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Disclosery

DFTX DEFINIUM THERAPEUTICS INC

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COM SHS (common), issuer CIK 1813814

237 managers (246 13F filers) reported a position in DFTX shares at 2026-03-31, 78,037,597 shares in all. 232 filers opened a position and 1 filer sold out during the quarter.

Managers
237
13F filers
246
New
232
Added
2
Reduced
4
Sold out
1
Shares held by filers
78,037,597

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.8,480,230$160M<0.01%new13F-HRTimelineGroup
Driehaus Capital Management LLC5,911,889$112M0.82%-625,31313F-HRTimeline
Avoro Capital Advisors LLC5,000,000$94.5M0.93%new13F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson3,556,041$67.2M0.03%new13F-HR/ATimelineGroup
Deep Track Capital, LP3,000,000$56.7M1.17%new13F-HRTimeline
VANGUARD GROUP INCgroup of 7 filers holding2,668,136$50.4MnewTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,495,399$47.2M<0.01%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,471,873$46.7M<0.01%new13F-HRTimelineGroup
Octagon Capital Advisors LP2,440,000$46.1M5.1%new13F-HRTimeline
Commodore Capital LPin group Commodore Capital LP2,000,000$37.8M2.19%new13F-HRTimelineGroup
FMR LLCin group FMR LLC1,809,610$34.2M<0.01%new13F-HRTimelineGroup
Trails Edge Capital Partners, LP1,738,110$32.9M7.73%new13F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,675,411$31.7M<0.01%new13F-HRTimelineGroup
ArrowMark Colorado Holdings LLC1,594,717$30.1M0.8%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,333,442$25.2M0.02%new13F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,304,749$24.7M<0.01%new13F-HRTimelineGroup
Candriam S.C.A.1,293,629$24.4M0.13%new13F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management1,274,221$24.1M0.05%new13F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP1,201,610$22.7M0.02%new13F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP1,200,825$22.7M0.02%-1,774,87713F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,150,000$21.7M0.03%new13F-HRTimelineGroup
Holocene Advisors, LP1,091,967$20.6M0.05%new13F-HRTimeline
AWM Investment Company, Inc.1,076,893$20.4M2.25%-313,76913F-HRTimeline
Catalio Capital Management, LP1,037,984$19.6M4.1%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC966,608$18.3M<0.01%new13F-HR/ATimelineGroup
Siren, L.L.C.in group Siren, L.L.C.919,493$17.4M0.48%new13F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC846,896$16M0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co808,715$15.3M<0.01%new13F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC804,000$15.2M0.33%new13F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP798,987$15.1M<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp752,922$14.2M<0.01%new13F-HRTimelineGroup
Woodline Partners LP752,792$14.2M0.05%new13F-HR/ATimeline
Nuveen, LLCin group TIAA698,130$13.2M<0.01%new13F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC686,162$13M0.21%new13F-HRTimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC598,500$11.3M1.49%new13F-HRTimelineGroup
Ensign Peak Advisors, Inc546,783$10.3M0.02%+284,78313F-HR/ATimeline
Blackstone Inc.in group Blackstone Inc.508,668$9.61M0.03%new13F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
UBS Group AGgroup of 2 filers holding496,390$9.38MnewTimeline
MORGAN STANLEYin group MORGAN STANLEY438,573$8.29M<0.01%new13F-HRTimelineGroup
Qube Research & Technologies Ltd426,055$8.05M0.01%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\411,834$7.78M<0.01%new13F-HRTimelineGroup
Integral Health Asset Management, LLC400,000$7.56M0.4%new13F-HRTimeline
Tri Locum Partners LP369,588$6.99M0.98%new13F-HRTimeline
SUPERSTRING CAPITAL MANAGEMENT LP351,461$6.64M4.75%new13F-HRTimeline
Sofinnova Investments, Inc.344,166$6.5M0.33%new13F-HRTimeline
Patient Square Capital LP331,000$6.26M1.11%new13F-HRTimeline
STEMPOINT CAPITAL LP325,483$6.15M1.18%new13F-HR/ATimeline
RTW INVESTMENTS, LP300,000$5.67M0.06%new13F-HRTimeline
BIT Capital GmbH277,511$5.24M0.29%new13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.271,717$5.14M<0.01%new13F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC260,241$4.92M0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO264,545$4.63M<0.01%new13F-HR/ATimelineGroup
ROYCE & ASSOCIATES LP234,051$4.42M0.04%new13F-HRTimeline
SEVEN GRAND MANAGERS, LLC225,000$4.25M0.28%new13F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…211,488$4M0.04%new13F-HRTimelineGroup
PFM Health Sciences, LP205,317$3.88M0.41%new13F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd199,994$3.78M0.74%new13F-HRTimelineGroup
HighVista Strategies LLC185,856$3.51M0.97%new13F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.175,490$3.32M0.01%new13F-HRTimelineGroup
Eversept Partners, LP160,723$3.04M0.2%new13F-HRTimeline
Swiss National Bank158,400$2.99M<0.01%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/158,345$2.99M<0.01%new13F-HRTimelineGroup
Soviero Asset Management, LP140,000$2.65M1.49%new13F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC133,369$2.52M<0.01%new13F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC125,522$2.37M0.01%new13F-HRTimelineGroup
Rosalind Advisors, Inc.125,000$2.36M0.97%new13F-HRTimeline
RHUMBLINE ADVISERS119,972$2.27M<0.01%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…119,464$2.26M<0.01%new13F-HRTimelineGroup
ExodusPoint Capital Management, LP104,915$1.98M0.02%new13F-HRTimeline
Data Collective IV GP, LLC100,350$1.9M3.39%new13F-HRTimeline
Burkehill Global Management, LP100,000$1.89M0.09%new13F-HRTimeline
Seven Fleet Capital Management LP99,887$1.89M0.59%new13F-HR/ATimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA97,192$1.84M<0.01%new13F-HRTimelineGroup
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC92,165$1.74M0.01%new13F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.91,703$1.73M<0.01%new13F-HRTimeline
AdvisorShares Investments LLC91,301$1.73M0.31%new13F-HRTimeline
HRT FINANCIAL LP89,141$1.68M<0.01%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.88,121$1.67M<0.01%new13F-HRTimelineGroup
GROUP ONE TRADING LLC87,832$1.66M0.05%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…81,456$1.54M<0.01%new13F-HRTimelineGroup
LPL Financial LLC78,271$1.48M<0.01%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/70,001$1.32M<0.01%+17,77113F-HRTimeline
PLATINUM INVESTMENT MANAGEMENT LTD70,000$1.32M0.33%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc59,799$1.13M<0.01%new13F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC58,803$1.11M0.16%new13F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC57,094$1.08M<0.01%new13F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…55,206$1.04M<0.01%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…54,261$1.03M0.01%new13F-HRTimelineGroup
BLAIR WILLIAM & CO/IL53,695$1.01M<0.01%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding51,393$971KnewTimeline
KESTRA PRIVATE WEALTH SERVICES, LLCin group Kestra Advisory Services, LLC50,588$956K0.01%new13F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD50,420$953K<0.01%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC48,903$924K<0.01%new13F-HRTimeline
ALLSTATE CORPin group ALLSTATE CORP45,366$857K0.01%new13F-HRTimelineGroup
CenterBook Partners LP42,829$809K0.04%new13F-HRTimeline
TWINBEECH CAPITAL LP42,100$796K0.08%new13F-HRTimeline
SIMPLEX TRADING, LLC41,156$778K0.02%new13F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding40,899$773KnewTimeline
SCOTIA CAPITAL INC.40,548$766K<0.01%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN39,973$755K<0.01%new13F-HR/ATimelineGroup
Quantinno Capital Management LP39,958$755K<0.01%new13F-HRTimeline
JENNISON ASSOCIATES LLC39,957$755K<0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC39,683$750K<0.01%new13F-HRTimelineGroup
Palumbo Wealth Management LLC37,966$718K0.18%new13F-HRTimeline
CAXTON ASSOCIATES LLP37,255$704K0.02%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC34,851$659K<0.01%new13F-HRTimelineGroup
PSP Research LLC34,800$658K0.47%new13F-HRTimeline
Caption Management, LLC33,758$638K0.03%new13F-HRTimeline
Cetera Investment Advisers31,824$601K<0.01%new13F-HRTimeline
Rathbones Group PLC30,200$571K<0.01%new13F-HR/ATimeline
Engineers Gate Manager LP29,767$563K0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND29,600$559K<0.01%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO28,117$531K<0.01%new13F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…27,441$519K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…27,361$517K<0.01%new13F-HRTimeline
KINGSWOOD WEALTH ADVISORS, LLC26,591$503K0.02%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC26,486$501K<0.01%new13F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …26,404$499K<0.01%new13F-HRTimelineGroup
Bay Rivers Group26,346$498K0.21%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC24,990$472K<0.01%new13F-HRTimeline
Campbell & CO Investment Adviser LLC24,755$468K0.03%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC23,713$448K<0.01%new13F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS23,356$441K<0.01%new13F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM22,054$417K<0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…21,727$411K0.11%new13F-HRTimelineGroup
Concurrent Investment Advisors, LLCin group Concurrent Investment Advisor…21,285$402K<0.01%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…20,868$394K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…20,192$382K0.03%new13F-HRTimeline
Marex Group Ltdin group Marex Group Ltd20,000$378K<0.01%new13F-HRTimelineGroup
STRS OHIO19,300$365K<0.01%new13F-HRTimeline
ProShare Advisors LLC18,731$354K<0.01%new13F-HRTimeline
HighTower Advisors, LLC18,559$351K<0.01%new13F-HRTimeline
GSA CAPITAL PARTNERS LLP18,155$343K0.02%new13F-HRTimeline
Sequoia Financial Advisors, LLC17,245$326K<0.01%new13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC16,384$310K<0.01%new13F-HRTimelineGroup
Persistent Asset Partners Ltd15,861$300K0.12%new13F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC14,460$273K0.01%new13F-HRTimelineGroup
Heritage Wealth Management, Inc. /CA/14,375$272K0.15%new13F-HRTimeline
PROFUND ADVISORS LLC14,196$268K0.01%new13F-HRTimeline
Amundiin group Amundi14,136$267K<0.01%new13F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC14,096$266K0.01%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.14,557$255K0.04%new13F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…13,295$251K<0.01%new13F-HRTimelineGroup
Steward Partners Investment Advisory, L…13,240$250K<0.01%new13F-HRTimeline
Magnetar Financial LLCin group Magnetar Financial LLC13,178$249K<0.01%new13F-HRTimelineGroup
MONEY CONCEPTS CAPITAL CORP13,000$246K0.01%new13F-HRTimeline
Summit Trail Advisors, LLC13,000$246K<0.01%new13F-HRTimeline
Federation des caisses Desjardins du Qu…12,644$239K<0.01%new13F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP12,626$239K<0.01%new13F-HRTimelineGroup
Cinctive Capital Management LP12,551$237K0.02%new13F-HRTimeline
Twelve Points Wealth Management LLC12,245$231K0.05%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/12,136$229K<0.01%new13F-HRTimelineGroup
DIVERSIFY WEALTH MANAGEMENT, LLCin group Diversify Advisory Services, …11,000$225K<0.01%new13F-HRTimelineGroup
Sanctuary Advisors, LLC11,466$217K<0.01%new13F-HRTimeline
Chicago Partners Investment Group LLC9,307$215K<0.01%new13F-HRTimeline
RPS ADVISORY SOLUTIONS LLC11,355$215K0.12%new13F-HRTimeline
Dynamic Technology Lab Private Ltd10,880$206K0.03%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.10,559$200K<0.01%new13F-HRTimelineGroup
SG Americas Securities, LLC10,493$198K<0.01%new13F-HRTimeline
Schonfeld Strategic Advisors LLC10,412$197K<0.01%new13F-HRTimeline
Verition Fund Management LLC10,384$196K<0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS10,300$195K<0.01%new13F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC10,251$194K<0.01%new13F-HRTimeline
CIBC WORLD MARKET INC.10,049$190K<0.01%new13F-HRTimeline
King Wealth Management Group10,000$189K0.02%new13F-HRTimeline
SHARPEPOINT LLC10,000$189K0.11%new13F-HRTimeline
Swiss Life Asset Management Ltdin group Swiss Life Asset Management L…17,745$187K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…7,641$144K<0.01%new13F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…7,620$144K<0.01%new13F-HRTimelineGroup
North Star Investment Management Corp.7,571$143K0.01%new13F-HRTimeline
HOLLENCREST CAPITAL MANAGEMENT7,386$140K0.01%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…7,305$138K<0.01%new13F-HRTimelineGroup
CWM, LLCin group CWM, LLC5,600$106K<0.01%new13F-HRTimelineGroup
Caitong International Asset Management …4,036$76.3K0.01%new13F-HRTimeline
Sound Income Strategies, LLC3,690$76K<0.01%013F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…3,300$62.4K<0.01%new13F-HRTimelineGroup
Advisory Services Network, LLC2,659$50.3K<0.01%new13F-HRTimeline
Sterling Capital Management LLC2,443$46.2K<0.01%new13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.2,213$41.8K<0.01%new13F-HRTimeline
KBC Group NVin group KBC Group NV2,172$41K<0.01%new13F-HRTimelineGroup
Crewe Advisors LLC1,999$37.8K<0.01%new13F-HRTimeline
TD Waterhouse Canada Inc.1,802$37.1K<0.01%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,812$34.2K<0.01%new13F-HRTimelineGroup
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/1,708$32.3K<0.01%new13F-HRTimelineGroup
High Note Wealth, LLC1,500$28.4K0.01%new13F-HRTimeline
GAMMA Investing LLC1,111$21K<0.01%new13F-HRTimeline
Opal Wealth Advisors, LLC1,101$20.8K<0.01%new13F-HRTimeline
Stone House Investment Management, LLC1,000$18.9K<0.01%new13F-HRTimeline
Bullock Wealth Management Group907$18.7K0.01%new13F-HRTimeline
FIRST HORIZON CORP962$18.2K<0.01%new13F-HRTimeline
Kemnay Advisory Services Inc.806$15.2K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC618$11.7K<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC567$11.7K<0.01%new13F-HRTimeline
MassMutual Private Wealth & Trust, FSB568$10.7K<0.01%new13F-HRTimeline
HARBOUR INVESTMENTS, INC.556$10.5K<0.01%new13F-HRTimeline
Larson Financial Group LLC535$10.1K<0.01%new13F-HRTimeline
Arax Advisory Partners466$8.81K<0.01%new13F-HRTimeline
Private Wealth Management Group, LLC450$8.51K<0.01%new13F-HRTimeline
NVWM, LLC416$7.86K<0.01%new13F-HRTimeline
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.353$6.67K<0.01%new13F-HRTimelineGroup