Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 5,985,347 $68.3M 2.73% 0 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 4,002,887 $45.7M 1.15% 0 13F-HR Timeline Group NEA Management Company, LLC More: the full row for NEA Management Company, LLC 3,614,486 $41.2M 3.1% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,266,628 $25.9M <0.01% -371,893 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 2,188,592 $25M 0.8% -830,343 13F-HR Timeline NVP ASSOCIATES, LLC More: the full row for NVP ASSOCIATES, LLC 2,136,335 $24.4M 13.24% 0 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 1,571,906 $17.9M 0.14% -7,301 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,346,910 $15.4M <0.01% +245,994 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 1,294,416 $14.8M 2.56% +161,466 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,149,794 $13.1M 0.78% -109,479 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,043,684 $11.9M <0.01% +378,121 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,011,546 $11.5M <0.01% +228,504 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 973,787 $11.1M 0.03% +863,305 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 901,103 $10.3M 0.05% +23,642 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 871,933 $9.95M 1.15% +543,610 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 766,840 $8.75M 0.01% +596,400 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 700,000 $7.99M 0.59% 0 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 650,000 $7.42M 0.85% 0 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 631,413 $7.2M 0.05% +430,771 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 494,852 $5.65M <0.01% +125,537 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 377,841 $4.31M 0.07% -1,133,493 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 348,447 $3.98M <0.01% +73,989 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 265,119 $3.03M <0.01% +87,899 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 241,000 $2.75M 1.1% new 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 239,319 $2.73M 0.55% -10,681 13F-HR/A Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 191,825 $2.19M 1.45% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 171,304 $1.95M <0.01% +19,800 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 141,021 $1.61M 0.52% +44,406 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 115,594 $1.32M <0.01% +19,087 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 112,743 $1.29M 0.09% -73,189 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 107,483 $1.23M <0.01% +12,937 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 87,097 $994K <0.01% +36,987 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 70,333 $802K 0.01% +37,843 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 63,076 $720K 0.59% -70,037 13F-HR/A Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 61,333 $700K <0.01% +17,093 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 58,541 $668K <0.01% +46,723 13F-HR/A Timeline Group Aaron Wealth Advisors LLC More: the full row for Aaron Wealth Advisors LLC 50,000 $570K 0.06% 0 13F-HR Timeline Resolute Capital Asset Partners LLC More: the full row for Resolute Capital Asset Partners LLC 49,670 $567K 0.3% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 42,387 $484K <0.01% +14,297 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 38,032 $434K <0.01% +14,122 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 34,135 $389K <0.01% new 13F-HR/A Timeline Group Koa Wealth Management, LLC More: the full row for Koa Wealth Management, LLC 31,752 $362K 0.29% +12,356 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 30,967 $353K <0.01% +3,468 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 29,200 $333K 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 27,632 $315K <0.01% +13,972 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 24,008 $274K <0.01% -90,602 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 23,662 $270K <0.01% +14,950 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 22,143 $253K <0.01% +7,672 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 18,048 $206K <0.01% -7,986 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 18,001 $205K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 15,617 $178K 0.02% -24,608 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,271 $163K <0.01% +3,543 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,861 $135K 0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 11,018 $126K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 10,943 $125K <0.01% +4,966 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 10,500 $120K <0.01% new 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 9,329 $106K <0.01% +2,682 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 8,772 $100K 0.03% +766 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 8,762 $100K <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 8,184 $93.4K <0.01% -193,051 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 8,000 $91.3K 0.02% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 5,723 $65.3K <0.01% -91,605 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,300 $49.1K <0.01% 0 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,143 $24.5K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,110 $24.1K <0.01% +745 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,802 $21K <0.01% +1,665 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,592 $18.2K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,551 $17.7K <0.01% +444 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,329 $15.2K <0.01% -29,587 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,298 $15K <0.01% +663 13F-HR/A Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,177 $13.4K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,064 $12.1K <0.01% +232 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 761 $8.68K <0.01% new 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 700 $7.99K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 460 $5.25K <0.01% +369 13F-HR/A Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 411 $4K <0.01% new 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 384 $4K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 337 $3.85K <0.01% +7 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 299 $3.41K <0.01% +279 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 109 $1.24K <0.01% new 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 108 $1.23K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 101 $1.15K <0.01% new 13F-HR Timeline Rise Advisors, LLC More: the full row for Rise Advisors, LLC 68 $776 <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 35 $399 <0.01% new 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 29 $331 <0.01% +20 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 25 $286 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $228 <0.01% new 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 2 $23 <0.01% 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.