Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 5,985,347 $44.2M 2.02% 0 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 4,002,887 $29.5M 0.71% +190,672 13F-HR Timeline Group NEA Management Company, LLC More: the full row for NEA Management Company, LLC 3,614,486 $26.7M 2.05% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,018,935 $22.3M 0.72% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,638,521 $19.5M <0.01% -271,118 13F-HR Timeline Group NVP ASSOCIATES, LLC More: the full row for NVP ASSOCIATES, LLC 2,136,335 $15.8M 14.05% 0 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 1,579,207 $11.7M 0.11% -2,553 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,511,334 $11.2M 0.19% 0 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,259,273 $9.29M 0.55% 0 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 1,132,950 $8.36M 1.44% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,100,916 $8.13M <0.01% -60,611 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 877,461 $6.48M 0.04% +268,740 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 783,042 $5.78M <0.01% +55,090 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 700,000 $5.17M 0.39% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 665,563 $4.91M <0.01% -5,385 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 650,000 $4.8M 0.65% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 369,315 $2.73M <0.01% +15 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 328,323 $2.42M 0.29% +158,323 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 274,458 $2.03M <0.01% +8,755 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 250,000 $1.84M 0.41% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 201,235 $1.49M <0.01% +192,129 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 200,642 $1.48M 0.01% +129,142 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 185,932 $1.37M 0.08% +23,842 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 177,220 $1.31M <0.01% +34,571 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 175,000 $1.29M 0.2% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 170,440 $1.26M <0.01% -163,202 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 151,504 $1.12M <0.01% +114,904 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 133,113 $982K 0.88% new 13F-HR/A Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 114,610 $846K <0.01% +90,775 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 111,211 $821K <0.01% +85,311 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 110,482 $815K <0.01% new 13F-HR/A Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 97,328 $718K <0.01% +88,464 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 96,615 $713K 0.23% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 96,507 $712K <0.01% +5,825 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 94,546 $698K <0.01% +1,235 13F-HR/A Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 50,110 $370K <0.01% +435 13F-HR Timeline Group Aaron Wealth Advisors LLC More: the full row for Aaron Wealth Advisors LLC 50,000 $369K 0.04% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 49,133 $363K 0.11% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 44,240 $326K <0.01% +19,667 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 40,225 $297K 0.03% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 33,833 $250K <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 32,490 $240K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 30,916 $228K <0.01% +29,430 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 28,996 $214K <0.01% new 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 28,090 $207K <0.01% +12,031 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 27,499 $203K <0.01% -18,402 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 26,034 $192K <0.01% -986 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 23,910 $176K <0.01% -4 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 20,098 $148K <0.01% new 13F-HR/A Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 19,815 $146K <0.01% new 13F-HR Timeline Koa Wealth Management, LLC More: the full row for Koa Wealth Management, LLC 19,396 $143K 0.12% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 15,168 $112K <0.01% -19,659 13F-HR/A Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 14,471 $107K <0.01% 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 13,660 $101K <0.01% new 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 12,369 $91K 0.01% new 13F-HR Timeline WEALTHEDGE INVESTMENT ADVISORS, LLC More: the full row for WEALTHEDGE INVESTMENT ADVISORS, LLC 11,864 $87.6K 0.04% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 11,818 $87.2K <0.01% -5,615 13F-HR/A Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 10,728 $79.2K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 8,762 $64.7K <0.01% +4,424 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 8,712 $64.3K <0.01% -760 13F-HR/A Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 8,006 $59.1K +4,538 Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 6,647 $49.1K <0.01% +312 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,977 $44.1K <0.01% +133 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 5,511 $40.7K <0.01% -82 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,300 $31.7K <0.01% new 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,143 $15.8K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,365 $10.1K <0.01% +562 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,177 $8.69K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,107 $8.17K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 832 $6.14K <0.01% 0 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 700 $5.17K <0.01% -1,400 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 635 $4K <0.01% -198 13F-HR/A Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 384 $3K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 330 $2.44K <0.01% new 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 137 $1K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 91 $672 <0.01% -70 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 20 $148 <0.01% new 13F-HR/A Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 9 $66 <0.01% new 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 3 $23 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.