13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 110 holding rows worth $4,194,646,405.
- Accession
- 0001172661-25-002355
- Filer
- CIK 1055951
- Filed
- 2025-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2025
A holdings report, 111 entries on the cover page, a total value of $4,194,646,405 stated on the cover page (in dollars after the unit check, H1), rows summing to $4,194,646,405 with VALUE read as dollars as filed, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,718,735 | $333,996,595 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 15,021,721 | $330,477,862 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 2,813,200 | $283,795,616 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 337,600 | $278,827,216 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 7,959,538 | $156,643,708 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 291,000 | $144,123,570 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 359,200 | $133,712,200 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 206,700 | $122,338,496 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 1,532,000 | $111,039,360 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 201,200 | $105,378,500 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 8,288,510 | $104,269,456 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 934,640 | $103,371,184 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 3,850,200 | $97,564,068 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 346,100 | $93,453,922 | dollars as filed | |
| INTEGER HLDGS CORP | 45826H109 | COM | 662,500 | $78,181,625 | dollars as filed | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 159,900 | $77,522,718 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 547,000 | $77,351,270 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 2,540,136 | $76,635,903 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,415,020 | $70,241,593 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 129,000 | $64,190,400 | dollars as filed | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 465,000 | $62,542,500 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 1,509,205 | $60,654,949 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 2,471,994 | $60,539,133 | dollars as filed | |
| ARRIVENT BIOPHARMA INC | 04272N102 | COM | 3,027,328 | $55,975,295 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 1,812,886 | $53,516,395 | dollars as filed | |
| SI BONE INC | 825704109 | COM | 3,442,853 | $48,303,228 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 386,700 | $45,100,821 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 22,362,850 | $42,489,415 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 950,200 | $41,932,326 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 3,406,335 | $41,863,857 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 3,704,959 | $38,753,871 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 5,693,589 | $34,844,765 | dollars as filed | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 73,114,592 | $34,363,858 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 653,743 | $33,582,778 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 999,000 | $33,506,460 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 947,877 | $31,801,273 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 1,432,300 | $31,324,401 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 4,002,887 | $29,541,306 | dollars as filed | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 679,816 | $29,429,235 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 197,500 | $22,129,875 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 6,943,654 | $22,080,820 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 7,562,971 | $20,873,800 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 758,566 | $20,481,282 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 380,000 | $20,128,600 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 5,779,071 | $20,053,376 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 2,285,400 | $18,648,864 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 2,862,448 | $17,260,561 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 1,752,831 | $16,301,328 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 13,135,260 | $16,025,017 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 6,059,528 | $15,936,559 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 2,248,249 | $14,568,654 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,923,855 | $14,563,582 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 3,087,462 | $13,924,454 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 44,200 | $13,770,510 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 500,000 | $12,670,000 | dollars as filed | call |
| 0 | 000000000 | 0 | 12,048,773 | $12,514,174 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 481,065 | $11,555,181 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 652,028 | $11,286,605 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 6,830,300 | $10,928,480 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 1,014,611 | $10,612,831 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 1,018,734 | $10,380,899 | dollars as filed | |
| ACELYRIN INC | 00445A100 | COM | 4,001,711 | $9,884,226 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 325,500 | $9,537,150 | dollars as filed | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 4,180,768 | $9,323,113 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 11,447,140 | $8,642,591 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 5,968,451 | $8,415,516 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,909,256 | $8,378,309 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 100,000 | $8,110,000 | dollars as filed | call |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 967,000 | $7,745,670 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 172,600 | $7,616,838 | dollars as filed | call |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 4,166,000 | $7,415,480 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 179,900 | $7,282,352 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 6,475,291 | $7,058,067 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 1,120,000 | $7,044,800 | dollars as filed | |
| KESTRA MED TECHNOLOGIES LTD | G52441105 | SHS | 250,000 | $6,230,000 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 1,172,287 | $6,224,844 | dollars as filed | |
| INSPIREMD INC | 45779A846 | COM | 2,133,405 | $5,738,859 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 151,800 | $4,880,370 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 593,088 | $4,602,363 | dollars as filed | |
| IKENA ONCOLOGY INC | 45175G108 | COM | 3,539,358 | $4,530,378 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 23,500 | $4,237,050 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 891,616 | $3,994,440 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 700,000 | $3,906,000 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 298,301 | $3,886,862 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 2,252,987 | $3,717,429 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 921,959 | $3,466,566 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,322,488 | $3,275,641 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 150,000 | $2,596,500 | dollars as filed | call |
| PASSAGE BIO INC | 702712100 | COM | 7,034,626 | $2,483,926 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 28,659 | $2,186,395 | dollars as filed | |
| CERIBELL INC | 15678C102 | COMMON STOCK | 112,500 | $2,161,125 | dollars as filed | |
| Instil Bio Inc | 45783C200 | COM NEW | 116,785 | $2,027,388 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 1,741,273 | $1,897,988 | dollars as filed | |
| CARDIFF ONCOLOGY INC | 14147L108 | COM | 573,884 | $1,801,996 | dollars as filed | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 6,776,515 | $1,601,968 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 821,400 | $1,511,376 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 605,531 | $1,392,721 | dollars as filed | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 1,680,580 | $1,327,826 | dollars as filed | |
| TURNSTONE BIOLOGICS CORP | 90042W100 | COM | 3,099,265 | $1,270,699 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 348,000 | $1,231,920 | dollars as filed | |
| BIOMX INC | 09090D301 | COM | 1,787,767 | $993,462 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 192,700 | $940,376 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 550,000 | $753,500 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 933,500 | $565,048 | dollars as filed | |
| KORRO BIO INC | 500946108 | COMMON STOCK | 32,400 | $564,084 | dollars as filed | |
| NEXTCURE INC | 65343E108 | COM | 1,141,200 | $548,118 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 250,000 | $540,000 | dollars as filed | |
| DIH HLDG US INC | 23290B106 | CL A | 1,915,000 | $442,940 | dollars as filed | |
| XERIS BIOPHARMA HOLDINGS INC | 98422E103 | COM | 80,420 | $441,506 | dollars as filed | |
| LAKESHORE BIOPHARMA CO LTD | G9845F208 | COM | 140,428 | $344,049 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-25-002355 | this filing | 2025-05-15 | acceptance time not in the bulk data set |