13F-HR filed by RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 85 holding rows worth $5,987,912,728.
- Accession
- 0001104659-25-049549
- Filer
- CIK 1346824
- Filed
- 2025-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2025
A holdings report, 86 entries on the cover page, a total value of $5,987,912,728 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,987,912,728 with VALUE read as dollars as filed, 13F file number 028-12884. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 10,281,496 | $1,602,473,967 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 12,189,149 | $460,262,266 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,084,412 | $322,291,304 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 11,189,693 | $302,121,711 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 10,138,938 | $207,544,061 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 3,036,527 | $199,196,171 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 8,909,091 | $196,000,002 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 6,300,408 | $185,988,044 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 18,202,009 | $147,072,233 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 19,889,683 | $144,597,995 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 10,860,977 | $136,631,091 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 10,445,322 | $109,258,068 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 4,178,823 | $107,437,539 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 9,714,392 | $101,612,540 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 10,637,290 | $98,926,797 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 6,147,280 | $97,618,806 | dollars as filed | |
| GERON CORP | 374163103 | COM | 60,379,366 | $96,003,192 | dollars as filed | |
| RXSIGHT INC | 78349D107 | COM | 3,743,018 | $94,511,205 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 6,955,993 | $90,636,589 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,577,106 | $78,287,542 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 6,944,648 | $76,599,467 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,569,491 | $58,636,184 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 2,866,733 | $52,002,537 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 1,295,040 | $46,802,746 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 5,755,577 | $45,641,726 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 6,995,858 | $40,506,018 | dollars as filed | |
| Tourmaline Bio Inc | 89157D105 | Common Stock | 2,538,925 | $38,617,049 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 31,419,267 | $38,331,506 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 1,136,453 | $36,536,964 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 3,206,271 | $35,461,357 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 9,853,302 | $29,559,906 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 10,229,099 | $29,459,805 | dollars as filed | |
| VOR BIOPHARMA INC | 929033108 | COM | 39,646,039 | $28,446,033 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 5,105,213 | $27,261,837 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 4,004,610 | $26,430,426 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 1,517,418 | $26,266,506 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 1,092,796 | $23,538,826 | dollars as filed | |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 9,192,092 | $23,072,151 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 1,347,252 | $22,067,988 | dollars as filed | |
| ITEOS THERAPEUTICS INC | 46565G104 | COM | 3,649,057 | $21,784,870 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 1,150,000 | $20,608,000 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 10,805,129 | $19,881,437 | dollars as filed | |
| GLAUKOS CORP COM | 377322102 | Stock | 190,256 | $18,724,996 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 511,207 | $18,613,047 | dollars as filed | |
| METSERA INC | 59267L107 | COM | 675,525 | $18,387,791 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 3,181,818 | $17,245,454 | dollars as filed | |
| 10X GENOMICS INC CL A COM | 88025U109 | Stock | 1,944,247 | $16,973,276 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 8,340,508 | $16,931,231 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 848,986 | $16,708,044 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 14,932,063 | $16,425,269 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 4,330,446 | $16,022,650 | dollars as filed | |
| CERIBELL INC | 15678C102 | COMMON STOCK | 824,582 | $15,840,220 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 1,333,333 | $15,839,996 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 200,000 | $15,258,000 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 10,872,503 | $15,112,779 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 10,689,545 | $15,018,811 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 4,563,211 | $14,739,172 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 3,400,000 | $14,484,000 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 6,045,351 | $12,997,505 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 3,566,338 | $12,089,886 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 9,695,228 | $11,925,130 | dollars as filed | |
| SERA PROGNOSTICS INC | 81749D107 | CMN | 3,032,808 | $11,160,733 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 1,511,334 | $11,153,645 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 1,093,477 | $9,283,620 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 1,136,364 | $8,920,457 | dollars as filed | |
| SURROZEN INC | 86889P208 | COMMON STOCK | 679,130 | $7,918,656 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 1,750,000 | $7,892,500 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 967,000 | $7,745,670 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 750,000 | $7,725,000 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 206,427 | $7,445,822 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 4,666,667 | $7,140,001 | dollars as filed | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 217,000 | $6,579,440 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 500,000 | $6,120,000 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 575,000 | $6,118,000 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 6,144,881 | $5,974,053 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 7,541,000 | $5,693,455 | dollars as filed | |
| HUMACYTE INC | 44486Q103 | COM | 3,312,356 | $5,647,567 | dollars as filed | |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 3,217,503 | $4,150,579 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 1,052,494 | $3,957,377 | dollars as filed | |
| BOUNDLESS BIO INC | 10170A100 | COM | 2,180,631 | $3,292,753 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 333,333 | $2,996,664 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 4,434,637 | $2,885,175 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 546,554 | $1,896,542 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 1,000,000 | $635,800 | dollars as filed | |
| SCILEX HOLDING CO | 80880W106 | COM | 1,036,218 | $257,500 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-25-049549 | this filing | 2025-05-15 | acceptance time not in the bulk data set |