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Disclosery

ZYME ZYMEWORKS INC

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COM (common), issuer CIK 1937653

181 managers (184 13F filers) reported a position in ZYME shares at 2025-09-30, 73,704,148 shares in all. 24 filers opened a position and 23 filers sold out during the quarter.

Managers
181
13F filers
184
New
24
Added
61
Reduced
65
Sold out
23
Shares held by filers
73,704,148

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09-13,832 S$25.85Form 4
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09+37,037 M$0Form 4

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC22,970,388$392M18.83%013F-HRTimeline
Rubric Capital Management LP4,710,551$80.5M1.08%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.3,989,533$68.1M<0.01%+195,26113F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY3,984,585$68.1M<0.01%-193,02913F-HR/ATimelineGroup
BVF INC/ILin group BVF INC/IL3,938,641$67.3M2.73%-370,29413F-HRTimelineGroup
Redmile Group, LLCin group Redmile Group, LLC3,705,750$63.3M6.16%-444,87713F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,154,434$36.8M<0.01%-310,25913F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,090,663$35.7M1.03%+815,38913F-HRTimelineGroup
Vestal Point Capital, LP1,765,000$30.1M1.37%+615,00013F-HRTimeline
UBS Group AGgroup of 2 filers holding1,762,304$30.1M-948,719Timeline
Blackstone Inc.in group Blackstone Inc.1,616,290$27.6M0.12%-40,50013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,544,898$26.4M0.01%+13513F-HRTimelineGroup
Assenagon Asset Management S.A.1,326,774$22.7M0.03%+833,99413F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,190,838$20.3M<0.01%-1,59413F-HRTimelineGroup
Nextech Invest Ltd.1,113,946$19M2.9%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC1,104,813$18.9M0.01%+988,71113F-HRTimelineGroup
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,100,000$18.8M0.72%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,081,189$18.5M<0.01%-7,27013F-HRTimelineGroup
Prosight Management, LP749,611$12.8M3.07%-560,29313F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC678,636$11.6M<0.01%-26,72813F-HRTimelineGroup
Nuveen, LLCin group TIAA565,385$9.66M<0.01%-89,53113F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…564,000$9.63M0.02%+88,00013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC443,525$7.58M<0.01%+14,66813F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC431,700$7.37M0.01%-101,60013F-HRTimeline
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD350,660$5.99M0.05%-18,83913F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP348,253$5.95M<0.01%-1,54613F-HRTimelineGroup
Granahan Investment Management, LLC345,331$5.9M0.24%-35,45213F-HRTimeline
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …313,753$5.36M<0.01%new13F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC272,797$4.66M0.03%-7,92913F-HRTimeline
Qube Research & Technologies Ltd255,002$4.36M0.01%+185,12813F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC219,948$3.76M0.01%+64,34913F-HRTimelineGroup
Hillsdale Investment Management Inc.216,422$3.7M0.11%+11,40013F-HRTimeline
ALGERT GLOBAL LLC207,926$3.55M0.06%+89,82213F-HR/ATimeline
SAMSARA BIOCAPITAL, LLC207,901$3.55M0.46%-102,39913F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC206,858$3.53M<0.01%-39,29713F-HRTimelineGroup
PICTON MAHONEY ASSET MANAGEMENT206,322$3.52M0.04%-1,28013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC199,023$3.4M<0.01%+76,20313F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co193,360$3.3M<0.01%+69,15613F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.182,847$3.12M0.01%+57713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN176,634$3.02M<0.01%+10,20613F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…168,685$2.88M<0.01%-12,00513F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP161,486$2.78M<0.01%-143,18013F-HRTimeline
Man Group plcin group Man Group plc158,616$2.71M0.01%+123,21013F-HRTimelineGroup
AXA Investment Managers S.A.158,416$2.71M0.01%13F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP154,858$2.64M<0.01%new13F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC152,632$2.61M<0.01%-13,51113F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC146,440$2.5M0.06%-51413F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC145,206$2.48M<0.01%+132,65713F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp137,552$2.35M<0.01%+4,46213F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding136,249$2.33M-208,616Timeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.126,923$2.17M<0.01%-128,36813F-HRTimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD124,784$2.13M0.14%-113,60713F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC122,868$2.1M<0.01%-1,56713F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC117,804$2.01M<0.01%-38,19413F-HRTimelineGroup
Schonfeld Strategic Advisors LLC107,788$1.84M0.01%new13F-HRTimeline
PANAGORA ASSET MANAGEMENT INC106,072$1.81M0.01%+72,51313F-HRTimeline
Opaleye Management Inc.100,000$1.71M0.24%-110,00013F-HRTimeline
Connor, Clark & Lunn Investment Managem…96,800$1.65M0.01%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.93,657$1.6M<0.01%+4,28613F-HRTimelineGroup
RHUMBLINE ADVISERS85,902$1.47M<0.01%-18113F-HRTimeline
Tejara Capital Ltd85,163$1.45M0.8%-114,98713F-HRTimeline
North Growth Management Ltd.82,000$1.41M0.25%-15,00013F-HRTimeline
ACUTA CAPITAL PARTNERS, LLC80,143$1.37M1.41%-3,51213F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC75,928$1.3M<0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/75,327$1.29M<0.01%-15,05113F-HR/ATimelineGroup
Swiss National Bank73,100$1.25M<0.01%013F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC72,787$1.24M0.25%+47,78713F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP72,530$1.24M<0.01%+2,80013F-HRTimelineGroup
Fisher Asset Management, LLC71,974$1.23M<0.01%-513F-HRTimeline
HRT FINANCIAL LP68,461$1.17M<0.01%+35,70313F-HRTimeline
NEOS Investment Management LLC63,663$1.09M0.01%+11,80813F-HRTimeline
Tema ETFs LLC63,663$1.09M0.09%+11,80813F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA57,925$989K<0.01%-15,05813F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…57,448$981K<0.01%+29,13613F-HRTimelineGroup
MACKENZIE FINANCIAL CORP56,377$963K<0.01%+35,02213F-HRTimeline
Engineers Gate Manager LP56,318$962K0.01%+37,37713F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD56,274$961K<0.01%+34,23913F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al55,975$956K0.01%+1,90013F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC51,016$871K<0.01%+19,86913F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.50,030$855K<0.01%013F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC41,768$713K<0.01%+54413F-HRTimeline
STRS OHIO40,900$699K<0.01%-5,40013F-HRTimeline
TUDOR INVESTMENT CORP ET AL37,583$642K<0.01%+3,29013F-HR/ATimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC37,600$640K<0.01%+1,10313F-HRTimelineGroup
DARK FOREST CAPITAL MANAGEMENT LP37,167$635K0.02%-59,82213F-HR/ATimeline
OXFORD ASSET MANAGEMENT LLP36,359$621K0.2%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
CALIFORNIA STATE TEACHERS RETIREMENT SY…35,231$602K<0.01%-7,64213F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC34,510$589K<0.01%-10013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO33,884$579K<0.01%-407,80613F-HR/ATimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources33,821$578K<0.01%new13F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC33,390$570K<0.01%-11,57513F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…33,309$569K<0.01%013F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC32,757$559K0.01%new13F-HRTimeline
Campbell & CO Investment Adviser LLC32,493$555K0.04%+17,50813F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC31,237$534K<0.01%-93313F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …30,432$520K<0.01%+16,13213F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…29,708$507K<0.01%-22613F-HRTimeline
JOURNEY STRATEGIC WEALTH LLC29,050$496K0.01%+1013F-HRTimeline
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…29,015$496K<0.01%+1,90613F-HRTimelineGroup
SIMPLEX TRADING, LLC28,761$491K0.01%+22,31613F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc28,369$485K<0.01%-15,39413F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/27,642$472K<0.01%013F-HRTimelineGroup
Creative Planningin group Creative Planning27,314$467K<0.01%+1,92513F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/26,816$459K<0.01%013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding25,851$442K-3,704Timeline
RITHOLTZ WEALTH MANAGEMENT24,722$422K0.01%-51313F-HRTimeline
Vinva Investment Management Ltd14,594$382K0.01%new13F-HRTimeline
Duncan Williams Asset Management, LLC22,095$377K0.11%013F-HRTimeline
DLD Asset Management, LP20,000$342K0.04%new13F-HR/ATimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson18,200$311K<0.01%013F-HRTimelineGroup
PharVision Advisers, LLC17,790$304K0.17%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …17,574$300K<0.01%-1,49613F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC16,982$290K<0.01%-6,18113F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.16,145$276K0.04%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS15,460$264K<0.01%+5,15313F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$262K<0.01%013F-HRTimeline
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC15,308$261K<0.01%new13F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC14,574$249K<0.01%-3213F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…14,518$248K<0.01%+3,89013F-HRTimelineGroup
Police & Firemen's Retirement System of…14,205$243K<0.01%+2,53613F-HRTimeline
SG Americas Securities, LLC13,624$233K<0.01%+4,95313F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND13,371$228K<0.01%013F-HRTimeline
China Universal Asset Management Co., L…13,176$225K0.02%-82013F-HRTimeline
TWO SIGMA SECURITIES, LLC12,225$209K0.03%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…11,301$193K0.01%+6,35413F-HRTimelineGroup
ProShare Advisors LLC11,201$191K<0.01%-1,46413F-HRTimeline
Janney Montgomery Scott LLC11,067$189K<0.01%-50013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM11,059$189K<0.01%-10013F-HRTimeline
Ewing Morris & Co. Investment Partners …10,850$185K0.08%new13F-HRTimeline
JAMES INVESTMENT RESEARCH, INC.10,578$181K0.02%013F-HRTimeline
Northwest & Ethical Investments L.P.10,030$173K<0.01%013F-HRTimeline
TPG Financial Advisors, LLC10,017$171K0.06%013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…8,686$148K0.04%+1,50813F-HRTimelineGroup
AlphaQuest LLC8,471$145K0.01%-5,55513F-HRTimeline
KLP KAPITALFORVALTNING AS7,300$125K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC6,968$119K<0.01%-1,60213F-HRTimelineGroup
GROUP ONE TRADING LLC6,868$117K<0.01%+6,76813F-HRTimeline
Clearstead Advisors, LLC5,001$85.4K<0.01%+113F-HRTimeline
SHELL ASSET MANAGEMENT CO4,212$72K0.01%-5,08413F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,164$71.1K<0.01%-1,45213F-HRTimelineGroup
DekaBank Deutsche Girozentrale3,843$65K<0.01%013F-HRTimeline
FMR LLCin group FMR LLC3,514$60K<0.01%+40413F-HRTimelineGroup
Arax Advisory Partners2,981$50.9K<0.01%new13F-HRTimeline
Quarry LP2,942$50.2K0.01%new13F-HRTimeline
AMALGAMATED BANK1,880$32K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,617$27.6K<0.01%-14613F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.1,510$25.8K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC968$16.5K<0.01%013F-HRTimeline
Federation des caisses Desjardins du Qu…870$14.9K<0.01%013F-HRTimeline
GAMMA Investing LLC805$13.7K<0.01%-513F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.775$12.3K<0.01%+10613F-HRTimelineGroup
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/549$9.37K<0.01%+7713F-HRTimelineGroup
SUMMIT SECURITIES GROUP LLC472$8.06K<0.01%new13F-HRTimeline
Parallel Advisors, LLC329$5.62K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…313$5.35K<0.01%-2513F-HRTimelineGroup
TD Waterhouse Canada Inc.311$5.28K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.286$5K<0.01%013F-HRTimelineGroup
HighMark Wealth Management LLC280$4.78K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\248$4.24K<0.01%013F-HRTimelineGroup
Truvestments Capital LLC231$3.94K<0.01%-7813F-HRTimeline
COMERICA BANK211$3.6K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…182$3.11K<0.01%+113F-HRTimelineGroup
Allworth Financial LP140$2.39K<0.01%+1813F-HRTimeline
Sterling Capital Management LLC121$2.07K<0.01%+213F-HRTimeline
IFP Advisors, Inc96$1.64K<0.01%013F-HR/ATimeline
Walleye Capital LLCin group Walleye Capital LLC76$1.3K<0.01%new13F-HRTimelineGroup
Kilter Group LLC66$1.13K<0.01%013F-HRTimeline
Bare Financial Services, Inc64$1.09K<0.01%+1913F-HRTimeline
Farther Finance Advisors, LLC62$1.06K<0.01%+3713F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC73$1K<0.01%new13F-HRTimelineGroup
Covestor Ltd53$1K<0.01%+2713F-HRTimeline
True Wealth Design, LLC58$991<0.01%+5113F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$939<0.01%013F-HRTimeline
Steward Partners Investment Advisory, L…53$905<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.51$872<0.01%013F-HRTimeline
Sunbelt Securities, Inc.27$461<0.01%new13F-HRTimeline
CoreCap Advisors, LLC18$307<0.01%013F-HRTimeline
Smartleaf Asset Management LLC12$206<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.12$205<0.01%+213F-HRTimeline
Essential Partners LLC12$205<0.01%-213F-HRTimeline
Innovative Advisory Group, LLC8$137<0.01%013F-HRTimeline

Events

  • Schayowitz Adam acquired 23,205 ZYME shares on 2026-10-09, Form 4 filed 2026-10-09. 0002127119-26-000006

    Accepted , ingested