13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2026-03-31, filed 2026-05-15, with 96 holding rows worth $629,683,422.
- Accession
- 0001496201-26-000003
- Filer
- CIK 1496201
- Filed
- 2026-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2026
A holdings report, 97 entries on the cover page, a total value of $629,683,422 stated on the cover page (in dollars after the unit check, H1), rows summing to $629,683,422 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 1,339,971 | $36,299,814 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,136,975 | $34,245,687 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 145,735 | $25,573,578 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 200,000 | $25,546,001 | dollars as filed | put |
| NOVA LTD COM | M7516K103 | Stock | 53,366 | $23,175,786 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 245,246 | $18,211,968 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 259,300 | $17,090,464 | dollars as filed | call |
| BIOGEN INC COM | 09062X103 | Stock | 92,526 | $16,962,792 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 809,333 | $16,955,526 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 724,563 | $16,925,792 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 416,340 | $16,024,927 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 269,515 | $12,985,233 | dollars as filed | |
| ASTRAZENECA PLC ORD | G0593M107 | ADR | 62,530 | $12,332,167 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 603,377 | $8,724,831 | dollars as filed | |
| CELLEBRITE DI LTD ORDINARY SHARES | M2197Q107 | Stock | 631,521 | $8,702,359 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 214,914 | $8,645,990 | dollars as filed | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 52,800 | $8,464,896 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 9,040 | $8,314,721 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 866,464 | $8,248,737 | dollars as filed | |
| CAMTEK LTD ORD | M20791105 | Stock | 53,020 | $8,038,362 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 139,900 | $7,902,951 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 243,575 | $7,726,199 | dollars as filed | |
| ORMAT TECHNOLOGIES INC | 686688102 | COM | 68,250 | $7,638,540 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 127,000 | $7,385,050 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 216,281 | $7,241,088 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 343,563 | $7,187,338 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 28,831 | $7,047,450 | dollars as filed | |
| Solaredge Technologies Inc Note 2.250 percent 7/0 | 83417MAE4 | Convertible | 4,000,000 | $6,909,620 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 696,105 | $6,849,673 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 574,029 | $6,848,166 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 537,628 | $6,811,747 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 227,343 | $6,786,189 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 122,000 | $6,733,180 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 31,940 | $6,652,144 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 30,256 | $6,580,377 | dollars as filed | |
| APPLIED OPTOELECTRONICS INC | 03823U102 | COM | 73,400 | $6,208,906 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 153,265 | $6,007,988 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 48,600 | $5,846,094 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 321,917 | $5,742,999 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 256,202 | $5,703,057 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 37,000 | $5,651,750 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 1,772,131 | $5,458,163 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 142,419 | $5,384,862 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 55,110 | $5,359,448 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 186,000 | $5,222,880 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 594,000 | $5,025,240 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 184,984 | $4,791,086 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 987,090 | $4,738,032 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 9,040 | $4,732,169 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 94,265 | $4,634,067 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 120,677 | $4,434,880 | dollars as filed | |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 273,192 | $4,401,123 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 114,796 | $4,376,024 | dollars as filed | |
| ZENAS BIOPHARMA INC COM | 98937L105 | Stock | 214,334 | $4,190,230 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M505 | COM SHS | 325,591 | $4,135,012 | dollars as filed | |
| ISHARES TR | 464287432 | 20 YR TR BD ETF | 47,000 | $4,074,430 | dollars as filed | call |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 408,436 | $4,063,938 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 739,164 | $4,035,835 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 548,272 | $3,974,972 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 247,961 | $3,627,669 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 1,622,828 | $3,602,678 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 53,538 | $3,423,220 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 358,000 | $3,222,000 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 567,616 | $3,116,212 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 1,733,471 | $3,033,574 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 160,594 | $2,911,569 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 419,247 | $2,871,842 | dollars as filed | |
| ZIM INTEGRATED SHIPPING SERV | M9T951109 | SHS | 105,950 | $2,791,783 | dollars as filed | |
| SATELLOS BIOSCIENCE INC | 80401L803 | COM | 489,207 | $2,754,235 | dollars as filed | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 52,836 | $2,697,278 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 7,500 | $2,638,875 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 39,817 | $2,624,338 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 50,800 | $2,448,560 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 295,522 | $2,402,594 | dollars as filed | |
| GENERATE BIOMEDICINES INC | 370920100 | COMMON STOCK | 185,000 | $2,312,500 | dollars as filed | |
| IShares Bitcoin Trust Registered | 46438F101 | SHS | 59,505 | $2,286,182 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 173,475 | $2,265,584 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 136,015 | $2,174,880 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 558,339 | $1,909,519 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 8,000 | $1,829,840 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 343,678 | $1,821,493 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 469,761 | $1,813,277 | dollars as filed | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 280,786 | $1,805,454 | dollars as filed | |
| EVOMMUNE INC | 30054Y107 | COMMON STOCK | 78,234 | $1,798,600 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 86,518 | $1,513,200 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 100,000 | $1,491,000 | dollars as filed | call |
| ORGANOGENESIS HOLDINGS INC | 68621F102 | COMMON STOCK | 550,000 | $1,303,500 | dollars as filed | |
| CURIS INC | 231269309 | COM | 1,994,937 | $1,091,829 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 17,500 | $1,061,375 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 220,000 | $1,034,000 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 5,611 | $618,669 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $521,882 | dollars as filed | |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 678,928 | $417,269 | dollars as filed | |
| PRECISION BIOSCIENCES INC | 74019P207 | COM NEW | 40,000 | $220,000 | dollars as filed | |
| APREA THERAPEUTICS INC | 03836J201 | COM NEW | 270,000 | $205,983 | dollars as filed | |
| FOGHORN THERAPEUTICS INC | 344174107 | COMMON STOCK | 12,224 | $58,431 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-26-000003 | this filing | 2026-05-15 | acceptance time not in the bulk data set |