalbank (Zurich Cantonalba…20,421$538K<0.01%-9,28713F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC20,330$535K<0.01%+3,34813F-HRTimeline
PSP Research LLC20,312$535K0.47%13F-HRTimeline
Duncan Williams Asset Management, LLC22,095$511K0.13%013F-HRTimeline
Vinva Investment Management Ltd12,216$484K0.01%-2,37813F-HRTimeline
CreativeOne Wealth, LLCin group CreativeOne Wealth, LLC18,264$481K0.01%new13F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson18,200$479K<0.01%013F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC17,868$476K<0.01%-19,73213F-HR/ATimelineGroup
SG Americas Securities, LLC17,557$462K<0.01%+3,93313F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/17,468$460K<0.01%-10,17413F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …17,433$459K<0.01%-14113F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND17,371$457K<0.01%+4,00013F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$404K<0.01%013F-HRTimeline
AGF MANAGEMENT LTDin group AGF MANAGEMENT LTD15,000$395K<0.01%new13F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC13,776$363K<0.01%-1,53213F-HRTimelineGroup
Police & Firemen's Retirement System of…13,702$361K<0.01%-50313F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC12,755$336K<0.01%-20,63513F-HRTimelineGroup
ProShare Advisors LLC12,387$326K<0.01%+1,18613F-HRTimeline
China Universal Asset Management Co., L…12,195$321K0.02%-98113F-HRTimeline
Northwest & Ethical Investments L.P.12,044$320K0.01%+2,01413F-HR/ATimeline
WINTON GROUP Ltdin group WINTON GROUP Ltd11,180$294K0.01%new13F-HRTimelineGroup
Janney Montgomery Scott LLC11,067$291K<0.01%013F-HRTimeline
Ewing Morris & Co. Investment Partners …10,850$289K0.13%013F-HRTimeline
JAMES INVESTMENT RESEARCH, INC.10,925$288K0.03%+34713F-HRTimeline
State of Wyoming10,875$286K0.03%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…10,441$275K0.07%+1,75513F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM10,395$274K<0.01%-66413F-HRTimeline
Abacus Wealth Partners, LLC10,222$269K0.03%new13F-HRTimeline
Baader Bank Aktiengesellschaft10,013$264K0.02%new13F-HRTimeline
VARCOV Co.9,818$259K0.1%13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC9,234$243K<0.01%new13F-HRTimelineGroup
GROUP ONE TRADING LLC8,841$233K0.01%+1,97313F-HRTimeline
AlphaQuest LLC8,313$219K0.01%-15813F-HRTimeline
Brooklyn Investment Group8,020$214K0.01%new13F-HRTimeline
Cresset Asset Management, LLC8,120$214K<0.01%new13F-HRTimeline
KLP KAPITALFORVALTNING AS8,000$211K<0.01%+70013F-HRTimeline
Apollon Wealth Management, LLCin group Apollon Wealth Management, LLC7,875$207K<0.01%new13F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …7,707$205K<0.01%new13F-HRTimelineGroup
Persistent Asset Partners Ltd7,346$193K0.09%new13F-HRTimeline
CWM, LLCin group CWM, LLC6,975$184K<0.01%+713F-HRTimelineGroup
Cygnus Capital Advisors, LLC5,997$158K0.12%13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,164$110K<0.01%013F-HRTimelineGroup
CFG Wealth Management Services, Inc.3,080$81.1K0.07%13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.2,510$66.1K<0.01%+1,73513F-HRTimelineGroup
AMALGAMATED BANK1,566$41K<0.01%-31413F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,470$38.7K<0.01%-14713F-HRTimeline
Caitong International Asset Management …1,399$36.8K0.01%new13F-HR/ATimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,353$35.6K<0.01%-9,94813F-HRTimelineGroup
DekaBank Deutsche Girozentrale3,843$35K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.1,148$30.3K<0.01%-36213F-HRTimelineGroup
GAMMA Investing LLC985$25.9K<0.01%+18013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC968$25.5K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…781$20.6K<0.01%+46813F-HRTimelineGroup
LANARK FINANCIAL, INC.623$16.4K<0.01%new13F-HRTimeline
THURSTON, SPRINGER, MILLER, HERD & TITA…610$16.1K0.01%new13F-HRTimeline
Federation des caisses Desjardins du Qu…570$15K<0.01%-30013F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/545$14.3K<0.01%-413F-HRTimelineGroup
UMB Bank, n.a.466$12.3K<0.01%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK364$9.58K<0.01%new13F-HRTimelineGroup
Sterling Capital Management LLC331$8.71K<0.01%+21013F-HRTimeline
Parallel Advisors, LLC329$8.66K<0.01%013F-HRTimeline
TD Waterhouse Canada Inc.311$8.19K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\287$7.56K<0.01%+3913F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC387$7.4K<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC279$7.35K<0.01%+21713F-HRTimeline
Truvestments Capital LLC231$6.08K<0.01%013F-HRTimeline
HighMark Wealth Management LLC230$6.05K<0.01%-5013F-HRTimeline
COMERICA BANK211$5.56K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.186$5K<0.01%-10013F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…182$4.79K<0.01%013F-HRTimelineGroup
Arax Advisory Partners169$4.45K<0.01%-2,81213F-HRTimeline
Allworth Financial LP146$3.85K<0.01%+613F-HRTimeline
IFP Advisors, Inc96$2.53K<0.01%013F-HRTimeline
Quarry LP90$2.37K<0.01%-2,85213F-HRTimeline
Kilter Group LLC66$1.74K<0.01%013F-HRTimeline
Bare Financial Services, Inc64$1.69K<0.01%013F-HRTimeline
True Wealth Design, LLC58$1.53K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC56$1.47K<0.01%+113F-HRTimeline
Steward Partners Investment Advisory, L…53$1.4K<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.51$1.34K<0.01%013F-HRTimeline
SIGNATUREFD, LLC42$1.11K<0.01%new13F-HRTimeline
Covestor Ltd54$1K<0.01%+113F-HRTimeline
Sunbelt Securities, Inc.27$711<0.01%013F-HRTimeline
INTERNATIONAL ASSETS INVESTMENT MANAGEM…25$658<0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP20$527<0.01%new13F-HRTimelineGroup
CoreCap Advisors, LLC18$474<0.01%013F-HRTimeline

Events

  • Schayowitz Adam acquired 23,205 ZYME shares on 2026-10-09, Form 4 filed 2026-10-09. 0002127119-26-000006

    Accepted , ingested