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Disclosery

MBX MBX BIOSCIENCES INC

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Stock (common), issuer CIK 1776111

136 managers (138 13F filers) reported a position in MBX shares at 2025-12-31, 48,428,720 shares in all. 39 filers opened a position and 25 filers sold out during the quarter.

Managers
136
13F filers
138
New
39
Added
53
Reduced
25
Sold out
25
Shares held by filers
48,428,720

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Frazier Life Sciences Management, L.P.6,652,013$210M5.64%013F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC3,935,203$124M2.54%-67,68413F-HRTimelineGroup
NEA Management Company, LLC3,614,486$114M5.81%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…3,349,961$106M0.02%-1,473,37513F-HRTimelineGroup
Deep Track Capital, LP3,249,790$102M2.34%+99,79013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.2,919,756$92.1M<0.01%+962,29513F-HRTimelineGroup
NVP ASSOCIATES, LLC2,136,335$67.4M26.4%013F-HRTimeline
EcoR1 Capital, LLC2,123,604$67M3.06%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC1,817,811$57.3M<0.01%+140,44913F-HRTimelineGroup
Driehaus Capital Management LLC1,408,159$44.4M0.3%-131,48013F-HRTimeline
Cormorant Asset Management, LP1,120,000$35.3M2%-105,00013F-HRTimeline
BRAIDWELL LP1,018,600$32.1M1.03%new13F-HRTimeline
Woodline Partners LP1,000,063$31.5M0.12%-201,08713F-HRTimeline
Kynam Capital Management, LP934,799$29.5M1.92%-1,065,20113F-HRTimeline
EVENTIDE ASSET MANAGEMENT, LLC890,000$28.1M0.44%new13F-HRTimeline
Parkman Healthcare Partners LLC885,639$27.9M2.66%+112,33513F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/840,506$26.5M<0.01%-114,22013F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC809,857$25.5M0.02%-186,22613F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.680,609$21.5M0.03%+52,94213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP672,740$21.2M<0.01%+353,46613F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.671,838$21.2M0.02%new13F-HRTimelineGroup
TCG Crossover Management, LLC650,000$20.5M0.68%013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC649,391$20.5M<0.01%+175,45913F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC462,049$14.6M0.01%-193,36713F-HRTimelineGroup
Soleus Capital Management, L.P.408,900$12.9M0.55%+133,90013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC331,938$10.5M<0.01%-26,18313F-HR/ATimelineGroup
Trails Edge Capital Partners, LP315,158$9.94M2.46%13F-HRTimeline
Rock Springs Capital Management LP282,624$8.91M0.46%013F-HRTimeline
UBS Group AGgroup of 2 filers holding281,312$8.87M+220,587Timeline
Opaleye Management Inc.260,000$8.2M1.08%+7,00013F-HR/ATimeline
Affinity Asset Advisors, LLC250,000$7.88M0.57%+85,00013F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co222,180$7.01M<0.01%+52,17413F-HRTimelineGroup
Goelzer Investment Management, Inc.221,672$6.99M0.32%new13F-HRTimeline
Elmind Capital, LP211,000$6.65M1.96%13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP190,881$6.02M<0.01%+57,61613F-HRTimelineGroup
Schonfeld Strategic Advisors LLC167,125$5.27M0.03%-115,55213F-HRTimeline
DAFNA Capital Management LLC165,265$5.21M1.21%+80,26513F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd143,327$4.52M0.95%-34,51313F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP138,571$4.37M0.01%+124,98413F-HRTimelineGroup
KVP Capital Advisors, LP121,524$3.83M3.96%13F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management119,726$3.78M0.01%+94,08513F-HRTimelineGroup
TD Asset Management Inc101,450$3.2M<0.01%-17,34213F-HRTimeline
Burkehill Global Management, LP100,000$3.15M0.21%013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC86,581$2.73M<0.01%new13F-HRTimelineGroup
PFM Health Sciences, LP79,310$2.5M0.25%-142,19513F-HRTimeline
STEMPOINT CAPITAL LP78,553$2.48M0.43%+3,55313F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.77,601$2.45M<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…76,528$2.41M<0.01%new13F-HRTimelineGroup
Nuveen, LLCin group TIAA75,565$2.38M<0.01%+53,42213F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp75,262$2.37M<0.01%+27,52713F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP73,736$2.28M<0.01%-10,03013F-HRTimeline
Aaron Wealth Advisors LLC70,000$2.21M0.12%+20,00013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …69,551$2.15M<0.01%+1,17513F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY59,026$1.86M<0.01%+14,15813F-HR/ATimelineGroup
Verition Fund Management LLC57,575$1.82M0.01%new13F-HRTimeline
ExodusPoint Capital Management, LP57,005$1.8M0.02%-42,99513F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC52,691$1.66M<0.01%+31,06513F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC48,614$1.53M<0.01%+43,60513F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC46,702$1.47M<0.01%new13F-HRTimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD43,597$1.38M0.32%-25,83113F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/37,894$1.2M<0.01%+11,27813F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC36,872$1.16M0.01%+20,03213F-HRTimelineGroup
Creative Planningin group Creative Planning33,651$1.06M<0.01%+4,91913F-HRTimelineGroup
RHUMBLINE ADVISERS33,420$1.05M<0.01%+11,59913F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC32,644$1.03M<0.01%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN31,931$1.01M<0.01%+20,17613F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC31,409$991K<0.01%+15,64513F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.27,900$880K<0.01%+17,40013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…25,663$809K0.02%new13F-HRTimelineGroup
Trexquant Investment LP24,268$765K0.01%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.23,820$751K0.12%new13F-HRTimeline
Qube Research & Technologies Ltd23,213$732K<0.01%new13F-HRTimeline
Cerity Partners LLCin group Cerity Partners LLC21,323$673K<0.01%new13F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.21,203$669K<0.01%+9,41513F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd20,139$635K0.02%-18,23913F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\20,027$632K<0.01%+9,10413F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP19,295$609K0.05%new13F-HRTimeline
Koa Wealth Management, LLC18,413$581K0.4%-8,30013F-HRTimeline
Seven Fleet Capital Management LP18,200$574K0.39%13F-HR/ATimeline
CITIGROUP INCin group CITIGROUP INC16,391$517K<0.01%+16,21313F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…16,018$505K<0.01%+5,00013F-HRTimelineGroup
FMR LLCin group FMR LLC15,746$497K<0.01%-53,23013F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding15,440$487K+8,320Timeline
China Universal Asset Management Co., L…15,317$483K0.04%+10,31713F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO14,645$462K<0.01%+8,47013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC12,236$386K<0.01%new13F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD11,600$366K<0.01%new13F-HRTimeline
Graham Capital Management, L.P.11,254$355K0.01%new13F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC10,000$315K0.01%-4,20013F-HRTimeline
GROUP ONE TRADING LLC9,428$297K0.01%new13F-HRTimeline
PROFUND ADVISORS LLC9,214$291K0.01%new13F-HRTimeline
SIMPLEX TRADING, LLC8,925$281K0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…8,910$281K0.08%-1,70413F-HRTimelineGroup
Rafferty Asset Management, LLC8,113$256K<0.01%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO7,657$242K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…7,520$237K<0.01%+3,01113F-HRTimeline
ProShare Advisors LLC7,187$227K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC10,360$226K<0.01%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC6,858$216K<0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS6,784$214K<0.01%+3,88813F-HRTimelineGroup
AXQ CAPITAL, LP6,463$204K0.05%new13F-HRTimeline
SG Americas Securities, LLC4,765$150K<0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND4,300$136K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,416$108K<0.01%+2,14913F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…3,000$94.6K<0.01%013F-HR/ATimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…2,856$90.1K<0.01%+1,37513F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc2,539$80.1K<0.01%+1,21113F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,312$72.9K<0.01%+1,13513F-HRTimelineGroup
Cygnus Capital Advisors, LLC1,800$57K0.04%13F-HRTimeline
CWM, LLCin group CWM, LLC1,784$56K<0.01%+40013F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,754$55.3K<0.01%+68913F-HRTimeline
Sterling Capital Management LLC1,641$51.8K<0.01%+58313F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,592$50.2K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,532$49K<0.01%+57213F-HRTimelineGroup
AMALGAMATED BANK895$28K<0.01%+51113F-HRTimeline
GF FUND MANAGEMENT CO. LTD.882$27.8K<0.01%new13F-HRTimeline
STRS OHIO700$22.1K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\312$9.84K<0.01%-2513F-HRTimelineGroup
GAMMA Investing LLC299$9.43K<0.01%013F-HRTimeline
Aster Capital Management (DIFC) Ltd265$8.36K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…196$6.18K<0.01%-5613F-HRTimelineGroup
SIGNATUREFD, LLC179$5.65K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.150$5K<0.01%new13F-HRTimelineGroup
Physician Wealth Advisors, Inc.109$3.44K<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP80$2.52K<0.01%new13F-HRTimelineGroup
Parallel Advisors, LLC61$1.92K<0.01%013F-HRTimeline
Allworth Financial LP52$1.64K<0.01%+2713F-HRTimeline
Cornerstone Financial Management LLC34$1.07K<0.01%13F-HR/ATimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…25$789<0.01%+213F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC24$757<0.01%+413F-HRTimeline
Global Retirement Partners, LLC19$599<0.01%new13F-HRTimeline
Essential Partners LLC15$473<0.01%+1313F-HRTimeline
Farther Finance Advisors, LLC10$315<0.01%-31813F-HRTimeline
SBI Securities Co., Ltd.9$284<0.01%new13F-HRTimeline
True Wealth Design, LLC2$64<0.01%new13F-HRTimeline
IFP Advisors, Inc1$32<0.01%new13F-HRTimeline