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Disclosery

ZYME ZYMEWORKS INC

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COM (common), issuer CIK 1937653

204 managers (212 13F filers) reported a position in ZYME shares at 2026-03-31, 70,293,314 shares in all. 34 filers opened a position and 36 filers sold out during the quarter.

Managers
204
13F filers
212
New
34
Added
77
Reduced
58
Sold out
36
Shares held by filers
70,293,314

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09-13,832 S$25.85Form 4
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09+37,037 M$0Form 4

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC22,970,388$575M24.58%013F-HRTimeline
Rubric Capital Management LP7,000,000$175M2.15%+1,250,00013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.4,553,888$114M<0.01%-41,66013F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL3,734,142$93.5M2.98%-204,49913F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC3,510,078$87.9M1.74%+248,22813F-HR/ATimelineGroup
MORGAN STANLEYin group MORGAN STANLEY2,480,568$62.1M<0.01%-112,51213F-HRTimelineGroup
VANGUARD GROUP INCgroup of 6 filers holding2,330,399$58.4MnewTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,908,039$47.8M0.06%+85,99113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,150,018$28.8M0.02%+894,66713F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,139,135$28.5M0.01%-20,08013F-HRTimelineGroup
Nextech Invest Ltd.1,113,946$27.9M1.96%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,011,777$25.3M<0.01%-25,86513F-HRTimelineGroup
Capricorn Fund Managers Ltd1,007,210$25.2M3.93%-15,63013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\921,250$23.1M0.01%-674,58313F-HRTimelineGroup
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …743,898$18.6M0.01%+43,89613F-HRTimelineGroup
Assenagon Asset Management S.A.727,986$18.2M0.03%+80,61213F-HRTimeline
FMR LLCin group FMR LLC667,153$16.7M<0.01%+107,06713F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC659,940$16.5M<0.01%+11,97013F-HRTimelineGroup
Nuveen, LLCin group TIAA651,662$16.3M<0.01%+3,33613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC599,486$15M<0.01%+179,27913F-HRTimelineGroup
MPM BIOIMPACT LLC565,249$14.2M1.09%new13F-HRTimeline
Prosight Management, LP539,049$13.5M2.21%+8,65613F-HRTimeline
Qube Research & Technologies Ltd511,937$12.8M0.02%+37,64713F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC491,654$12.3M0.82%013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding491,164$12.3M-107,951Timeline
Hillsdale Investment Management Inc.345,622$8.65M0.24%+107,70013F-HRTimeline
SummitTX Capital, L.P.321,427$8.05M0.26%+97,15913F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP320,210$8.02M<0.01%+12,23113F-HRTimelineGroup
ROYCE & ASSOCIATES LP299,202$7.49M0.07%new13F-HRTimeline
PICTON MAHONEY ASSET MANAGEMENT256,690$6.43M0.07%+11,89213F-HRTimeline
Granahan Investment Management, LLC250,773$6.28M0.3%+26,36513F-HRTimeline
HRT FINANCIAL LP237,889$5.96M0.01%+116,82513F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/236,754$5.93M<0.01%+147,23013F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.235,621$5.9M<0.01%+11,83513F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC226,967$5.68M0.01%+156,52213F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC206,854$5.18M0.02%+128,51813F-HRTimeline
Man Group plcin group Man Group plc189,890$4.75M0.01%+114,57213F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN189,636$4.75M<0.01%-18,67713F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co185,124$4.64M<0.01%-35,78513F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.182,410$4.57M0.01%+29,72113F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC176,411$4.42M<0.01%-11,27413F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC163,649$4.1M0.03%-18,14113F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC148,226$3.71M0.08%+2,69213F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd143,882$3.6M0.06%+50,41313F-HRTimelineGroup
DIADEMA PARTNERS LP142,132$3.56M1.47%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…138,690$3.47M<0.01%-43,01513F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.125,630$3.15M<0.01%-131,95013F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding124,216$3.11M-151,667Timeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp124,105$3.11M<0.01%-4,02613F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC114,327$2.86M<0.01%+3,12013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO114,072$2.76M<0.01%+79,06413F-HR/ATimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD105,184$2.63M0.66%013F-HRTimeline
Tidal Investments LLCin group Tidal Investments LLC104,931$2.63M0.01%new13F-HRTimelineGroup
Tema ETFs LLC104,931$2.63M0.18%+28,95613F-HRTimeline
Fisher Asset Management, LLC101,439$2.54M<0.01%+33,24213F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC90,669$2.27M<0.01%-40613F-HRTimelineGroup
KORNITZER CAPITAL MANAGEMENT INC /KS88,800$2.22M0.05%013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC83,146$2.08M<0.01%new13F-HRTimelineGroup
MACKENZIE FINANCIAL CORP82,726$2.07M<0.01%+37,26613F-HRTimeline
Verdad Advisers, LP82,698$2.07M2.33%new13F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC78,547$1.97M<0.01%new13F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources77,659$1.94M<0.01%+18,67213F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP76,756$1.92M<0.01%+90913F-HRTimelineGroup
RHUMBLINE ADVISERS75,399$1.89M<0.01%-9913F-HRTimeline
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A75,000$1.88M0.01%013F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC74,222$1.86M<0.01%-38,91913F-HR/ATimelineGroup
Swiss National Bank74,200$1.86M<0.01%013F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC70,851$1.77M<0.01%+12,01913F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD66,106$1.66M<0.01%-9,46013F-HRTimeline
ALLIANCEBERNSTEIN L.P.55,896$1.47M<0.01%+5,86613F-HRTimeline
Dana Investment Advisors, Inc.56,107$1.4M0.04%+7,78913F-HRTimeline
Campbell & CO Investment Adviser LLC54,883$1.37M0.08%+21,29513F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…47,450$1.19M<0.01%-10,90013F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA47,360$1.19M<0.01%-7,69513F-HRTimelineGroup
SEGALL BRYANT & HAMILL, LLC45,726$1.14M0.02%new13F-HR/ATimeline
North Growth Management Ltd.46,000$1.14M0.17%+1,00013F-HRTimeline
JACOBS LEVY EQUITY MANAGEMENT, INC42,786$1.07M<0.01%new13F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC42,404$1.06M<0.01%-50113F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC40,419$1.01M<0.01%-39313F-HRTimelineGroup
Manatuck Hill Partners, LLC40,000$1M0.33%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC39,750$995K<0.01%+39,36313F-HRTimeline
Quantinno Capital Management LP39,640$993K<0.01%+10,75713F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…39,355$985K<0.01%+18,93413F-HRTimeline
Connor, Clark & Lunn Investment Managem…37,919$949K<0.01%new13F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC37,777$940K<0.01%+19,90913F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…37,389$936K<0.01%-37213F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC37,129$930K<0.01%-5,92313F-HRTimeline
TUDOR INVESTMENT CORP ET AL36,875$923K<0.01%+6,55113F-HRTimeline
HighTower Advisors, LLC36,262$908K<0.01%new13F-HRTimeline
Persistent Asset Partners Ltd35,935$900K0.35%+28,58913F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/35,487$889K<0.01%+6,70313F-HRTimeline
HighVista Strategies LLC34,085$853K0.24%new13F-HRTimeline
Vinva Investment Management Ltd24,090$851K0.01%+11,87413F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P32,764$820K0.02%new13F-HRTimeline
Creative Planningin group Creative Planning32,394$811K<0.01%+4,10113F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP32,223$807K<0.01%new13F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …31,592$791K<0.01%+14,15913F-HRTimelineGroup
Engineers Gate Manager LP31,548$790K0.01%new13F-HRTimeline
SBI Okasan Asset Management Co.Ltd.32,000$775K0.03%013F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …30,432$762K<0.01%-2,38313F-HRTimelineGroup
STRS OHIO30,100$754K<0.01%+3,50013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…29,653$743K<0.01%+1,02313F-HRTimelineGroup
JOURNEY STRATEGIC WEALTH LLC29,050$727K0.02%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS28,119$704K<0.01%+4,82113F-HRTimelineGroup
OXFORD ASSET MANAGEMENT LLP27,812$696K0.28%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
SCHRODER INVESTMENT MANAGEMENT GROUP28,349$686K<0.01%-69,55813F-HRTimeline
ExodusPoint Capital Management, LP27,374$685K0.01%new13F-HRTimeline
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…27,354$685K<0.01%-72913F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding27,276$683K+530Timeline
Legal & General Group Plcin group Legal & General Group Plc26,209$656K<0.01%-5,94013F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC26,031$652K<0.01%-6413F-HRTimeline
RITHOLTZ WEALTH MANAGEMENT24,243$607K0.01%-9513F-HRTimeline
Headlands Technologies LLC22,845$572K0.07%new13F-HRTimeline
Duncan Williams Asset Management, LLC22,095$553K0.15%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC21,970$550K<0.01%+9,21513F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP20,511$514K0.03%new13F-HRTimeline
Jackson Creek Investment Advisors LLC18,695$468K0.14%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC18,374$460K<0.01%-61,59213F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson18,200$456K<0.01%013F-HR/ATimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/17,468$437K<0.01%013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND17,371$435K<0.01%013F-HRTimeline
State of Wyoming17,148$429K0.05%+6,27313F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd16,735$419K<0.01%-6,28213F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$384K<0.01%013F-HRTimeline
AGF MANAGEMENT LTDin group AGF MANAGEMENT LTD15,000$376K<0.01%013F-HRTimelineGroup
Amundiin group Amundi14,084$353K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…13,702$343K<0.01%013F-HRTimeline
China Universal Asset Management Co., L…13,280$333K0.03%+1,08513F-HRTimeline
Freestone Grove Partners LP12,945$324K<0.01%new13F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…12,788$320K<0.01%new13F-HRTimelineGroup
Northwest & Ethical Investments L.P.12,244$316K0.01%+20013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC12,541$314K<0.01%-7,78913F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al11,935$299K<0.01%-16,00013F-HRTimeline
Abacus Wealth Partners, LLC11,669$292K0.03%+1,44713F-HRTimeline
Janney Montgomery Scott LLC11,487$288K<0.01%+42013F-HRTimeline
JAMES INVESTMENT RESEARCH, INC.10,925$274K0.03%013F-HRTimeline
Ewing Morris & Co. Investment Partners …10,850$272K0.12%013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…10,702$268K0.07%+26113F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC10,602$265K<0.01%-3,17413F-HRTimelineGroup
ProShare Advisors LLC10,574$265K<0.01%-1,81313F-HRTimeline
SG Americas Securities, LLC10,429$261K<0.01%-7,12813F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM10,277$257K<0.01%-11813F-HRTimeline
Soleus Capital Management, L.P.10,000$250K0.01%-90,00013F-HRTimeline
PSP Research LLC10,000$250K0.18%-10,31213F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…9,256$232K<0.01%-64,37113F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC8,993$225K<0.01%-24113F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …8,507$221K<0.01%+80013F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd8,400$210K0.01%-2,78013F-HRTimelineGroup
Cygnus Capital Advisors, LLC8,197$205K0.14%+2,20013F-HRTimeline
KLP KAPITALFORVALTNING AS8,000$200K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC6,955$174K<0.01%-2013F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,868$122K<0.01%+3,51513F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,164$104K<0.01%013F-HRTimelineGroup
DekaBank Deutsche Girozentrale3,843$96K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,681$42.1K<0.01%+21113F-HRTimeline
Global Wealth Strategies & Associates1,635$40.9K0.01%new13F-HRTimeline
Sofinnova Investments, Inc.1,610$40.3K<0.01%new13F-HRTimeline
TD Waterhouse Canada Inc.1,439$37.2K<0.01%+1,12813F-HRTimeline
SIMPLEX TRADING, LLC1,336$33.5K<0.01%-46,70413F-HRTimeline
Aviso Financial Inc.1,146$28.7K<0.01%new13F-HRTimeline
GAMMA Investing LLC1,097$27.5K<0.01%+11213F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…987$24.7K<0.01%+20613F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC971$24.3K<0.01%+313F-HRTimeline
Steward Partners Investment Advisory, L…971$24.3K<0.01%+91813F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.958$24K<0.01%-19013F-HR/ATimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.882$22.1K<0.01%-1,62813F-HRTimelineGroup
LANARK FINANCIAL, INC.623$15.6K<0.01%013F-HRTimeline
Federation des caisses Desjardins du Qu…570$14.3K<0.01%013F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/554$13.9K<0.01%+913F-HRTimelineGroup
UMB Bank, n.a.466$11.7K<0.01%013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP465$11.2K<0.01%+44513F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\352$8.81K<0.01%+6513F-HRTimelineGroup
Parallel Advisors, LLC352$8.81K<0.01%+2313F-HR/ATimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK343$8.59K<0.01%-2113F-HRTimelineGroup
Sterling Capital Management LLC324$8.11K<0.01%-713F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…218$5.46K<0.01%+3613F-HR/ATimelineGroup
Caitong International Asset Management …216$5.41K<0.01%-1,18313F-HRTimeline
Allworth Financial LP109$2.73K<0.01%-3713F-HRTimeline
IFP Advisors, Inc96$2.4K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC80$2K<0.01%+2413F-HRTimeline
HighMark Wealth Management LLC80$2K<0.01%-15013F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding78$1.95K-26,841Timeline
SIGNATUREFD, LLC77$1.93K<0.01%+3513F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…67$1.68K<0.01%new13F-HRTimelineGroup
Kilter Group LLC66$1.65K<0.01%013F-HRTimeline
Bare Financial Services, Inc64$1.6K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…61$1.53K<0.01%new13F-HRTimelineGroup
Farther Finance Advisors, LLC57$1.48K<0.01%-22213F-HRTimeline
True Wealth Design, LLC58$1.45K<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.51$1.28K<0.01%013F-HRTimeline
Versant Capital Management, Inc45$1.13K<0.01%new13F-HRTimeline
Covestor Ltd28$1K<0.01%-2613F-HRTimeline
Sunbelt Securities, Inc.27$676<0.01%013F-HRTimeline
INTERNATIONAL ASSETS INVESTMENT MANAGEM…25$649<0.01%013F-HRTimeline
TWIN PEAKS WEALTH ADVISORS, LLC20$501<0.01%new13F-HRTimeline
Aster Capital Management (DIFC) Ltd42$500<0.01%new13F-HRTimeline
CoreCap Advisors, LLC18$451<0.01%013F-HRTimeline
Root Financial Partners, LLC12$300<0.01%new13F-HRTimeline
Essential Partners LLC12$300<0.01%013F-HRTimeline
Smartleaf Asset Management LLC12$291<0.01%013F-HRTimeline

Events

  • Schayowitz Adam acquired 23,205 ZYME shares on 2026-10-09, Form 4 filed 2026-10-09. 0002127119-26-000006

    Accepted , ingested