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BAKER BROS. ADVISORS LP

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13F filer, CIK 1263508, NEW YORK, NY

BAKER BROS. ADVISORS LP reported $17,415,689,929 across 84 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 73.49% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-26-062547

Period
2026-03-31
Reported value
$17.4B
Holdings
84
Top 10 weight
73.49%
New
8
Sold out
10

Part of the filer group BAKER BROS. ADVISORS LP

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
PRAXadded+626,710$202M
INSMadded+828,365$135M
GRALadded+1,943,281$100M
CELCUITY INCnew+30,750,000$74.9M
MIRMnew+445,975$41.2M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
RAREexited-2,772,692-$63.8M
IMCRreduced-1,588,259-$47.9M
TERNexited-950,000-$38.4M
BNTXreduced-249,180-$22.1M
BCRXexited-2,822,727-$22M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001104659-26-062547, largest first. % of portfolio is the value over $17,415,689,929, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
INCYINCYTE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 30,739,020 shares; 2024Q4: 30,739,466 shares; 2025Q1: 30,739,953 shares; 2025Q2: 30,743,275 shares; 2025Q3: 30,743,663 shares; 2025Q4: 30,743,991 shares; 2026Q1: 30,744,412 shares 30,744,412$2.89B16.62%+421Timeline
ONCBEONE MEDICINES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 10,568,897 shares; 2024Q4: 9,531,880 shares; 2025Q1: 8,799,053 shares; 2025Q2: 8,799,053 shares; 2025Q3: 8,799,053 shares; 2025Q4: 8,799,053 shares; 2026Q1: 8,799,053 shares 8,799,053$2.61B15%0Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,415,918 shares; 2024Q4: 5,006,863 shares; 2025Q1: 5,380,626 shares; 2025Q2: 7,712,900 shares; 2025Q3: 6,703,484 shares; 2025Q4: 6,592,746 shares; 2026Q1: 7,421,111 shares 7,421,111$1.21B6.97%+828,365Timeline
MDGLMADRIGAL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,974,590 shares; 2024Q4: 1,974,590 shares; 2025Q1: 1,974,590 shares; 2025Q2: 1,976,018 shares; 2025Q3: 2,141,701 shares; 2025Q4: 2,141,701 shares; 2026Q1: 2,141,701 shares 2,141,701$1.12B6.44%0Timeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 42,877,916 shares; 2024Q4: 42,877,916 shares; 2025Q1: 42,877,916 shares; 2025Q2: 42,896,690 shares; 2025Q3: 42,896,690 shares; 2025Q4: 42,896,690 shares; 2026Q1: 42,896,690 shares 42,896,690$955M5.48%0Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 7,569,090 shares; 2024Q4: 7,936,972 shares; 2025Q1: 7,936,972 shares; 2025Q2: 9,364,972 shares; 2025Q3: 9,455,357 shares; 2025Q4: 9,455,357 shares; 2026Q1: 9,555,357 shares 9,555,357$929M5.34%+100,000Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,874,978 shares; 2024Q4: 2,678,553 shares; 2025Q1: 4,257,735 shares; 2025Q2: 5,450,445 shares; 2025Q3: 7,915,792 shares; 2025Q4: 7,915,792 shares; 2026Q1: 7,915,792 shares 7,915,792$904M5.19%0Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 17,310,490 shares; 2024Q4: 17,310,490 shares; 2025Q1: 17,310,490 shares; 2025Q2: 17,310,490 shares; 2025Q3: 17,310,490 shares; 2025Q4: 19,919,186 shares; 2026Q1: 19,919,186 shares 19,919,186$759M4.36%02026-09-28, 13D/A: 22,049,297 shares, 35% of the class, 13D/A filed 2026-09-30 Timeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,995,929 shares; 2024Q4: 5,995,929 shares; 2025Q1: 5,995,929 shares; 2025Q2: 6,651,429 shares; 2025Q3: 6,651,429 shares; 2025Q4: 8,657,242 shares; 2026Q1: 8,657,242 shares 8,657,242$721M4.14%0Timeline
SMMTSUMMIT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 24,424,865 shares; 2024Q4: 24,424,865 shares; 2025Q1: 24,424,865 shares; 2025Q2: 33,722,974 shares; 2025Q3: 33,722,974 shares; 2025Q4: 36,391,063 shares; 2026Q1: 36,391,063 shares 36,391,063$690M3.96%0Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 323,105 shares; 2024Q4: 331,533 shares; 2025Q1: 331,533 shares; 2025Q2: 689,488 shares; 2025Q3: 689,488 shares; 2025Q4: 1,126,488 shares; 2026Q1: 1,753,198 shares 1,753,198$565M3.24%+626,710Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,398,366 shares; 2024Q4: 6,084,249 shares; 2025Q1: 5,604,483 shares; 2025Q2: 5,604,483 shares; 2025Q3: 5,604,483 shares; 2025Q4: 5,604,483 shares; 2026Q1: 5,604,483 shares 5,604,483$487M2.8%0Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,181,751 shares; 2024Q4: 4,181,751 shares; 2025Q1: 4,483,285 shares; 2025Q2: 6,410,603 shares; 2025Q3: 8,091,351 shares; 2025Q4: 10,012,267 shares; 2026Q1: 10,012,267 shares 10,012,267$354M2.03%0Timeline
GRALGRAIL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,630,125 shares; 2025Q1: 1,630,125 shares; 2025Q2: 1,630,125 shares; 2025Q3: 1,630,125 shares; 2025Q4: 2,085,333 shares; 2026Q1: 4,028,614 shares 4,028,614$208M1.2%+1,943,281Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,840,059 shares; 2024Q4: 6,155,940 shares; 2025Q1: 6,155,940 shares; 2025Q2: 7,305,940 shares; 2025Q3: 7,305,940 shares; 2025Q4: 6,575,940 shares; 2026Q1: 6,575,940 shares 6,575,940$207M1.19%0Timeline
IONSIONIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 223,470 shares; 2024Q4: 357,915 shares; 2025Q1: 357,915 shares; 2025Q2: not reported; 2025Q3: 566,798 shares; 2025Q4: 1,791,841 shares; 2026Q1: 2,047,727 shares 2,047,727$154M0.88%+255,886Timeline
KNSAKINIKSA PHARMACEUTICALS INTLQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,818,323 shares; 2024Q4: 2,818,323 shares; 2025Q1: 2,818,323 shares; 2025Q2: 2,824,669 shares; 2025Q3: 2,824,669 shares; 2025Q4: 2,826,246 shares; 2026Q1: 2,826,246 shares 2,826,246$136M0.78%0Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,225,410 shares; 2024Q4: 1,707,881 shares; 2025Q1: 5,457,881 shares; 2025Q2: 5,457,881 shares; 2025Q3: 5,457,881 shares; 2025Q4: 5,457,881 shares; 2026Q1: 5,457,881 shares 5,457,881$136M0.78%0Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,798,716 shares; 2024Q4: 3,767,773 shares; 2025Q1: 3,767,773 shares; 2025Q2: 3,767,773 shares; 2025Q3: 3,767,773 shares; 2025Q4: 5,555,017 shares; 2026Q1: 4,867,723 shares 4,867,723$135M0.77%-687,294Timeline
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,062,123 shares; 2024Q4: 1,062,123 shares; 2025Q1: 1,062,123 shares; 2025Q2: 2,118,728 shares; 2025Q3: 3,275,444 shares; 2025Q4: 3,618,826 shares; 2026Q1: 3,946,515 shares 3,946,515$131M0.76%+327,689Timeline
ARWRARROWHEAD PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 939,174 shares; 2025Q3: 1,670,762 shares; 2025Q4: 2,175,645 shares; 2026Q1: 1,992,783 shares 1,992,783$125M0.72%-182,862Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,368,443 shares; 2024Q4: 4,633,838 shares; 2025Q1: 4,633,838 shares; 2025Q2: 4,633,838 shares; 2025Q3: 4,633,838 shares; 2025Q4: 3,336,697 shares; 2026Q1: 3,336,697 shares 3,336,697$109M0.62%0Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,443,398 shares; 2024Q4: 7,275,830 shares; 2025Q1: 7,275,830 shares; 2025Q2: 10,168,901 shares; 2025Q3: 12,094,094 shares; 2025Q4: 12,094,094 shares; 2026Q1: 10,916,693 shares 10,916,693$107M0.62%-1,177,401Timeline
ABCLABCELLERA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 27,525,640 shares; 2024Q4: 27,525,640 shares; 2025Q1: 27,525,640 shares; 2025Q2: 27,525,640 shares; 2025Q3: 27,525,640 shares; 2025Q4: 27,525,640 shares; 2026Q1: 30,275,938 shares 30,275,938$106M0.61%+2,750,298Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 875,796 shares; 2025Q4: 875,796 shares; 2026Q1: 875,796 shares 875,796$97.5M0.56%0Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 103,927 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 280,000 shares; 2025Q3: 280,000 shares; 2025Q4: 1,648,869 shares; 2026Q1: 2,351,465 shares 2,351,465$85.4M0.49%+702,596Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 11,045,336 shares; 2024Q4: 11,045,336 shares; 2025Q1: 11,045,336 shares; 2025Q2: 11,045,336 shares; 2025Q3: 11,045,336 shares; 2025Q4: 11,045,336 shares; 2026Q1: 11,045,336 shares 11,045,336$84.5M0.49%0Timeline
CELCUITY INCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 30,750,000 shares 30,750,000$74.9M0.43%new
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,882,125 shares; 2024Q4: 3,882,125 shares; 2025Q1: 3,882,125 shares; 2025Q2: 3,882,125 shares; 2025Q3: 3,882,125 shares; 2025Q4: 4,658,556 shares; 2026Q1: 4,658,556 shares 4,658,556$72.2M0.41%0Timeline
DNLIDENALI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,731,695 shares; 2024Q4: 3,731,695 shares; 2025Q1: 3,731,695 shares; 2025Q2: 3,731,695 shares; 2025Q3: 3,731,695 shares; 2025Q4: 3,731,695 shares; 2026Q1: 3,731,695 shares 3,731,695$71.6M0.41%0Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 789,759 shares; 2025Q3: 789,759 shares; 2025Q4: 789,759 shares; 2026Q1: 852,164 shares 852,164$71.5M0.41%+62,405Timeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,916,095 shares; 2024Q4: 4,916,095 shares; 2025Q1: 4,916,095 shares; 2025Q2: 4,916,095 shares; 2025Q3: 4,916,095 shares; 2025Q4: 4,345,736 shares; 2026Q1: 4,345,736 shares 4,345,736$71.5M0.41%0Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 85,500 shares; 2024Q4: 361,565 shares; 2025Q1: 361,565 shares; 2025Q2: 2,508,767 shares; 2025Q3: 1,556,109 shares; 2025Q4: 1,432,529 shares; 2026Q1: 1,432,529 shares 1,432,529$69M0.4%0Timeline
TRDAENTRADA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,865,819 shares; 2024Q4: 4,865,819 shares; 2025Q1: 4,865,819 shares; 2025Q2: 4,865,819 shares; 2025Q3: 4,865,819 shares; 2025Q4: 5,072,730 shares; 2026Q1: 5,072,730 shares 5,072,730$64M0.37%0Timeline
BCYCBICYCLE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 9,399,960 shares; 2024Q4: 10,885,357 shares; 2025Q1: 10,885,357 shares; 2025Q2: 10,885,357 shares; 2025Q3: 10,885,357 shares; 2025Q4: 10,885,357 shares; 2026Q1: 10,885,357 shares 10,885,357$50.5M0.29%0Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 626,703 shares; 2025Q3: 1,000,000 shares; 2025Q4: 1,000,000 shares; 2026Q1: 1,000,000 shares 1,000,000$50.4M0.29%0Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 550,090 shares; 2025Q3: 1,547,090 shares; 2025Q4: 1,547,090 shares; 2026Q1: 1,547,090 shares 1,547,090$48.4M0.28%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,562,500 shares; 2024Q4: 1,562,500 shares; 2025Q1: 1,562,500 shares; 2025Q2: 1,562,500 shares; 2025Q3: 1,562,500 shares; 2025Q4: 1,562,500 shares; 2026Q1: 2,012,500 shares 2,012,500$44.3M0.25%+450,000Timeline
MIRMMIRUM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 190,476 shares; 2024Q4: 190,476 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 445,975 shares 445,975$41.2M0.24%newTimeline
VRDNVIRIDIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,744,406 shares; 2025Q3: 1,744,406 shares; 2025Q4: 1,971,678 shares; 2026Q1: 1,971,678 shares 1,971,678$38.6M0.22%0Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 114,833 shares; 2024Q4: 114,833 shares; 2025Q1: 114,833 shares; 2025Q2: 114,833 shares; 2025Q3: 114,833 shares; 2025Q4: 271,406 shares; 2026Q1: 905,191 shares 905,191$35.5M0.2%+633,785Timeline
PRLDPRELUDE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 10,123,824 shares; 2024Q4: 10,123,824 shares; 2025Q1: 10,123,824 shares; 2025Q2: 10,123,824 shares; 2025Q3: 10,123,824 shares; 2025Q4: 10,123,824 shares; 2026Q1: 10,123,824 shares 10,123,824$34.6M0.2%0Timeline
DBVTDBV TECHNOLOGIES S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,461,425 shares; 2025Q1: 1,461,425 shares; 2025Q2: 1,461,425 shares; 2025Q3: 1,461,425 shares; 2025Q4: 1,461,425 shares; 2026Q1: 1,461,425 shares 1,461,425$30.5M0.18%0Timeline
DSGNDESIGN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,743,725 shares; 2024Q4: 1,743,725 shares; 2025Q1: 1,743,725 shares; 2025Q2: 1,712,882 shares; 2025Q3: 1,712,882 shares; 2025Q4: 2,233,099 shares; 2026Q1: 2,585,978 shares 2,585,978$27.5M0.16%+352,879Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,227,178 shares; 2024Q4: 1,227,178 shares; 2025Q1: 1,227,178 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 670,751 shares; 2026Q1: 670,751 shares 670,751$26.6M0.15%0Timeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,484,226 shares; 2025Q3: 4,250,826 shares; 2025Q4: 4,250,826 shares; 2026Q1: 4,975,826 shares 4,975,826$23.4M0.13%+725,000Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,641,137 shares; 2026Q1: 1,641,137 shares 1,641,137$23.1M0.13%0Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 77,050 shares; 2025Q1: 77,050 shares; 2025Q2: 337,050 shares; 2025Q3: 337,050 shares; 2025Q4: 337,050 shares; 2026Q1: 349,657 shares 349,657$22.4M0.13%+12,607Timeline
IMCRIMMUNOCORE HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,515,318 shares; 2024Q4: 1,515,318 shares; 2025Q1: 2,322,656 shares; 2025Q2: 2,322,656 shares; 2025Q3: 2,322,656 shares; 2025Q4: 2,322,656 shares; 2026Q1: 734,397 shares 734,397$22.1M0.13%-1,588,259Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 993,679 shares; 2024Q4: 993,679 shares; 2025Q1: 347,408 shares; 2025Q2: 370,208 shares; 2025Q3: 370,208 shares; 2025Q4: 370,208 shares; 2026Q1: 370,208 shares 370,208$21.5M0.12%0Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 247,644 shares; 2024Q4: 247,644 shares; 2025Q1: 247,644 shares; 2025Q2: 665,370 shares; 2025Q3: 665,370 shares; 2025Q4: 665,370 shares; 2026Q1: 665,370 shares 665,370$21.1M0.12%0Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 456,015 shares; 2024Q4: 674,450 shares; 2025Q1: 1,486,200 shares; 2025Q2: 991,691 shares; 2025Q3: 991,691 shares; 2025Q4: 991,691 shares; 2026Q1: 991,691 shares 991,691$20M0.11%0Timeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 847,390 shares 847,390$19.5M0.11%newTimeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 100,000 shares; 2025Q2: 100,000 shares; 2025Q3: 100,000 shares; 2025Q4: 903,400 shares; 2026Q1: 607,788 shares 607,788$18.8M0.11%-295,612Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 312,500 shares; 2024Q4: 312,500 shares; 2025Q1: 312,500 shares; 2025Q2: 312,500 shares; 2025Q3: 77,670 shares; 2025Q4: 1,420,838 shares; 2026Q1: 1,420,838 shares 1,420,838$18.6M0.11%0Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 111,904 shares; 2024Q4: 111,904 shares; 2025Q1: 77,760 shares; 2025Q2: 37,760 shares; 2025Q3: 37,760 shares; 2025Q4: 25,174 shares; 2026Q1: 25,174 shares 25,174$18.4M0.11%0Timeline
CERSCERUS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 19,477,339 shares; 2024Q4: 19,477,339 shares; 2025Q1: 19,351,087 shares; 2025Q2: 12,883,844 shares; 2025Q3: 10,008,345 shares; 2025Q4: 10,008,345 shares; 2026Q1: 10,008,345 shares 10,008,345$18.2M0.1%0Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,004,756 shares; 2024Q4: 4,004,756 shares; 2025Q1: 4,004,756 shares; 2025Q2: 4,004,756 shares; 2025Q3: 4,004,756 shares; 2025Q4: 4,004,756 shares; 2026Q1: 4,004,756 shares 4,004,756$17.9M0.1%0Timeline
AKTSAKTIS ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 996,351 shares 996,351$17.8M0.1%newTimeline
GENBGENERATE BIOMEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,423,602 shares 1,423,602$17.8M0.1%newTimeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 400,000 shares; 2025Q2: 400,000 shares; 2025Q3: 400,000 shares; 2025Q4: 400,000 shares; 2026Q1: 400,000 shares 400,000$16M0.09%0Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 672,096 shares; 2024Q4: 672,096 shares; 2025Q1: 672,096 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 813,449 shares; 2026Q1: 813,449 shares 813,449$14.7M0.08%0Timeline
XNCRXENCOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 670,431 shares; 2024Q4: 670,431 shares; 2025Q1: 670,431 shares; 2025Q2: 670,431 shares; 2025Q3: 1,102,106 shares; 2025Q4: 1,102,106 shares; 2026Q1: 1,102,106 shares 1,102,106$13.3M0.08%0Timeline
CMPSCOMPASS PATHWAYS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 2,344,720 shares 2,344,720$13M0.07%newTimeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,160,117 shares; 2024Q4: 1,160,117 shares; 2025Q1: 1,160,117 shares; 2025Q2: 1,160,117 shares; 2025Q3: 1,160,117 shares; 2025Q4: 1,160,117 shares; 2026Q1: 1,160,117 shares 1,160,117$11.5M0.07%0Timeline
SERASERA PROGNOSTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,434,399 shares; 2024Q4: 5,434,399 shares; 2025Q1: 5,498,170 shares; 2025Q2: 5,498,170 shares; 2025Q3: 5,498,170 shares; 2025Q4: 5,498,170 shares; 2026Q1: 5,498,170 shares 5,498,170$11.2M0.06%0Timeline
BNTXBIONTECH SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 45,031 shares; 2025Q1: 45,031 shares; 2025Q2: 368,923 shares; 2025Q3: 368,923 shares; 2025Q4: 368,923 shares; 2026Q1: 119,743 shares 119,743$10.6M0.06%-249,180Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 375,000 shares; 2025Q4: 375,000 shares; 2026Q1: 375,000 shares 375,000$10.6M0.06%0Timeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 270,000 shares; 2026Q1: 415,621 shares 415,621$8.98M0.05%+145,621Timeline
MPLTMAPLIGHT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 364,705 shares; 2026Q1: 364,705 shares 364,705$7.41M0.04%0Timeline
ABSIABSCI CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,134,803 shares; 2026Q1: 2,134,803 shares 2,134,803$6.4M0.04%0Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 344,063 shares; 2024Q4: 344,063 shares; 2025Q1: 344,063 shares; 2025Q2: 344,063 shares; 2025Q3: 344,063 shares; 2025Q4: 344,063 shares; 2026Q1: 822,638 shares 822,638$5.96M0.03%+478,575Timeline
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 97,314 shares; 2024Q4: 97,314 shares; 2025Q1: 97,314 shares; 2025Q2: 97,314 shares; 2025Q3: 148,314 shares; 2025Q4: 148,314 shares; 2026Q1: 148,314 shares 148,314$5.88M0.03%0Timeline
EIKNEIKON THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 555,555 shares 555,555$5.88M0.03%newTimeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 536,832 shares; 2024Q4: 536,832 shares; 2025Q1: 536,832 shares; 2025Q2: 536,832 shares; 2025Q3: 536,832 shares; 2025Q4: 971,614 shares; 2026Q1: 971,614 shares 971,614$5.06M0.03%0Timeline
SGMTSAGIMET BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,381,898 shares; 2024Q4: 952,996 shares; 2025Q1: 952,996 shares; 2025Q2: 952,996 shares; 2025Q3: 952,996 shares; 2025Q4: 952,996 shares; 2026Q1: 952,996 shares 952,996$4.98M0.03%0Timeline
LBRXLB PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 200,000 shares; 2025Q4: 200,000 shares; 2026Q1: 200,000 shares 200,000$4.93M0.03%0Timeline
VSTMVERASTEM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 584,757 shares 584,757$3.1M0.02%newTimeline
TCRXTSCAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,784,792 shares; 2024Q4: 2,784,792 shares; 2025Q1: 2,784,792 shares; 2025Q2: 2,784,792 shares; 2025Q3: 2,784,792 shares; 2025Q4: 2,784,792 shares; 2026Q1: 2,784,792 shares 2,784,792$2.81M0.02%0Timeline
SKYESKYE BIOSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,434,634 shares; 2024Q4: 1,450,638 shares; 2025Q1: 1,450,638 shares; 2025Q2: 1,450,638 shares; 2025Q3: 1,450,638 shares; 2025Q4: 1,450,638 shares; 2026Q1: 1,575,243 shares 1,575,243$968K0.01%+124,605Timeline
SANASANA BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,380,949 shares; 2024Q4: 2,380,949 shares; 2025Q1: 2,030,949 shares; 2025Q2: 2,030,949 shares; 2025Q3: 2,030,949 shares; 2025Q4: 310,483 shares; 2026Q1: 310,483 shares 310,483$894K0.01%0Timeline
ALGSALIGOS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 83,055 shares; 2024Q4: 83,055 shares; 2025Q1: 83,055 shares; 2025Q2: 83,055 shares; 2025Q3: 83,055 shares; 2025Q4: 83,055 shares; 2026Q1: 83,055 shares 83,055$617K<0.01%0Timeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 10,607 shares; 2024Q4: 10,607 shares; 2025Q1: 10,607 shares; 2025Q2: 10,607 shares; 2025Q3: 10,607 shares; 2025Q4: 10,607 shares; 2026Q1: 10,607 shares 10,607$406K<0.01%0Timeline
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 833,333 shares; 2024Q4: 833,333 shares; 2025Q1: 833,333 shares; 2025Q2: 833,333 shares; 2025Q3: 833,333 shares; 2025Q4: 833,333 shares; 2026Q1: 833,333 shares 833,333$13.3K<0.01%0Timeline

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
CELCUITY INCCELCUITY INC30,750,000$66.6Mprincipal
RAREULTRAGENYX PHARMACEUTICAL IN2,772,692$63.8Mshares
TERNTERNS PHARMACEUTICALS INC950,000$38.4Mshares
BCRXBIOCRYST PHARMACEUTICALS INC2,822,727$22Mshares
VTYXVENTYX BIOSCIENCES INC2,349,280$21.2Mshares
NUVLNUVALENT INC143,937$14.5Mshares
FDMT4D MOLECULAR THERAPEUTICS IN475,737$3.57Mshares
VIRVIR BIOTECHNOLOGY INC542,539$3.27Mshares
KALAKALA BIO INC1,804,055$1Mshares
ACRVACRIVON THERAPEUTICS INC22,809$55Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-26-062547 base2026-05-15acceptance time not in the bulk data set