Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 5,985,347 $110M 4.58% 0 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 3,812,215 $70.3M 1.46% 0 13F-HR Timeline Group NEA Management Company, LLC More: the full row for NEA Management Company, LLC 3,614,486 $66.6M 3.76% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,018,935 $55.6M 2.09% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,909,639 $53M 0.01% -28,214 13F-HR Timeline Group NVP ASSOCIATES, LLC More: the full row for NVP ASSOCIATES, LLC 2,136,335 $39.4M 21.06% 0 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 1,581,760 $29.2M 0.24% +600,438 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,511,334 $27.9M 0.37% 0 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,259,273 $23.2M 0.93% +83,464 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,161,527 $21.4M <0.01% -31,411 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 727,952 $13.4M <0.01% new 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 700,000 $12.9M 0.71% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 670,948 $12.4M <0.01% +620,948 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 650,000 $12M 1.17% 0 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 608,721 $11.2M 0.08% +89,046 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 369,300 $6.81M <0.01% -80,700 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 333,642 $6.15M 0.01% -106,769 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 265,703 $4.9M <0.01% +243,434 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 220,330 $4.06M <0.01% +84,722 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 174,700 $3.22M 0.01% -50,300 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 170,000 $3.13M 0.42% new 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 162,090 $2.99M 0.18% +12,090 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 142,649 $2.63M <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 93,311 $1.72M <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 90,682 $1.67M <0.01% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 71,500 $1.32M 0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 49,675 $916K <0.01% +3,481 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 45,901 $846K <0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 36,600 $675K <0.01% -8,182 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 34,827 $642K <0.01% -16,173 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 27,020 $498K <0.01% new 13F-HR Timeline Group TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 26,708 $492K <0.01% 0 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 25,900 $477K <0.01% +13,900 13F-HR Timeline Group NORGES BANK More: the full row for NORGES BANK 25,000 $461K <0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 24,573 $453K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 23,914 $441K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 23,835 $439K <0.01% new 13F-HR/A Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 18,000 $332K 0.13% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 17,433 $321K <0.01% +1,033 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 16,059 $296K <0.01% new 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 14,471 $267K <0.01% new 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 12,743 $235K 0.02% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 9,472 $175K <0.01% new 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 9,106 $168K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 8,864 $163K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 7,230 $133K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 6,335 $117K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,844 $108K <0.01% new 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 5,593 $103K <0.01% new 13F-HR Timeline Group Sandia Investment Management LP More: the full row for Sandia Investment Management LP 5,000 $92.2K 0.17% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 4,338 $79.9K <0.01% new 13F-HR/A Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 3,468 $63.9K 0.03% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,143 $39.5K <0.01% 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 2,100 $38.7K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,486 $27.4K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,177 $21.7K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,107 $20.4K <0.01% -3,893 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 833 $16K <0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 832 $15.3K <0.01% new 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 803 $14.8K <0.01% +649 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 400 $7.37K 0.01% 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 384 $7K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 161 $2.97K <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.