DIADEMA PARTNERS LP
Follow13F filer, CIK 2026172, MORRISTOWN, NJ
DIADEMA PARTNERS LP reported $580,539,432 across 145 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 51.15% of the portfolio.
Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001892688-26-000036
- Period
- 2025-12-31
- Reported value
- $581M
- Holdings
- 145
- Top 10 weight
- 51.15%
- New
- 71
- Sold out
- 56
Largest buys vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| JNJnew | +66,444 | $13.8M |
| BBIOnew | +70,000 | $5.35M |
| VKTXadded | +143,160 | $5.04M |
| UTHRnew | +10,000 | $4.87M |
| ABVXadded | +34,024 | $4.59M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Largest sells vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| REGNreduced | -19,860 | -$15.3M |
| PCVXreduced | -195,313 | -$9.01M |
| INDIVIOR PLCreduced | -236,932 | -$8.5M |
| SLNOreduced | -150,438 | -$6.97M |
| BMYexited | -130,000 | -$5.86M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Holdings, Q4 2025
Share positions as resolved from 13F-HR 0001892688-26-000036, largest first. % of portfolio is the value over $167,913,829, the sum of the share positions whose value is usable for ratios (method).
| Security | History | Shares | Value | % of portfolio | Change | Latest event | Timeline |
|---|---|---|---|---|---|---|---|
| TERNTERNS PHARMACEUTICALS INC | 345,880 | $14M | 8.32% | +22,721 | Timeline | ||
| JNJJOHNSON & JOHNSON | 66,444 | $13.8M | 8.19% | new | Timeline | ||
| VKTXVIKING THERAPEUTICS INC | 336,849 | $11.9M | 7.06% | +143,160 | Timeline | ||
| ABVXABIVAX SA | 75,644 | $10.2M | 6.08% | +34,024 | Timeline | ||
| BMRNBIOMARIN PHARMACEUTICAL INC | 146,361 | $8.7M | 5.18% | -66,516 | Timeline | ||
| REGNREGENERON PHARMACEUTICALS | 10,300 | $7.95M | 4.73% | -19,860 | Timeline | ||
| BBIOBRIDGEBIO PHARMA INC | 70,000 | $5.35M | 3.19% | new | Timeline | ||
| UTHRUNITED THERAPEUTICS CORP DEL | 10,000 | $4.87M | 2.9% | new | Timeline | ||
| COGTCOGENT BIOSCIENCES INC | 131,852 | $4.68M | 2.79% | +34,039 | Timeline | ||
| CAPRCAPRICOR THERAPEUTICS INC | 158,075 | $4.56M | 2.72% | new | Timeline | ||
| VRTXVERTEX PHARMACEUTICALS INC | 10,000 | $4.53M | 2.7% | new | Timeline | ||
| ANIPANI PHARMACEUTICALS INC | 53,354 | $4.21M | 2.51% | +21,954 | Timeline | ||
| TGTXTG THERAPEUTICS INC | 123,283 | $3.68M | 2.19% | +62,535 | Timeline | ||
| BIOABIOAGE LABS INC | 271,164 | $3.59M | 2.14% | new | Timeline | ||
| CORTCORCEPT THERAPEUTICS INC | 97,445 | $3.39M | 2.02% | new | Timeline | ||
| TENXTENAX THERAPEUTICS INC | 243,170 | $2.96M | 1.77% | new | Timeline | ||
| RVMDREVOLUTION MEDICINES INC | 37,020 | $2.95M | 1.76% | -22,059 | Timeline | ||
| IMCRIMMUNOCORE HLDGS PLC | 70,300 | $2.44M | 1.45% | -54,084 | Timeline | ||
| IRWDIRONWOOD PHARMACEUTICALS INC | 683,611 | $2.3M | 1.37% | new | Timeline | ||
| CNTACENTESSA PHARMACEUTICALS PLC | 90,000 | $2.25M | 1.34% | new | Timeline | ||
| REPLREPLIMUNE GROUP INC | 230,997 | $2.25M | 1.34% | new | Timeline | ||
| LLYELI LILLY & CO | 2,000 | $2.15M | 1.28% | new | Timeline | ||
| ALNYALNYLAM PHARMACEUTICALS INC | 5,341 | $2.12M | 1.26% | -4,659 | Timeline | ||
| LPCNLIPOCINE INC NEW | 260,939 | $2.1M | 1.25% | new | Timeline | ||
| PTGXPROTAGONIST THERAPEUTICS INC | 22,700 | $1.98M | 1.18% | -28,485 | Timeline | ||
| RLMDRELMADA THERAPEUTICS INC | 389,395 | $1.88M | 1.12% | new | Timeline | ||
| VTYXVENTYX BIOSCIENCES INC | 200,000 | $1.81M | 1.08% | +128,796 | Timeline | ||
| ANNXANNEXON INC | 350,000 | $1.76M | 1.05% | new | Timeline | ||
| MNKDMANNKIND CORP | 302,000 | $1.71M | 1.02% | +89,525 | Timeline | ||
| IVAINVENTIVA SA | 334,251 | $1.55M | 0.93% | new | Timeline | ||
| BCRXBIOCRYST PHARMACEUTICALS INC | 190,928 | $1.49M | 0.89% | new | Timeline | ||
| ARDXARDELYX INC | 252,198 | $1.47M | 0.88% | -147,802 | Timeline | ||
| ASNDASCENDIS PHARMA A/S | 6,840 | $1.46M | 0.87% | -20,732 | Timeline | ||
| XERSXERIS BIOPHARMA HOLDINGS INC | 170,568 | $1.34M | 0.8% | +95,815 | Timeline | ||
| RIGLRIGEL PHARMACEUTICALS INC | 30,000 | $1.28M | 0.77% | new | Timeline | ||
| SLNOSOLENO THERAPEUTICS INC | 26,892 | $1.25M | 0.74% | -150,438 | Timeline | ||
| PCRXPACIRA BIOSCIENCES INC | 48,025 | $1.24M | 0.74% | -10,901 | Timeline | ||
| TRVITREVI THERAPEUTICS INC | 97,184 | $1.22M | 0.72% | +11,354 | Timeline | ||
| MPLTMAPLIGHT THERAPEUTICS INC | 63,791 | $1.12M | 0.67% | new | Timeline | ||
| QUREUNIQURE NV | 45,000 | $1.08M | 0.64% | new | Timeline | ||
| PCVXVAXCYTE INC | 22,972 | $1.06M | 0.63% | -195,313 | Timeline | ||
| ENTAENANTA PHARMACEUTICALS INC | 65,138 | $1.03M | 0.61% | new | Timeline | ||
| PRTAPROTHENA CORP PLC | 106,539 | $1.02M | 0.61% | new | Timeline | ||
| GLUEMONTE ROSA THERAPEUTICS INC | 62,281 | $977K | 0.58% | new | Timeline | ||
| DSGNDESIGN THERAPEUTICS INC | 100,320 | $941K | 0.56% | new | Timeline | ||
| INOINOVIO PHARMACEUTICALS INC | 533,682 | $929K | 0.55% | new | Timeline | ||
| MLYSMINERALYS THERAPEUTICS INC | 25,000 | $907K | 0.54% | new | Timeline | ||
| AYTUAYTU BIOPHARMA INC | 305,788 | $795K | 0.47% | +33,118 | Timeline | ||
| PTHSPELTHOS THERAPEUTICS INC | 25,000 | $775K | 0.46% | +14,502 | Timeline | ||
| LQDALIQUIDIA CORPORATION | 21,881 | $755K | 0.45% | new | Timeline | ||
| EWTXEDGEWISE THERAPEUTICS INC | 30,000 | $744K | 0.44% | new | Timeline | ||
| VRDNVIRIDIAN THERAPEUTICS INC | 21,114 | $657K | 0.39% | new | Timeline | ||
| INDIVIOR PLCINDIVIOR PLC | 17,320 | $621K | 0.37% | -236,932 | |||
| VIRVIR BIOTECHNOLOGY INC | 100,000 | $603K | 0.36% | new | Timeline | ||
| LGNDLIGAND PHARMACEUTICALS INC | 2,987 | $565K | 0.34% | new | Timeline | ||
| UPBUPSTREAM BIO INC | 20,500 | $557K | 0.33% | new | Timeline | ||
| STOKSTOKE THERAPEUTICS INC | 17,181 | $545K | 0.32% | new | Timeline | ||
| EQEQUILLIUM INC | 347,393 | $538K | 0.32% | +47,393 | Timeline | ||
| URGNUROGEN PHARMA LTD | 21,810 | $511K | 0.3% | -68,190 | Timeline | ||
| IMNMIMMUNOME INC | 22,500 | $483K | 0.29% | new | Timeline | ||
| PALIPALISADE BIO INC | 166,049 | $390K | 0.23% | new | Timeline | ||
| PRQRPROQR THRAPEUTICS N V | 167,532 | $338K | 0.2% | +9,838 | Timeline | ||
| HRMYHARMONY BIOSCIENCES HLDGS IN | 7,500 | $281K | 0.17% | -42,500 | Timeline | ||
| AARDAARDVARK THERAPEUTICS INC | 15,882 | $208K | 0.12% | new | Timeline | ||
| NEUPNEUPHORIA THERAPEUTICS INC | 50,000 | $194K | 0.12% | +28,548 | Timeline | ||
| PLRXPLIANT THERAPEUTICS INC | 144,914 | $177K | 0.11% | new | Timeline | ||
| ONCBEONE MEDICINES LTD | 7,500 | $173K | 0.1% | new | Timeline | ||
| FHTXFOGHORN THERAPEUTICS INC | 30,630 | $165K | 0.1% | -19,370 | Timeline | ||
| TLPHTALPHERA INC | 136,923 | $156K | 0.09% | new | Timeline | ||
| PRTCYPURETECH HEALTH PLC | 7,442 | $124K | 0.07% | +118 | Timeline | ||
| INBXINHIBRX BIOSCIENCES INC | 1,299 | $103K | 0.06% | new | Timeline | ||
| EDSAEDESA BIOTECH INC | 54,025 | $76.7K | 0.05% | new | Timeline | ||
| VTGNVISTAGEN THERAPEUTICS INC | 100,000 | $66.2K | 0.04% | -249,789 | Timeline |
Options
Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).
| Security | Type | Amount | Value | Change |
|---|---|---|---|---|
| VRTXVERTEX PHARMACEUTICALS INC COM | call | 88,300 | $40M | new |
| XBISPDR SERIES TRUST S&P BIOTECH | put | 250,000 | $30.5M | new |
| PRAXPRAXIS PRECISION MEDICINES I COM NEW | put | 100,600 | $29.7M | +600 |
| VKTXVIKING THERAPEUTICS INC COM | call | 688,900 | $24.2M | +283,800 |
| RNAMAVIDITY BIOSCIENCES INC Stock | call | 328,000 | $23.7M | +127,900 |
| QQQINVESCO QQQ TR COM | put | 30,000 | $18.4M | new |
| JAZZJAZZ PHARMACEUTICALS PLC Stock | call | 105,300 | $17.9M | +5,300 |
| APGEAPOGEE THERAPEUTICS INC Stock | call | 211,100 | $15.9M | +83,700 |
| BBIOBRIDGEBIO PHARMA INC COM | put | 200,000 | $15.3M | new |
| GPCRSTRUCTURE THERAPEUTICS INC EQUITY | call | 191,700 | $13.3M | new |
| VKTXVIKING THERAPEUTICS INC COM | put | 316,700 | $11.1M | new |
| BBIOBRIDGEBIO PHARMA INC COM | call | 139,600 | $10.7M | +8,200 |
| JNJJOHNSON & JOHNSON COM | call | 50,000 | $10.3M | new |
| INCYINCYTE CORP Stock | put | 100,000 | $9.88M | new |
| INSMINSMED INC Stock | call | 52,800 | $9.19M | new |
| CAPRCAPRICOR THERAPEUTICS INC COMMON STOCK | call | 312,300 | $9.01M | +12,300 |
| IONSIONIS PHARMACEUTICALS INC Stock | call | 106,200 | $8.4M | +6,200 |
| INDIVIOR PLCINDIVIOR PLC Common Stock | call | 220,300 | $7.9M | new |
| QUREUNIQURE NV SHS | put | 301,800 | $7.22M | +1,800 |
| ROIVROIVANT SCIENCES LTD SHS | put | 318,700 | $6.92M | +18,700 |
| OCULOCULAR THERAPEUTIX INC COM | call | 545,200 | $6.62M | +408,500 |
| ZYMEZYMEWORKS INC COM | call | 240,600 | $6.33M | +44,100 |
| CRSPCRISPR THERAPEUTICS AG Stock | call | 112,700 | $5.91M | +700 |
| CAPRCAPRICOR THERAPEUTICS INC COMMON STOCK | put | 200,000 | $5.77M | new |
| CORTCORCEPT THERAPEUTICS INC COM | put | 134,800 | $4.69M | +108,300 |
| REGNREGENERON PHARMACEUTICALS Stock | call | 5,000 | $3.86M | new |
| MNKDMANNKIND CORP Stock | call | 552,300 | $3.13M | -487,200 |
| RXRXRECURSION PHARMACEUTICALS IN CL A | call | 741,900 | $3.03M | +43,500 |
| TGTXTG THERAPEUTICS INC Stock | put | 100,000 | $2.98M | new |
| NTLAINTELLIA THERAPEUTICS INC COM | put | 316,900 | $2.85M | new |
| GOSSGOSSAMER BIO INC Stock | call | 877,100 | $2.72M | +52,300 |
| NVONOVO-NORDISK A S ADR | put | 53,100 | $2.7M | -46,900 |
| ABUSARBUTUS BIOPHARMA CORP Common Shares, without par value | call | 548,600 | $2.64M | +32,300 |
| TERNTERNS PHARMACEUTICALS INC Stock | call | 64,700 | $2.61M | -160,500 |
| SLNOSOLENO THERAPEUTICS INC COM | call | 53,100 | $2.46M | +3,100 |
| OLMAOLEMA PHARMACEUTICALS INC COM | call | 96,100 | $2.4M | +5,600 |
| RAREULTRAGENYX PHARMACEUTICAL IN COM | call | 100,000 | $2.3M | -50,000 |
| BHVNBIOHAVEN LTD COM | call | 200,000 | $2.26M | new |
| AQSTAQUESTIVE THERAPEUTICS INC Stock | put | 337,700 | $2.18M | new |
| TECXTECTONIC THERAPEUTIC INC COMMON STOCK | call | 100,600 | $2.1M | +600 |
| TVTXTRAVERE THERAPEUTICS INC COM | put | 50,300 | $1.92M | +50,000 |
| NTLAINTELLIA THERAPEUTICS INC COM | call | 212,400 | $1.91M | -257,800 |
| CRMDCORMEDIX INC Stock | put | 159,000 | $1.85M | +59,000 |
| ALTALTIMMUNE INC COM NEW | call | 491,800 | $1.78M | +28,800 |
| VNDAVANDA PHARMACEUTICALS INC COM | call | 200,000 | $1.76M | new |
| SLSSELLAS LIFE SCIENCES GROUP I COM NEW | call | 424,900 | $1.6M | +24,900 |
| ANNXANNEXON INC COM | call | 309,100 | $1.55M | new |
| LEGNLEGEND BIOTECH CORP SPONSORED ADS | call | 69,000 | $1.5M | new |
| AQSTAQUESTIVE THERAPEUTICS INC Stock | call | 211,100 | $1.36M | new |
| MREOMEREO BIOPHARMA GROUP PLC CMN | call | 1,999,500 | $833K | +479,300 |
| KODKODIAK SCIENCES INC COM | call | 29,600 | $828K | +1,800 |
| EOLSEVOLUS INC COM | call | 118,800 | $790K | new |
| EDITEDITAS MEDICINE INC COM | call | 318,700 | $653K | +18,700 |
| MLTXMOONLAKE IMMUNOTHERAPEUTICS Stock | call | 47,200 | $622K | +21,100 |
| ZYMEZYMEWORKS INC COM | put | 21,400 | $563K | new |
| VIRVIR BIOTECHNOLOGY INC COM | call | 89,200 | $538K | new |
| CNTACENTESSA PHARMACEUTICALS PLC SPONSORED ADS | call | 21,100 | $528K | new |
| AVXLANAVEX LIFE SCIENCES CORP COM NEW | call | 140,600 | $501K | +800 |
| BDTXBLACK DIAMOND THERAPEUTICS I COM | call | 190,400 | $463K | new |
| JANXJANUX THERAPEUTICS INC COM | call | 30,000 | $414K | new |
| CRVSCORVUS PHARMACEUTICALS INC COM | put | 53,100 | $409K | +3,100 |
| BIOABIOAGE LABS INC Stock | call | 22,600 | $299K | new |
| PBYIPUMA BIOTECHNOLOGY INC COMMON STOCK | call | 33,800 | $201K | -102,100 |
| INOINOVIO PHARMACEUTICALS INC COMMON STOCK | call | 100,000 | $174K | new |
| Reviva Pharmaceuticals Hold…Reviva Pharmaceuticals Holdings I… Common Stock | call | 500,000 | $140K | new |
| LYELLYELL IMMUNOPHARMA INC Stock | put | 3,800 | $117K | new |
| VTGNVISTAGEN THERAPEUTICS INC COM | call | 106,500 | $70.5K | +6,300 |
| FLNAFILANA THERAPEUTICS INC CMN | put | 10,600 | $21K | +700 |
| ATYRATYR PHARMA INC COM NEW | call | 15,500 | $12.1K | -113,200 |
| ATYRATYR PHARMA INC COM NEW | put | 11,800 | $9.24K | -64,400 |
| JBIOJADE BIOSCIENCES INC COM NEW | put | 1,046 | $2.97K | 0 |
| Applied Therapeutics IncApplied Therapeutics Inc Common Stock | call | 20,200 | $2.02K | +1,200 |
Sold out in Q4 2025
Positions in the previous quarter's report that this quarter's report no longer lists.
| Security | Shares before | Value before | Type |
|---|---|---|---|
| SPYSTATE STR SPDR S&P 500 ETF T | 20,000 | $13.3M | put |
| AGIOAGIOS PHARMACEUTICALS INC | 222,100 | $8.92M | call |
| INCYINCYTE CORP | 100,000 | $8.48M | call |
| BMYBRISTOL-MYERS SQUIBB CO | 180,000 | $8.12M | call |
| LLYELI LILLY & CO | 10,000 | $7.63M | put |
| SLNOSOLENO THERAPEUTICS INC | 100,000 | $6.76M | put |
| JAZZJAZZ PHARMACEUTICALS PLC | 50,000 | $6.59M | put |
| BMYBRISTOL-MYERS SQUIBB CO | 130,000 | $5.86M | shares |
| NBIXNEUROCRINE BIOSCIENCES INC | 37,754 | $5.3M | shares |
| NKTRNEKTAR THERAPEUTICS | 75,000 | $4.27M | shares |
| HRMYHARMONY BIOSCIENCES HLDGS IN | 150,000 | $4.13M | call |
| UPBUPSTREAM BIO INC | 200,000 | $3.76M | call |
| SRRKSCHOLAR ROCK HLDG CORP | 100,000 | $3.72M | call |
| RAREULTRAGENYX PHARMACEUTICAL IN | 123,300 | $3.71M | put |
| JAZZJAZZ PHARMACEUTICALS PLC | 23,140 | $3.05M | shares |
| COGTCOGENT BIOSCIENCES INC | 200,000 | $2.87M | call |
| ARCTARCTURUS THERAPEUTICS HLDGS | 150,900 | $2.78M | put |
| MRNAMODERNA INC | 102,100 | $2.64M | call |
| SCPHARMACEUTICALS INCSCPHARMACEUTICALS INC | 462,000 | $2.62M | call |
| MRNAMODERNA INC | 100,000 | $2.58M | put |
| REPLREPLIMUNE GROUP INC | 612,300 | $2.57M | call |
| APGEAPOGEE THERAPEUTICS INC | 64,250 | $2.55M | shares |
| ALKSALKERMES PLC | 72,079 | $2.16M | shares |
| ACADACADIA PHARMACEUTICALS INC | 89,000 | $1.9M | call |
| ROIVROIVANT SCIENCES LTD | 120,000 | $1.82M | shares |
| MBXMBX BIOSCIENCES INC | 100,000 | $1.75M | call |
| SMMTSUMMIT THERAPEUTICS INC | 74,700 | $1.54M | call |
| NVAXNOVAVAX INC | 173,500 | $1.5M | call |
| NVONOVO-NORDISK A S | 25,000 | $1.39M | shares |
| HRMYHARMONY BIOSCIENCES HLDGS IN | 50,100 | $1.38M | put |
| AMLXAMYLYX PHARMACEUTICALS INC | 100,000 | $1.36M | shares |
| RNAMAVIDITY BIOSCIENCES INC | 30,000 | $1.31M | shares |
| MIND MEDICINE MINDMED INCMIND MEDICINE MINDMED INC | 105,891 | $1.25M | shares |
| SKYESKYE BIOSCIENCE INC | 300,000 | $1.18M | call |
| SUPNSUPERNUS PHARMACEUTICALS | 22,348 | $1.07M | shares |
| FOLDAMICUS THERAPEUTIC | 131,400 | $1.04M | call |
| CPRXCATALYST PHARMACEUTICALS INC | 50,000 | $985K | shares |
| Reviva Pharmaceuticals Hold…Reviva Pharmaceuticals Holdings I… | 2,506,921 | $924K | shares |
| ARCTARCTURUS THERAPEUTICS HLDGS | 48,811 | $900K | shares |
| CTMXCYTOMX THERAPEUTICS INC. | 185,286 | $591K | shares |
| MRNAMODERNA INC | 20,000 | $517K | shares |
| TNYATENAYA THERAPEUTICS INC | 315,519 | $511K | shares |
| ALECALECTOR INC | 136,023 | $403K | shares |
| PYXSPYXIS ONCOLOGY INC | 150,000 | $333K | shares |
| CCCCC4 THERAPEUTICS INC | 140,700 | $312K | call |
| RAREULTRAGENYX PHARMACEUTICAL IN | 9,189 | $276K | shares |
| CLYMCLIMB BIO INC | 136,488 | $274K | shares |
| OVIDOVID THERAPEUTICS INC | 187,739 | $244K | shares |
| RLAYRELAY THERAPEUTICS INC | 43,616 | $228K | shares |
| RCELAVITA MEDICAL INC | 25,100 | $128K | call |
| ANABANAPTYSBIO INC | 3,295 | $101K | shares |
| TVRDTVARDI THERAPEUTICS INC | 2,185 | $85.1K | shares |
| MREOMEREO BIOPHARMA GROUP PLC | 39,400 | $81.2K | put |
| KODKODIAK SCIENCES INC | 1,100 | $18K | put |
| PMVPPMV PHARMACEUTICALS INC | 11,300 | $15.8K | shares |
| AUPHAURINIA PHARMACEUTICALS INC | 700 | $7.74K | put |
How Q4 2025 was built
Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).
| Filing | Role | Amendment | Filed | Accepted | Ingested |
|---|---|---|---|---|---|
| 13F-HR 0001892688-26-000036 | base | 2026-02-17 | acceptance time not in the bulk data set |