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Disclosery

ZYME ZYMEWORKS INC

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COM (common), issuer CIK 1937653

172 managers (175 13F filers) reported a position in ZYME shares at 2024-12-31, 66,481,125 shares in all. 23 filers opened a position and 20 filers sold out during the quarter.

Managers
172
13F filers
175
New
23
Added
47
Reduced
61
Sold out
20
Shares held by filers
66,481,125

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

The latest Form 4 transactions, non-derivative.
OwnerDateSharesPriceFiling
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09-13,832 S$25.85Form 4
Schayowitz Adamofficer (EVP, Head of R&D)2026-10-09+37,037 M$0Form 4

13F holders, Q4 2024

Filers in the available 13F reports with a share position at 2024-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC15,028,079$220M8.79%+1,590,60613F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC4,840,463$70.9M4.94%-261,44813F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL4,308,935$63.1M2.14%-299,00013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY4,201,437$61.5M<0.01%-905,43213F-HR/ATimelineGroup
BlackRock, Inc.in group BlackRock, Inc.4,184,956$61.3M<0.01%-78,63913F-HRTimelineGroup
Rubric Capital Management LP3,917,331$57.3M1.04%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC2,493,288$36.5M<0.01%-365,22613F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …2,137,653$31.3M0.08%+192,16213F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,130,020$31.2M0.87%-50,00013F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,546,772$22.6M0.01%+17,84913F-HR/ATimelineGroup
UBS Group AGgroup of 2 filers holding1,532,007$22.4M-127,632Timeline
FARALLON CAPITAL MANAGEMENT, L.L.C.1,329,974$19.5M0.1%-31,02613F-HRTimeline
Nextech Invest Ltd.1,113,946$16.3M2.65%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,100,000$16.1M1.07%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,084,961$15.9M<0.01%-86,81613F-HRTimelineGroup
SAMSARA BIOCAPITAL, LLC1,000,000$14.6M2.01%013F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP972,742$14.2M<0.01%+123,24013F-HRTimelineGroup
Prosight Management, LP820,000$12M3.36%-97,59913F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC759,653$11.1M0.25%+17,09213F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC689,884$10.1M<0.01%-24,03113F-HRTimelineGroup
Assenagon Asset Management S.A.642,251$9.4M0.02%+311,10713F-HRTimeline
Blackstone Inc.in group Blackstone Inc.569,715$8.34M0.04%+544,63313F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC452,804$6.63M0.06%new13F-HRTimelineGroup
Granahan Investment Management, LLC411,120$6.02M0.25%-202,38313F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP394,830$5.78M<0.01%+23,90313F-HRTimelineGroup
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD369,499$5.41M0.05%-57,44513F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC356,168$5.21M0.02%-166,47213F-HRTimeline
Empowered Funds, LLC352,753$5.16M0.08%+17,09213F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP337,161$4.89M<0.01%new13F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.330,127$4.83M0.01%+280,54413F-HRTimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD306,460$4.49M0.26%-21,06213F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC285,700$4.18M0.01%+101,10013F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC282,345$4.13M0.03%-2,77013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC249,960$3.66M<0.01%-1,51713F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC230,970$3.38M0.01%-214,80613F-HRTimelineGroup
Hillsdale Investment Management Inc.230,025$3.37M0.17%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC220,890$3.23M<0.01%+66,50613F-HR/ATimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…219,098$3.21M<0.01%-24,09113F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC214,338$3.14M0.01%+113,47213F-HRTimeline
Nuveen Asset Management, LLCin group TIAA207,023$3.03M<0.01%+88613F-HRTimelineGroup
PICTON MAHONEY ASSET MANAGEMENT206,569$3.02M0.11%-38,08713F-HR/ATimeline
NORGES BANK201,700$2.95M<0.01%013F-HRTimeline
Vestal Point Capital, LP185,000$2.71M0.16%-430,00013F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.181,626$2.66M0.01%+3,36713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN164,058$2.4M<0.01%-13,35213F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding149,069$2.18M+108,012Timeline
KENNEDY CAPITAL MANAGEMENT LLC139,953$2.05M0.05%-3,62713F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC132,577$1.94M0.02%-12,27113F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co131,306$1.92M<0.01%-1,49213F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC121,526$1.78M<0.01%-15,80013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp120,683$1.77M<0.01%-129,30813F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO111,983$1.64M<0.01%+72,70313F-HRTimelineGroup
RHUMBLINE ADVISERS103,876$1.52M<0.01%+15,92013F-HR/ATimeline
Trexquant Investment LP101,996$1.49M0.02%new13F-HRTimeline
North Growth Management Ltd.97,000$1.42M0.27%013F-HRTimeline
HRT FINANCIAL LP95,974$1.41M0.01%+47,16613F-HRTimeline
Swiss National Bank90,200$1.32M<0.01%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC83,136$1.22M<0.01%+3,24613F-HRTimelineGroup
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A75,000$1.1M<0.01%013F-HRTimelineGroup
RITHOLTZ WEALTH MANAGEMENT74,466$1.09M0.03%+4,29713F-HRTimeline
Invesco Ltd.in group Invesco Ltd.69,382$1.02M<0.01%-93,65713F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC67,240$984K0.99%new13F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD65,381$957K<0.01%-19,77713F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP64,330$942K<0.01%-9,32413F-HRTimelineGroup
Fisher Asset Management, LLC63,600$931K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA60,926$893K<0.01%-95213F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC60,642$888K<0.01%13F-HR/ATimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC59,514$871K<0.01%+40,17213F-HR/ATimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC58,358$854K<0.01%+37,55013F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC54,090$792K<0.01%-11,58813F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC51,580$755K<0.01%-2,81013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…50,583$741K<0.01%-10,40013F-HRTimeline
ALLIANCEBERNSTEIN L.P.50,030$732K<0.01%013F-HRTimeline
STRS OHIO49,000$717K<0.01%new13F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC48,612$712K0.01%new13F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc47,082$689K<0.01%+7,51113F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…44,945$658K<0.01%-4,82613F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…43,783$641K<0.01%-38313F-HR/ATimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC43,708$640K<0.01%new13F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC39,942$585K<0.01%new13F-HRTimelineGroup
Tejara Capital Ltd38,537$564K0.37%new13F-HRTimeline
Polar Asset Management Partners Inc.36,000$527K0.01%new13F-HR/ATimeline
MetLife Investment Management, LLCin group MetLife Investment Management…33,946$497K<0.01%+2,05313F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC33,858$496K<0.01%+12,69813F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd33,702$493K0.04%new13F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding33,253$487K+18Timeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/31,700$464K<0.01%-38,03013F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC30,960$453K<0.01%+4,29413F-HRTimeline
Cresset Asset Management, LLC30,806$451K<0.01%-8,58313F-HRTimeline
JOURNEY STRATEGIC WEALTH LLC28,897$423K0.02%013F-HRTimeline
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…27,385$401K<0.01%-52,47113F-HRTimelineGroup
Corebridge Financial, Inc.in group Corebridge Financial, Inc.27,115$397K<0.01%-2,76313F-HRTimelineGroup
SG Americas Securities, LLC26,782$392K<0.01%+6,23913F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC26,074$382K<0.01%+1,21213F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/25,948$380K<0.01%-2,63713F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC23,127$339K<0.01%-57,19913F-HRTimelineGroup
Schonfeld Strategic Advisors LLC22,800$334K<0.01%new13F-HRTimeline
FMR LLCin group FMR LLC21,966$322K<0.01%+18,63013F-HRTimelineGroup
Qube Research & Technologies Ltd21,868$320K<0.01%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/21,583$316K<0.01%+3,23513F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …20,958$307K<0.01%-1,08913F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.20,840$305K<0.01%-94213F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC19,660$288K<0.01%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…19,611$287K<0.01%+2,52913F-HRTimeline
ProShare Advisors LLC18,623$273K<0.01%-10,88913F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson18,200$266K<0.01%013F-HRTimelineGroup
Verition Fund Management LLC15,814$232K<0.01%new13F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$225K<0.01%013F-HRTimeline
Monaco Asset Management SAM15,000$220K0.1%-285,00013F-HRTimeline
China Universal Asset Management Co., L…14,605$214K0.02%+94013F-HRTimeline
One Wealth Advisors, LLC13,979$205K0.03%-10,36613F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS13,743$201K<0.01%+2,21613F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM13,412$196K<0.01%+17813F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC13,386$196K<0.01%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND13,371$196K<0.01%+4,00013F-HR/ATimeline
SHELL ASSET MANAGEMENT CO12,357$181K0.01%013F-HRTimeline
Police & Firemen's Retirement System of…11,669$171K<0.01%13F-HRTimeline
JAMES INVESTMENT RESEARCH, INC.10,578$155K0.02%013F-HRTimeline
KLP KAPITALFORVALTNING AS10,300$151K<0.01%13F-HRTimeline
Janney Montgomery Scott LLC10,267$150K<0.01%013F-HRTimeline
TPG Financial Advisors, LLC10,017$147K0.06%-1,00013F-HRTimeline
Jain Global LLC10,010$147K<0.01%13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…9,704$142K<0.01%+7,51813F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS7,363$108K<0.01%new13F-HRTimelineGroup
Compagnie Lombard Odier SCmA7,000$102K<0.01%-3,00013F-HRTimeline
Virtus Investment Advisers, LLCgroup of 3 filers holding5,633$82.5K-16,208Timeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,616$82.2K<0.01%013F-HRTimelineGroup
Northwest & Ethical Investments L.P.5,471$80K<0.01%-90013F-HRTimeline
Clearstead Advisors, LLC5,000$73.2K<0.01%013F-HRTimeline
DekaBank Deutsche Girozentrale3,843$55K<0.01%013F-HRTimeline
AlphaQuest LLC2,808$41.1K0.01%+2,32413F-HRTimeline
AMALGAMATED BANK1,799$26K<0.01%013F-HRTimeline
Sterling Capital Management LLC1,719$25.2K<0.01%+1,52413F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,446$21.2K<0.01%13F-HRTimeline
SIMPLEX TRADING, LLC1,087$15K<0.01%-44313F-HRTimeline
CURIO WEALTH, LLC1,000$14.6K0.01%13F-HRTimeline
GROUP ONE TRADING LLC800$11.7K<0.01%-29,04113F-HR/ATimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.717$10.5K<0.01%-13213F-HR/ATimelineGroup
Brooklyn Investment Group589$8.62K<0.01%new13F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/548$8.02K<0.01%-2113F-HRTimelineGroup
GAMMA Investing LLC533$7.8K<0.01%+10013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\488$7.14K<0.01%-41613F-HRTimelineGroup
Truvestments Capital LLC434$6.35K<0.01%+17513F-HRTimeline
Lindbrook Capital, LLC371$5.43K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC332$4.86K<0.01%-1713F-HRTimeline
Parallel Advisors, LLC329$4.82K<0.01%013F-HRTimeline
TD Waterhouse Canada Inc.311$4.54K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…284$4.16K<0.01%+28013F-HRTimelineGroup
HighMark Wealth Management LLC280$4.1K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.286$4K<0.01%013F-HRTimelineGroup
Smartleaf Asset Management LLC243$3.52K<0.01%+10113F-HRTimeline
CWM, LLCin group CWM, LLC193$3K<0.01%+12113F-HRTimelineGroup
Arax Advisory Partners169$2.48K<0.01%-4713F-HRTimeline
Cornerstone Planning Group LLC161$2.33K<0.01%013F-HRTimeline
Farther Finance Advisors, LLC150$2.2K<0.01%013F-HRTimeline
Eagle Bay Advisors LLC110$1.61K<0.01%013F-HRTimeline
Aster Capital Management (DIFC) Ltd70$1.02K<0.01%-68613F-HRTimeline
Federation des caisses Desjardins du Qu…60$878<0.01%new13F-HRTimeline
Creative Planningin group Creative Planning57$834<0.01%new13F-HRTimelineGroup
Steward Partners Investment Advisory, L…53$776<0.01%013F-HRTimeline
Amundiin group Amundi52$735<0.01%new13F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC50$732<0.01%-1013F-HRTimeline
Allworth Financial LP34$499<0.01%013F-HRTimeline
WR Wealth Planners, LLC28$410<0.01%013F-HRTimeline
RICHARDS, MERRILL & PETERSON, INC.20$293<0.01%13F-HRTimeline
CoreCap Advisors, LLC18$264<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…10$146<0.01%new13F-HRTimelineGroup
SBI Securities Co., Ltd.10$146<0.01%13F-HRTimeline
Innovative Advisory Group, LLC8$117<0.01%13F-HRTimeline
IFP Advisors, Inc0$59<0.01%new13F-HRTimelineAmount filed as zero, left out of ratios.
Covestor Ltd27$00%+913F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$00%013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Schayowitz Adam acquired 23,205 ZYME shares on 2026-10-09, Form 4 filed 2026-10-09. 0002127119-26-000006

    Accepted , ingested