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Disclosery

ZYME ZYMEWORKS INC

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COM (common), issuer CIK 1937653

184 managers (187 13F filers) reported a position in ZYME shares at 2025-03-31, 70,591,171 shares in all. 29 filers opened a position and 17 filers sold out during the quarter.

Managers
184
13F filers
187
New
29
Added
60
Reduced
64
Sold out
17
Shares held by filers
70,591,171

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09-13,832 S$25.85Form 4
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09+37,037 M$0Form 4

13F holders, Q1 2025

Filers in the available 13F reports with a share position at 2025-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC17,259,548$206M12.21%+2,231,46913F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC4,788,945$57M5.39%-51,51813F-HRTimelineGroup
Rubric Capital Management LP4,338,444$51.7M0.93%+421,11313F-HRTimeline
BVF INC/ILin group BVF INC/IL4,308,935$51.3M2.09%013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding4,094,245$48.8M+2,562,238Timeline
BlackRock, Inc.in group BlackRock, Inc.4,089,421$48.7M<0.01%-95,53513F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY4,073,463$48.5M<0.01%-127,97413F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …2,197,879$26.2M0.07%+60,22613F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,864,672$22.2M0.79%-265,34813F-HR/ATimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,767,041$21M<0.01%-726,24713F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,552,612$18.5M0.01%+5,84013F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.1,382,587$16.5M0.07%+812,87213F-HRTimelineGroup
Nextech Invest Ltd.1,113,946$13.3M3.08%13F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,100,000$13.1M0.72%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,085,133$12.9M<0.01%+17213F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,079,458$12.9M<0.01%+106,71613F-HRTimelineGroup
Prosight Management, LP957,229$11.4M3.75%+137,22913F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC766,944$9.13M0.23%+7,29113F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC705,035$8.4M<0.01%+15,15113F-HRTimelineGroup
SAMSARA BIOCAPITAL, LLC666,667$7.94M1.42%-333,33313F-HRTimeline
Vestal Point Capital, LP500,000$5.96M0.43%+315,00013F-HRTimeline
Assenagon Asset Management S.A.495,067$5.9M0.01%-147,18413F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC450,600$5.37M0.01%+164,90013F-HRTimeline
Granahan Investment Management, LLC407,589$4.85M0.24%-3,53113F-HRTimeline
FARALLON CAPITAL MANAGEMENT, L.L.C.400,000$4.76M0.03%-929,97413F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
NORTHERN TRUST CORPin group NORTHERN TRUST CORP386,923$4.61M<0.01%-7,90713F-HRTimelineGroup
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD369,499$4.4M0.04%013F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding368,251$4.39M+219,182Timeline
Empowered Funds, LLC360,044$4.29M0.06%+7,29113F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP321,949$3.98M<0.01%-15,21213F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC295,606$3.52M<0.01%new13F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC280,726$3.34M0.02%-1,61913F-HRTimeline
PLATINUM INVESTMENT MANAGEMENT LTD278,658$3.32M0.19%-27,80213F-HRTimeline
Walleye Capital LLCin group Walleye Capital LLC247,959$2.95M0.03%-204,84513F-HRTimelineGroup
Hillsdale Investment Management Inc.236,925$2.82M0.14%+6,90013F-HRTimeline
Trexquant Investment LP220,809$2.63M0.03%+118,81313F-HRTimeline
PICTON MAHONEY ASSET MANAGEMENT208,029$2.48M0.08%+1,46013F-HRTimeline
NORGES BANK201,700$2.4M<0.01%013F-HR/ATimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC200,047$2.38M<0.01%-49,91313F-HR/ATimelineGroup
Nuveen, LLCin group TIAA198,812$2.37M<0.01%13F-HRTimelineGroup
Tejara Capital Ltd189,409$2.26M1.11%+150,87213F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…182,246$2.17M<0.01%-36,85213F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.181,912$2.17M<0.01%+28613F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC180,670$2.15M<0.01%+122,31213F-HRTimelineGroup
Opaleye Management Inc.175,000$2.08M0.46%new13F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC136,319$1.62M0.04%-3,63413F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC135,763$1.62M<0.01%+112,63613F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co133,639$1.59M<0.01%+2,33313F-HR/ATimelineGroup
ExodusPoint Capital Management, LP133,320$1.59M0.02%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp120,727$1.44M<0.01%+4413F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC116,711$1.39M<0.01%+56,06913F-HRTimelineGroup
Verition Fund Management LLC114,156$1.36M0.01%+98,34213F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP105,829$1.26M0.06%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN100,309$1.19M<0.01%-63,74913F-HRTimelineGroup
SG Americas Securities, LLC98,165$1.17M<0.01%+71,38313F-HRTimeline
North Growth Management Ltd.97,000$1.15M0.24%013F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC96,329$1.15M0.01%-36,24813F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC95,394$1.14M<0.01%+51,68613F-HRTimeline
Aquilo Capital Management, LLC84,482$1.01M2.71%new13F-HRTimeline
RHUMBLINE ADVISERS82,738$985K<0.01%-21,13813F-HR/ATimeline
Swiss National Bank80,100$954K<0.01%-10,10013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.78,206$931K<0.01%+8,82413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC75,430$898K<0.01%-145,46013F-HR/ATimelineGroup
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A75,000$893K<0.01%013F-HRTimelineGroup
Fisher Asset Management, LLC71,974$857K<0.01%+8,37413F-HRTimeline
ACUTA CAPITAL PARTNERS, LLC68,459$815K0.95%+1,21913F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP67,030$798K<0.01%+2,70013F-HRTimelineGroup
HRT FINANCIAL LP65,380$778K<0.01%-30,59413F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC63,602$758K<0.01%new13F-HR/ATimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.63,099$752K<0.01%+42,25913F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/62,131$740K<0.01%+30,43113F-HRTimelineGroup
RITHOLTZ WEALTH MANAGEMENT60,494$720K0.02%-13,97213F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA56,771$676K<0.01%-4,15513F-HR/ATimelineGroup
ALLIANCEBERNSTEIN L.P.50,030$596K<0.01%013F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC50,000$596K0.11%new13F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC49,512$590K<0.01%-4,57813F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC48,485$577K<0.01%+22,41113F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc46,790$557K<0.01%-29213F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC44,270$527K<0.01%-7,31013F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al44,175$526K<0.01%13F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…43,783$521K<0.01%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC42,570$507K<0.01%+22,91013F-HRTimelineGroup
HighVista Strategies LLC41,607$496K0.19%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC41,198$491K<0.01%-41,93813F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC40,263$480K<0.01%+6,40513F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO38,409$457K<0.01%-73,57413F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD37,824$450K<0.01%-27,55713F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC37,642$448K<0.01%+6,68213F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding34,715$415K+1,462Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…33,309$397K<0.01%-63713F-HRTimelineGroup
NEOS Investment Management LLC33,001$393K0.01%new13F-HRTimeline
Tema ETFs LLC33,001$393K0.12%new13F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources32,160$383K<0.01%new13F-HRTimelineGroup
AlphaQuest LLC31,676$377K0.04%+28,86813F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC31,147$371K<0.01%-8,79513F-HRTimelineGroup
JOURNEY STRATEGIC WEALTH LLC28,941$345K0.01%+4413F-HRTimeline
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…26,775$319K<0.01%-61013F-HRTimelineGroup
Corebridge Financial, Inc.in group Corebridge Financial, Inc.26,719$318K<0.01%-39613F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/25,912$309K<0.01%-3613F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…24,531$292K<0.01%+4,92013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/24,113$288K<0.01%+2,53013F-HRTimeline
Duncan Williams Asset Management, LLC22,095$263K0.1%new13F-HRTimeline
Schonfeld Strategic Advisors LLC21,900$261K<0.01%-90013F-HRTimeline
Cresset Asset Management, LLC21,320$254K<0.01%-9,48613F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …20,460$244K<0.01%-49813F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd20,205$241K0.01%-13,49713F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson18,200$225K<0.01%013F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC15,653$186K<0.01%-43,86113F-HR/ATimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$183K<0.01%013F-HRTimeline
ProShare Advisors LLC14,912$178K<0.01%-3,71113F-HRTimeline
Quantinno Capital Management LP14,245$170K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…13,816$165K0.02%-78913F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND13,371$159K<0.01%013F-HR/ATimeline
Virtus Investment Advisers, LLCgroup of 2 filers holding13,006$155K+7,373Timeline
FMR LLCin group FMR LLC12,830$153K<0.01%-9,13613F-HRTimelineGroup
Magnetar Financial LLCin group Magnetar Financial LLC12,448$148K<0.01%new13F-HRTimelineGroup
Engineers Gate Manager LP12,399$148K<0.01%new13F-HRTimeline
CIBC WORLD MARKETS CORP12,102$144K<0.01%new13F-HRTimeline
SHELL ASSET MANAGEMENT CO12,101$144K0.01%-25613F-HRTimeline
JACOBS LEVY EQUITY MANAGEMENT, INC12,040$143K<0.01%-344,12813F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM11,846$141K<0.01%-1,56613F-HRTimeline
Creative Planningin group Creative Planning11,822$141K<0.01%+11,76513F-HRTimelineGroup
Police & Firemen's Retirement System of…11,669$139K<0.01%013F-HRTimeline
Janney Montgomery Scott LLC11,567$138K<0.01%+1,30013F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS11,168$133K<0.01%-2,57513F-HRTimeline
Man Group plcin group Man Group plc10,859$129K<0.01%new13F-HRTimelineGroup
JAMES INVESTMENT RESEARCH, INC.10,578$126K0.02%013F-HRTimeline
One Wealth Advisors, LLC10,404$124K0.02%-3,57513F-HRTimeline
KLP KAPITALFORVALTNING AS10,300$123K<0.01%013F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC10,126$121K<0.01%-3,26013F-HRTimeline
TPG Financial Advisors, LLC10,017$119K0.05%013F-HRTimeline
Northwest & Ethical Investments L.P.10,030$119K<0.01%+4,55913F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,616$66.9K<0.01%013F-HRTimelineGroup
Clearstead Advisors, LLC5,000$59.5K<0.01%013F-HRTimeline
SIMPLEX TRADING, LLC4,168$49K<0.01%+3,08113F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS4,000$47.6K<0.01%-3,36313F-HRTimelineGroup
DekaBank Deutsche Girozentrale3,843$47K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,816$45.4K<0.01%-5,88813F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC3,787$45K<0.01%new13F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…3,053$36.4K<0.01%-41,89213F-HRTimelineGroup
CWM, LLCin group CWM, LLC2,299$27K<0.01%+2,10613F-HRTimelineGroup
Aquatic Capital Management LLC2,049$24.4K<0.01%new13F-HRTimeline
AMALGAMATED BANK1,880$22K<0.01%+8113F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,763$21K<0.01%+31713F-HRTimeline
Sterling Capital Management LLC941$11.2K<0.01%-77813F-HRTimeline
Wayfinding Financial, LLC981$11K<0.01%new13F-HRTimeline
Federation des caisses Desjardins du Qu…870$10.4K<0.01%+81013F-HRTimeline
GAMMA Investing LLC543$6.47K<0.01%+1013F-HR/ATimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/524$6.24K<0.01%-2413F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\423$5.04K<0.01%-6513F-HRTimelineGroup
Smartleaf Asset Management LLC401$4.96K<0.01%+15813F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.405$4.82K<0.01%-31213F-HRTimelineGroup
Lindbrook Capital, LLC371$4.42K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC332$3.95K<0.01%013F-HRTimeline
Parallel Advisors, LLC329$3.92K<0.01%013F-HRTimeline
Truvestments Capital LLC309$3.68K<0.01%-12513F-HRTimeline
TD Waterhouse Canada Inc.311$3.6K<0.01%013F-HRTimeline
Brooklyn Investment Group289$3.44K<0.01%-30013F-HRTimeline
HighMark Wealth Management LLC280$3.33K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.286$3K<0.01%013F-HRTimelineGroup
Aster Capital Management (DIFC) Ltd217$2.91K<0.01%+14713F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…230$2.74K<0.01%-5413F-HRTimelineGroup
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.206$2.45K<0.01%new13F-HRTimelineGroup
Parkside Financial Bank & Trust156$1.86K<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC139$1.61K<0.01%-1113F-HRTimeline
COLDSTREAM CAPITAL MANAGEMENT INC129$1.54K<0.01%new13F-HRTimeline
Allworth Financial LP110$1.38K<0.01%+7613F-HRTimeline
Amundiin group Amundi106$1.25K<0.01%+5413F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC100$1.19K<0.01%+5013F-HRTimeline
GROUP ONE TRADING LLC100$1.19K<0.01%-70013F-HRTimeline
Steward Partners Investment Advisory, L…53$631<0.01%013F-HRTimeline
Stephens Consulting, LLC30$358<0.01%new13F-HRTimeline
True Wealth Design, LLC20$239<0.01%new13F-HRTimeline
AMERIFLEX GROUP, INC.20$238<0.01%new13F-HRTimeline
SIGNATUREFD, LLC19$226<0.01%new13F-HRTimeline
CoreCap Advisors, LLC18$214<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…13$155<0.01%+313F-HRTimelineGroup
Versant Capital Management, Inc12$143<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.10$119<0.01%013F-HRTimeline
Innovative Advisory Group, LLC8$95<0.01%013F-HRTimeline
IFP Advisors, Inc0$48<0.01%013F-HRTimelineAmount filed as zero, left out of ratios.
Covestor Ltd27$00%013F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.
CURIO WEALTH, LLC1$14.6K-99913F-HRTimelineValue about 1,000 times the price other filers imply, kept as filed and left out of ratios.

Events

  • Schayowitz Adam acquired 23,205 ZYME shares on 2026-10-09, Form 4 filed 2026-10-09. 0002127119-26-000006

    Accepted , ingested