Skip to content
Disclosery

ZYME ZYMEWORKS INC

Follow

COM (common), issuer CIK 1937653

180 managers (183 13F filers) reported a position in ZYME shares at 2025-06-30, 75,616,916 shares in all. 27 filers opened a position and 30 filers sold out during the quarter.

Managers
180
13F filers
183
New
27
Added
63
Reduced
55
Sold out
30
Shares held by filers
75,616,916

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09-13,832 S$25.85Form 4
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09+37,037 M$0Form 4

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC22,970,388$288M17.09%+5,710,84013F-HRTimeline
Rubric Capital Management LP4,710,551$59.1M0.95%+372,10713F-HRTimeline
BVF INC/ILin group BVF INC/IL4,308,935$54.1M1.93%013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY4,177,614$52.4M<0.01%+104,15113F-HRTimelineGroup
Redmile Group, LLCin group Redmile Group, LLC4,150,627$52.1M5.54%-638,31813F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,794,272$47.6M<0.01%-295,14913F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding2,711,023$34M-1,383,222Timeline
VANGUARD GROUP INCin group VANGUARD GROUP INC2,464,693$30.9M<0.01%+697,65213F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …2,039,656$25.6M0.06%-158,22313F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.1,656,790$20.8M0.09%+274,20313F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,544,763$19.4M0.01%-7,84913F-HRTimelineGroup
Prosight Management, LP1,309,904$16.4M4.01%+352,67513F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,275,274$16M0.6%-589,39813F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,192,432$15M<0.01%+112,97413F-HRTimelineGroup
Vestal Point Capital, LP1,150,000$14.4M0.76%+650,00013F-HRTimeline
Nextech Invest Ltd.1,113,946$14M2.65%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,100,000$13.8M0.7%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,088,459$13.7M<0.01%+3,32613F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC705,364$8.85M<0.01%+32913F-HRTimelineGroup
Nuveen, LLCin group TIAA654,916$8.22M<0.01%+456,10413F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC533,300$6.69M0.01%+82,70013F-HRTimeline
Assenagon Asset Management S.A.492,780$6.18M0.01%-2,28713F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…476,000$5.97M0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO441,690$5.54M<0.01%+403,28113F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC428,857$5.38M<0.01%+228,81013F-HRTimelineGroup
Granahan Investment Management, LLC380,783$4.78M0.19%-26,80613F-HRTimeline
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD369,499$4.64M0.04%013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP349,799$4.39M<0.01%-37,12413F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding344,865$4.33M-23,386Timeline
SAMSARA BIOCAPITAL, LLC310,300$3.89M0.8%-356,36713F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP304,666$3.8M<0.01%-17,28313F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC280,726$3.52M0.02%013F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.255,291$3.2M<0.01%+192,19213F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC246,155$3.09M<0.01%+65,48513F-HRTimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD238,391$2.99M0.2%-40,26713F-HRTimeline
Trexquant Investment LP220,982$2.77M0.03%+17313F-HRTimeline
Opaleye Management Inc.210,000$2.64M0.53%+35,00013F-HR/ATimeline
PICTON MAHONEY ASSET MANAGEMENT207,602$2.6M0.04%-42713F-HRTimeline
Hillsdale Investment Management Inc.205,022$2.57M0.09%-31,90313F-HRTimeline
NORGES BANK201,700$2.53M<0.01%013F-HRTimeline
Tejara Capital Ltd200,150$2.51M1.16%+10,74113F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.182,270$2.29M<0.01%+35813F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…180,690$2.27M<0.01%-1,55613F-HRTimelineGroup
AXA S.A.in group AXA S.A.175,121$2.2M0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN166,428$2.09M<0.01%+66,11913F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC166,143$2.09M<0.01%+117,65813F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC155,998$1.96M<0.01%+114,80013F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC155,599$1.95M<0.01%+91,99713F-HR/ATimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC146,954$1.84M0.04%+10,63513F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp133,090$1.67M<0.01%+12,36313F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC124,435$1.56M<0.01%+7,72413F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co124,204$1.56M<0.01%-9,43513F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC122,820$1.54M<0.01%+47,39013F-HR/ATimelineGroup
Cubist Systematic Strategies, LLC119,962$1.51M0.02%new13F-HRTimeline
ALGERT GLOBAL LLC118,104$1.48M0.03%new13F-HR/ATimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC116,102$1.46M<0.01%-179,50413F-HRTimelineGroup
DARK FOREST CAPITAL MANAGEMENT LP96,989$1.22M0.05%-8,84013F-HRTimeline
North Growth Management Ltd.97,000$1.22M0.23%013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/90,378$1.13M<0.01%+28,24713F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.89,371$1.12M<0.01%+11,16513F-HRTimelineGroup
RHUMBLINE ADVISERS86,083$1.08M<0.01%+3,34513F-HRTimeline
ACUTA CAPITAL PARTNERS, LLC83,655$1.05M1.47%+15,19613F-HRTimeline
Swiss National Bank73,100$917K<0.01%-7,00013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA72,983$915K<0.01%+16,21213F-HR/ATimelineGroup
Fisher Asset Management, LLC71,979$903K<0.01%+513F-HRTimeline
Qube Research & Technologies Ltd69,874$877K<0.01%new13F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP69,730$875K<0.01%+2,70013F-HRTimelineGroup
Weiss Asset Management LPin group Weiss Asset Management LP54,171$680K0.01%new13F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
VIRGINIA RETIREMENT SYSTEMS ET Al54,075$679K<0.01%+9,90013F-HRTimeline
NEOS Investment Management LLC51,855$651K0.01%+18,85413F-HRTimeline
Tema ETFs LLC51,855$651K0.17%+18,85413F-HRTimeline
ExodusPoint Capital Management, LP51,669$648K0.01%-81,65113F-HRTimeline
ALLIANCEBERNSTEIN L.P.50,030$628K<0.01%013F-HRTimeline
STRS OHIO46,300$581K<0.01%new13F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC44,965$564K<0.01%+2,39513F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc43,763$549K<0.01%-3,02713F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…42,873$538K<0.01%-91013F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC41,224$517K<0.01%-55,10513F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC36,497$461K<0.01%new13F-HRTimelineGroup
Man Group plcin group Man Group plc35,406$444K<0.01%+24,54713F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC34,610$434K<0.01%-9,66013F-HRTimeline
TUDOR INVESTMENT CORP ET AL34,293$430K<0.01%new13F-HRTimeline
PANAGORA ASSET MANAGEMENT INC33,559$421K<0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…33,309$418K<0.01%013F-HRTimelineGroup
HRT FINANCIAL LP32,758$411K<0.01%-32,62213F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC32,170$404K<0.01%-5,47213F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC31,147$391K<0.01%013F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd31,021$389K0.02%+10,81613F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…29,934$376K<0.01%+5,40313F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding29,555$371K-5,160Timeline
JOURNEY STRATEGIC WEALTH LLC29,040$364K0.01%+9913F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…28,312$355K<0.01%+25,25913F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/27,642$347K<0.01%+1,73013F-HRTimelineGroup
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…27,109$340K<0.01%+33413F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/26,816$337K<0.01%+2,70313F-HRTimeline
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…26,667$335K0.03%new13F-HRTimelineGroup
Creative Planningin group Creative Planning25,389$319K<0.01%+13,56713F-HRTimelineGroup
RITHOLTZ WEALTH MANAGEMENT25,235$317K0.01%-35,25913F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC25,000$314K0.1%new13F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC23,163$291K<0.01%-17,10013F-HRTimeline
Duncan Williams Asset Management, LLC22,095$277K0.09%013F-HR/ATimeline
STATE OF WISCONSIN INVESTMENT BOARD22,035$277K<0.01%-15,78913F-HRTimeline
Graham Capital Management, L.P.21,660$272K0.01%new13F-HRTimeline
MACKENZIE FINANCIAL CORP21,355$268K<0.01%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …19,070$239K<0.01%-1,39013F-HRTimelineGroup
Engineers Gate Manager LP18,941$238K<0.01%+6,54213F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson18,200$229K<0.01%013F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$193K<0.01%013F-HRTimeline
Campbell & CO Investment Adviser LLC14,985$188K0.01%new13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC14,887$187K<0.01%-76613F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC14,606$183K<0.01%-34,90613F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …14,300$179K<0.01%new13F-HRTimelineGroup
IEQ CAPITAL, LLC14,169$178K<0.01%new13F-HRTimeline
AlphaQuest LLC14,026$176K0.02%-17,65013F-HRTimeline
China Universal Asset Management Co., L…13,996$176K0.02%+18013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND13,371$168K<0.01%013F-HR/ATimeline
ProShare Advisors LLC12,665$159K<0.01%-2,24713F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC12,549$157K<0.01%-123,21413F-HRTimelineGroup
Magnetar Financial LLCin group Magnetar Financial LLC12,168$153K<0.01%-28013F-HRTimelineGroup
Cresset Asset Management, LLC12,153$153K<0.01%-9,16713F-HR/ATimeline
Quantinno Capital Management LP11,746$147K<0.01%-2,49913F-HRTimeline
Police & Firemen's Retirement System of…11,669$146K<0.01%013F-HRTimeline
Janney Montgomery Scott LLC11,567$145K<0.01%013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM11,159$140K<0.01%-68713F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…10,628$133K<0.01%new13F-HRTimelineGroup
JAMES INVESTMENT RESEARCH, INC.10,578$133K0.02%013F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS10,368$130K<0.01%-80013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS10,307$129K<0.01%+6,30713F-HRTimelineGroup
TPG Financial Advisors, LLC10,017$126K0.05%013F-HRTimeline
Northwest & Ethical Investments L.P.10,030$125K<0.01%013F-HRTimeline
SHELL ASSET MANAGEMENT CO9,296$117K<0.01%-2,80513F-HRTimeline
SG Americas Securities, LLC8,671$109K<0.01%-89,49413F-HRTimeline
CWM, LLCin group CWM, LLC8,570$108K<0.01%+6,27113F-HRTimelineGroup
KLP KAPITALFORVALTNING AS7,300$91.6K<0.01%-3,00013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…7,178$90.1K0.03%-5,82813F-HRTimelineGroup
SIMPLEX TRADING, LLC6,445$80K<0.01%+2,27713F-HRTimeline
Point72 Asia (Singapore) Pte. Ltd.6,311$79.2K0.01%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,616$70.5K<0.01%013F-HRTimelineGroup
Clearstead Advisors, LLC5,000$62.8K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,947$62.1K<0.01%+1,13113F-HRTimelineGroup
DekaBank Deutsche Girozentrale3,843$48K<0.01%013F-HRTimeline
FMR LLCin group FMR LLC3,110$39K<0.01%-9,72013F-HRTimelineGroup
AMALGAMATED BANK1,880$24K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,763$22.1K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC968$12.1K<0.01%+63613F-HRTimeline
Federation des caisses Desjardins du Qu…870$10.9K<0.01%013F-HRTimeline
GAMMA Investing LLC810$10.2K<0.01%+26713F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.669$8.38K<0.01%+26413F-HR/ATimelineGroup
Caitong International Asset Management …564$7.08K0.01%new13F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/472$5.92K<0.01%-5213F-HR/ATimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…338$4.24K<0.01%+10813F-HRTimelineGroup
Parallel Advisors, LLC329$4.13K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.286$4K<0.01%013F-HRTimelineGroup
Truvestments Capital LLC309$3.88K<0.01%013F-HRTimeline
TD Waterhouse Canada Inc.311$3.85K<0.01%013F-HRTimeline
HighMark Wealth Management LLC280$3.51K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\248$3.11K<0.01%-17513F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…181$2.27K<0.01%+16813F-HRTimelineGroup
Allworth Financial LP122$1.53K<0.01%+1213F-HRTimeline
Sterling Capital Management LLC119$1.49K<0.01%-82213F-HR/ATimeline
Brooklyn Investment Group111$1.39K<0.01%-17813F-HR/ATimeline
GROUP ONE TRADING LLC100$1.25K<0.01%013F-HRTimeline
IFP Advisors, Inc96$1.21K<0.01%+9613F-HRTimeline
Point72 (DIFC) Ltd77$966<0.01%new13F-HRTimeline
Kilter Group LLC66$829<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$690<0.01%-4513F-HRTimeline
Steward Partners Investment Advisory, L…53$665<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.51$641<0.01%new13F-HRTimeline
Bare Financial Services, Inc45$565<0.01%new13F-HRTimeline
Cornerstone Planning Group LLC35$439<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC25$314<0.01%-11413F-HRTimeline
AMERIFLEX GROUP, INC.20$247<0.01%013F-HRTimeline
CoreCap Advisors, LLC18$226<0.01%013F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…14$176<0.01%new13F-HRTimelineGroup
Essential Partners LLC14$176<0.01%13F-HRTimeline
SBI Securities Co., Ltd.10$126<0.01%013F-HRTimeline
Innovative Advisory Group, LLC8$100<0.01%013F-HRTimeline
True Wealth Design, LLC7$88<0.01%-1313F-HRTimeline
Covestor Ltd26$00%-113F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Schayowitz Adam acquired 23,205 ZYME shares on 2026-10-09, Form 4 filed 2026-10-09. 0002127119-26-000006

    Accepted , ingested